Effect of repeated treatment of pregnant women with sulfadoxine- pyrimethamine and azithromycin on preterm delivery in Malawi: A randomized controlled trial

American Journal of Tropical Medicine and Hygiene

Volumn 83, Issue 6, 2010, Pages 1212-1220

  Luntamo, Mari ^a   Kulmala, Teija ^b   Mbewe, Bernard ^c   Cheung, Yin Bun ^d   Maleta, Kenneth ^c   Ashorn, Per ^b  

^a ARVO Building ^*  (Mozambique)

^b UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

^c UNIVERSITY OF MALAWI   (Malawi)

^d Biostatistics   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; AZITHROMYCIN; BENZATHINE PENICILLIN; CIPROFLOXACIN; FERROUS SULFATE; FOLIC ACID; METRONIDAZOLE; NEVIRAPINE; PLACEBO; PYRIMETHAMINE; PYRIMETHAMINE PLUS SULFADOXINE; QUININE; SULFADOXINE;

ABORTION; ANEMIA; ARTICLE; CHILD DEATH; CHLAMYDIASIS; CONGENITAL MALFORMATION; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GENITAL TRACT INFECTION; GONORRHEA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INCIDENCE; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; MALARIA; MALAWI; MATERNAL TREATMENT; PREGNANT WOMAN; PREMATURE LABOR; PROPHYLAXIS; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; STILLBIRTH; SYPHILIS; TRICHOMONIASIS;

ADOLESCENT; ADULT; AZITHROMYCIN; DRUG ADMINISTRATION SCHEDULE; DRUG COMBINATIONS; FEMALE; HUMANS; INFANT, LOW BIRTH WEIGHT; INFANT, NEWBORN; MALAWI; PREGNANCY; PREGNANCY COMPLICATIONS, PARASITIC; PREMATURE BIRTH; PYRIMETHAMINE; SULFADOXINE; YOUNG ADULT;

EID: 79551644398     PISSN: 00029637     EISSN: None     Source Type: Journal    
DOI: 10.4269/ajtmh.2010.10-0264     Document Type: Article

References (44)

