Phosphodiesterase 4B mediates extracellular signal-regulated kinase-dependent up-regulation of mucin MUC5AC protein by Streptococcus pneumoniae by inhibiting cAMP-protein kinase A-dependent MKP-1 phosphatase pathway

Journal of Biological Chemistry

Volumn 287, Issue 27, 2012, Pages 22799-22811

  Lee, Jiyun ^a   Komatsu, Kensei ^a   Lee, Byung Cheol ^a   Lim, Jae Hyang ^a   Jono, Hirofumi ^b   Xu, Haidong ^a   Kai, Hirofumi ^b   Zhang, Z John ^c   Yan, Chen ^d   Li, Jian Dong ^a  

^a GEORGIA STATE UNIVERSITY   (United States)

^b KUMAMOTO UNIVERSITY   (Japan)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^d UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL INFECTIONS; BACTERIAL PATHOGENS; CONDUCTIVE HEARING LOSS; ERK ACTIVATION; EXTRACELLULAR; HUMAN PATIENTS; IN-VITRO; MIDDLE EAR MUCOSA; MIDDLE EARS; MOLECULAR MECHANISM; NEGATIVE REGULATORS; OTITIS MEDIA; PHOSPHODIESTERASE 4B; SPECIFIC INHIBITORS; STREPTOCOCCUS PNEUMONIAE; THERAPEUTIC POTENTIALS; THERAPEUTIC STRATEGY; UP-REGULATION;

AUDITION; BIOLOGICAL ORGANS; ESTERS; GENES; PHOSPHATASES;

BODY FLUIDS;

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP; MITOGEN ACTIVATED PROTEIN KINASE; MUCIN; MUCIN 5AC; PHOSPHODIESTERASE; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM; TOLL LIKE RECEPTOR;

ARTICLE; BACTERIAL INFECTION; GRAM POSITIVE BACTERIUM; IN VITRO STUDY; IN VIVO STUDY; MIDDLE EAR MUCOSA; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STREPTOCOCCUS PNEUMONIAE; UPREGULATION;

ANIMALS; CELL LINE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DUAL SPECIFICITY PHOSPHATASE 1; EAR, MIDDLE; EPITHELIAL CELLS; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MUCIN 5AC; MUCUS; OTITIS MEDIA; PNEUMOCOCCAL INFECTIONS; RESPIRATORY MUCOSA; RNA, SMALL INTERFERING; STREPTOCOCCUS PNEUMONIAE; UP-REGULATION;

BACTERIA (MICROORGANISMS); POSIBACTERIA; STREPTOCOCCUS PNEUMONIAE;

EID: 84863336938     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.337378     Document Type: Article

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