Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS)

Journal of Neuroimmunology

Volumn 159, Issue 1-2, 2005, Pages 215-224

  Zhang, Rongzhen ^a   Gascon, Ron ^a   Miller, Robert G ^b   Gelinas, Deborah F ^b   Mass, Jason ^b   Hadlock, Ken ^c   Jin, Xia ^c   Reis, Jeremy ^a   Narvaez, Amy ^a   McGrath, Michael S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^c Pathologica LLC   (United States)

Author keywords

Alzheimer's disease (AD); Amyotrophic lateral sclerosis (ALS); Immune activation; Monocyte macrophage; Motor neuron disease

Indexed keywords

IMMUNOGLOBULIN;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BLOOD ANALYSIS; CELL ACTIVATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IMMUNOGLOBULIN BLOOD LEVEL; MACROPHAGE; MALE; MONOCYTE; NEUROIMMUNOLOGY; PARAMETER; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

ADULT; AGED; AGED, 80 AND OVER; AMYOTROPHIC LATERAL SCLEROSIS; CD4-POSITIVE T-LYMPHOCYTES; CROSS-SECTIONAL STUDIES; DISEASE PROGRESSION; FEMALE; HUMANS; IMMUNE SYSTEM; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; IMMUNOSUPPRESSION; LYMPHOCYTE ACTIVATION; MACROPHAGE ACTIVATION; MALE; MIDDLE AGED; SEVERITY OF ILLNESS INDEX;

EID: 19944434347     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2004.10.009     Document Type: Article

References (58)