1. Beck S, Wojdyla D, Say L, Betran AP, Merialdi M, Requejo JH, Rubens C, Menonf R, Van Look PF, 2010. The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity. Bull World Health Organ 88: 31-38
2. Schultz LJ, Steketee RW, Macheso A, Kazembe P, Chitsulo L, Wirima JJ, 1994. The efficacy of antimalarial regimens containing sulfadoxine-pyrimethamine and/or chloroquine in preventing peripheral and placental Plasmodium falciparum infection among pregnant women in Malawi. Am J Trop Med Hyg 51: 515-522.
3. Kulmala T, Vaahtera M, Ndekha M, Koivisto AM, Cullinan T, Salin ML, Ashorn P, 2000. The importance of preterm births for periand neonatal mortality in rural Malawi. Paediatr Perinat Epidemiol 14: 219-226.
4. Osman NB, Challis K, Cotiro M, Nordahl G, Bergström S, 2001. Perinatal outcome in an obstetric cohort of Mozambican women. J Trop Pediatr 47: 30-38.
5. van den Broek N, Ntonya C, Kayira E, White S, Neilson JP, 2005. Preterm birth in rural Malawi: high incidence in ultrasounddated population. Hum Reprod 20: 3235-3237. (Pubitemid 41662685)
6. Goldenberg RL, Culhane JF, Iams JD, Romero R, 2008. Epidemiology and causes of preterm birth. Lancet 371: 75-84.
7. Saigal S, Doyle LW, 2008. An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet 371: 261-269.
8. Moster D, Lie RT, Markestad T, 2008. Long-term medical and social consequences of preterm birth. N Engl J Med 359: 262-273. (Pubitemid 352008441)
9. Baraldi E, Filippone M, 2007. Chronic lung disease after premature birth. N Engl J Med 357: 1946-1955.
10. Espo M, Kulmala T, Maleta K, Cullinan T, Salin ML, Ashorn P, 2002. Determinants of linear growth and predictors of severe stunting during infancy in rural Malawi. Acta Paediatr 91: 1364-1370.
11. Victora CG, Adair L, Fall C, Hallal PC, Martorell R, Richter L, Sachdev HS, 2008. Maternal and child undernutrition: consequences for adult health and human capital. Lancet 371: 340-357.
12. Meuris S, Piko BB, Eerens P, Vanbellinghen AM, Dramaix M, Hennart P, 1993. Gestational malaria: assessment of its consequences on fetal growth. Am J Trop Med Hyg 48: 603-609.
13. Gray RH, Wabwire-Mangen F, Kigozi G, Sewankambo NK, Serwadda D, Moulton LH, Quinn TC, O'Brien KL, Meehan M, Abramowsky C, Robb M, Wawer MJ, 2001. Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda. Am J Obstet Gynecol 185: 1209-1217.
14. Sullivan AD, Nyirenda T, Cullinan T, Taylor T, Harlow SD, James SA, Meshnick SR, 1999. Malaria infection during pregnancy: intrauterine growth retardation and preterm delivery in Malawi. J Infect Dis 179: 1580-1583.
15. World Health Organization, 2009. World Malaria Report 2009. Geneva: World Health Organization. Available at: http://whqlibdoc.who.int/publications/2009/ 9789241563901-eng.pdf. Accessed June 21, 2010.
16. Verhoeff FH, Brabin BJ, Chimsuku L, Kazembe P, Russell WB, Broadhead RL, 1998. An evaluation of the effects of intermittent sulfadoxine-pyrimethamine treatment in pregnancy on parasite clearance and risk of low birthweight in rural Malawi. Ann Trop Med Parasitol 92: 141-150.
17. Rogerson SJ, Chaluluka E, Kanjala M, Mkundika P, Mhango C, Molyneux ME, 2000. Intermittent sulfadoxine-pyrimethamine in pregnancy: effectiveness against malaria morbidity in Blantyre, Malawi, in 1997-99. Trans R Soc Trop Med Hyg 94: 549-553.
18. White NJ, 2005. Intermittent presumptive treatment for malaria. PLoS Med 2: e3.
19. Menéndez C, D'Alessandro U, ter Kuile FO, 2007. Reducing the burden of malaria in pregnancy by preventive strategies. Lancet Infect Dis 7: 126-135.
20. Ter Kuile FO, Steketee RW, 2007. Intermittent preventive therapy with sulfadoxine-pyrimethamine during pregnancy: seeking information on optimal dosing frequency. J Infect Dis 196: 1574-1576.
21. van den Broek NR, White SA, Goodall M, Ntonya C, Kayira E, Kafulafula G, Neilson JP, 2009. The APPLe study: a randomized, community-based, placebo-controlled trial of azithromycin for the prevention of preterm birth, with meta-analysis. PLoS Med 6: e1000191.
22. Anderson SL, Berman J, Kuschner R, Wesche D, Magill A, Wellde B, Schneider I, Dunne M, Schuster BG, 1995. Prophylaxis of Plasmodium falciparum malaria with azithromycin administered to volunteers. Ann Intern Med 123: 771-773.
23. Taylor WR, Richie TL, Fryauff DJ, Picarima H, Ohrt C, Tang D, Braitman D, Murphy GS, Widjaja H, Tjitra E, Ganjar A, Jones TR, Basri H, Berman J, 1999. Malaria prophylaxis using azithromycin: a double-blind, placebo-controlled trial in Irian Jaya, Indonesia. Clin Infect Dis 28: 74-81.
24. Ohrt C, Willingmyre GD, Lee P, Knirsch C, Milhous W, 2002. Assessment of azithromycin in combination with other antimalarial drugs against Plasmodium falciparum in vitro. Antimicrob Agents Chemother 46: 2518-2524.
