A truncated isoform of the protein phosphatase 2A B56γ regulatory subunit may promote genetic instability and cause tumor progression

American Journal of Pathology

Volumn 162, Issue 1, 2003, Pages 81-91

  Ito, Akihiko ^a   Koma, Yu ichiro ^a   Watabe, Kenji ^a   Nagano, Teruaki ^b   Endo, Yuichi ^c   Nojima, Hiroshi ^b   Kitamura, Yukihiko ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN SUBUNIT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE; CELL LINE; CONTROLLED STUDY; CORRELATION ANALYSIS; FOOT PAD; GAMMA IRRADIATION; GENETIC TRANSFECTION; MELANOMA CELL; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR GROWTH;

EID: 0037221975     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)63800-X     Document Type: Article

References (38)

1. Lengauer C, Kinzler KW, Vogelstein B: Genetic instabilities in human cancers. Nature 1998, 396:643-649
2. Cahill DP, Kinzler KW, Vogelstein B, Lengauer C: Genetic instability and Darwinian selection in tumours. Trends Cell Biol 1999, 9:57-60
3. Chambers AF, Hill RP: Tumor progression and metastasis. The Basic Science of Oncology. Edited by IF Tannock, RP Hill. New York, McGraw-Hill, 1992, pp 219-239
4. Nowell PC: The clonal evolution of tumor cell populations. Science 1976, 194:23-28
5. Sherr CJ: Cancer cell cycles. Science 1996, 274:1672-1677
6. Paulovich AG, Toczyski DP, Hartwell LH: When checkpoints fail. Cell 1997, 88:315-321
7. Illidge TM, Cragg MS, Fringes B, Olive P, Erenpreisa JA: Polyploid giant cells provide a survival mechanism for p53 mutant cells after DNA damage. Cell Biol Int 2000, 24:621-633
8. Brown JM, Wouters BG: Apoptosis, p53, and tumor cell sensitivity to anticancer agents. Cancer Res 1999, 59:1391-1399
9. Cifone MA, Fidler IJ: Increasing metastatic potential is associated with increasing genetic instability of clones isolated from murine neoplasms. Proc Natl Acad Sci USA 1981, 78:6949-6952
10. Shapiro JR, Yung WK, Shapiro WR: Isolation, karyotype, and clonal growth of heterogeneous subpopulations of human malignant gliomas. Cancer Res 1981, 41:2349-2359
11. Hart IR: The selection and characterization of an invasive variant of the B16 melanoma. Am J Pathol 1979, 97:587-600
12. Poste G, Doll J, Hart IR, Fidler IJ: In vitro selection of murine B16 melanoma variants with enhanced tissue-invasive properties. Cancer Res 1980, 40:1636-1644
13. Nakaji T, Kataoka TR, Watabe K, Nishiyama K, Nojima H, Shimada Y, Sato F, Matsushima H, Endo Y, Kuroda Y, Kitamura Y, Ito A, Maeda S: A new member of the GTPase superfamily that is upregulated in highly metastatic cells. Cancer Lett 1999, 147:139-147
14. Kataoka TR, Ito A, Asada H, Watabe K, Nishiyama K, Nakamoto K, Itami S, Yoshikawa K, Ito M, Nojima H, Kitamura Y: Annexin VII as a novel marker for invasive phenotype of malignant melanoma. Jpn J Cancer Res 2000, 91:75-83
15. Ito A, Kataoka TR, Watanabe M, Nishiyama K, Mazaki Y, Sabe H, Kitamura Y, Nojima H: A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation. EMBO J 2000, 19:562-571
16. Ito A, Katoh F, Kataoka TR, Okada M, Tsubota N, Asada H, Yoshikawa K, Maeda S, Kitamura Y, Yamasaki H, Nojima H: A role for heterologous gap junctions between melanoma and endothelial cells in metastasis. J Clin Invest 2000, 105:1189-1197
17. Watabe K, Ito A, Asada H, Endo Y, Kobayashi T, Nakamoto K, Itami S, Takao S, Shinomura Y, Aikou T, Yoshikawa K, Matsuzawa Y, Kitamura Y, Nojima H: Structure, expression and chromosome mapping of MLZE, a novel gene which is preferentially expressed in metastatic melanoma cells. Jpn J Cancer Res 2001, 92:140-151
18. Nakamoto K, Ito A, Watabe K, Koma Y, Asada H, Yoshikawa K, Shinomura Y, Matsuzawa Y, Nojima H, Kitamura Y: Increased expression of a nucleolar Nop5/Sik family member in metastatic melanoma cells: Evidence for its role in nucleolar sizing and function. Am J Pathol 2001, 159:1363-1374