1. D.C. Adamson, T.M. McArthur, T.M. Dawson, and V.L. Dawson Rate and severity of HIV-associated dementia (HAD): correlations with Gp41 and iNOS Mol. Med. 5 1999 98 109
2. H. Akiyama, S. Barger, S. Barnum, B. Bradt, J. Bauer, G.M. Cole, N.R. Cooper, P. Eikelenboom, M. Emmerling, B.L. Fiebich, C.E. Finch, S. Frautschy, W.S.T. Griffin, H. Hampel, M. Hull, G. Landreth, L.F. Lue, R. Mrak, I.R. Mackenzie, P.L. McGeer, M.K. O'Banion, J. Pachter, G. Pasinetti, C. Plata-Salaman, J. Rogers, R. Rydel, Y. Shen, W. Streit, R. Strohmeyer, I. Tooyoma, F.L. Van Muiswinkel, R. Veerhuis, D. Walker, S. Webster, B. Wegrzyniak, G. Wenk, and T. Wyss-Coray Inflammation and Alzheimer's disease Neurobiol. Aging 21 2000 383 421
3. M.E. Alexianu, M. Kozovska, and S.H. Appel Immune reactivity in a mouse model of familial ALS correlates with disease progression Neurology 57 2001 1282 1289
4. P.R. Andjus, Z. Stevic-Marinkovic, and E. Cherubini Immunoglobulins from motoneurone disease patients enhance glutamate release from rat hippocampal neurones in culture J. Physiol. 504 1997 103 112
5. S. Apostolski, J. Nikolic, C. Bugarski-Prokopljevic, V. Miletic, S. Pavlovic, and S. Filipovic Serum and CSF immunological findings in ALS Acta Neurol. Scand. 83 1991 96 98
6. S.H. Appel, V. Stockton-Appel, S.S. Stewart, and R.H. Kerman Amyotrophic lateral sclerosis. Associated clinical disorders and immunological evaluations Arch. Neurol. 43 1986 234 238
7. S.H. Appel, R.G. Smith, J.I. Engelhardt, and E. Stefani Evidence for autoimmunity in amyotrophic lateral sclerosis J. Neurol. Sci. 118 1993 169 174
8. A. Bar-Or, R.K. Nuttall, M. Duddy, A. Alter, H.J. Kim, I. Ifergan, C.J. Pennington, P. Bourgoin, D.R. Edwards, and V.W. Yong Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis Brain 126 2003 2738 2749
9. B.R. Brooks El escorial world federation of neurology criteria for the diagnosis of amyotrophic lateral sclerosis. Subcommittee on motor neuron diseases/amyotrophic lateral sclerosis of the world federation of neurology research group on neuromuscular diseases and the el escorial clinical limits of amyotrophic lateral sclerosis workshop contributors J. Neurol. Sci. 124 1994 96 107 (suppl)
10. J.A. Casal, A. Robles, and J.C. Tutor Serum markers of monocyte/macrophage activation in patients with Alzheimer's disease and other types of dementia Clin. Biochem. 36 2003 553 556
11. J.M. Cedarbaum, N. Stambler, E. Malta, C. Fuller, D. Hilt, B. Thurmond, A. Nakanshi, and BDNF ALS Study Group (Phase III) The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function J. Neurol. Sci. 169 1999 13 21
12. D. Curti, A. Malaspina, G. Facchetti, C. Camana, L. Mazzini, P. Tosca, F. Zerbi, and M. Ceroni Amyotrophic lateral sclerosis: oxidative energy metabolism and calcium homeostasis in peripheral blood lymphocytes Neurology 47 1996 1060 1064
13. H.X. Deng, A. Hentati, J.A. Tainer, Z. Iqbal, A. Cayabyab, W.Y. Hung, E.D. Getzoff, P. Hu, B. Herzfeldt, R.P. Roos, C. Warner, G. Deng, E. Soriano, C. Smyth, H.E. Parge, A. Ahmed, A.D. Roses, R.A. Hallewell, M.A. Pericak-Vance, and T. Siddique Amyotrophic lateral sclerosis and structural defects in Cu, Zn superoxide dismutase Science 261 1993 1047 1051
14. T.S. Diesing, S. Swindells, H. Gelbard, and H.E. Gendelman HIV-1-associated dementia: a basic science and clinical perspective AIDS Read. 12 2002 358 368
15. F. Duarte, S. Binet, L. Lacomblez, P. Bouche, J.L. Preud'homme, and V. Meininger Quantitative analysis of monoclonal immunoglobulins in serum of patients with amyotrophic lateral sclerosis J. Neurol. Sci. 104 1991 88 91
16. H.D. Durham, J. Roy, L. Dong, and D.A. Figlewicz Aggregation of mutant Cu/Zn superoxide dismutase proteins in a culture model of ALS J. Neuropathol. Exp. Neurol. 56 1997 523 530
17. J.I. Engelhardt, and S.H. Appel IgG reactivity in the spinal cord and motor cortex in amyotrophic lateral sclerosis Arch. Neurol. 47 1990 1210 1216
18. M. Fiala, Q.N. Liu, J. Sayre, V. Pop, V. Brahmandam, M.C. Graves, and H.V. Vinters Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer's disease brain and damage the blood-brain barrier Eur. J. Clin. Investig. 32 2002 360 371
