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Volumn 69, Issue 12, 2010, Pages 1191-1200

Microglial upregulation of progranulin as a marker of motor neuron degeneration

Author keywords

Amyotrophic lateral sclerosis; Frontotemporal lobar degeneration; Microglia; Progranulin; Tau

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; PROGRANULIN;

EID: 78650178041     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3181fc9aea     Document Type: Article
Times cited : (59)

References (59)
  • 2
    • 0026580016 scopus 로고
    • Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains
    • Bhandari V, Palfree RG, Bateman A. Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains. Proc Natl Acad Sci USA 1992;89: 1715-19
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1715-19
    • Bhandari, V.1    Palfree, R.G.2    Bateman, A.3
  • 3
    • 0025133297 scopus 로고
    • Epithelins 1 and 2: Isolation and characterization of two cysteine-rich growth-modulating proteins
    • Shoyab M, McDonald VL, Byles C, et al. Epithelins 1 and 2: Isolation and characterization of two cysteine-rich growth-modulating proteins. Proc Natl Acad Sci USA 1990;87:7912-16
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 7912-16
    • Shoyab, M.1    McDonald, V.L.2    Byles, C.3
  • 4
    • 0037074016 scopus 로고    scopus 로고
    • Conversion of proepithelin to epithelins: Roles of SLPI and elastase in host defense and wound repair
    • Zhu J, Nathan C, Jin W, et al. Conversion of proepithelin to epithelins: Roles of SLPI and elastase in host defense and wound repair. Cell 2002; 111:867-78
    • (2002) Cell , vol.111 , pp. 867-78
    • Zhu, J.1    Nathan, C.2    Jin, W.3
  • 5
    • 0037329891 scopus 로고    scopus 로고
    • Progranulin is a mediator of the wound response
    • He Z, Ong CH, Halper J, et al. Progranulin is a mediator of the wound response. Nat Med 2003;9:225-29
    • (2003) Nat Med , vol.9 , pp. 225-29
    • He, Z.1    Ong, C.H.2    Halper, J.3
  • 6
    • 0242320195 scopus 로고    scopus 로고
    • Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumori-genesis
    • He Z, Bateman A. Progranulin (granulin-epithelin precursor, PC-cell-derived growth factor, acrogranin) mediates tissue repair and tumori-genesis. J Mol Med 2003;81:600-12
    • (2003) J Mol Med , vol.81 , pp. 600-12
    • He, Z.1    Bateman, A.2
  • 7
    • 33847654643 scopus 로고    scopus 로고
    • Progranulin in frontotemporal lobar degeneration and neuroinflammation
    • Ahmed Z, Mackenzie IR, Hutton ML, et al. Progranulin in frontotemporal lobar degeneration and neuroinflammation. J Neuroinflammation 2007;4:7
    • (2007) J Neuroinflammation , vol.4 , pp. 7
    • Ahmed, Z.1    MacKenzie, I.R.2    Hutton, M.L.3
  • 8
    • 0032749572 scopus 로고    scopus 로고
    • Biological activities and signaling pathways of the granulin/epithelin precursor
    • Zanocco-Marani T, Bateman A, Romano G, et al. Biological activities and signaling pathways of the granulin/epithelin precursor. Cancer Res 1999;59:5331-40
    • (1999) Cancer Res , vol.59 , pp. 5331-40
    • Zanocco-Marani, T.1    Bateman, A.2    Romano, G.3
  • 9
    • 0027241980 scopus 로고
    • Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line
    • Zhou J, Gao G, Crabb JW, et al. Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line. J Biol Chem 1993;268:10863-69
    • (1993) J Biol Chem , vol.268 , pp. 10863-69
    • Zhou, J.1    Gao, G.2    Crabb, J.W.3
  • 10
    • 33746919083 scopus 로고    scopus 로고
    • Mutations in pro-granulin cause tau-negative frontotemporal dementia linked to chromosome 17
    • Baker M, Mackenzie IR, Pickering-Brown SM, et al. Mutations in pro-granulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature 2006; 442:916-19.
