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Volumn 58, Issue 7, 1999, Pages 719-728

Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration

Author keywords

Glutamate toxicity; Motor neuron disease; Neurotrophic factor; PEDF; Serpin; Spinal cord; Tissue culture

Indexed keywords

CHOLINE ACETYLTRANSFERASE; GLUTAMIC ACID; MESSENGER RNA; NEUROPROTECTIVE AGENT; PIGMENT EPITHELIUM DERIVED FACTOR; UNCLASSIFIED DRUG;

EID: 0032796456     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005072-199907000-00006     Document Type: Article
Times cited : (177)

References (51)
  • 1
    • 0027094145 scopus 로고
    • Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death
    • Oppenheim RW, Yin QW, Prevette D, Yan Q. Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death. Nature 1992;360:755-57
    • (1992) Nature , vol.360 , pp. 755-757
    • Oppenheim, R.W.1    Yin, Q.W.2    Prevette, D.3    Yan, Q.4
  • 3
    • 0028597994 scopus 로고
    • Glial cell line-derived neurotrophic factor, a new neurotrophic factor for motoneurons
    • Zurn AD, Baetge EE, Hammang JP, Tan SA, Aebischer P. Glial cell line-derived neurotrophic factor, a new neurotrophic factor for motoneurons. NeuroReport 1994;6:113-18
    • (1994) Neuroreport , vol.6 , pp. 113-118
    • Zurn, A.D.1    Baetge, E.E.2    Hammang, J.P.3    Tan, S.A.4    Aebischer, P.5
  • 4
    • 0024345451 scopus 로고
    • Fibroblast growth factor and glutamate: Opposing roles in the generation and degeneration of hippocampal neuroarchitecture
    • Mattson MP, Murrain M, Guthrie PB, Kater, SB. Fibroblast growth factor and glutamate: Opposing roles in the generation and degeneration of hippocampal neuroarchitecture. J Neurosci 1989;9:3728-40
    • (1989) J Neurosci , vol.9 , pp. 3728-3740
    • Mattson, M.P.1    Murrain, M.2    Guthrie, P.B.3    Kater, S.B.4
  • 5
    • 0026644178 scopus 로고
    • Growth factors and vitamin E modify neuronal glutamate toxicity
    • Schubert D, Kimura H, Maher P. Growth factors and vitamin E modify neuronal glutamate toxicity. Proc Natl Acad Sci USA 1992;89:8264-67
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 8264-8267
    • Schubert, D.1    Kimura, H.2    Maher, P.3
  • 6
    • 0025298782 scopus 로고
    • Glutamate dysfunction and selective motor neuron degeneration in amyotrophic lateral sclerosis: A hypothesis
    • Plaitakis A. Glutamate dysfunction and selective motor neuron degeneration in amyotrophic lateral sclerosis: A hypothesis. Ann Neurol 1990;28:3-8
    • (1990) Ann Neurol , vol.28 , pp. 3-8
    • Plaitakis, A.1
  • 7
    • 0025365750 scopus 로고
    • What's the excitement about excitatory amino acids in amyotrophic lateral sclerosis?
    • Young AB. What's the excitement about excitatory amino acids in amyotrophic lateral sclerosis? Ann Neurol 1990;28:9-11
    • (1990) Ann Neurol , vol.28 , pp. 9-11
    • Young, A.B.1
  • 8
    • 0026597010 scopus 로고
    • Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
    • Rothstein JD, Martin LJ, Kuncl RW. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N Engl J Med 1992;326:1464-68
    • (1992) N Engl J Med , vol.326 , pp. 1464-1468
    • Rothstein, J.D.1    Martin, L.J.2    Kuncl, R.W.3
  • 9
    • 0029030610 scopus 로고
    • Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
    • Rothstein JD, Van Kammen M, Levey AI, Martin L, Kuncl RW. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann Neurol 1995;38:73-84
    • (1995) Ann Neurol , vol.38 , pp. 73-84
    • Rothstein, J.D.1    Van Kammen, M.2    Levey, A.I.3    Martin, L.4    Kuncl, R.W.5
  • 10
    • 0027274623 scopus 로고
    • Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity
    • Rothstein JD, Jin L, Dykes-Hoberg M, Kuncl RW. Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc Natl Acad Sci USA 1993;90:6591-95
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6591-6595
    • Rothstein, J.D.1    Jin, L.2    Dykes-Hoberg, M.3    Kuncl, R.W.4
  • 11
    • 0003299278 scopus 로고
    • Organotypic spinal cord cultures and a model of chronic glutamate-mediated motor neuron degeneration
    • Ohnishi ST, Ohnishi T, eds. Philadelphia: CRC Press
    • Corse AM, Rothstein JD. Organotypic spinal cord cultures and a model of chronic glutamate-mediated motor neuron degeneration. In: Ohnishi ST, Ohnishi T, eds. Membrane-linked diseases - CNS trauma: laboratory techniques and recent advancement. Philadelphia: CRC Press, 1995:341-51