19. L.G. Filion, G. Graziani-Bowering, D. Matusevicius, and M.S. Freedman Monocyte-derived cytokines in multiple sclerosis Clin. Exp. Immunol. 131 2003 324 334
20. T. Fischer-Smith, S. Croul, A.E. Sverstiuk, C. Capini, D. L'Heureux, E.G. Regulier, M.W. Richardson, S. Amini, S. Morgello, K. Khalili, and J. Rappaport CNS invasion by CD14+/CD16+ peripheral blood-derived monocytes in HIV dementia: perivascular accumulation and reservoir of HIV infection J. Neurovirology 7 2001 528 541
21. S. Floris, A. van der Goes, J. Killestein, D.L. Knol, F. Barkhof, C.H. Polman, C.D. Dijkstra, H.E. de Vries, and J.F. Meilof Monocyte activation and disease activity in multiple sclerosis. A longitudinal analysis of serum MRP8/14 levels J. Neuroimmunol. 148 2004 172 177
22. M. Frankenberger, T. Sternsdorf, H. Pechumer, A. Pforte, and H.W. Ziegler-Heitbrock Differential cytokine expression in human blood monocyte subpopulations: a polymerase chain reaction analysis Blood 87 1996 373 377
23. A.E. Fray, P.G. Ince, S.J. Banner, I.D. Milton, P.A. Usher, and P.J. Shaw Expression of the glial glutamate transporter EAAT2 in motor neurone disease: an immunocytochemiscal study Eur. J. Neurosci. 10 1998 2481 2489
24. R.L. Gascon, A.B. Narvaez, R.Z. Zhang, J.O. Kahn, F.M. Hecht, B.G. Herndier, and M.S. McGrath Increased HLA-DR expression on peripheral blood monocytes in subsets of subjects with primary HIV infection is associated with elevated CD4 T-cell apoptosis and CD4 T-cell depletion J. Acquir. Immune Defic. Syndr. 30 2002 146 153
25. J.D. Glass, H. Fedor, S.L. Wesselingh, and J.C. McArthur Immunocytochemical quantitation of human immunodeficiency virus in the brain: correlation with dementia Ann. Neurol. 38 1995 755 762
26. Y.J. Gu, and W. van Oeveren Time course of proinflammatory and anti-inflammatory responses after cardiac operation: monocyte HLA-DR expression Ann. Thorac. Surg. 76 2003 654 655
27. S. Hayashi, A. Sakurai, M. Amari, and K. Okamoto Pathological study of the diffuse myelin pallor in the anterolateral columns of the spinal cord in amyotrophic lateral sclerosis J. Neurol. Sci. 188 2001 3 7
28. J.S. Henkel, J.I. Engelhardt, L. Siklos, E.P. Simpson, S.H. Kim, T. Pan, J.C. Goodman, T. Siddique, D.R. Beers, and S.H. Appel Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue Ann. Neurol. 55 2004 221 235
29. K. Hensley, R.A. Floyd, B. Gordon, S. Mou, Q.N. Pye, C. Stewart, M. West, and K. Williamson Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis J. Neurochem. 82 2002 365 374
30. E.C. Hirsch, T. Breidert, E. Rousselet, S. Hunot, A. Hartmann, and P.P. Michel The role of glial reaction and inflammation in Parkinson's disease Ann. N.Y. Acad. Sci. 991 2003 214 228
31. L. Kusdra, H. Rempel, K. Yaffe, and L. Pulliam Elevation of CD69+ monocyte/macrophages in patients with Alzheimer's disease Immunobiology 202 2000 26 33
32. V. La Bella, J.C. Goodman, and S.H. Appel Increased CSF glutamate following injection of ALS immunoglobulins Neurology 48 1997 1270 1272
33. Y. Liu, X.P. Tang, J.C. McArthur, J. Scott, and S. Gartner Analysis of human immunodeficiency virus type 1gp160 sequences from a patient with HIV dementia: evidence for monocyte trafficking into brain J. Neurovirology 6 suppl 1 2000 S70 S81
34. E.G. McGeer, and P.L. McGeer The importance of inflammatory mechanisms in Alzheimer disease Exp. Gerontol. 33 1998 371 378
35. P.L. McGeer, and E.G. McGeer Inflammatory processes in amyotrophic lateral sclerosis Muscle Nerve 26 2002 459 470
36. P.L. McGeer, S. Itagaki, B.E. Boyes, and E.G. McGeer Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains Neurology 38 1988 1285 1291
37. B. Melichar, C.A. Savary, R. Patenia, S. Templin, K. Melicharova, and R.S. Freedman Phenotype and antitumor activity of ascitic fluid monocytes in patients with ovarian carcinoma Int. J. Gynecol. Cancer 13 2003 435 443
38. A. Minagar, P. Shapshak, R. Fujimura, R. Ownby, M. Heyes, and C. Eisdorfer The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis J. Neurol. Sci. 202 2002 13 23