    • (2006) Nature , vol.442 , pp. 916-19
    • Baker, M.1    MacKenzie, I.R.2    Pickering-Brown, S.M.3
  • 11
    • 33746910649 scopus 로고    scopus 로고
    • Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21
    • Cruts M, Gijselinck I, van der Zee J, et al. Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21. Nature 2006;442:920-24
    • (2006) Nature , vol.442 , pp. 920-24
    • Cruts, M.1    Gijselinck, I.2    Van Der Zee, J.3
  • 12
    • 60949099072 scopus 로고    scopus 로고
    • Progranulin Leu271LeufsX10 is one of the most common FTLD and CBS associated mutations worldwide
    • Benussi L, Ghidoni R, Pegoiani E, et al. Progranulin Leu271LeufsX10 is one of the most common FTLD and CBS associated mutations worldwide. Neurobiol Dis 2009;33:379-85
    • (2009) Neurobiol Dis , vol.33 , pp. 379-85
    • Benussi, L.1    Ghidoni, R.2    Pegoiani, E.3
  • 13
    • 42949138769 scopus 로고    scopus 로고
    • Mutations in pro-granulin gene: Clinical, pathological, and ribonucleic acid expression findings
    • Lopez de Munain A, Alzualde A, Gorostidi A, et al. Mutations in pro-granulin gene: Clinical, pathological, and ribonucleic acid expression findings. Biol Psychiatry 2008;63:946-52
    • (2008) Biol Psychiatry , vol.63 , pp. 946-52
    • Lopez De Munain, A.1    Alzualde, A.2    Gorostidi, A.3
  • 14
    • 0034326242 scopus 로고    scopus 로고
    • Cognitive change in motor neurone disease/amyotrophic lateral sclerosis (MND/ALS)
    • Neary D, Snowden JS, Mann DM. Cognitive change in motor neurone disease/amyotrophic lateral sclerosis (MND/ALS). J Neurol Sci 2000; 180:15-20
    • (2000) J Neurol Sci , vol.180 , pp. 15-20
    • Neary, D.1    Snowden, J.S.2    Mann, D.M.3
  • 15
    • 2642559477 scopus 로고    scopus 로고
    • Characterization of amyotrophic lateral sclerosis and frontotemporal dementia
    • Lomen-Hoerth C. Characterization of amyotrophic lateral sclerosis and frontotemporal dementia. Dement Geriatr Cogn Disord 2004;17:337-41
    • (2004) Dement Geriatr Cogn Disord , vol.17 , pp. 337-41
    • Lomen-Hoerth, C.1
  • 16
    • 0037044240 scopus 로고    scopus 로고
    • The overlap of amyotrophic lateral sclerosis and frontotemporal dementia
    • Lomen-Hoerth C, Anderson T, Miller B. The overlap of amyotrophic lateral sclerosis and frontotemporal dementia. Neurology 2002;59: 1077-79
    • (2002) Neurology , vol.59 , pp. 1077-79
    • Lomen-Hoerth, C.1    Anderson, T.2    Miller, B.3
  • 17
    • 3142628291 scopus 로고    scopus 로고
    • Word retrieval in amyo-trophic lateral sclerosis: A functional magnetic resonance imaging study
    • Abrahams S, Goldstein LH, Simmons A, et al. Word retrieval in amyo-trophic lateral sclerosis: A functional magnetic resonance imaging study. Brain 2004;127:1507-17
    • (2004) Brain , vol.127 , pp. 1507-17
    • Abrahams, S.1    Goldstein, L.H.2    Simmons, A.3
  • 18
    • 42049108445 scopus 로고    scopus 로고
    • Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia
    • Mukherjee O, Wang J, Gitcho M, et al. Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia. Hum Mutat 2008;29:512-21
    • (2008) Hum Mutat , vol.29 , pp. 512-21
    • Mukherjee, O.1    Wang, J.2    Gitcho, M.3
  • 19
    • 42049087853 scopus 로고    scopus 로고
    • Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival
    • Van Damme P, Van Hoecke A, Lambrechts D, et al. Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival. J Cell Biol 2008;181:37-41
    • (2008) J Cell Biol , vol.181 , pp. 37-41
    • Van Damme, P.1    Van Hoecke, A.2    Lambrechts, D.3
  • 20
    • 54449085260 scopus 로고    scopus 로고
    • Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration
    • Ghidoni R, Benussi L, Glionna M, et al. Low plasma progranulin levels predict progranulin mutations in frontotemporal lobar degeneration. Neurology 2008;71:1235-39
    • (2008) Neurology , vol.71 , pp. 1235-39
    • Ghidoni, R.1    Benussi, L.2    Glionna, M.3
  • 21
