Microglial upregulation of progranulin as a marker of motor neuron degeneration

Journal of Neuropathology and Experimental Neurology

Volumn 69, Issue 12, 2010, Pages 1191-1200

  Philips, Thomas ^a,b   De Muynck, Louis ^a,b   Thu, Hoai Nguyen Thi ^a,b   Weynants, Bea ^a,b   Vanacker, Peter ^b   Dhondt, Joke ^a,b   Sleegers, Kristel ^a,d   Schelhaas, Helenius J ^c   Verbeek, Marcel ^c   Vandenberghe, Rik ^b   Sciot, Raf ^b   Van Broeckhoven, Christine ^a,d   Lambrechts, Diether ^a,b   Van Leuven, Fred ^b   Van Den Bosch, Ludo ^a,b   Robberecht, Wim ^a,b   Van Damme, Philip ^a,b  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Amyotrophic lateral sclerosis; Frontotemporal lobar degeneration; Microglia; Progranulin; Tau

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; PROGRANULIN;

ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; FRONTOTEMPORAL DEMENTIA; HUMAN; MALE; MICROGLIA; MOTONEURON; MOUSE; NERVE CELL DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN EXPRESSION; SPINAL CORD; UPREGULATION;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BIOLOGICAL MARKERS; DISEASE PROGRESSION; FEMALE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, TRANSGENIC; MICROGLIA; MIDDLE AGED; MOTOR NEURON DISEASE; NERVE DEGENERATION; UP-REGULATION;

EID: 78650178041     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3181fc9aea     Document Type: Article

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