메뉴 건너뛰기




Volumn 119, Issue 7, 2012, Pages 747-757

CSF markers in amyotrophic lateral sclerosis

Author keywords

Amyotrophic lateral sclerosis; Biomarker; Blood brain barrier; Blood CSF barrier; Cerebrospinal fluid; Motor neuron disease

Indexed keywords

3 NITROTYROSINE; 4 HYDROXYNONENAL; 8 HYDROXYDEOXYGUANOSINE; ALBUMIN; AMYLOID BETA PROTEIN[1-42]; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; COPPER ZINC SUPEROXIDE DISMUTASE; CYSTATIN C; GELATINASE A; GELATINASE B; GLUTAMIC ACID; GLUTATHIONE; GLUTATHIONE PEROXIDASE; IMMUNOGLOBULIN G; INTERLEUKIN 6; INTERLEUKIN 8; IRON; NEUROFILAMENT PROTEIN; NITRATE; PEROXYNITRITE; PIGMENT EPITHELIUM DERIVED FACTOR; PROGRANULIN; PROSTAGLANDIN E2; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE; TAR DNA BINDING PROTEIN; TAU PROTEIN; UNINDEXED DRUG; URIC ACID; VASCULOTROPIN;

EID: 84863462965     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-012-0806-y     Document Type: Review
Times cited : (51)

References (136)
  • 4
    • 0034113502 scopus 로고    scopus 로고
    • Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegenerative diseases
    • Aoyama K, Matsubara K, Fujikawa Y, Nagahiro Y, Shimizu K, Umegae N, Hayase N, Shiono H, Kobayashi S (2000) Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegenerative diseases. Ann Neurol 47:524-527
    • (2000) Ann Neurol , vol.47 , pp. 524-527
    • Aoyama, K.1    Matsubara, K.2    Fujikawa, Y.3    Nagahiro, Y.4    Shimizu, K.5    Umegae, N.6    Hayase, N.7    Shiono, H.8    Kobayashi, S.9
  • 6
    • 2342471420 scopus 로고    scopus 로고
    • The blood-brain barrier: An overview: Structure, regulation, and clinical implications
    • Ballabh P, Braun A, Nedergaard M (2004) The blood-brain barrier: an overview: structure, regulation, and clinical implications. Neurobiol Dis 16:1-13
    • (2004) Neurobiol Dis , vol.16 , pp. 1-13
    • Ballabh, P.1    Braun, A.2    Nedergaard, M.3
  • 7
    • 0025937118 scopus 로고
    • Amyotrophic lateral sclerosis: Changes of noradrenergic and serotonergic transmitter systems in the spinal cord
    • Bertel O, Malessa S, Sluga E, Hornykiewicz O (1991) Amyotrophic lateral sclerosis: changes of noradrenergic and serotonergic transmitter systems in the spinal cord. Brain Res 566:54-60
    • (1991) Brain Res , vol.566 , pp. 54-60
    • Bertel, O.1    Malessa, S.2    Sluga, E.3    Hornykiewicz, O.4
  • 8
    • 0034626855 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 is elevated in serum of patients with amyotrophic lateral sclerosis
    • Beuche W, Yushchenko M, Mäder M, Maliszewska M, Felgenhauer K, Weber F (2000) Matrix metalloproteinase-9 is elevated in serum of patients with amyotrophic lateral sclerosis. NeuroReport 11:3419-3422
    • (2000) NeuroReport , vol.11 , pp. 3419-3422
    • Beuche, W.1    Yushchenko, M.2    Mäder, M.3    Maliszewska, M.4    Felgenhauer, K.5    Weber, F.6
  • 9
    • 0032796456 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration
    • Bilak MM, Corse AM, Bilak SR, Lehar M, Tombran-Tink J, Kuncl RW (1999) Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration. J Neuropathol Exp Neurol 58:719-728
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 719-728
    • Bilak, M.M.1    Corse, A.M.2    Bilak, S.R.3    Lehar, M.4    Tombran-Tink, J.5    Kuncl, R.W.6
  • 10
    • 33749056809 scopus 로고    scopus 로고
    • ALS: A disease of motor neurons and their nonneuronal neighbors
    • Boillée S, Vande Velde C, Cleveland DW (2006a) ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron 52:39-59
    • (2006) Neuron , vol.52 , pp. 39-59
    • Boillée, S.1    Vande Velde, C.2    Cleveland, D.W.3
  • 14
    • 33645806333 scopus 로고    scopus 로고
    • Axonal damage markers in the cerebrospinal fluid of patients with clinically isolated syndrome improve predicting conversion to definite multiple sclerosis
    • Brettschneider J, Petzold A, Junker A, Tumani H (2006a) Axonal damage markers in the cerebrospinal fluid of patients with clinically isolated syndrome improve predicting conversion to definite multiple sclerosis. Mult Scler 12:143-148
    • (2006) Mult Scler , vol.12 , pp. 143-148
    • Brettschneider, J.1    Petzold, A.2    Junker, A.3    Tumani, H.4
  • 19
    • 3943102116 scopus 로고    scopus 로고
    • Unraveling the mechanisms involved in motor neuron degeneration in ALS
    • Bruijn LI, Miller TM, Cleveland DW (2004) Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci 27:723-749
    • (2004) Annu Rev Neurosci , vol.27 , pp. 723-749
    • Bruijn, L.I.1    Miller, T.M.2    Cleveland, D.W.3
  • 20
    • 17444419749 scopus 로고    scopus 로고
    • Beta-amyloid 42 accumulation in the lumbar spinal cord motor neurons of amyotrophic lateral sclerosis patients
    • Calingasan NY, Chen J, Kiaei M, Beal MF (2005) Beta-amyloid 42 accumulation in the lumbar spinal cord motor neurons of amyotrophic lateral sclerosis patients. Neurobiol Dis 19: 340-347
    • (2005) Neurobiol Dis , vol.19 , pp. 340-347
    • Calingasan, N.Y.1    Chen, J.2    Kiaei, M.3    Beal, M.F.4
  • 21
    • 59349113948 scopus 로고    scopus 로고
    • Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia
    • Candelario-Jalil E, Yang Y, Rosenberg GA (2009) Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia. Neuroscience 158:983-994
    • (2009) Neuroscience , vol.158 , pp. 983-994
    • Candelario-Jalil, E.1    Yang, Y.2    Rosenberg, G.A.3
  • 22
    • 0034530030 scopus 로고    scopus 로고
    • Oxidation versus aggregation-how doSOD1 mutants cause ALS?