25. Vallely A, Vallely L, Changalucha J, Greenwood B, Chandramohan D, 2007. Intermittent preventive treatment for malaria in pregnancy in Africa: what's new, what's needed? Malar J 6: 16.
26. Pfizer Inc. Zithromax® Product Information. Available at: http://www.pfizer.com/files/products/uspi-zithromax600mg.pdf. Accessed May 31, 2009.
27. Sarkar M, Woodland C, Koren G, Einarson AR, 2006. Pregnancy outcome following gestational exposure to azithromycin. BMC Pregnancy Childbirth 6: 18.
28. Kulmala T, Vaahtera M, Ndekha M, Koivisto AM, Cullinan T, Salin ML, Ashorn P, 2001. Gestational health and predictors of newborn weight amongst pregnant women in rural Malawi. Afr J Reprod Health 5: 99-108.
29. Center for Social Research, Save the Children Federation USA, Malawi Ministry of Health and Population, MEASURE Evaluation, 2004. Avoiding Unwanted Pregnancy and Sexually Transmitted Infections: A Rural Malawi District Study. Chapel Hill, NC: MEASURE Evaluation. Available at: www.cpc.unc.edu/measure/ publications/pdf/tr-04-27.pdf. Accessed October 8, 2009.
30. Binder DA, 1983. On the variances of asymptotically normal esti mators from complex surveys. Int Stat Rev 51: 279-292.
31. Swadpanich U, Lumbiganon P, Prasertcharoensook W, Laopaiboon M, 2008. Antenatal lower genital tract infection screening and treatment programs for preventing preterm delivery. Cochrane Database Syst Rev CD006178.
32. Goldenberg RL, Mwatha A, Read JS, Adeniyi-Jones S, Sinkala M, Msmanga G, Martinson F, Hoffman I, Fawzi W, Valentine M, Emel L, Brown E, Mudenda V, Taha TE, 2006. The HPTN 024 Study: the efficacy of antibiotics to prevent chorioamnionitis and preterm birth. Am J Obstet Gynecol 194: 650-661.
33. Gichangi PB, Ndinya-Achola JO, Ombete J, Nagelkerke NJ, Temmerman M, 1997. Antimicrobial prophylaxis in pregnancy: a randomized, placebo-controlled trial with cefetamet-pivoxil in pregnant women with a poor obstetric history. Am J Obstet Gynecol 177: 680-684.
34. Parise ME, Ayisi JG, Nahlen BL, Schultz LI, Roberts JM, Misore A, Muga R, Oloo AJ, Steketee RW, 1998. Efficacy of sulfadoxine-pyrimethamine for prevention of placental malaria in an area of Kenya with a high prevalence of malaria and human immunodeficiency virus infection. Am J Trop Med Hyg 59: 813-822.
35. Filler SJ, Kazembe P, Thigpen M, Macheso A, Parise ME, Newman RD, Steketee RW, Hamel M, 2006. Randomized trial of 2-dose versus monthly sulfadoxine-pyrimethamine intermittent preventive treatment for malaria in HIV-positive and HIV-negative pregnant women in Malawi. J Infect Dis 194: 286-293.
36. Hamer DH, Mwanakasale V, Macleod WB, Chalwe V, Mukwamataba D, Champo D, Mwananyanda L, Chilengi R, Mubikayi L, Mulele CK, Mulenga M, Thea DM, Gill CJ, 2007. Two-dose versus monthly intermittent preventive treatment of malaria with sulfadoxine-pyrimethamine in HIV-seropositive pregnant Zambian women. J Infect Dis 196: 1585-1594.
37. Nkhoma S, Molyneux M, Ward S, 2007. Molecular surveillance for drug-resistant Plasmodium falciparum malaria in Malawi. Acta Trop 102: 138-142.
38. Brunham RC, Kuo C, Stevens CE, Holmes KK, 1982. Treatment of concomitant Neisseria gonorrhoeae and Chlamydia trachomatis infections in women: comparison of trimethoprimsulfamethoxazole with ampicillin-probenecid. Rev Infect Dis 4: 491-499.
39. Mumtaz G, Ridgway GL, Felmingham D, 1988. In vitro activity of sulphamethoxazole/trimethoprim and sulfadoxine/pyrimethamine against Chlamydia trachomatis SA2f in McCoy cell culture. Eur J Clin Microbiol Infect Dis 7: 415-417.
40. Dewey KG, Adu-Afarwuah S, 2008. Systematic review of the efficacy and effectiveness of complementary feeding interventions in developing countries. Matern Child Nutr 4 (Suppl 1): 24-85.
41. Peters PJ, Thigpen MC, Parise ME, Newman RD, 2007. Safety and toxicity of sulfadoxine/pyrimethamine: implications for malaria prevention in pregnancy using intermittent preventive treatment. Drug Saf 30: 481-501.
42. Kalilani L, Mofolo I, Chaponda M, Rogerson SJ, Alker AP, Kwiek JJ, Meshnick SR, 2007. A randomized controlled pilot trial of azithromycin or artesunate added to sulfadoxine-pyrimethamine as treatment for malaria in pregnant women. PLoS ONE 2: e1166.
43. Kenyon S, Pike K, Jones D, Brocklehurst P, Marlow N, Salt A, Taylor DJ, 2008. Childhood outcomes after prescription of antibiotics to pregnant women with spontaneous preterm labour: 7-year follow-up of the ORACLE II trial. Lancet 372: 1319-1327.
44. Moher D, Schulz F, Altman DG, 2001. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials. Lancet 357: 1191-1194. (Pubitemid 32378696)