    • 64849103956 scopus 로고    scopus 로고
    • Plasma progranulin levels predict pro-granulin mutation status in frontotemporal dementia patients and asymptomatic family members
    • Finch N, Baker M, Crook R, et al. Plasma progranulin levels predict pro-granulin mutation status in frontotemporal dementia patients and asymptomatic family members. Brain 2009;132:583-91
    • (2009) Brain , vol.132 , pp. 583-91
    • Finch, N.1    Baker, M.2    Crook, R.3
  • 22
    • 67249111266 scopus 로고    scopus 로고
    • Serum biomarker for progranulin-associated frontotemporal lobar degeneration
    • Sleegers K, Brouwers N, Van Damme P, et al. Serum biomarker for progranulin-associated frontotemporal lobar degeneration. Ann Neurol 2009;65:603-9
    • (2009) Ann Neurol , vol.65 , pp. 603-9
    • Sleegers, K.1    Brouwers, N.2    Van Damme, P.3
  • 23
    • 70350618915 scopus 로고    scopus 로고
    • Progranulin plasma levels as potential biomarker for the identification of GRN deletion carriers. A case with atypical onset as clinical amnestic Mild Cognitive Impairment converted to Alzheimer's disease
    • Carecchio M, Fenoglio C, De Riz M, et al. Progranulin plasma levels as potential biomarker for the identification of GRN deletion carriers. A case with atypical onset as clinical amnestic Mild Cognitive Impairment converted to Alzheimer's disease. J Neurol Sci 2009;287:291-93
    • (2009) J Neurol Sci , vol.287 , pp. 291-93
    • Carecchio, M.1    Fenoglio, C.2    De Riz, M.3
  • 24
    • 67651091752 scopus 로고    scopus 로고
    • Cortical atrophy and language network reorganization associated with a novel progranulin mutation
    • Cruchaga C, Fernandez-Seara MA, Seijo-Martinez M, et al. Cortical atrophy and language network reorganization associated with a novel progranulin mutation. Cereb Cortex 2009;19:1751-60
    • (2009) Cereb Cortex , vol.19 , pp. 1751-60
    • Cruchaga, C.1    Fernandez-Seara, M.A.2    Seijo-Martinez, M.3
  • 25
    • 34247868937 scopus 로고    scopus 로고
    • Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia
    • Van Der Zee J, Le Ber I, Maurer-Stroh S, et al. Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia. Hum Mutat 2007;28:416
    • (2007) Hum Mutat , vol.28 , pp. 416
    • Van Der Zee, J.1    Le Ber, I.2    Maurer-Stroh, S.3
  • 26
    • 34047224991 scopus 로고    scopus 로고
    • Clinicopathologic features of frontotemporal dementia with progranulin sequence variation
    • Spina S, Murrell JR, Huey ED, et al. Clinicopathologic features of frontotemporal dementia with progranulin sequence variation. Neurology 2007;68:820-27
    • (2007) Neurology , vol.68 , pp. 820-27
    • Spina, S.1    Murrell, J.R.2    Huey, E.D.3
  • 27
    • 52449110477 scopus 로고    scopus 로고
    • Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease
    • Brouwers N, Sleegers K, Engelborghs S, et al. Genetic variability in progranulin contributes to risk for clinically diagnosed Alzheimer disease. Neurology 2008;71:656-64
    • (2008) Neurology , vol.71 , pp. 656-64
    • Brouwers, N.1    Sleegers, K.2    Engelborghs, S.3
  • 28
    • 34347245619 scopus 로고    scopus 로고
    • Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosisY frontotemporal dementia phenotypes
    • Schymick JC, Yang Y, Andersen PM, et al. Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosisY frontotemporal dementia phenotypes. J Neurol Neurosurg Psychiatry 2007;78:754-56
    • (2007) J Neurol Neurosurg Psychiatry , vol.78 , pp. 754-56
    • Schymick, J.C.1    Yang, Y.2    Andersen, P.M.3
  • 29
    • 42049120518 scopus 로고    scopus 로고
    • Progranulin genetic variability contributes to amyotrophic lateral sclerosis
    • Sleegers K, Brouwers N, Maurer-Stroh S, et al. Progranulin genetic variability contributes to amyotrophic lateral sclerosis. Neurology 2008; 71:253-59
    • (2008) Neurology , vol.71 , pp. 253-59
    • Sleegers, K.1    Brouwers, N.2    Maurer-Stroh, S.3
  • 30
    • 78650173120 scopus 로고    scopus 로고