    • (1995) Membrane-linked Diseases - CNS Trauma: Laboratory Techniques and Recent Advancement , pp. 341-351
    • Corse, A.M.1    Rothstein, J.D.2
  • 12
    • 0025772716 scopus 로고
    • A pigment epithelium-derived factor with potent neuronal differentiative activity
    • Tombran-Tink J, Chader GJ, Johnson LV. A pigment epithelium-derived factor with potent neuronal differentiative activity. Exp Eye Res 1991;53:411-14
    • (1991) Exp Eye Res , vol.53 , pp. 411-414
    • Tombran-Tink, J.1    Chader, G.J.2    Johnson, L.V.3
  • 13
    • 0030476601 scopus 로고    scopus 로고
    • Gene expression of the neurotrophic pigment epithelium-derived factor in the human ciliary epithelium
    • Ortego J, Escribano J, Becerra SP, Coca-Prados M. Gene expression of the neurotrophic pigment epithelium-derived factor in the human ciliary epithelium. Invest Ophthal Vis Sci 1996;37:2759-67
    • (1996) Invest Ophthal Vis Sci , vol.37 , pp. 2759-2767
    • Ortego, J.1    Escribano, J.2    Becerra, S.P.3    Coca-Prados, M.4
  • 14
    • 0029025831 scopus 로고
    • Expression, secretion, and age-related downregulation of pigment epithelial-derived factor, a serpin with neurotrophic activity
    • Tombran-Tink J, Shivaram SM, Chader GJ, Johnson LV, Bok D. Expression, secretion, and age-related downregulation of pigment epithelial-derived factor, a serpin with neurotrophic activity. J Neurosci 1995;15:4992-5003
    • (1995) J Neurosci , vol.15 , pp. 4992-5003
    • Tombran-Tink, J.1    Shivaram, S.M.2    Chader, G.J.3    Johnson, L.V.4    Bok, D.5
  • 15
    • 0029347070 scopus 로고
    • Identification of pigment epithelial-derived factor in the interphotoreceptor matrix of bovine eyes
    • Wu YQ, Notario V, Chader GJ, Becerra SP. Identification of pigment epithelial-derived factor in the interphotoreceptor matrix of bovine eyes. Protein Expr Purif 1995;6:447-56
    • (1995) Protein Expr Purif , vol.6 , pp. 447-456
    • Wu, Y.Q.1    Notario, V.2    Chader, G.J.3    Becerra, S.P.4
  • 16
    • 0030569057 scopus 로고    scopus 로고
    • Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelial-derived factor, a unique neurotrophic serpin
    • Tombran-Tink J, Mazuruk K, Rodriguez IR, et al. Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelial-derived factor, a unique neurotrophic serpin. Mol Vis 1996;2:1-12
    • (1996) Mol Vis , vol.2 , pp. 1-12
    • Tombran-Tink, J.1    Mazuruk, K.2    Rodriguez, I.R.3
  • 17
    • 0027446940 scopus 로고
    • Pigment epithelium-derived factor (PEDF): Neurotrophic activity and identification as a unique member of the serine protease inhibitor (SERPIN) gene family
    • Steele FR, Chader GJ, Johnson LV, Tombran-Tink J. Pigment epithelium-derived factor (PEDF): Neurotrophic activity and identification as a unique member of the serine protease inhibitor (SERPIN) gene family. Proc Natl Acad Sci USA 1993;90:1526-30
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1526-1530
    • Steele, F.R.1    Chader, G.J.2    Johnson, L.V.3    Tombran-Tink, J.4
  • 18
    • 0029064939 scopus 로고
    • Pigment epithelial-derived factor is a surviving factor for cerebellar granule cells in culture
    • Taniwaki T, Becerra SP, Chader GJ, Schwartz JP. Pigment epithelial-derived factor is a surviving factor for cerebellar granule cells in culture. J Neurochem 1995;64:2509-17
    • (1995) J Neurochem , vol.64 , pp. 2509-2517
    • Taniwaki, T.1    Becerra, S.P.2    Chader, G.J.3    Schwartz, J.P.4
  • 19
    • 0031028637 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor protects cultured cerebellar granule cells against glutamate-induced neurotoxicity
    • Taniwaki T, Hirashima N, Becerra SP, Chader GJ, Etcheberrigaray R, Schwartz JP. Pigment epithelium-derived factor protects cultured cerebellar granule cells against glutamate-induced neurotoxicity. J Neurochem 1997;68:26-32
    • (1997) J Neurochem , vol.68 , pp. 26-32
    • Taniwaki, T.1    Hirashima, N.2    Becerra, S.P.3    Chader, G.J.4    Etcheberrigaray, R.5    Schwartz, J.P.6
  • 20
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-85
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 21
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
    • Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc Natl Acad Sci USA 1979;76:4350-54
