Spinal cord GLT-1 glutamate transporter and blood glutamic acid alterations in motor neuron degeneration (Mnd) mice

Journal of the Neurological Sciences

Volumn 157, Issue 1, 1998, Pages 31-36

  Mennini, T ^a   Bastone, A ^a   Crespi, D ^a   Comoletti, D ^a   Manzoni, C ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Dopamine; Glutamate transporters; Motor neuron degeneration; Serotonin; Spinal cord; Uptake

Indexed keywords

GLUTAMIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLINDNESS; DOPAMINE BRAIN LEVEL; MALE; MOTOR NEURON DISEASE; MOUSE; NERVE DEGENERATION; NEUROLOGIC DISEASE; NEURONAL CEROID LIPOFUSCINOSIS; NONHUMAN; PRIORITY JOURNAL; SEROTONIN BRAIN LEVEL; SYNAPTOSOME;

AMINO ACID TRANSPORT SYSTEM X-AG; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CORPUS STRIATUM; DOPAMINE; GLUTAMIC ACID; HIPPOCAMPUS; IMMUNOBLOTTING; MALE; MICE; MOTOR NEURONS; NERVE DEGENERATION; SEROTONIN; SPINAL CORD;

EID: 0032522699     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-510X(98)00072-0     Document Type: Article

References (28)

1. Bastone A, Micheli A, Beghi E, Salmona M The imbalance of brain large-chain amino acid availability in amyotrophic lateral sclerosis patients treated with high doses of branched-chain amino acids. Neurochem Int. 27:1995;467-472.
2. Battaglioli G, Martin DL, Plummer J, Messer A Synaptosomal glutamate uptake declines progressively in the spinal cord of a mutant mouse with motor neuron disease. J Neurochem. 60:1993;1567-1569.
3. Bronson RT, Lake BD, Path F, Cook S, Taylor S, Davisson MT Motor neuron degeneration of mice is a model of neuronal ceroid lipofuscinosis (Batten's disease). Ann Neurol. 33:1993;381-385.
4. Bruijn LI, Becher MW, Lee MKet al. ALS-Linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD-1 containing inclusions. Neuron. 18:1997;327-338.
5. +)-ATPase activity in brain slices and synaptosomes by arachidonic acid. J Neurochem. 40:1983;309-316.
6. +] coupled L-glutamate transporter purified from rat brain is located in glial cell processes. Neuroscience. 51:1992;295-310.
7. 3H]serotonin. Naunyn-Schmiedeberg's Arch Pharmacol. 345:1992;1-6.
8. Kanai Y, Hediger MA Primary structure and functional characterization of a high-affinity glutamate transporter. Nature. 360:1992;467-471.
9. Kanai Y, Smith CP, Hediger MA A new family of neurotransmitter transporters: the high-affinity glutamate transporters. FASEB J. 8:1994;1450-1459.
10. Mennini T, Mocaer E, Garattini S Tianeptine, a selective enhancer of serotonin uptake in rat brain. Naunyn-Schmiedeberg's Arch Pharmacol. 336:1987;478-482.
11. Messer A, Strominger NL, Mazurkiewicz JE Histopathology of the late-onset motor neuron degeneration (Mnd) mutant in the mouse. J Neurogenet. 4:1987;201-213.
12. Messer A, Plummer J Accumulating autofluorescent material as a marker for early changes in the spinal cord of the Mnd mouse. Neuromusc Disord. 3:1993;129-134.
13. Messer A, Flaherty L Autosomal dominance in a late-onset motor neuron disease in the mouse. J Neurogenet. 3:1986;345-355.
14. Pardo CA, Rabin BA, Palmer DN, Price DL Accumulation of the adenosine triphosphate synthase subunit c in the Mnd mutant mouse. Am J Pathol. 144:1994;829-835.
15. Pardridge WM. Regulation of amino acid availability to brain: selective control mechanisms for glutamate. In: Filer LJ, Garattini S, Kare MR, Reynolds WA, Wurtman RJ, editors. Glutamic acid: advances in biochemistry and physiology. New York: Raven Press, 1979:125-137.
16. Pines G, Danbolt NC, Bjorås Met al. Cloning and expression of a rat brain L-glutamate transporter. Nature. 360:1992;464-467.
17. 3H-glutamate transport in synaptosomes. Synapse. 18:1994;21-26.
18. Rothstein JD, Martin LJ, Kuncl RW Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N Engl J Med. 326:1992;1464-1468.
19. Rothstein JD, Martin L, Levey AIet al. Localization of neuronal and glial glutamate transporters. Neuron. 13:1994;713-725.
20. Rothstein JD. Excitotoxic mechanisms in the pathogenesis of amyotrophic lateral sclerosis. In: Serratrice G, Munsat T, editors. Pathogenesis and therapy of amyotrophic lateral sclerosis. Philadelphia: Lippincott-Raven, 1995:7-27.
21. Rothstein JD, Kuncl RW Neuroprotective strategies in a model of chronic glutamate-mediated motor neuron toxicity. J Neurochem. 65:1995;643-651.
22. Rothstein JD, Van Kammen M, Levey AI, Martin LJ, Kuncl RW Selective loss of glial glutamate transporter glt-1 in amyotrophic lateral sclerosis. Ann Neurol. 38:1995;73-84.
23. Rothstein JD, Dykes-Hoberg M, Pardo CAet al. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron. 16:1996;675-686.
24. +-dependent glutamate/aspartate transporter from rat brain. Proc Natl Acad Sci USA. 89:1992;10955-10959.
25. Stotz EH, Palacios JM, Landwehrmeyer Bet al. Alterations in dopamine and serotonin uptake systems in the striatum of the weaver mutant mouse. J Neural Transm. 97:1994;51-64.
26. Tellez-Nagel I, Johnson AB, Terry RD Ultrastructural and histochemical study of cerebral biopsies in Huntington's Chorea. Adv Neurol. 1:1973;387-398.
27. Volterra A, Trotti D, Cassutti Pet al. High sensitivity of glutamate uptake to extracellular free arachidonic acid levels in rat cortical synaptosomes and astrocytes. J Neurochem. 59:1992;600-606.
28. Volterra A, Trotti D, Troma C, Floridi S, Racagni G Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes. J Neurosci. 14:1994;2924-2932.