    • Cleveland DW, Liu J (2000) Oxidation versus aggregation-how doSOD1 mutants cause ALS? Nat Med 6:1320-1321
    • (2000) Nat Med , vol.6 , pp. 1320-1321
    • Cleveland, D.W.1    Liu, J.2
  • 23
  • 26
    • 12344286247 scopus 로고    scopus 로고
    • The pro and the active form of matrix metalloproteinase-9 is increased in serum of patients with amyotrophic lateral sclerosis
    • Demestre M, Parkin-Smith G, Petzold A, Pullen AH (2005) The pro and the active form of matrix metalloproteinase-9 is increased in serum of patients with amyotrophic lateral sclerosis. J Neuroimmunol 159:146-154
    • (2005) J Neuroimmunol , vol.159 , pp. 146-154
    • Demestre, M.1    Parkin-Smith, G.2    Petzold, A.3    Pullen, A.H.4
  • 28
    • 0029753270 scopus 로고    scopus 로고
    • The pharmacology and mechanism of action of riluzole
    • Doble A (1996) The pharmacology and mechanism of action of riluzole. Neurology 47:S233-S241
    • (1996) Neurology , vol.47
    • Doble, A.1
  • 29
    • 0034995073 scopus 로고    scopus 로고
    • S100: A multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles
    • Donato R (2001) S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol 33:637-668
    • (2001) Int J Biochem Cell Biol , vol.33 , pp. 637-668
    • Donato, R.1
  • 30
    • 33749002256 scopus 로고    scopus 로고
    • Regulation of immune cell entry into the central nervous system
    • Engelhardt B (2006) Regulation of immune cell entry into the central nervous system. Results Probl Cell Differ 43:259-280
    • (2006) Results Probl Cell Differ , vol.43 , pp. 259-280
    • Engelhardt, B.1
  • 32
    • 47249153535 scopus 로고    scopus 로고
    • Gender difference in levels of Cu/Zn superoxide dismutase (SOD1) in cerebrospinal fluid of patients with amyotrophic lateral sclerosis
    • Frutiger K, Lukas TJ, Gorrie G, Ajroud-Driss S, Siddique T (2008) Gender difference in levels of Cu/Zn superoxide dismutase (SOD1) in cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler 9:184-187
    • (2008) Amyotroph Lateral Scler , vol.9 , pp. 184-187
    • Frutiger, K.1    Lukas, T.J.2    Gorrie, G.3    Ajroud-Driss, S.4    Siddique, T.5
  • 33
    • 0032507891 scopus 로고    scopus 로고
    • Transglutaminase activity in serum and cerebrospinal fluid in sporadic amyotrophic lateral sclerosis: A possible use as an indicator of extent of the motor neuron loss
    • Fujita K, Honda M, Hayashi R, Ogawa K, Ando M, Yamauchi M, Nagata Y (1998) Transglutaminase activity in serum and cerebrospinal fluid in sporadic amyotrophic lateral sclerosis: a possible use as an indicator of extent of the motor neuron loss. J Neurol Sci 158:53-57
    • (1998) J Neurol Sci , vol.158 , pp. 53-57
    • Fujita, K.1    Honda, M.2    Hayashi, R.3    Ogawa, K.4    Ando, M.5    Yamauchi, M.6    Nagata, Y.7
  • 34
    • 79954414960 scopus 로고    scopus 로고
    • Combination of neurofilament heavy chain and complement C3 as CSF biomarkers for ALS
    • Ganesalingam J, An J, Shaw CE, Shaw G, Lacomis D, Bowser R (2011) Combination of neurofilament heavy chain and complement C3 as CSF biomarkers for ALS. J Neurochem 117:528-537
    • (2011) J Neurochem , vol.117 , pp. 528-537
    • Ganesalingam, J.1    An, J.2    Shaw, C.E.3    Shaw, G.4    Lacomis, D.5    Bowser, R.6
  • 35
  • 39
    • 32844471431 scopus 로고    scopus 로고
    • Matrix metalloproteinases and diseases of the central nervous system with a special emphasis on ischemic brain
    • Gasche Y, Soccal PM, Kanemitsu M, Copin JC (2006) Matrix metalloproteinases and diseases of the central nervous system with a special emphasis on ischemic brain. Front Biosci 11:1289-1301
    • (2006) Front Biosci , vol.11 , pp. 1289-1301
    • Gasche, Y.1    Soccal, P.M.2    Kanemitsu, M.3    Copin, J.C.4
  • 40
    • 0031033952 scopus 로고    scopus 로고
    • Synchronous synthesis of alpha- and beta-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis
    • Glabinski AR, Tani M, Strieter RM, Tuohy VK, Ransohoff RM (1997) Synchronous synthesis of alpha- and beta-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis. Am J Pathol 150:617-630
    • (1997) Am J Pathol , vol.150 , pp. 617-630
    • Glabinski, A.R.1    Tani, M.2    Strieter, R.M.3    Tuohy, V.K.4    Ransohoff, R.M.5
  • 43
    • 0344628897 scopus 로고    scopus 로고
    • Oligoclonal bands and blood-cerebrospinal-fluid barrier dysfunction in a subset of patients with Alzheimer disease: Comparison with vascular dementia, major depression, and multiple sclerosis
    • Hampel H, Kötter HU, Padberg F, Körschenhausen DA, Möller HJ (1999) Oligoclonal bands and blood-cerebrospinal-fluid barrier dysfunction in a subset of patients with Alzheimer disease: comparison with vascular dementia, major depression, and multiple sclerosis. Alzheimer Dis Assoc Disord 13:9-19
    • (1999) Alzheimer Dis Assoc Disord , vol.13 , pp. 9-19
    • Hampel, H.1    Kötter, H.U.2    Padberg, F.3    Körschenhausen, D.A.4    Möller, H.J.5
  • 44
    • 0029037348 scopus 로고
    • Natural history of amyotrophic lateral sclerosis in a database population. Validation of a scoring system and a model for survival prediction
    • Haverkamp LJ, Appel V, Appel SH (1995) Natural history of amyotrophic lateral sclerosis in a database population. Validation of a scoring system and a model for survival prediction. Brain 118(Pt 3):707-719
    • (1995) Brain , vol.118 , Issue.PART 3 , pp. 707-719
    • Haverkamp, L.J.1    Appel, V.2    Appel, S.H.3
  • 46
    • 67649391341 scopus 로고    scopus 로고
    • Decreased mRNA expression of tight junction proteins in lumbar spinal cords of patients with ALS
    • Henkel JS, Beers DR, Wen S, Bowser R, Appel SH (2009) Decreased mRNA expression of tight junction proteins in lumbar spinal cords of patients with ALS. Neurology 72:1614-1616
    • (2009) Neurology , vol.72 , pp. 1614-1616
    • Henkel, J.S.1    Beers, D.R.2    Wen, S.3    Bowser, R.4    Appel, S.H.5
  • 47
    • 13244275028 scopus 로고    scopus 로고
    • Oxidative stress and metal content in blood and cerebrospinal fluid of amyotrophic lateral sclerosis patients with and without a Cu, Znsuperoxide dismutase mutation
    • Ihara Y, Nobukuni K, Takata H, Hayabara T (2005) Oxidative stress and metal content in blood and cerebrospinal fluid of amyotrophic lateral sclerosis patients with and without a Cu, Znsuperoxide dismutase mutation. Neurol Res 27:105-108
    • (2005) Neurol Res , vol.27 , pp. 105-108
    • Ihara, Y.1    Nobukuni, K.2    Takata, H.3    Hayabara, T.4
  • 48
    • 3543056930 scopus 로고    scopus 로고
    • Cerebrospinal fluid vascular endothelial growth factor in patients with amyotrophic lateral sclerosis
    • Iłzecka J (2004) Cerebrospinal fluid vascular endothelial growth factor in patients with amyotrophic lateral sclerosis. Clin Neurol Neurosurg 106:289-293
    • (2004) Clin Neurol Neurosurg , vol.106 , pp. 289-293
    • Iłzecka, J.1
  • 49
    • 1242337428 scopus 로고    scopus 로고
    • The prevalence of oligoclonal bands in the CSF of patients with primary neurodegenerative dementia
    • Janssen JC, Godbolt AK, Ioannidis P, Thompson EJ, Rossor MN (2004) The prevalence of oligoclonal bands in the CSF of patients with primary neurodegenerative dementia. J Neurol 251:184-188
    • (2004) J Neurol , vol.251 , pp. 184-188
    • Janssen, J.C.1    Godbolt, A.K.2    Ioannidis, P.3    Thompson, E.J.4    Rossor, M.N.5
  • 52
    • 0026605961 scopus 로고
    • Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue
    • Kawamata T, Akiyama H, Yamada T, McGeer PL (1992) Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. Am J Pathol 140:691-707
    • (1992) Am J Pathol , vol.140 , pp. 691-707
    • Kawamata, T.1    Akiyama, H.2    Yamada, T.3    McGeer, P.L.4
  • 53
    • 0031840571 scopus 로고    scopus 로고
    • Roles of lipid peroxidation in modulation of cellular signaling pathways, cell dysfunction, and death in the nervous system