    • No major progranulin genetic variability contribution to disease etiopathogenesis in an ALS Italian cohort
    • July 24 Epub ahead of print]
    • Del Bo R, Corti S, Santoro D, et al. No major progranulin genetic variability contribution to disease etiopathogenesis in an ALS Italian cohort. Neurobiol Aging July 24, 2009 [Epub ahead of print]
    • (2009) Neurobiol Aging
    • Del Bo, R.1    Corti, S.2    Santoro, D.3
  • 31
    • 0036500643 scopus 로고    scopus 로고
    • High-density microarray analysis of hippocampal gene expression following experimental brain injury
    • Matzilevich DA, Rall JM, Moore AN, et al. High-density microarray analysis of hippocampal gene expression following experimental brain injury. J Neurosci Res 2002;67:646-63
    • (2002) J Neurosci Res , vol.67 , pp. 646-63
    • Matzilevich, D.A.1    Rall, J.M.2    Moore, A.N.3
  • 32
    • 0034797275 scopus 로고    scopus 로고
    • Identification of genes involved in the host response to neurovirulent alphavirus infection
    • Johnston C, Jiang W, Chu T, et al. Identification of genes involved in the host response to neurovirulent alphavirus infection. J Virol 2001;75: 10431-45
    • (2001) J Virol , vol.75 , pp. 10431-45
    • Johnston, C.1    Jiang, W.2    Chu, T.3
  • 33
    • 77649192710 scopus 로고    scopus 로고
    • Progranulin expression is upregulated after spinal contusion in mice
    • Naphade SB, Kigerl KA, Jakeman LB, et al. Progranulin expression is upregulated after spinal contusion in mice. Acta Neuropathol 2009;119: 123-33
    • (2009) Acta Neuropathol , vol.119 , pp. 123-33
    • Naphade, S.B.1    Kigerl, K.A.2    Jakeman, L.B.3
  • 34
    • 33750590113 scopus 로고    scopus 로고
    • The neuropathology of frontotemporal lobar degeneration caused by mutations in the pro-granulin gene
    • Mackenzie IR, Baker M, Pickering-Brown S, et al. The neuropathology of frontotemporal lobar degeneration caused by mutations in the pro-granulin gene. Brain 2006;129:3081-90
    • (2006) Brain , vol.129 , pp. 3081-90
    • MacKenzie, I.R.1    Baker, M.2    Pickering-Brown, S.3
  • 35
    • 33749499157 scopus 로고    scopus 로고
    • HDDD2 is a familial fronto-temporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin
    • Mukherjee O, Pastor P, Cairns NJ, et al. HDDD2 is a familial fronto-temporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin. Ann Neurol 2006;60:314-22
    • (2006) Ann Neurol , vol.60 , pp. 314-22
    • Mukherjee, O.1    Pastor, P.2    Cairns, N.J.3
  • 36
    • 0037457875 scopus 로고    scopus 로고
    • Unique inflammatory RNA profiles of micro-glia in Creutzfeldt-Jakob disease
    • Baker CA, Manuelidis L. Unique inflammatory RNA profiles of micro-glia in Creutzfeldt-Jakob disease. Proc Natl Acad Sci USA 2003, 100: 675-79.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 675-79
    • Baker, C.A.1    Manuelidis, L.2
  • 37
    • 0037452606 scopus 로고    scopus 로고
    • Activated microglia in cortex of mouse models of mucopolysaccharidoses i and IIIB
    • Ohmi K, Greenberg DS, Rajavel KS, et al. Activated microglia in cortex of mouse models of mucopolysaccharidoses I and IIIB. Proc Natl Acad Sci USA 2003;100:1902-7
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1902-7
    • Ohmi, K.1    Greenberg, D.S.2    Rajavel, K.S.3
  • 38
    • 0035085455 scopus 로고    scopus 로고
    • Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays
    • Malaspina A, Kaushik N, de Belleroche J. Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays. J Neurochem 2001;77:132-45
    • (2001) J Neurochem , vol.77 , pp. 132-45
    • Malaspina, A.1    Kaushik, N.2    De Belleroche, J.3
  • 39
    • 70349091081 scopus 로고    scopus 로고
    • Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models
    • Pereson S, Wils H, Kleinberger G, et al. Progranulin expression correlates with dense-core amyloid plaque burden in Alzheimer disease mouse models. J Pathol 2009;219:173-81