    • (1979) Proc Natl Acad Sci USA , vol.76 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 23
    • 0014984942 scopus 로고
    • Glutamate-induced neuronal necrosis in the infant mouse hypothalamus
    • Olney JW. Glutamate-induced neuronal necrosis in the infant mouse hypothalamus. J Neuropathol Exp Neurol 1971;30:75-90
    • (1971) J Neuropathol Exp Neurol , vol.30 , pp. 75-90
    • Olney, J.W.1
  • 25
    • 0016468979 scopus 로고
    • A rapid radiochemical method for the determination of choline acetyltransferase
    • Fonnum F. A rapid radiochemical method for the determination of choline acetyltransferase. J Neurochem 1975;24:407-9
    • (1975) J Neurochem , vol.24 , pp. 407-409
    • Fonnum, F.1
  • 26
    • 0021705087 scopus 로고
    • Postnatal development of neurons containing choline acetyltransferase in rat spinal cord: An immunocytochemical study
    • Phelps PE, Barber RP, Houser CR, Crawford GD, Salvaterra PM, Vaughn JE. Postnatal development of neurons containing choline acetyltransferase in rat spinal cord: An immunocytochemical study. J Comp Neurol 1984;229:347-61
    • (1984) J Comp Neurol , vol.229 , pp. 347-361
    • Phelps, P.E.1    Barber, R.P.2    Houser, C.R.3    Crawford, G.D.4    Salvaterra, P.M.5    Vaughn, J.E.6
  • 27
    • 0026098977 scopus 로고
    • Expression of choline acetyltransferase and nerve growth factor receptor within hypoglossal motoneuron following nerve injury
    • Armstrong DM, Brady R, Hersh LB, Hayes RC, Wiley RG. Expression of choline acetyltransferase and nerve growth factor receptor within hypoglossal motoneuron following nerve injury. J Comp Neurol 1991;304:596-607
    • (1991) J Comp Neurol , vol.304 , pp. 596-607
    • Armstrong, D.M.1    Brady, R.2    Hersh, L.B.3    Hayes, R.C.4    Wiley, R.G.5
  • 28
    • 0002918293 scopus 로고
    • Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ
    • Sternberger LA, Sternberger NH. Monoclonal antibodies distinguish phosphorylated and nonphosphorylated forms of neurofilaments in situ. Proc Natl Acad Sci USA 1983;80:6126-30
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 6126-6130
    • Sternberger, L.A.1    Sternberger, N.H.2
  • 29
    • 0024550350 scopus 로고
    • Monoclonal antibody to neurofilament protein (SMI-32) labels a subpopulation of pyramidal neurons in the human and monkey neocortex
    • Campbell MJ, Morrison JH. Monoclonal antibody to neurofilament protein (SMI-32) labels a subpopulation of pyramidal neurons in the human and monkey neocortex. J Comp Neurol 1989;282:191-205
    • (1989) J Comp Neurol , vol.282 , pp. 191-205
    • Campbell, M.J.1    Morrison, J.H.2
  • 30
    • 0029113872 scopus 로고
    • Neuroprotective strategies in a model of chronic glutamate-mediated motor neuron toxicity
    • Rothstein JD, Kuncl RW. Neuroprotective strategies in a model of chronic glutamate-mediated motor neuron toxicity. J Neurochem 1995;65:643-51
    • (1995) J Neurochem , vol.65 , pp. 643-651
    • Rothstein, J.D.1    Kuncl, R.W.2
  • 32
    • 10544254257 scopus 로고    scopus 로고
    • Placebo-controlled trial of gabapentin in patients with amyotrophic lateral sclerosis. WALS study group
    • Miller RG, Moore D, Young LA, et al. Placebo-controlled trial of gabapentin in patients with amyotrophic lateral sclerosis. WALS study group. Neurology 1996;47:1383-88
    • (1996) Neurology , vol.47 , pp. 1383-1388
    • Miller, R.G.1    Moore, D.2    Young, L.A.3
  • 33
    • 6844266272 scopus 로고    scopus 로고
    • Effect of recombinant human insulin-like growth factor-I on progression of ALS
    • Lai EC, Felice KJ, Festoff BW, et al. Effect of recombinant human insulin-like growth factor-I on progression of ALS. Neurology 1997;49:1621-30
    • (1997) Neurology , vol.49 , pp. 1621-1630
    • Lai, E.C.1    Felice, K.J.2    Festoff, B.W.3
  • 34
    • 2442646665 scopus 로고    scopus 로고
    • A double-blind placebo-controlled clinical trial of subcutaneous recombinant human neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis
    • ALS CNTF Treatment Study [ACTS] Group. A double-blind placebo-controlled clinical trial of subcutaneous recombinant human neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. Neurology 1996;46:1244-49
    • (1996) Neurology , vol.46 , pp. 1244-1249
  • 35
    • 0000675639 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in amyotrophic lateral sclerosis: A failed drug or a failed trial?