    • Keller JN, Mattson MP (1998) Roles of lipid peroxidation in modulation of cellular signaling pathways, cell dysfunction, and death in the nervous system. Rev Neurosci 9:105-116
    • (1998) Rev Neurosci , vol.9 , pp. 105-116
    • Keller, J.N.1    Mattson, M.P.2
  • 55
    • 0036074844 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor is elevated in CSF of patients with amyotrophic lateral sclerosis
    • Kuncl RW, Bilak MM, Bilak SR, Corse AM, Royal W, Becerra SP (2002) Pigment epithelium-derived factor is elevated in CSF of patients with amyotrophic lateral sclerosis. J Neurochem 81:178-184
    • (2002) J Neurochem , vol.81 , pp. 178-184
    • Kuncl, R.W.1    Bilak, M.M.2    Bilak, S.R.3    Corse, A.M.4    Royal, W.5    Becerra, S.P.6
  • 56
    • 31044438718 scopus 로고    scopus 로고
    • Activity and expression of glutathione S-transferase pi in patients with amyotrophic lateral sclerosis
    • Kuźma M, Jamrozik Z, Barańczyk-Kuźma A (2006) Activity and expression of glutathione S-transferase pi in patients with amyotrophic lateral sclerosis. Clin Chim Acta 364:217-221
    • (2006) Clin Chim Acta , vol.364 , pp. 217-221
    • Kuźma, M.1    Jamrozik, Z.2    Barańczyk-Kuźma, A.3
  • 57
    • 0029977337 scopus 로고    scopus 로고
    • Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis/riluzole study group II
    • Lacomblez L, Bensimon G, Leigh PN, Guillet P, Meininger V (1996) Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II. Lancet 347:1425-1431
    • (1996) Lancet , vol.347 , pp. 1425-1431
    • Lacomblez, L.1    Bensimon, G.2    Leigh, P.N.3    Guillet, P.4    Meininger, V.5
  • 60
    • 0021247422 scopus 로고
    • Cerebrospinal fluid (CSF) findings in amyotrophic lateral sclerosis
    • Leonardi A, Aβbruzzese G, Arata L, Cocito L, Vische M (1984) Cerebrospinal fluid (CSF) findings in amyotrophic lateral sclerosis. J Neurol 231:75-78
    • (1984) J Neurol , vol.231 , pp. 75-78
    • Leonardi, A.1    Abruzzese, G.2    Arata, L.3    Cocito, L.4    Vische, M.5
  • 61
    • 0023918762 scopus 로고
    • Comparison of sporadic and familial disease amongst 580 cases of motor neuron disease
    • Li TM, Alberman E, Swash M (1988) Comparison of sporadic and familial disease amongst 580 cases of motor neuron disease. J Neurol Neurosurg Psychiatry 51:778-784
    • (1988) J Neurol Neurosurg Psychiatry , vol.51 , pp. 778-784
    • Li, T.M.1    Alberman, E.2    Swash, M.3
  • 62
    • 0036787810 scopus 로고    scopus 로고
    • Inflammatory processes in amyotrophic lateral sclerosis
    • McGeer PL, McGeer EG (2002) Inflammatory processes in amyotrophic lateral sclerosis. Muscle Nerve 26:459-470
    • (2002) Muscle Nerve , vol.26 , pp. 459-470
    • McGeer, P.L.1    McGeer, E.G.2
  • 63
    • 0033547879 scopus 로고    scopus 로고
    • S-100beta protein is upregulated in astrocytes and motor neurons in the spinal cord of patients with amyotrophic lateral sclerosis
    • Migheli A, Cordera S, Bendotti C, Atzori C, Piva R, Schiffer D (1999) S-100beta protein is upregulated in astrocytes and motor neurons in the spinal cord of patients with amyotrophic lateral sclerosis. Neurosci Lett 261:25-28
    • (1999) Neurosci Lett , vol.261 , pp. 25-28
    • Migheli, A.1    Cordera, S.2    Bendotti, C.3    Atzori, C.4    Piva, R.5    Schiffer, D.6
  • 64
    • 34250209501 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis
    • Mitchell JD, Borasio GD (2007) Amyotrophic lateral sclerosis. Lancet 369:2031-2041
    • (2007) Lancet , vol.369 , pp. 2031-2041
    • Mitchell, J.D.1    Borasio, G.D.2
  • 68
    • 8444231660 scopus 로고    scopus 로고
    • Biochemistry and clinical role of human cystatin C
    • Mussap M, Plebani M (2004) Biochemistry and clinical role of human cystatin C. Crit Rev Clin Lab Sci 41:467-550
    • (2004) Crit Rev Clin Lab Sci , vol.41 , pp. 467-550
    • Mussap, M.1    Plebani, M.2
  • 70
    • 34249670157 scopus 로고    scopus 로고
    • Glia cells in amyotrophic lateral sclerosis: New clues to understanding an old disease?
