A single-monomer derived linear-like PEI-co-PEG for siRNA delivery and silencing

Biomaterials

Volumn 32, Issue 14, 2011, Pages 3647-3653

  Tsai, Lin Ren ^a   Chen, Min Hua ^a   Chien, Chih Te ^a   Chen, Meng Kai ^a   Lin, Fong Sian ^b   Lin, Kurt Ming Chao ^a   Hwu, Yeu Kuang ^c   Yang, Chung Shi ^a,b   Lin, Shu Yi ^a  

^a NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c INSTITUTE OF PHYSICS   (Taiwan)

Author keywords

A non toxic vehicle; A single monomer copolymerization; Enhanced siRNA release and mRNA silencing; Linear like polyethylenimine co poly(ethylene glycol); LPEI co PEG; Synchrotron X rays irradiation

Indexed keywords

A NON-TOXIC VEHICLE; A SINGLE-MONOMER COPOLYMERIZATION; ENHANCED SIRNA RELEASE AND MRNA SILENCING; LINEAR-LIKE POLYETHYLENIMINE-CO-POLY(ETHYLENE GLYCOL); LPEI-CO-PEG; SYNCHROTRON X-RAYS IRRADIATION;

COMPLEXATION; COPOLYMERIZATION; COPOLYMERS; ETHYLENE; ETHYLENE GLYCOL; IRRADIATION; MONOMERS; NUCLEIC ACIDS; PHOTOLUMINESCENCE; POLYETHYLENE OXIDES; SYNCHROTRONS; TOXIC MATERIALS; VEHICLES; X RAYS;

POLYETHYLENE GLYCOLS;

COPOLYMER; GREEN FLUORESCENT PROTEIN; LIPOFECTAMINE; MACROGOL DERIVATIVE; POLYETHYLENEIMINE DERIVATIVE; SMALL INTERFERING RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER INHIBITION; COMPLEX FORMATION; CONTROLLED STUDY; CYTOTOXICITY TEST; ENZYME DEGRADATION; FEMALE; GENE FUNCTION; GENE SILENCING; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PHOTOLUMINESCENCE; POLYMERIZATION; PRIORITY JOURNAL; SYNCHROTRON; SYNTHESIS; X IRRADIATION;

ANIMALS; CELL LINE, TUMOR; GENE SILENCING; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MICROSCOPY, CONFOCAL; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; RNA INTERFERENCE; RNA, SMALL INTERFERING; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79952107509     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.01.059     Document Type: Article

References (39)

