Pigment epithelium-derived factor is elevated in CSF of patients with amyotrophic lateral sclerosis

Journal of Neurochemistry

Volumn 81, Issue 1, 2002, Pages 178-184

  Kuncl, Ralph W ^a   Bilak, Masako M ^a   Bilak, Stephan R ^a   Corse, Andrea M ^a   Royal, Walter ^a   Becerra, S Patricia ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL EYE INSTITUTE   (United States)

Author keywords

Amyotrophic lateral sclerosis; Cerebrospinal fluid; Neurotrophic factors; Pigment epithelium derived factor; Serine protease inhibitors; Spinal cord

Indexed keywords

PIGMENT EPITHELIUM DERIVED FACTOR;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DENERVATION; HUMAN; MOTONEURON; NERVE DEGENERATION; NEUROPROTECTION; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN SYNTHESIS;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AMYOTROPHIC LATERAL SCLEROSIS; BLOTTING, WESTERN; DENSITOMETRY; EYE PROTEINS; FEMALE; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; NERVE GROWTH FACTORS; NEURODEGENERATIVE DISEASES; PROTEINS; REPRODUCIBILITY OF RESULTS; SERPINS; SURVIVAL RATE;

EID: 0036074844     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.00813.x     Document Type: Article

References (47)

1. Pigment epithelium-derived factor (PEDF) differentially protects immature but not mature cerebellar granule cells against apoptotic cell death
2. Somatomedin levels in cerebrospinal fluid from adults with pituitary disorders
3. Structure-function relationships of PEDF. A non-inhibitory serpin with neurotrophic activity
4. Pigment epithelium-derived factor behaves like a noninhibitory serpin
5. Matrix metalloproteinase-9 is elevated in serum of patients with amyotrophic lateral sclerosis
6. A small peptide from human pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated degeneration
7. Pigment epithelium-derived factor (PEDF) protects motor neurons from chronic glutamate-mediated neurodegeneration
8. Neuroprotective utility and neurotrophic action of neurturin in postnatal motor neurons: Comparison with GDNF and persephin
9. Pigment epithelium-derived factor delays the death of photoreceptors in mouse models of inherited retinal degenerations
10. Serpin=serine protease-like complexes within neurofilament conglomerates of motoneurons in amyotrophic lateral sclerosis
11. Epidermal growth factor in human cerebrospinal fluid: Reduced levels in amyotrophic lateral sclerosis
12. Cerebrospinal fluid levels of MMP-2, 7, and 9 are elevated in association with human immunodeficiency virus dementia
13. Preclinical testing of neuroprotective neurotrophic factors in a model of chronic motor neuron degeneration
14. Pigment epithelium-derived factor: A potent inhibitor of angiogenesis
15. Neuroprotection by pigment epithelial-derived factor against glutamate toxicity in developing primary hippocampal neurons
16. Aging and Alzheimer's disease: Protease inhibitors in cerebrospinal fluid
17. Protease nexin I, thrombinand urokinase-inhibiting serpin, concentrated in normal human cerebrospinal fluid
18. Gelatinase in the cerebrospinal fluid of patients with multiple sclerosis and other inflammatory neurological disorders
19. GDNF but not BDNF is increased in cerebrospinal fluid in amyotrophic lateral sclerosis
20. Pigment epithelium-derived factor promotes the survival and differentiation of developing spinal motor neurons
21. Is 'unilateral' moyamoya disease different from moyamoya disease?
22. Amyotrophic lateral sclerosis: Evidence for intact hepatocyte growth factor/met signalling axis
23. Matrix metalloproteinases and tissue inhibitors of metalloproteinases in viral meningitis: Upregulation of MMP-9 and TIMP-1 in cerebrospinal fluid
24. BDNF is increased in cerebrospinal fluid of children suffering from asphyxia
25. Isolation, purification, and characterization of a collagen-associated serpin, caspin, produced by murine colon adenocarcinoma cells
26. Electromyography in amyotrophic lateral sclerosis
27. Matrix metalloproteinases in the neocortex and spinal cord of amyotrophic lateral sclerosis patients
28. Marked increase of matrix metalloproteinase 9 in cerebrospinal fluid of patients with fungal or tuberculous meningoencephalitis
29. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
30. Neurotrophic factors and neuromuscular disease. I. General comments, the neurotrophin family, and neuropoietic cytokines
31. Neurotrophic factors and neuromuscular disease. II. GDNF, other neurotrophic factors, and future directions
32. Neurofilament phosphorylation is enhanced in cultured chick spinal cord neurons exposed to cerebrospinal fluid from amyotrophic lateral sclerosis patients
33. o State
34. Plasminogen activator inhibitor 1, the primary regulator of fibrinolysis, in normal human cerebrospinal fluid
35. Neurofilament phosphorylation is increased in ventral horn neurons of neonatal rat spinal cord exposed to cerebrospinal fluid from patients with amyotrophic lateral sclerosis
36. Characterization of the serpin, alpha 1-antichymotrypsin, in normal human cerebrospinal fluid
37. Location and secretion of brain angiotensinogen
38. Current concepts in the pathogenesis of amyotrophic lateral sclerosis
39. Alterations in serum thrombospondin in patients with amyotrophic lateral sclerosis
40. Pigment epithelium-derived factor (PEDF): Neurotrophic activity and identification as a unique member of the serine protease inhibitor (SERPIN) gene family
41. Pigment epithelium-derived factor protects cultured cerebellar granule cells against glutamate-induced neurotoxicity
42. Organization, evolutionary conservation, expression and unusual Alu density of the human gene for pigment epithelium-derived factor, a unique neurotrophic serpin
43. Carboxyterminal propeptide of type I procollagen in cerebrospinal fluid in childhood and in children with leukemia undergoing intrathecall treatment
44. Gelatinase activity of matrix metalloproteinases in the cerebrospinal fluid of various patient populations
45. Proteolytic activity directed toward pigment epithelium-derived factor in vitreous of bovine eyes. Implications of proteolytic processing
46. Identification of pigment epithelium-derived factor in the interphotoreceptor matrix of bovine eyes
47. Angiogenic factors in moyamoya disease