Antimalarial activity of 9a-N substituted 15-membered azalides with improved in vitro and in vivo activity over azithromycin

Journal of Medicinal Chemistry

Volumn 55, Issue 3, 2012, Pages 1389-1401

  Perić, Mihaela ^a,e   Fajdetić, Andrea ^a,g   Rupčić, Renata ^a,g   Alihodžić, Sulejman ^a,g   Žiher, Dinko ^a,g   Bukvić Krajačić, Mirjana ^a,g   Smith, Kirsten S ^b,d   Ivezić Schönfeld, Zrinka ^a,h   Padovan, Jasna ^a,g   Landek, Goran ^a,g   Jelić, Dubravko ^a,g   Hutinec, Antun ^a,g   Mesić, Milan ^a,g   Ager, Arba ^c   Ellis, William Y ^b   Milhous, Wilbur K ^b,f   Ohrt, Colin ^b   Spaventi, Radan ^a,g  

^a GLAXOSMITHKLINE   (United Kingdom)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d US Army Medical Materiel Development Activity   (United States)

^e UNIVERSITY OF ZAGREB   (Croatia)

^f UNIVERSITY OF SOUTH FLORIDA   (United States)

^g Galapagos Research Centre   (Croatia)

^h Nabriva Therapeutics Inc   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; AMINE; ANTIMALARIAL AGENT; AZITHROMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; RAT;

AMIDES; AMINES; AMINOQUINOLINES; ANIMALS; ANTIMALARIALS; AZITHROMYCIN; CELL LINE, TUMOR; DRUG RESISTANCE; ERYTHROMYCIN; HUMANS; MACROLIDES; MALARIA; MALE; MICE; MICROSOMES, LIVER; PARASITIC SENSITIVITY TESTS; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863393640     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201615t     Document Type: Article

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