    • (2009) J Pathol , vol.219 , pp. 173-81
    • Pereson, S.1    Wils, H.2    Kleinberger, G.3
  • 40
    • 77649192195 scopus 로고    scopus 로고
    • Brain progranulin expression in GRN-associated frontotemporal lobar degeneration
    • Chen-Plotkin AS, Xiao J, Geser F, et al. Brain progranulin expression in GRN-associated frontotemporal lobar degeneration. Acta Neuropathol 2010;119:111-22
    • (2010) Acta Neuropathol , vol.119 , pp. 111-22
    • Chen-Plotkin, A.S.1    Xiao, J.2    Geser, F.3
  • 42
    • 0031672540 scopus 로고    scopus 로고
    • Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria
    • Neary D, Snowden JS, Gustafson L, et al. Frontotemporal lobar degeneration: A consensus on clinical diagnostic criteria. Neurology 1998;51: 1546-54
    • (1998) Neurology , vol.51 , pp. 1546-54
    • Neary, D.1    Snowden, J.S.2    Gustafson, L.3
  • 43
    • 34447322271 scopus 로고    scopus 로고
    • Research criteria for the diagnosis of Alzheimer's disease: Revising the NINCDS-ADRDA criteria
    • Dubois B, Feldman HH, Jacova C, et al. Research criteria for the diagnosis of Alzheimer's disease: Revising the NINCDS-ADRDA criteria. Lancet Neurol 2007;6:734-46
    • (2007) Lancet Neurol , vol.6 , pp. 734-46
    • Dubois, B.1    Feldman, H.H.2    Jacova, C.3
  • 44
    • 0032831462 scopus 로고    scopus 로고
    • Vascular endothelial growth factor measured in platelet poor plasma allows optimal separation between cancer patients and volunteers: A key to study an angiogenic marker in vivo?
    • Wynendaele W, Derua R, Hoylaerts MF, et al. Vascular endothelial growth factor measured in platelet poor plasma allows optimal separation between cancer patients and volunteers: A key to study an angiogenic marker in vivo? Ann Oncol 1999;10:965-71
    • (1999) Ann Oncol , vol.10 , pp. 965-71
    • Wynendaele, W.1    Derua, R.2    Hoylaerts, M.F.3
  • 45
    • 0034978562 scopus 로고    scopus 로고
    • Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
    • Oosthuyse B, Moons L, Storkebaum E, et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet 2001;28:131-38
    • (2001) Nat Genet , vol.28 , pp. 131-38
    • Oosthuyse, B.1    Moons, L.2    Storkebaum, E.3
  • 46
    • 13644268449 scopus 로고    scopus 로고
    • Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in pro-gressive, nonlethal axonopathy of Tau-4R/2N transgenic mice
    • Terwel D, Lasrado R, Snauwaert J, et al. Changed conformation of mutant Tau-P301L underlies the moribund tauopathy, absent in pro-gressive, nonlethal axonopathy of Tau-4R/2N transgenic mice. J Biol Chem 2005;280:3963-73
    • (2005) J Biol Chem , vol.280 , pp. 3963-73
    • Terwel, D.1    Lasrado, R.2    Snauwaert, J.3
  • 47
    • 0028284779 scopus 로고
    • Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
    • Gurney ME, Pu H, Chiu AY, et al. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 1994;264:1772-75
    • (1994) Science , vol.264 , pp. 1772-75
    • Gurney, M.E.1    Pu, H.2    Chiu, A.Y.3
  • 48
    • 40449098952 scopus 로고    scopus 로고
    • Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice
    • Terwel D, Muyllaert D, Dewachter I, et al. Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice. Am J Pathol 2008;172: 786-98
    • (2008) Am J Pathol , vol.172 , pp. 786-98
    • Terwel, D.1    Muyllaert, D.2    Dewachter, I.3
  • 49
    • 55049120934 scopus 로고    scopus 로고
    • Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase
    • Gowing G, Philips T, Van Wijmeersch B, et al. Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase. J Neurosci 2008; 28:10234-44
    • (2008) J Neurosci , vol.28 , pp. 10234-44
    • Gowing, G.1    Philips, T.2    Van Wijmeersch, B.3
  • 50
    • 58149147341 scopus 로고    scopus 로고
    • Progranulin (PGRN) expression in ALS: An immunohistochemical study
    • Irwin D, Lippa CF, Rosso A. Progranulin (PGRN) expression in ALS: An immunohistochemical study. J Neurol Sci 2009; 276:9-13.
