Neuronal hyperexcitability and seizures are associated with changes in glial-neuronal interactions in the hippocampus of a mouse model of epilepsy with mental retardation

Journal of Neurochemistry

Volumn 115, Issue 6, 2010, Pages 1445-1454

  Melø, Torun ^a   Bigini, Paolo ^b   Sonnewald, Ursula ^a   Balosso, Silvia ^b   Cagnotto, Alfredo ^b   Barbera, Sara ^b   Uboldi, Sarah ^b   Vezzani, Annamaria ^b   Mennini, Tiziana ^b  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

13C nuclear magnetic resonance spectroscopy; astrocytes and microglia; glutamate and GABA; hippocampus; neuronal ceroid lipofuscinosis; seizures

Indexed keywords

4 AMINOBUTYRIC ACID; ALANINE; AMINO ACID; ASPARTIC ACID; CD11B ANTIGEN; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; INTERLEUKIN 1BETA; KAINIC ACID; N ACETYLASPARTIC ACID; PROTEIN C FOS; SERINE; TAURINE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL ACTIVATION; CELL INTERACTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; ENCEPHALITIS; EPILEPSY; FEMALE; GENE OVEREXPRESSION; GLIA CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; IMMUNOREACTIVITY; LATENT PERIOD; MENTAL DEFICIENCY; MOUSE; NERVE CELL; NERVE CELL EXCITABILITY; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; SEIZURE; SPIKE;

ANIMALS; CELL COMMUNICATION; DISEASE MODELS, ANIMAL; EPILEPSY; FEMALE; HIPPOCAMPUS; MENTAL RETARDATION; MICE; MICE, INBRED C57BL; NEUROGLIA; NEURONS; SEIZURES;

MUS;

EID: 78649995400     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.07048.x     Document Type: Article

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