Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress

Cell Death and Disease

Volumn 3, Issue 6, 2012, Pages

  Tay, K H ^a,b   Jin, L ^c   Tseng, Hs Y ^a,c   Jiang, C C ^a,b   Ye, Y ^a,b   Thorne, R F ^b   Liu, T ^d   Guo, S T ^e   Verrills, N M ^b   Hersey, P ^c   Zhang, X D ^a,b,e  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b UNIVERSITY OF NEWCASTLE   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

^e Shanxi Cancer Hospital and Institution   (China)

Author keywords

Bim; ER stress; MEK ERK; melanoma; PP2A

Indexed keywords

BIM PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; APOPTOSIS REGULATORY PROTEIN; BCL 2 LIKE PROTEIN 11; BCL-2-LIKE PROTEIN 11; MEMBRANE PROTEIN; ONCOPROTEIN; PHOSPHOPROTEIN PHOSPHATASE 2;

APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DEPHOSPHORYLATION; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SUBUNIT; HUMAN; HUMAN TISSUE; MELANOMA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; GENETIC TRANSCRIPTION; GENETICS; MELANOMA; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR CELL LINE; UPREGULATION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; DOWN-REGULATION; ENDOPLASMIC RETICULUM STRESS; HUMANS; MELANOMA; MEMBRANE PROTEINS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; PROTO-ONCOGENE PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 84863442225     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.79     Document Type: Article

References (40)