19. Usui H, Imazu M, Maeta K, Tsukamoto H, Azuma K, Takeda M: Three distinct forms of type 2A protein phosphatase in human erythrocyte cytosol. J Biol Chem 1988, 263:3752-3761
20. Virshup DM: Protein phosphatase 2A: A panoply of enzymes. Curr Opin Cell Biol 2000, 12:180-185
21. Kinoshita N, Ohkura H, Yanagida M: Distinct, essential roles of type 1 and 2A protein phosphatases in the control of the fission yeast cell division cycle. Cell 1990, 63:405-415
22. Millward TA, Zolnierowicz S, Hemmings BA: Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem Sci 1999, 24:186-191
23. Yamashita K, Yasuda H, Pines J, Yasumoto K, Nishitani H, Ohtsubo M, Hunter T, Sugimura T, Nishimoto T: Okadaic acid, a potent inhibitor of type 1 and type 2A protein phosphatases, activates cdc2/H1 kinase and transiently induces a premature mitosis-like state in BHK21 cells. EMBO J 1990, 9:4331-4338
24. Kawabe T, Muslin AJ, Korsmeyer SJ: HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint. Nature 1997, 385:454-458
25. Okamoto K, Li H, Jensen RM, Zhang T, Taya Y, Thorgeirsson SS, Prives C: Cyclin G recruits PP2A to dephosphorylate Mdm2. Mol Cell 2002, 9:761-771
26. Ito A, Morii E, Maeyama K, Jippo T, Kim DK, Lee YM, Ogihara H, Hashimoto K, Kitamura Y, Nojima H: Systematic method to obtain novel genes that are regulated by mi transcription factor: Impaired expression of granzyme B and tryptophan hydroxylase in mi/mi cultured mast cells. Blood 1998, 91:3210-3221
27. Ito A, Kataoka TR, Kim DK, Koma Y, Lee YM, Kitamura Y: Inhibitory effect on natural killer activity of microphthalmia transcription factor encoded by the mutant mi allele of mice. Blood 2001, 97:2075-2083
28. Basik M, Stoler DL, Kontzoglou KC, Rodriguez-Bigas MA, Petrelli NJ, Anderson GR: Genomic instability in sporadic colorectal cancer quantitated by inter-simple sequence repeat PCR analysis. Genes Chromosom Cancer 1997, 18:19-29
29. Jackson JA, Matthews D: Modified inter-simple sequence repeat PCR protocol for use in conjunction with the LI-COR Gene ImaglR2 DNA analyzer. Biotechniques 2000, 28:914-916
30. Nathanson SD, Westrick P, Anaya P, Hetzel FW, Jacobsen G: Relationship of spontaneous regional lymph node metastases to dose of local irradiation of primary B16 melanomas. Cancer Res 1989, 49: 4412-4416
31. Nathanson SD, Nelson L, Anaya P, Havstad S, Hetzel FW: Development of lymph node and pulmonary metastases after local irradiation and hyperthermia of footpad melanomas. Clin Exp Metastasis 1991, 9:377-392
32. Waldman T, Lengauer C, Kinzler KW, Vogelstein B: Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 1996, 381:713-716
33. Li Q, Dang CV: c-Myc overexpression uncouples DNA replication from mitosis. Mol Cell Biol 1999, 19:5339-5351
34. Kitadai Y, Bucana CD, Ellis LM, Anzai H, Tahara E, Fidler IJ: In situ mRNA hybridization technique for analysis of metastasis-related genes in human colon carcinoma cells. Am J Pathol 1995, 147:1238-1247
35. Fidler IJ: Angiogenic heterogeneity: Regulation of neoplastic angiogenesis by the organ microenvironment. J Natl Cancer Inst 2001, 93:1040-1041
36. Tsuzuki Y, Carreira CM, Bockhorn M, Xu L, Jain RK, Fukumura D: Pancreas microenvironment promotes VEGF expression and tumor growth: Novel window models for pancreatic tumor angiogenesis and microcirculation. Lab Invest 2001, 81:1439-1451
37. Essen CF: Radiation enhancement of metastasis: Review. Clin Exp Metastasis 1991, 9:77-104
38. Nakagama H, Kaneko S, Shima H, Inamori H, Fukuda H, Kominami R, Sugimura T, Nagao M: Induction of minisatellite mutation in NIH3T3 cells by treatment with the tumor promoter okadaic acid. Proc Natl Acad Sci USA 1997, 94:10813-10816