    • (2009) J Neurol Sci , vol.276 , pp. 9-13
    • Irwin, D.1    Lippa, C.F.2    Rosso, A.3
  • 51
    • 0029658019 scopus 로고    scopus 로고
    • Neuromuscular function impairment is not caused by motor neurone loss in FALS mice: An electromyo-graphic study
    • Kennel PF, Finiels F, Revah F, et al. Neuromuscular function impairment is not caused by motor neurone loss in FALS mice: An electromyo-graphic study. Neuroreport 1996;7:1427-31
    • (1996) Neuroreport , vol.7 , pp. 1427-31
    • Kennel, P.F.1    Finiels, F.2    Revah, F.3
  • 52
    • 0345742771 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis is a distal axonopathy: Evidence in mice and man
    • Fischer LR, Culver DG, Tennant P, et al. Amyotrophic lateral sclerosis is a distal axonopathy: Evidence in mice and man. Exp Neurol 2004;185: 232-40
    • (2004) Exp Neurol , vol.185 , pp. 232-240
    • Fischer, L.R.1    Culver, D.G.2    Tennant, P.3
  • 53
    • 0035833937 scopus 로고    scopus 로고
    • Immune reactivity in a mouse model of familial ALS correlates with disease progression
    • Alexianu ME, Kozovska M, Appel SH. Immune reactivity in a mouse model of familial ALS correlates with disease progression. Neurology 2001;57:1282-89
    • (2001) Neurology , vol.57 , pp. 1282-89
    • Alexianu, M.E.1    Kozovska, M.2    Appel, S.H.3
  • 54
    • 75949130374 scopus 로고    scopus 로고
    • Pathogenic cysteine mutations affect progranulin function and production of mature granulins
    • Wang J, Van Damme P, Cruchaga C, et al. Pathogenic cysteine mutations affect progranulin function and production of mature granulins. J Neu-rochem 2010;112:1305-15
    • (2010) J Neu-rochem , vol.112 , pp. 1305-15
    • Wang, J.1    Van Damme, P.2    Cruchaga, C.3
  • 55
    • 0033917655 scopus 로고    scopus 로고
    • Cellular localization of gene expression for progranulin
    • Daniel R, He Z, Carmichael KP, et al. Cellular localization of gene expression for progranulin. J Histochem Cytochem 2000;48:999-1009
    • (2000) J Histochem Cytochem , vol.48 , pp. 999-1009
    • Daniel, R.1    He, Z.2    Carmichael, K.P.3
  • 56
    • 70749120467 scopus 로고    scopus 로고
    • Progranulin is expressed within motor neurons and promotes neuronal cell survival
    • Ryan CL, Baranowski DC, Chitramuthu BP, et al. Progranulin is expressed within motor neurons and promotes neuronal cell survival. BMC Neurosci 2009;10:130
    • (2009) BMC Neurosci , vol.10 , pp. 130
    • Ryan, C.L.1    Baranowski, D.C.2    Chitramuthu, B.P.3
  • 57
    • 58049221032 scopus 로고    scopus 로고
    • Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axot-omy: Implications for TDP-43 in the physiological response to neuronal injury
    • Moisse K, Volkening K, Leystra-Lantz C, et al. Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axot-omy: Implications for TDP-43 in the physiological response to neuronal injury. Brain Res 2009;1249:202-11
    • (2009) Brain Res , vol.1249 , pp. 202-11
    • Moisse, K.1    Volkening, K.2    Leystra-Lantz, C.3
  • 58
    • 57149120501 scopus 로고    scopus 로고
    • Biomarkers in amyotrophic lateral sclerosis
    • Turner MR, Kiernan MC, Leigh PN, et al. Biomarkers in amyotrophic lateral sclerosis. Lancet Neurol 2009;8:94-109
    • (2009) Lancet Neurol , vol.8 , pp. 94-109
    • Turner, M.R.1    Kiernan, M.C.2    Leigh, P.N.3
  • 59


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.