1. Boussif O., Lezoualc'h F., Zanta M.A., Mergny M.D., Scherman D., Demeneix B., et al. A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc Natl Acad Sci U S A 1995, 92(16):7297-7301.
2. Verma I.M., Somia N. Gene therapy-promises, problems and prospects. Nature 1997, 389(6648):239-242.
3. Merdan T., Kopecek J., Kissel T. Prospects for cationic polymers in gene and oligonucleotide therapy against cancer. Adv Drug Deliv Rev 2002, 54(5):715-758.
4. Niidome T., Huang L. Gene therapy progress and prospects: nonviral vectors. Gene Ther 2002, 9(24):1647-1652.
5. Pack D.W., Hoffman A.S., Pun S., Stayton P.S. Design and development of polymers for gene delivery. Nat Rev Drug Discov 2005, 4(7):581-593.
6. Sontheimer E.J. Assembly and function of RNA silencing complexes. Nat Rev Mol Cell Biol 2005, 6(2):127-138.
7. Urban-Klein B., Werth S., Abuharbeid S., Czubayko F., Aigner A. RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo. Gene Ther 2005, 12(5):461-466.
8. De Laporte L., Cruz Rea J., Shea L.D. Design of modular non-viral gene therapy vectors. Biomaterials 2006, 27(7):947-954.
9. Putnam D. Polymers for gene delivery across length scales. Nat Mater 2006, 5(6):439-451.
10. Bolcato-Bellemin A.L., Bonnet M.E., Creusatt G., Erbacher P., Behr J.P. Sticky overhangs enhance siRNA-mediated gene silencing. Proc Natl Acad Sci U S A 2007, 104(41):16050-16055.
11. Zhang S., Zhao B., Jiang H., Wang B., Ma B. Cationic lipids and polymers mediated vectors for delivery of siRNA. J Control Release 2007, 123(1):1-10.
12. Schaffert D., Wagner E. Gene therapy progress and prospects: synthetic polymer-based systems. Gene Ther 2008, 15(16):1131-1138.
13. Mintzer M.A., Simanek E.E. Nonviral vectors for gene delivery. Chem Rev 2009, 109(2):259-302.
14. Rao D.D., Vorhies J.S., Senzer N., Nemunaitis J. siRNA vs. shRNA: similarities and differences. Adv Drug Deliv Rev 2009, 61(9):746-759.
15. Frohlich T., Wagner E. Peptide- and polymer-based delivery of therapeutic RNA. Soft Matter 2010, 6(2):226-234.
16. Behr J.P. The proton sponge: a trick to enter cells the viruses did not exploit. Chimia 1997, 51:34-36.
17. Sonawane N.D., Szoka F.C., Verkman A.S. Chloride accumulation and swelling in endosomes enhances DNA transfer by polyamine-DNA polyplexes. J Biol Chem 2003, 278(45):44826-44831.
18. Ziebarth J.D., Wang Y. Understanding the protonation behavior of linear polyethylenimine in solutions through Monte Carlo simulations. Biomacromolecules 2010, 11(1):29-38.
19. Fischer D., Bieber T., Li Y.X., Elsasser H.P., Kissel T. A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethylenimine: effect of molecular weight on transfection efficiency and cytotoxicity. Pharm Res 1999, 16(8):1273-1279.
20. Bieber T., Meissner W., Kostin S., Niemann A., Elsasser H.P. Intracellular route and transcriptional competence of polyethylenimine-DNA complexes. J Control Release 2002, 82(2-3):441-454.
21. Kunath K., von Harpe A., Fischer D., Petersen H., Bickel U., Voigt K., et al. Low-molecular-weight polyethylenimine as a non-viral vector for DNA delivery: comparison of physicochemical properties, transfection efficiency and in vivo distribution with high-molecular-weight polyethylenimine. J Control Release 2003, 89(1):113-125.
22. Kawakami S., Ito Y., Charoensit P., Yamashita F., Hashida M. Evaluation of proinflammatory cytokine production induced by linear and branched polyethylenimine/plasmid DNA complexes in mice. J Pharmacol Exp Ther 2006, 317(3):1382-1390.
23. Bonnet M.E., Erbacher P., Bolcato-Bellemin A.L. Systemic delivery of DNA or siRNA mediated by linear polyethylenimine (L-PEI) does not induce an inflammatory response. Pharm Res 2008, 25(12):2972-2982.
24. Hassani Z., Lemkine G.F., Erbacher P., Palmier K., Alfama G., Giovannangeli C., et al. Lipid-mediated siRNA delivery down-regulates exogenous gene expression in the mouse brain at picomolar levels. J Gene Med 2005, 7(2):198-207.
25. Niola F., Evangelisti C., Campagnolo L., Massalini S., Bue M.C., Mangiola A., et al. A plasmid-encoded VEGF siRNA reduces glioblastoma angiogenesis and its combination with interleukin-4 blocks tumor growth in a xenograft mouse model. Cancer Biol Ther 2006, 5(2):174-179.
26. Petersen H., Fechner P.M., Fischer D., Kissel T. Synthesis, characterization, and biocompatibility of polyethylenimine-graft-poly(ethylene glycol) block copolymers. Macromolecules 2002, 35(18):6867-6874.
27. Jere D., Xu C.X., Arote R., Yun C.H., Cho M.H., Cho C.S. Poly(beta-amino ester) as a carrier for si/shRNA delivery in lung cancer cells. Biomaterials 2008, 29(16):2535-2547.
28. Meyer M., Philipp A., Oskuee R., Schmidt C., Wagner E. Breathing life into polycations: functionalization with pH-responsive endosomolytic peptides and polyethylene glycol enables siRNA delivery. J Am Chem Soc 2008, 130(11):3272-3273.
29. Zintchenko A., Philipp A., Dehshahri A., Wagner E. Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity. Bioconjug Chem 2008, 19(7):1448-1455.
30. Beyerle A., Irmler M., Beckers J., Kissel T., Stoeger T. Toxicity pathway focused gene expression profiling of PEI-based polymers for pulmonary applications. Mol Pharmacol 2010, 7(3):727-737.
31. Kem K.M. Kinetics of the hydrolysis of linear poly[(acylimino)-ethylenes]. J Polym Sci Part A Polym Chem 1979, 17(7):1977-1990.
32. Lin S.Y., Lin F.S., Chen M.K., Tsai L.R., Jao Y.C., Lin H.Y., et al. One-pot synthesis of linear-like and photoluminescent polyethylenimines for intracellular imaging and siRNA delivery. Chem Commun 2010, 46(30):5554-5556.
33. Mao S., Neu M., Germershaus O., Merkel O., Sitterberg J., Bakowsky U., et al. Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes. Bioconjug Chem 2006, 17(5):1209-1218.
34. Clough R.L. High-energy radiation and polymers: a submitted for publication of commercial processes and emerging applications. Nucl Instrum Methods Phys Res B 2001, 185:8-33.
35. Podzimek S., Vlcek T., Johann C. Characterization of branched polymers by size exclusion chromatography coupled with multiangle light scattering detector. I. Size exclusion chromatography elution behavior of branched polymers. J Appl Polym Sci 2001, 81(7):1588-1594.
36. Pastor-Perez L., Chen Y., Shen Z., Lahoz A., Stiriba S.E. Unprecedented blue intrinsic photoluminescence from hyperbranched and linear polyethylenimines: polymer architectures and pH-effects. Macromol Rapid Commun 2007, 28(13):1404-1409.
37. Yemul O., Imae T. Synthesis and characterization of poly(ethyleneimine) dendrimers. Colloid Polym Sci 2008, 286(7):747-752.
38. Klemm A.R., Young D., Lloyd J.B. Effects of polyethyleneimine on endocytosis and lysosome stability. Biochem Pharmacol 1998, 56(1):41-46.
39. Hicklin D.J., Ellis L.M. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005, 23(5):1011-1027.