    • Cedarbaum JM, Stambler N, Brooks BR, Bradley W. Brain-derived neurotrophic factor in amyotrophic lateral sclerosis: A failed drug or a failed trial? Ann Neurol 1998;44:506-7
    • (1998) Ann Neurol , vol.44 , pp. 506-507
    • Cedarbaum, J.M.1    Stambler, N.2    Brooks, B.R.3    Bradley, W.4
  • 36
    • 0025325548 scopus 로고
    • Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy
    • Sendtner M, Kreutzberg GW, Thoenen H. Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy. Nature 1990;345:440-41
    • (1990) Nature , vol.345 , pp. 440-441
    • Sendtner, M.1    Kreutzberg, G.W.2    Thoenen, H.3
  • 37
    • 0027481752 scopus 로고
    • Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo
    • Koliatsos VE, Clatterbuck RE, Winslow JW, Cavouette MH, Price DL. Evidence that brain-derived neurotrophic factor is a trophic factor for motor neurons in vivo. Neuron 1993;10:359-67
    • (1993) Neuron , vol.10 , pp. 359-367
    • Koliatsos, V.E.1    Clatterbuck, R.E.2    Winslow, J.W.3    Cavouette, M.H.4    Price, D.L.5
  • 39
    • 0022633995 scopus 로고
    • The absence of significant postnatal motoneuron death in the brachial and lumbar spinal cord of the rat
    • Oppenheim RW. The absence of significant postnatal motoneuron death in the brachial and lumbar spinal cord of the rat. J Comp Neurol 1986;246:281-86
    • (1986) J Comp Neurol , vol.246 , pp. 281-286
    • Oppenheim, R.W.1
  • 40
    • 0028279370 scopus 로고
    • Neurotrophic agents prevent motoneuron death following sciatic nerve section in the neonatal mouse
    • Li L, Oppenheim RW, Lei M, Houenou LJ. Neurotrophic agents prevent motoneuron death following sciatic nerve section in the neonatal mouse. J Neurobio 1994;25:759-66
    • (1994) J Neurobio , vol.25 , pp. 759-766
    • Li, L.1    Oppenheim, R.W.2    Lei, M.3    Houenou, L.J.4
  • 41
    • 0018932068 scopus 로고
    • Protease-nexin: A cellular component that links thrombin and plasminogen activator and mediates their binding to cells
    • Baker JB, Low DA, Simmer RL, Cunningham DD. Protease-nexin: A cellular component that links thrombin and plasminogen activator and mediates their binding to cells. Cell 1980;21:37-45
    • (1980) Cell , vol.21 , pp. 37-45
    • Baker, J.B.1    Low, D.A.2    Simmer, R.L.3    Cunningham, D.D.4
  • 42
    • 0023646684 scopus 로고
    • cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily
    • Sommer J, Gloor SM, Rovelli GF, et al. cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily. Biochem 1987;26:6407-10
    • (1987) Biochem , vol.26 , pp. 6407-6410
    • Sommer, J.1    Gloor, S.M.2    Rovelli, G.F.3
  • 43
    • 0031000275 scopus 로고
    • Identity of neurotrophic molecules released from astroglia by vasoactive intestinal peptide
    • Brenneman DE, Phillips TM, Festoff BW, Gozes I. Identity of neurotrophic molecules released from astroglia by vasoactive intestinal peptide. Ann NY Acad Sci 1987;814:167-73
    • (1987) Ann NY Acad Sci , vol.814 , pp. 167-173
    • Brenneman, D.E.1    Phillips, T.M.2    Festoff, B.W.3    Gozes, I.4
  • 44
    • 0028800603 scopus 로고
    • A serine protease inhibitor, protease nexin i, rescues motoneurons from naturally occurring and axotomy-induced cell death
    • Houenou LJ, Turner PL, Li L, Oppenheim RW, Festoff BW. A serine protease inhibitor, protease nexin I, rescues motoneurons from naturally occurring and axotomy-induced cell death. Proc Natl Acad Sci USA 1995;92:895-99
