An automated, polymer-assisted strategy for the preparation of urea and thiourea derivatives of 15-membered azalides as potential antimalarial chemotherapeutics

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 5, 2011, Pages 1692-1701

  Hutinec, Antun ^a,c   Rupčić, Renata ^a,c   Žiher, Dinko ^a,c   Smith, Kirsten S ^b   Milhous, Wilbur ^b   Ellis, William ^b   Ohrt, Colin ^b   Schönfeld, Zrinka Ivezić ^a,d  

^a GLAXOSMITHKLINE   (United Kingdom)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c Galapagos Research Centre Zagreb Ltd   (Croatia)

^d Nabriva Therapeutics Inc   (Austria)

Author keywords

Antimalarial; Automated parallel synthesis; Azalide; Plasmodium falciparum; Thiourea; Ureas

Indexed keywords

AZITHROMYCIN; CHLOROQUINE; HETEROCYCLIC COMPOUND; MACROLIDE; POLYMER; PYRIMETHAMINE; THIOUREA DERIVATIVE; UREA DERIVATIVE;

ANTIMALARIAL ACTIVITY; ARTICLE; AUTOMATION; BACTERIAL STRAIN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM; QUANTUM YIELD;

ANTIMALARIALS; AUTOMATION; AZITHROMYCIN; DRUG RESISTANCE, MULTIPLE; INHIBITORY CONCENTRATION 50; MACROLIDES; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA; UREA;

PLASMODIUM FALCIPARUM;

EID: 79952189814     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.01.030     Document Type: Article

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