Synthesis, structure-activity relationship, and antimalarial activity of ureas and thioureas of 15-membered azalides

Journal of Medicinal Chemistry

Volumn 54, Issue 10, 2011, Pages 3595-3605

  Bukvić Krajačić, Mirjana ^a,h   Perić, Mihaela ^a,d   Smith, Kirsten S ^b,i   Ivezić Schönfeld, Zrinka ^a,e   Žiher, Dinko ^a,h   Fajdetić, Andrea ^a,h   Kujundžić, Nedjeljko ^a   Schönfeld, Wolfgang ^a,f   Landek, Goran ^a,h   Padovan, Jasna ^a,h   Jelić, Dubravko ^a,h   Ager, Arba ^c   Milhous, Wilbur K ^b,g   Ellis, William ^b   Spaventi, Radan ^a,h   Ohrt, Colin ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF ZAGREB   (Croatia)

^e Nabriva Therapeutics Inc   (Austria)

^f Green River Pharma AG   (Switzerland)

^g UNIVERSITY OF SOUTH FLORIDA   (United States)

^h Galapagos Istraživački Centar Doo ^*  (Croatia)

ⁱ US Army Medical Materiel Development Activity   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZALIDE; AZITHROMYCIN; MACROLIDE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL EXPERIMENT; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LIPOPHILICITY; MALE; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; RAT;

ANIMALS; ANTIMALARIALS; AZITHROMYCIN; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MACROLIDES; MICE; MODELS, CHEMICAL; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA; UREA;

EID: 79957754724     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2001585     Document Type: Article

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