1. Harding HP, Calfon M, Urano F, Novoa I, Ron D. Transcriptional and translational control in the mammalian unfolded protein response. Annu Rev Cell Dev Biol 2002; 18: 575-599.
2. Schroder M, Kaufman RJ. The mammalian unfolded protein response. Annu Rev Biochem 2005; 74: 739-789.
3. Boyce M, Yuan J. Cellular response to endoplasmic reticulum stress: a matter of life or death. Cell Death Differ 2006; 13: 363-373.
4. Xu C, Bailly-Maitre B, Reed JC. Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 2005; 115: 2656-2664.
5. Zhang L, Lopez H, George NM, Liu X, Pang X, Luo X. Selective involvement of BH3-only proteins and differential targets of Noxa in diverse apoptotic pathways. Cell Death Differ 2011; 18: 864-873.
6. Puthalakath H, O'Reilly LA, Gunn P, Lee L, Kelly PN, Huntington ND et al. ER stress triggers apoptosis by activating BH3-only protein Bim. Cell 2007; 129: 1337-1349.
7. Ley R, Ewings KE, Hadfield K, Cook SJ. Regulatory phosphorylation of Bim: sorting out the ERK from the JNK. Cell Death Differ 2005; 12: 1008-1014.
8. Ley R, Ewings KE, Hadfield K, Howes E, Balmanno K, Cook SJ. Extracellular signalregulated kinases 1/2 are serum-stimulated "Bim(EL) kinases" that bind to the BH3-only protein Bim(EL) causing its phosphorylation and turnover. J Biol Chem 2004; 279: 8837-8847.
9. Shi Y. Serine/threonine phosphatases: mechanism through structure. Cell 2009; 139(3): 468-484.
10. Janssens V, Longin S, Goris J. PP2A holoenzyme assembly: in cauda venenum (the sting is in the tail).Trends Biochem Sci 2008; 33: 113-121.
11. Janssens V, Goris J, Van Hoof C. PP2A: the expected tumor suppressor. Curr Opin Genet Dev 2005; 15: 34-41.
12. Roberts KG, Smith AM, McDougall F, Carpenter H, Horan M, Neviani P et al. Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT cancers. Cancer Res 2010; 70: 5438-5447.
13. Ito A, Koma Y, Watabe K, Nagano T, Endo Y, Nojima H et al. A truncated isoform of the protein phosphatase 2A B56gamma regulatory subunit may promote genetic instability and cause tumor progression. Am J Pathol 2003; 162: 81-91.
14. Jiang CC, Lucas K, Avery-Kiejda KA, Wade M, deBock CE, Thorne RF et al. Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress. Cancer Res 2008; 68: 6708-6717.
15. Hersey P, Zhang XD. Adaptation to ER stress as a driver of malignancy and resistance to therapy in human melanoma. Pigment Cell Melanoma Res 2008; 21: 358-367.
16. Jiang CC, Mao ZG, Avery-Kiejda KA, Wade M, Hersey P, Zhang XD. Glucose-regulated protein 78 antagonizes cisplatin and adriamycin in human melanoma cells. Carcinogenesis 2009; 30: 197-204.
17. Zhuang L, Scolyer RA, Lee CS, McCarthy SW, Cooper WA, Zhang XD et al. Expression of glucose-regulated stress protein GRP78 is related to progression of melanoma. Histopathology 2009; 54: 462-470.
18. Vince JE, Wong WW, Khan N, Feltham R, Chau D, Ahmed AU et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell 2007; 131: 682-693.
19. Jiang CC, Lai F, Tay KH, Croft A, Rizos H, Becker TM et al. Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS. Cell Death Dis 2010; 1: e69.
20. Yin KJ, Hsu CY, Hu XY, Chen H, Chen SW, Xu J et al. Protein phosphatase 2A regulates bim expression via the Akt/FKHRL1 signaling pathway in amyloid-beta peptide-induced cerebrovascular endothelial cell death. J Neurosci 2006; 26: 2290-2299.
21. Hsu W, Zeng L, Costantini F. Identification of a domain of Axin that binds to the serine/ threonine protein phosphatase 2A and a self-binding domain. J Biol Chem 1999; 274: 3439-3445.
22. Gillespie S, Borrow J, Zhang XD, Hersey P. Bim plays a crucial role in synergistic induction of apoptosis by the histone deacetylase inhibitor SBHA and TRAIL in melanoma cells. Apoptosis 2006; 11: 2251-2265.
23. Wang YF, Jiang CC, Kiejda KA, Gillespie S, Zhang XD, Hersey P. Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1. Clin Cancer Res 2007; 13: 4934-4942.
24. Chen LH, Jiang CC, Watts R, Thorne RF, Kiejda KA, Zhang XD et al. Inhibition of endoplasmic reticulum stress-induced apoptosis of melanoma cells by the ARC protein. Cancer Res 2008; 68: 834-842.
25. Jiang CC, Chen LH, Gillespie S, Wang YF, Kiejda KA, Zhang XD et al. Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis. Cancer Res 2007; 67: 9750-9761.
26. Coley AM, Moujalled D, Puthalakath H. The PKA paradox: is Bim the answer? Cell Cycle 2011; 10: 729-730.
27. Zhang L, Insel PA. The pro-apoptotic protein Bim is a convergence point for cAMP/protein kinase A- and glucocorticoid-promoted apoptosis of lymphoid cells. J Biol Chem 2004; 279: 20858-20865.
28. Woo CW, Kutzler L, Kimball SR, Tabas I. Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B. Nat Cell Biol 2012; 14: 192-200.
29. Christen V, Treves S, Duong FH, Heim MH. Activation of endoplasmic reticulum stress response by hepatitis viruses up-regulates protein phosphatase 2A. Hepatology 2007; 46: 558-565.
30. Deichmann M, Polychronidis M, Wacker J, Thome M, Näher H. The protein phosphatase 2A subunit B gamma gene is identified to be differentially expressed in malignant melanomas by subtractive suppression hybridization. Melanoma Res 2001; 11: 577-585.
31. Mannava S, Omilian AR, Wawrzyniak JA, Fink EE, Zhuang D, Miecznikowski JC et al. PP2A-B56a controls oncogene-induced senescence in normal and tumor human melanocytic cells. Oncogene 2011; 31: 1484-1492.
32. Hu P, Han Z, Couvillon AD, Exton JH. Critical role of endogenous Akt/IAPs and MEK1/ERK pathways in counteracting endoplasmic reticulum stress-induced cell death. J Biol Chem 2004; 279: 49420-49429.
33. Strack S. Overexpression of the protein phosphatase 2A regulatory subunit B gamma promotes neuronal differentiation by activating the MAP kinase (MAPK) cascade. J Biol Chem 2002; 277: 41525-41532.
34. Van Kanegan MJ, Adams DG, Wadzinski BE, Strack S. Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt. J Biol Chem 2005; 280: 36029-36036.
35. Mandic A, Hansson J, Linder S, Shoshan MC. Cisplatin induces endoplasmic reticulum stress and nucleus-independent apoptotic signaling. J Biol Chem 2003; 278: 9100-9106.
36. Rahmani M, Davis EM, Crabtree TR, Habibi JR, Nguyen TK, Dent P et al. The kinase inhibitor sorafenib induces cell death through a process involving induction of endoplasmic reticulum stress. Mol Cell Biol 2007; 27: 5499-5513.
37. Fecher LA, Amaravadi RK, Flaherty KT. The MAPK pathway in melanoma. Curr Opin Oncol. 2008; 20: 183-189.
38. Nikolaou VA, Stratigos AJ, Flaherty KT, Tsao H. Melanoma: new insights and new therapies. J Invest Dermatol 2012; 132: 854-863.
39. Sullivan A, Uff CR, Isacke CM, Thorne RF. PACE-1, a novel protein that interacts with the C-terminal domain of ezrin. Exp Cell Res 2003; 284: 224-238.
40. Yang F, Tay KH, Dong L, Thorne RF, Jiang CC, Yang E et al. Cystatin B inhibition of TRAIL-induced apoptosis is associated with the protection of FLIP(L) from degradation by the E3 ligase itch in human melanoma cells. Cell Death Differ 2010; 17: 1354-1367.