Activation of NF-κB via a Src-dependent Ras-MAPK-pp90rsk pathway is required for Pseudomonas aeruginosa-induced mucin overproduction in epithelial cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 10, 1998, Pages 5718-5723

  Li, Jian Dong ^a   Feng, Weijun ^a   Gallup, Marianne ^a   Kim, Jae Ho ^a   Gum, James ^a   Kim, Young ^a   Basbaum, Carol ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AIRWAY OBSTRUCTION; BACTERIAL PNEUMONIA; CONFERENCE PAPER; CYSTIC FIBROSIS; GENETIC LINKAGE; GRAM NEGATIVE INFECTION; HUMAN; HUMAN CELL; INFECTION SENSITIVITY; MUCUS; NONHUMAN; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; ARTICLE; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; ENZYME ACTIVATION; EPITHELIUM CELL; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MICROBIOLOGY; PROMOTER REGION; REPORTER GENE; UPREGULATION;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; LUCIFERASE; MUCIN; PROTEIN KINASE (CALCIUM,CALMODULIN); S6 KINASE;

CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELLS, CULTURED; CYSTIC FIBROSIS; ENZYME ACTIVATION; EPITHELIAL CELLS; GENES, REPORTER; HUMANS; LIPOPOLYSACCHARIDES; LUCIFERASES; MODELS, BIOLOGICAL; MUCINS; NF-KAPPA B; PROMOTER REGIONS (GENETICS); PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; RIBOSOMAL PROTEIN S6 KINASES; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 0032510596     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.10.5718     Document Type: Article

References (30)

1. Collins, F. S. & Wilson, J. M. (1992) Nature (London) 358, 708-709.
2. Pier, G. B., Grout, M., Zaidi, T. S., Oslen, J. C., Johnson, L. G., Yankasas, J. R. & Goldberg, J. B. (1996) Science 271, 64-67.
3. Smith, J. J., Travis, S. M., Greenberg, E. P. & Welsh, M. J. (1996) Cell 85, 229-236.
4. Saiman, L. & Prince, A. (1993) J. Clin. Invest. 92, 1875-1880.
5. J. D. Li, Dohrman, A. F., Gallup, M. G., Miyata, S., Gum, J. R., Kim, Y. S., Nadel, J. A., Price, A. & Basbaum, C. B. (1997) Proc. Natl. Acad. Sci. USA 94, 967-972.
6. Gum, J., Hicks, J. W. & Kim, Y. S. (1997) Biochem. J. 325, 259-267.
7. Gum, J., Hicks, J. W., Torbara, N. W., Siddiki, B. & Kim, Y. S. (1994) J. Biol. Chem. 269, 2440-2446.
8. Nogami, H., Ohmori, H., Li, J. D., Gallup, M. G., Gum, J., Kim, Y. & Basbaum, C. (1997) Gene 198, 191-201.
9. Natarajan, S., Singh, T., Burke, D., Grunberger, B. & Aggarwal, B. (1996) Proc. Natl. Acad. Sci. USA 93, 9090-9095.
10. DiDonato, J., Hayakawa, M., Rothwarf, D., Zandi, E. & Karin, M. (1997) Nature (London) 388, 548-554.
11. Ghoda, L., Lin, X. & Greene, W. (1997) J. Biol. Chem. 272, 21281-21288.
12. Schouten, G. I., Schouten, G. J., Vertegaal, A. C., Whiteside, S. T., Israel, A., Toebes, M., Dorsman, J. C., van der Eb, A. J. & Zantema, A. (1997) EMBO J. 16, 3133-3144.
13. Baeuerle, P. A. & Baltimore, D. (1996) Cell 87, 13-20.
14. Beauparlant, P., Kwon, H., Clarke, M., Lin, R. Sonenberg, N., Wainberg, M. & Hiscott, J. (1996) J. Virol. 70, 5777-5785.
15. Baldwin, A. S. (1996) Annu. Rev. Immunol. 14, 649-681.
16. Stokoe, D., Campbell, D.G., Nakielny, S., Hidaka, H., Leevers, S. J., Marshall, C. & Cohen, P. (1992) EMBO J. 11, 3985-3994.
17. Treisman, R. (1996) Curr. Opin. Cell Biol. 8, 205-215.
18. Minden, A., Lin, A., Claret, F., Abo, A. &. Karin, M. (1995) Cell 81, 1147-1157.
19. Aless, D. R., Cuenda, A., Cohen, P., Dudley, D. T. & Saltiel, A. R. (1993) J. Biol. Chem. 270, 27489-27494.
20. Howe, L., Leevers, S. J., Gomez, N., Nakielny, S., Cohen, P. & Marshall, C. J. (1992) Cell 71, 335-352.
21. Moodie, S., Willumsen, B., Weber, M. & Wolfman, A. (1993) Science 260, 1658-1661.
22. Stokoe, D. & McCormick, F. (1997) EMBO J. 16(9), 2384-2396.
23. Wood, K. W., Sarnecki, C., Roberts, T. M. & Blenis, J. (1992) Cell 68, 1041-1050.
24. Katz, M. E. & McCormick, F. (1997) Curr. Opin. Genet. Dev. 7, 75-79.
25. Feig, L. A. & Cooper, G. M. (1988) Mol Cell Biol. 8, 2472-2478.
26. Mukhopadhyay, D., Tsiokas, L., Zhou, X. M., Foster, D., Brugge, J. S. & Sukhatme, V. P. (1995) Nature (London) 375, 577-581.
27. Hanke, J. A., Gardner, J. P., Dow, R. L., Changelian, P. S., Brissette, W. H., Weringer, E. J., Pollok, B. A. & Connelly, P. A. (1996) J. Biol. Chem. 271, 695-701.
28. Sweet, M. J. & Hume, D. A. (1996) J. Leukocyte Biol. 60, 8-26.
29. Zahm, J. M., Gaillard, D. Dupuit, F., Hinnrasky, J., Porteous, D., Dorin, J. R. & Puchelle, E. (1997) Am. J. Physiol. 272, C853-C859.
30. Davidson, D. J., Dorin, J. R., McLachlan, G., Ranaldi, V., Lamb, D., Doherty, C., Govan, J. & Porteous, D. J. (1995) Nat. Genet. 9, 351-357.