    • Neusch C, Bähr M, Schneider-Gold C (2007) Glia cells in amyotrophic lateral sclerosis: new clues to understanding an old disease? Muscle Nerve 35:712-724
    • (2007) Muscle Nerve , vol.35 , pp. 712-724
    • Neusch, C.1    Bähr, M.2    Schneider-Gold, C.3
  • 74
    • 74549186988 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis
    • Niebroj-Dobosz I, Janik P, Sokołowska B, Kwiecinski H (2010) Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Eur J Neurol 17:226-231
    • (2010) Eur J Neurol , vol.17 , pp. 226-231
    • Niebroj-Dobosz, I.1    Janik, P.2    Sokołowska, B.3    Kwiecinski, H.4
  • 75
    • 0142011171 scopus 로고    scopus 로고
    • Elevated neurofilament levels in neurological diseases
    • Norgren N, Rosengren L, Stigbrand T (2003) Elevated neurofilament levels in neurological diseases. Brain Res 987:25-31
    • (2003) Brain Res , vol.987 , pp. 25-31
    • Norgren, N.1    Rosengren, L.2    Stigbrand, T.3
  • 77
    • 0034063520 scopus 로고    scopus 로고
    • Increased expression of laminin 1 in the skin of amyotrophic lateral sclerosis
    • Ono S, Imai T, Shimizu N, Nagao K (2000) Increased expression of laminin 1 in the skin of amyotrophic lateral sclerosis. Eur Neurol 43:215-220
    • (2000) Eur Neurol , vol.43 , pp. 215-220
    • Ono, S.1    Imai, T.2    Shimizu, N.3    Nagao, K.4
  • 78
    • 0032535979 scopus 로고    scopus 로고
    • Decrease of S100 beta protein in serum of patients with amyotrophic lateral sclerosis
    • Otto M, Bahn E, Wiltfang J, Boekhoff I, Beuche W (1998) Decrease of S100 beta protein in serum of patients with amyotrophic lateral sclerosis. Neurosci Lett 240:171-173
    • (1998) Neurosci Lett , vol.240 , pp. 171-173
    • Otto, M.1    Bahn, E.2    Wiltfang, J.3    Boekhoff, I.4    Beuche, W.5
  • 79
    • 0033391691 scopus 로고    scopus 로고
    • Blood-brain barrier biology and methodology
    • Pardridge WM (1999) Blood-brain barrier biology and methodology. J Neurovirol 5:556-569
    • (1999) J Neurovirol , vol.5 , pp. 556-569
    • Pardridge, W.M.1
  • 80
    • 33747605320 scopus 로고    scopus 로고
    • Molecular biology of amyotrophic lateral sclerosis: Insights from genetics
    • Pasinelli P, Brown RH (2006) Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat Rev Neurosci 7:710-723
    • (2006) Nat Rev Neurosci , vol.7 , pp. 710-723
    • Pasinelli, P.1    Brown, R.H.2
  • 83
    • 2342614161 scopus 로고    scopus 로고
    • Cerebrospinal fluid insulin-like growth factor-1, insulin growth factor binding protein-2 or nitric oxide are not increased in MS or ALS
    • PirttiläT, Vanhatalo S, Turpeinen U, Riikonen R (2004) Cerebrospinal fluid insulin-like growth factor-1, insulin growth factor binding protein-2 or nitric oxide are not increased in MS or ALS. Acta Neurol Scand 109:337-341
    • (2004) Acta Neurol Scand , vol.109 , pp. 337-341
    • Pirttilä, T.1    Vanhatalo, S.2    Turpeinen, U.3    Riikonen, R.4
  • 85
    • 33750371447 scopus 로고    scopus 로고
    • Chemokines, mononuclear cells and the nervous system: Heaven (or hell) is in the details
    • Rebenko-Moll NM, Liu L, Cardona A, Ransohoff RM (2006) Chemokines, mononuclear cells and the nervous system: heaven (or hell) is in the details. Curr Opin Immunol 18:683-689
    • (2006) Curr Opin Immunol , vol.18 , pp. 683-689
    • Rebenko-Moll, N.M.1    Liu, L.2    Cardona, A.3    Ransohoff, R.M.4
  • 86
    • 0031663125 scopus 로고    scopus 로고
    • The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis
    • Reiber H, Ungefehr S, Jacobi C (1998) The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis. Mult Scler 4:111-117
    • (1998) Mult Scler , vol.4 , pp. 111-117
    • Reiber, H.1    Ungefehr, S.2    Jacobi, C.3
  • 88
    • 0027164824 scopus 로고
    • Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
    • Rosen DR (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 364:362
    • (1993) Nature , vol.364 , pp. 362
    • Rosen, D.R.1
  • 89
    • 0029828676 scopus 로고    scopus 로고
    • Patients with amyotrophic lateral sclerosis and other neurodegenerative diseases have increased levels of neurofilament protein in CSF
    • Rosengren LE, Karlsson JE, Karlsson JO, Persson LI, Wikkelsø C (1996) Patients with amyotrophic lateral sclerosis and other neurodegenerative diseases have increased levels of neurofilament protein in CSF. J Neurochem 67:2013-2018
    • (1996) J Neurochem , vol.67 , pp. 2013-2018
    • Rosengren, L.E.1    Karlsson, J.E.2    Karlsson, J.O.3    Persson, L.I.4    Wikkelsø, C.5
  • 90
    • 60849093466 scopus 로고    scopus 로고
    • Current hypotheses for the underlying biology of amyotrophic lateral sclerosis
    • Rothstein JD (2009) Current hypotheses for the underlying biology of amyotrophic lateral sclerosis. Ann Neurol 65(Suppl 1):S3-S9
    • (2009) Ann Neurol , vol.65 , Issue.SUPPL. 1
    • Rothstein, J.D.1
  • 91
