Broad spectrum neuroprotection profile of phosphodiesterase inhibitors as related to modulation of cell-cycle elements and caspase-3 activation

Neuroscience Letters

Volumn 418, Issue 2, 2007, Pages 165-169

  Chen, Ren Wu ^a   Williams, Anthony J ^a   Liao, Zhilin ^a   Yao, Changping ^a   Tortella, Frank C ^a   Dave, Jitendra R ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

Caspase 3; Cell cycle elements; Neuroprotection; Phosphodiesterase inhibitors

Indexed keywords

CASPASE 3; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR; FLAVOPIRIDOL; GLUTAMIC ACID; PHOSPHODIESTERASE III INHIBITOR; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM; STAUROSPORINE; TREQUINSIN; VERATRIDINE; VINPOCETINE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CELL ASSAY; CELL CYCLE REGULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; EXCITOTOXICITY; HYPOGLYCEMIA; HYPOXIA; IN VITRO STUDY; NERVE CELL LESION; NERVE INJURY; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; UPREGULATION;

ANIMALS; APOPTOSIS; CASPASE 3; CELL CYCLE PROTEINS; CELLS, CULTURED; CEREBRAL CORTEX; CYCLIN D1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; NERVE DEGENERATION; NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 34247366877     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2007.03.033     Document Type: Article

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