39. I. Obal, J.S. Jakab, L. Siklos, and J.I. Engelhardt Recruitment of activated microglia cells in the spinal cord of mice by ALS IgG NeuroReport 12 2001 2449 2452
40. L. Provinciali, A.R. Giovagnoli, S. Battucci, C. Bartocci, and M. Montroni Immunological assessment in sporadic amyotrophic lateral sclerosis (ALS) Adv. Exp. Med. Biol. 209 1987 149 153
41. L. Provinciali, M.A. Laurenzi, L. Vesprini, A.R. Giovagnoli, C. Bartocci, M. Montroni, P. Bagnarelli, M. Clementi, and P.E. Varaldo Immunity assessment in the early stages of amyotrophic lateral sclerosis: a study of virus antibodies and lymphocyte subsets Acta Neurol. Scand. 78 1988 449 454
42. L. Pulliam, R. Gascon, M. Stubblebine, D. McGuire, and M.S. McGrath Unique monocyte subset in patients with AIDS dementia Lancet 349 1997 692 695
43. C. Richter, J.W. Park, and B.N. Ames Normal oxidative damage to mitochondrial and nuclear DNA is extensive Proc. Natl. Acad. Sci. U. S. A. 85 1988 6465 6467
44. G.E. Ringheim, and K. Conant Neurodegenerative disease and the neuroimmune axis (Alzheimer's and Parkinson's disease, and viral infections) J. Neuroimmunol. 147 2004 43 49
45. J.D. Rothstein, M. Van Kammen, A.I. Levey, L.J. Martin, and R.W. Kuncl Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis Ann. Neurol. 38 1995 73 84
46. S. Sanchez-Ramon, J.M. Bellon, S. Resino, C. Canto-Nogues, D. Gurbindo, J.T. Ramos, and M.A. Munoz-Fernandez Low blood CD8+T-lymphocytes and high circulating monocytes are predictors of HIV-1-associated progressive encephalopathy in children Pediatrics 111 2003 E168 E175
47. C. Scali, C. Prosperi, L. Bracco, C. Piccini, R. Baronti, A. Ginestroni, S. Sorbi, G. Pepeu, and F. Casamenti Neutrophils CD11b and fibroblasts PGE(2) are elevated in Alzheimer's disease Neurobiol. Aging 23 2002 523 530
48. D. Schiffer, S. Cordera, P. Cavalla, and A. Migheli Reactive astrogliosis of the spinal cord in amyotrophic lateral sclerosis J. Neurol. Sci. 139 1996 27 33 (suppl)
49. F. Shalit, B. Sredni, C. Brodie, E. Kott, and M. Huberman T lymphocyte subpopulations and activation markers correlate with severity of Alzheimer's disease Clin. Immunol. Immunopathol. 75 1995 246 550
50. E.P. Simpson, Y.K. Henry, J.S. Henkel, R.G. Smith, and S.H. Appel Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden Neurology 62 2004 1758 1765
51. H.A. Smits, L.A. Boven, C.F. Pereira, J. Verhoef, and H.S. Nottet Role of macrophage activation in the pathogenesis of Alzheimer's disease and human immunodeficiency virus type 1-associated dementia Eur. J. Clin. Investig. 30 2000 526 535
52. T. Tikka, B.L. Fiebich, G. Goldsteins, R. Keinanen, and J. Koistinaho Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia J. Neurosci. 21 2001 2580 2588
53. D. Troost, J.J. Van den Oord, J.M. de Jong, and D.F. Swaab Lymphocytic infiltration in the spinal cord of patients with amyotrophic lateral sclerosis Clin. Neuropathol. 8 1989 289 294
54. L. Van Den Bosch, P. Tilkin, G. Lemmens, and W. Robberecht Minocycline delays disease onset and mortality in a transgenic model of ALS NeuroReport 13 2002 1067 1070
55. K. Williams, A. Schwartz, S. Corey, M. Orandle, W. Kennedy, B. Thompson, X. Alvarez, C. Brown, S. Gartner, and A. Lackner Proliferating cellular nuclear antigen expression as a marker of perivascular macrophages in simian immunodeficiency virus encephalitis Am. J. Pathol. 161 2002 575 585
56. H. Wilms, J. Sievers, R. Dengler, J. Bufler, G. Deuschl, and R. Lucius Intrathecal synthesis of monocyte chemoattractant protein-1 (MCP-1) in amyotrophic lateral sclerosis: further evidence for microglial activation in neurodegeneration J. Neuroimmunol. 144 2003 139 142
57. P.C. Wong, C.A. Pardo, D.R. Borchelt, M.K. Lee, N.G. Copeland, N.A. Jenkins, S.S. Sisodia, D.W. Cleveland, and D.L. Price An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria Neuron 14 1995 1105 1116
58. H.W. Ziegler-Heitbrock, G. Fingerle, M. Strobel, W. Schraut, F. Stelter, C. Schutt, B. Passlick, and A. Pforte The novel subset of CD14+/CD16+blood monocytes exhibits features of tissue macrophages Eur. J. Immunol. 23 1993 2053 2058