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 895-899
    • Houenou, L.J.1    Turner, P.L.2    Li, L.3    Oppenheim, R.W.4    Festoff, B.W.5
  • 45
    • 0023851616 scopus 로고
    • A glia-derived nexin promotes neurite outgrowth in cultured chick sympathetic neurons
    • Zurn AD, Nick H, Monard D. A glia-derived nexin promotes neurite outgrowth in cultured chick sympathetic neurons. Dev Neurosci 1988;10:17-24
    • (1988) Dev Neurosci , vol.10 , pp. 17-24
    • Zurn, A.D.1    Nick, H.2    Monard, D.3
  • 46
    • 0023698784 scopus 로고
    • Cell-derived proteases and protease inhibitors as regulators of neurite outgrowth
    • Monard D. Cell-derived proteases and protease inhibitors as regulators of neurite outgrowth. Trends Neurosci 1988;11:541-44
    • (1988) Trends Neurosci , vol.11 , pp. 541-544
    • Monard, D.1
  • 47
    • 0029948143 scopus 로고    scopus 로고
    • Prevention of activity-dependent neuronal death: Vasoactive intestinal polypeptide stimulates astrocytes to secrete the thrombin-inhibiting neurotrophic serpin, protease nexin I
    • Festoff BW, Nelson PG, Brenneman DE. Prevention of activity-dependent neuronal death: Vasoactive intestinal polypeptide stimulates astrocytes to secrete the thrombin-inhibiting neurotrophic serpin, protease nexin I. J Neurobiol 1996;30:255-66
    • (1996) J Neurobiol , vol.30 , pp. 255-266
    • Festoff, B.W.1    Nelson, P.G.2    Brenneman, D.E.3
  • 48
    • 0028803776 scopus 로고
    • Pigment epithelium-derived factor behaves like a noninhibitory serpin
    • Becerra SP, Sagasti A, Spinella P, Notario V. Pigment epithelium-derived factor behaves like a noninhibitory serpin. J Biol Chem 1995;270:25992-99
    • (1995) J Biol Chem , vol.270 , pp. 25992-25999
    • Becerra, S.P.1    Sagasti, A.2    Spinella, P.3    Notario, V.4
  • 49
    • 0030921845 scopus 로고    scopus 로고
    • Pigment epithelial-derived factor (PEDF) has direct effects on the metabolism and proliferation of microglia and indirect effects on astrocytes
    • Sugita Y, Becerra SP, Chader GJ, Schwartz JP. Pigment epithelial-derived factor (PEDF) has direct effects on the metabolism and proliferation of microglia and indirect effects on astrocytes. J Neurosci Res 1997;49:710-18
    • (1997) J Neurosci Res , vol.49 , pp. 710-718
    • Sugita, Y.1    Becerra, S.P.2    Chader, G.J.3    Schwartz, J.P.4
  • 50
    • 85038167509 scopus 로고    scopus 로고
    • PEDF-binding to retinal cells: Characterization of a candidate receptor for the neurotrophic factor PEDF
    • held in Lake Tahoe, NV. March 1-7
    • Alberdi E, Notario V, Becerra SP. PEDF-binding to retinal cells: Characterization of a candidate receptor for the neurotrophic factor PEDF [abstract]. Keystone meeting: Specificity in signal transduction, held in Lake Tahoe, NV. March 1-7, 1998:66
    • (1998) Keystone Meeting: Specificity in Signal Transduction , pp. 66
    • Alberdi, E.1    Notario, V.2    Becerra, S.P.3
  • 51
    • 0032575347 scopus 로고    scopus 로고
    • PEDF binds to glycosaminoglycans: Analysis of binding site
    • Alberdi E, Hyde CC, Becerra SP. PEDF binds to glycosaminoglycans: Analysis of binding site. Biochemistry 1998;37:10643-52
    • (1998) Biochemistry , vol.37 , pp. 10643-10652
    • Alberdi, E.1    Hyde, C.C.2    Becerra, S.P.3


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