    • 0035978743 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis
    • Rowland LP, Shneider NA (2001) Amyotrophic lateral sclerosis. N Engl J Med 344:1688-1700
    • (2001) N Engl J Med , vol.344 , pp. 1688-1700
    • Rowland, L.P.1    Shneider, N.A.2
  • 92
    • 34249808244 scopus 로고    scopus 로고
    • Transglutaminase 2 in neurodegenerative disorders
    • Ruan Q, Johnson GV (2007) Transglutaminase 2 in neurodegenerative disorders. Front Biosci 12:891-904
    • (2007) Front Biosci , vol.12 , pp. 891-904
    • Ruan, Q.1    Johnson, G.V.2
  • 93
    • 0023722254 scopus 로고
    • The extracellular matrix of the central and peripheral nervous systems: Structure and function
    • Rutka JT, Apodaca G, Stern R, Rosenblum M (1988) The extracellular matrix of the central and peripheral nervous systems: structure and function. J Neurosurg 69:155-170
    • (1988) J Neurosurg , vol.69 , pp. 155-170
    • Rutka, J.T.1    Apodaca, G.2    Stern, R.3    Rosenblum, M.4
  • 94
    • 1842788079 scopus 로고    scopus 로고
    • Cerebrospinal fluid levels of free 3-nitrotyrosine are not elevated in the majority of patients with amyotrophic lateral sclerosis or Alzheimer's disease
    • Ryberg H, Söderling AS, Davidsson P, Blennow K, Caidahl K, Persson LI (2004) Cerebrospinal fluid levels of free 3-nitrotyrosine are not elevated in the majority of patients with amyotrophic lateral sclerosis or Alzheimer's disease. Neurochem Int 45:57-62
    • (2004) Neurochem Int , vol.45 , pp. 57-62
    • Ryberg, H.1    Söderling, A.S.2    Davidsson, P.3    Blennow, K.4    Caidahl, K.5    Persson, L.I.6
  • 96
    • 38449113556 scopus 로고    scopus 로고
    • Genetics of sporadic amyotrophic lateral sclerosis
    • Schymick JC, Talbot K, Traynor BJ (2007) Genetics of sporadic amyotrophic lateral sclerosis. Hum Mol Genet 16(Spec No. 2):R233-R242
    • (2007) Hum Mol Genet , vol.16 , Issue.SPEC NO. 2
    • Schymick, J.C.1    Talbot, K.2    Traynor, B.J.3
  • 97
    • 0032485033 scopus 로고    scopus 로고
    • Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: Immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases
    • Sekizawa T, Openshaw H, Ohbo K, Sugamura K, Itoyama Y, Niland JC (1998) Cerebrospinal fluid interleukin 6 in amyotrophic lateral sclerosis: immunological parameter and comparison with inflammatory and non-inflammatory central nervous system diseases. J Neurol Sci 154:194-199
    • (1998) J Neurol Sci , vol.154 , pp. 194-199
    • Sekizawa, T.1    Openshaw, H.2    Ohbo, K.3    Sugamura, K.4    Itoyama, Y.5    Niland, J.C.6
  • 98
    • 17844378527 scopus 로고    scopus 로고
    • Pathophysiology of blood-spinal cord barrier in traumatic injury and repair
    • Sharma HS (2005) Pathophysiology of blood-spinal cord barrier in traumatic injury and repair. Curr Pharm Des 11:1353-1389
    • (2005) Curr Pharm des , vol.11 , pp. 1353-1389
    • Sharma, H.S.1
  • 101
    • 0029810307 scopus 로고    scopus 로고
    • Genetics of amyotrophic lateral sclerosis
    • Siddique T, Deng HX (1996) Genetics of amyotrophic lateral sclerosis. Hum Mol Genet 5(Spec No):1465-1470
    • (1996) Hum Mol Genet , vol.5 , Issue.SPEC NO , pp. 1465-1470
    • Siddique, T.1    Deng, H.X.2
  • 102
    • 0742321930 scopus 로고    scopus 로고
    • Oxidative Stress: A common denominator in the pathogenesis of amyotrophic lateral sclerosis
    • Simpson EP, Yen AA, Appel SH (2003) Oxidative Stress: a common denominator in the pathogenesis of amyotrophic lateral sclerosis. Curr Opin Rheumatol 15:730-736
    • (2003) Curr Opin Rheumatol , vol.15 , pp. 730-736
    • Simpson, E.P.1    Yen, A.A.2    Appel, S.H.3
  • 103
    • 2442701519 scopus 로고    scopus 로고
    • Increased lipid peroxidation in sera of ALS patients: A potential biomarker of disease burden
    • Simpson EP, Henry YK, Henkel JS, Smith RG, Appel SH (2004) Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden. Neurology 62:1758-1765
    • (2004) Neurology , vol.62 , pp. 1758-1765
    • Simpson, E.P.1    Henry, Y.K.2    Henkel, J.S.3    Smith, R.G.4    Appel, S.H.5
  • 106
    • 0037081113 scopus 로고    scopus 로고
    • Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: A reappraisal using a new HPLC method with coulometric detection in a large cohort of patients
    • Spreux-Varoquaux O, Bensimon G, Lacomblez L, Salachas F, Pradat PF, Le Forestier N, Marouan A, Dib M, Meininger V (2002) Glutamate levels in cerebrospinal fluid in amyotrophic lateral sclerosis: a reappraisal using a new HPLC method with coulometric detection in a large cohort of patients. J Neurol Sci 193:73-78
    • (2002) J Neurol Sci , vol.193 , pp. 73-78
    • Spreux-Varoquaux, O.1    Bensimon, G.2    Lacomblez, L.3    Salachas, F.4    Pradat, P.F.5    Le Forestier, N.6    Marouan, A.7    Dib, M.8    Meininger, V.9
  • 109
    • 23844538993 scopus 로고    scopus 로고
    • The pathobiology of amyotrophic lateral sclerosis: A proteinopathy?
    • Strong MJ, Kesavapany S, Pant HC (2005) The pathobiology of amyotrophic lateral sclerosis: a proteinopathy? J Neuropathol Exp Neurol 64:649-664
    • (2005) J Neuropathol Exp Neurol , vol.64 , pp. 649-664
    • Strong, M.J.1    Kesavapany, S.2    Pant, H.C.3
  • 110
    • 17544398505 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis: Disease stage related changes of tau protein and S100 beta in cerebrospinal fluid and creatine kinase in serum
    • Süssmuth SD, Tumani H, Ecker D, Ludolph AC (2003) Amyotrophic lateral sclerosis: disease stage related changes of tau protein and S100 beta in cerebrospinal fluid and creatine kinase in serum.Neurosci Lett 353:57-60
    • (2003) Neurosci Lett , vol.353 , pp. 57-60
    • Süssmuth, S.D.1    Tumani, H.2    Ecker, D.3    Ludolph, A.C.4
  • 112
    • 0023872487 scopus 로고
    • Preclinical and subclinical events in motor neuron disease
    • Swash M, Ingram D (1988) Preclinical and subclinical events in motor neuron disease. J Neurol Neurosurg Psychiatry 51:165-168
    • (1988) J Neurol Neurosurg Psychiatry , vol.51 , pp. 165-168
    • Swash, M.1    Ingram, D.2
  • 114
    • 33746863745 scopus 로고    scopus 로고
    • Intrathecal upregulation of granulocyte colony stimulating factor and its neuroprotective actions on motor neurons in amyotrophic lateral sclerosis
    • Tanaka M, Kikuchi H, Ishizu T, Minohara M, Osoegawa M, Motomura K, Tateishi T, Ohyagi Y, Kira J (2006) Intrathecal upregulation of granulocyte colony stimulating factor and its neuroprotective actions on motor neurons in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 65:816-825
    • (2006) J Neuropathol Exp Neurol , vol.65 , pp. 816-825
    • Tanaka, M.1    Kikuchi, H.2    Ishizu, T.3    Minohara, M.4    Osoegawa, M.5    Motomura, K.6    Tateishi, T.7    Ohyagi, Y.8    Kira, J.9
  • 115
    • 0033524950 scopus 로고    scopus 로고
    • Increase in oxidized NO products and reduction in oxidized glutathione in cerebrospinal fluid from patients with sporadic form of amyotrophic lateral sclerosis
    • Tohgi H, Ae T, Yamazaki K, Murata T, Ishizaki E, Isobe C (1999) Increase in oxidized NO products and reduction in oxidized glutathione in cerebrospinal fluid from patients with sporadic form of amyotrophic lateral sclerosis. Neurosci Lett 260:204-206
    • (1999) Neurosci Lett , vol.260 , pp. 204-206
    • Tohgi, H.1    Ae, T.2    Yamazaki, K.3    Murata, T.4    Ishizaki, E.5    Isobe, C.6
  • 117
    • 0028178503 scopus 로고
    • Increased concentration of C4d complement protein in CSF in amyotrophic lateral sclerosis
    • Tsuboi Y, Yamada T (1994) Increased concentration of C4d complement protein in CSF in amyotrophic lateral sclerosis. J Neurol Neurosurg Psychiatry 57:859-861
    • (1994) J Neurol Neurosurg Psychiatry , vol.57 , pp. 859-861
    • Tsuboi, Y.1    Yamada, T.2
  • 118
    • 0032873640 scopus 로고    scopus 로고
    • Glutamine synthetase in cerebrospinal fluid, serum, and brain: A diagnostic marker for Alzheimer disease?
    • Tumani H, Shen G, Peter JB, Brück W (1999) Glutamine synthetase in cerebrospinal fluid, serum, and brain: a diagnostic marker for Alzheimer disease? Arch Neurol 56:1241-1246
    • (1999) Arch Neurol , vol.56 , pp. 1241-1246
    • Tumani, H.1    Shen, G.2    Peter, J.B.3    Brück, W.4
  • 120
    • 33751229311 scopus 로고    scopus 로고
    • The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis
    • Van Den Bosch L, Van Damme P, Bogaert E, Robberecht W (2006) The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis. Biochim Biophys Acta 1762:1068-1082
    • (2006) Biochim Biophys Acta , vol.1762 , pp. 1068-1082
    • Van Den Bosch, L.1    Van Damme, P.2    Bogaert, E.3    Robberecht, W.4
  • 122
    • 79955599523 scopus 로고    scopus 로고
    • Targeting the neurovascular unit for treatment of neurological disorders
    • Vangilder RL, Rosen CL, Barr TL, Huber JD (2011) Targeting the neurovascular unit for treatment of neurological disorders. Pharmacol Ther 130:239-247
    • (2011) Pharmacol Ther , vol.130 , pp. 239-247
    • Vangilder, R.L.1    Rosen, C.L.2    Barr, T.L.3    Huber, J.D.4
  • 123
    • 5344277492 scopus 로고    scopus 로고
    • Microglial reactivity to betaamyloid is modulated by astrocytes and proinflammatory factors
    • von Bernhardi R, Eugenín J (2004) Microglial reactivity to betaamyloid is modulated by astrocytes and proinflammatory factors. Brain Res 1025:186-193
    • (2004) Brain Res , vol.1025 , pp. 186-193
    • Von Bernhardi, R.1    Eugenín, J.2
  • 124
    • 0038730794 scopus 로고    scopus 로고
    • Molecular anatomy of intercellular junctions in brain endothelial and epithelial barriers: Electron microscopist's view
    • Vorbrodt AW, Dobrogowska DH (2003) Molecular anatomy of intercellular junctions in brain endothelial and epithelial barriers: electron microscopist's view. Brain Res Brain Res Rev 42:221-242
    • (2003) Brain Res Brain Res Rev , vol.42 , pp. 221-242
    • Vorbrodt, A.W.1    Dobrogowska, D.H.2
  • 125
    • 0032840008 scopus 로고    scopus 로고
    • Bunina bodies in amyotrophic lateral sclerosis on Guam: A histochemical, immunohistochemical and ultrastructural investigation
    • Wada M, Uchihara T, Nakamura A, Oyanagi K (1999) Bunina bodies in amyotrophic lateral sclerosis on Guam: a histochemical, immunohistochemical and ultrastructural investigation. Acta Neuropathol 98:150-156
    • (1999) Acta Neuropathol , vol.98 , pp. 150-156
    • Wada, M.1    Uchihara, T.2    Nakamura, A.3    Oyanagi, K.4
  • 126
    • 0142226956 scopus 로고    scopus 로고
    • Intrathecal synthesis of monocyte chemoattractant protein-1 (MCP-1) in amyotrophic lateral sclerosis: Further evidence for microglial activation in neurodegeneration
    • Wilms H, Sievers J, Dengler R, Bufler J, Deuschl G, Lucius R (2003) Intrathecal synthesis of monocyte chemoattractant protein-1 (MCP-1) in amyotrophic lateral sclerosis: further evidence for microglial activation in neurodegeneration. J Neuroimmunol 144:139-142
    • (2003) J Neuroimmunol , vol.144 , pp. 139-142
    • Wilms, H.1    Sievers, J.2    Dengler, R.3    Bufler, J.4    Deuschl, G.5    Lucius, R.6
  • 127
    • 78650087291 scopus 로고    scopus 로고
    • Cystatin C: A candidate biomarker for amyotrophic lateral sclerosis
    • Wilson ME, Boumaza I, Lacomis D, Bowser R (2010) Cystatin C: a candidate biomarker for amyotrophic lateral sclerosis. PLoS ONE 5:e15133
    • (2010) PLoS ONE , vol.5
    • Wilson, M.E.1    Boumaza, I.2    Lacomis, D.3    Bowser, R.4
  • 130
    • 33645224970 scopus 로고    scopus 로고
    • COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord
    • Yiangou Y, Facer P, Durrenberger P, Chessell IP, Naylor A, Bountra C, Banati RR, Anand P (2006) COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord. BMC Neurol 6:12
    • (2006) BMC Neurol , vol.6 , pp. 12
    • Yiangou, Y.1    Facer, P.2    Durrenberger, P.3    Chessell, I.P.4    Naylor, A.5    Bountra, C.6    Banati, R.R.7    Anand, P.8
  • 132
    • 79952572373 scopus 로고    scopus 로고
    • Misfolded superoxide dismutase-1 in CSF from amyotrophic lateral sclerosis patients
    • Zetterström P, Andersen PM, Brännström T, Marklund SL (2011) Misfolded superoxide dismutase-1 in CSF from amyotrophic lateral sclerosis patients. J Neurochem 117:91-99
    • (2011) J Neurochem , vol.117 , pp. 91-99
    • Zetterström, P.1    Andersen, P.M.2    Brännström, T.3    Marklund, S.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.