Nontypeable Haemophilus influenzae: Pathogenesis and prevention

Microbiology and Molecular Biology Reviews

Volumn 62, Issue 2, 1998, Pages 294-308

  Foxwell, A Ruth ^a   Kyd, Jennelle M ^a   Cripps, Allan W ^a,b  

^a UNIVERSITY OF CANBERRA   (Australia)

^b Faculty of Applied Science   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

HAEMOPHILUS VACCINE; IMMUNOGLOBULIN A; MUCIN; OUTER MEMBRANE PROTEIN; PROTEINASE;

BACTERIAL COLONIZATION; BACTERIUM IDENTIFICATION; CELL INVASION; DISEASE CLASSIFICATION; GENETIC SUSCEPTIBILITY; HAEMOPHILUS INFLUENZAE; HOST RESISTANCE; INFECTION PREVENTION; LOWER RESPIRATORY TRACT INFECTION; NONHUMAN; OTITIS MEDIA; PHENOTYPE; REVIEW; VACCINATION;

ANIMALIA; BACTERIA (MICROORGANISMS); CHINCHILLIDAE; HAEMOPHILUS; HAEMOPHILUS INFLUENZAE; MAMMALIA; NEGIBACTERIA;

EID: 0031811255     PISSN: 10922172     EISSN: None     Source Type: Journal    
DOI: 10.1128/mmbr.62.2.294-308.1998     Document Type: Review

References (227)

1. Adler, K. B., D. D. Hendley, and G. S. Davis. 1986. Bacteria associated with obstructive pulmonary disease elaborate extracellular products that stimulate mucin secretion by explants of guinea pig airways. Am. J. Pathol. 125:501-514.
2. Ambrosino, D. M., G. Schiffman, E. C. Gotschlich, P. H. Schur, G. A. Rosenberg, G. G. DeLange, E. van Loghem, and G. R. Siber. 1985. Correlation between G2m(n) immunoglobulin allotype and human antibody response and susceptibility to polysaccharide encapsulated bacteria. J. Clin. Invest. 75:1935-1942.
3. Appelmelk, B. J., Y.-Q. An, M. Geerts, B. G. Thijs, H. A. DeBoer, D. M. Maclaren, J. DeGraaff, and J. H. Nuijens. 1994. Lactoferrin is a lipid A-binding protein. Infect. Immun. 62:2628-2632.
4. Bakaletz, L. O., and K. A. Holmes. 1997. Evidence for transudation of specific antibody into the middle ears of parenterally immunized chinchillas after an upper respiratory tract infection with adenovirus. Clin. Diagn. Lab. Immunol. 4:223-225.
5. Bakaletz, L. O., E. R. Leake, J. M. Billy, and P. T. P. Kaumaya. 1997. Relative immunogenicity and efficacy of two synthetic chimeric peptides of fimbrin as vaccinogens against nasopharyngeal colonization by nontypeable Haemophilus influenzae in the chinchilla. Vaccine 15:955-961.
6. Bakaletz, L. O., B. M. Tallan, W. J. Andrzejewski, T. F. DeMaria, and D. J. Lim. 1989. Immunological responsiveness of chinchillas to outer membrane and isolated fimbrial proteins of nontypeable Haemophilus influenzae. Infect. Immun. 57:3226-3229.
7. Barenkamp, S. J. 1996. Immunization with high-molecular-weight adhesion proteins of nontypeable Haemophilus influenzae modifies experimental otitis media in chinchillas. Infect. Immun. 64:1246-1251.
8. Barenkamp, S. J., and F. F. Bodor. 1990. Development of serum bactericidal activity following nontypable Haemophilus influenzae acute otitis media. Pediatr. Infect. Dis. J. 9:333-339.
9. Barenkamp, S. J., and E. Leininger. 1992. Cloning, expression, and DNA sequence analysis of genes encoding nontypeable Haemophilus influenzae high-molecular-weight surface-exposed proteins related to filamentous hemagglutanin of Bordatella pertussis. Infect. Immun. 60:1302-1313.
10. Barenkamp, S. J., R. S. Munson, Jr., and D. M. Granoff. 1981. Subtyping isolates of Haemophilus influenzae type b by outer-membrane protein profiles. J. Infect. Dis. 143:668-676.
11. Barenkamp, S. J., R. S. Munson, Jr., and D. M. Granoff. 1982. Outer membrane protein and biotype analysis of pathogenic nontypeable Haemophilus influenzae. Infect. Immun. 36:535-540.
12. Barenkamp, S. J., and J. W. St. Geme III. 1996. Identification of a second family of high-molecular-weight adhesion proteins expressed by nontypable Haemophilus influenzae. Mol. Microbiol. 19:1215-1223.
13. Barker, J., M. Gratten, I. Riley, D. Lehmann, J. Montgomery, M. Kajoi, H. Gratten, D. Smith, T. F. D. Marshall, and M. P. Alpers. 1989. Pneumonia in children in the eastern highlands of Papua New Guinea: a bacteriological study of patients selected by standard clinical criteria. J. Infect. Dis. 159: 348-352.
14. Barrios, C., P. Brawand, M. Berney, C. Brandt, P.-H. Lambert, and C.-A. Siegrist. 1996. Neonatal and early life immune responses to various forms of vaccine antigens qualitatively differ from adult responses: predominance of a Th2-biased pattern which persists after adult boosting. Eur. J. Immunol. 26:1489-1496.
15. Bernstein, J. M., P. M. Bronson, and M. E. Wilson. 1997. Immunoglobulin G subclass response to major outer membrane proteins of nontypeable Haemophilus influenzae in children with acute otitis media. Otolaryngol. Head Neck Surg. 116:363-371.
16. Brunham, R. C., F. A. Plummer, and R. S. Stephens. 1993. Bacterial antigenic variation, host immune response, and pathogen-host coevolution. Infect. Immun. 61:2273-2276.
17. Burns, J. L., P. M. Menelman, J. Levy, T. L. Stull, and A. L. Small. 1985. A permeability barrier as a mechanism of chloramphenicol resistance in Haemophilus influenzae. Antimicrob. Agents. Chemother. 27:46-54.
18. Butt, H. L., R. L. Clancy, A. W. Cripps, K. Murree-Allen, N. A. Saunders, D. C. Sutherland, and M. J. Hensley. 1990. Bacterial colonisation of the respiratory tract in chronic bronchitis. Aust. N. Z. J. Med. 20:35-38.
19. Campagnari, A. A., M. R. Gupta, K. C. Dudas, T. F. Murphy, and M. A. Apicella. 1987. Antigenic diversity of lipooligosaccharides of nontypeable Haemophilus influenzae. Infect. Immun. 55:882-887.
20. Campagnari, A. A., S. M. Spinola, A. J. Lesse, Y. A. Kwaik, R. E. Mandrell, and M. A. Apicella. 1990. Lipooligosaccharide epitopes shared among gram-negative non-enteric mucosal pathogens. Microb. Pathog. 8:353-362.
21. Carson, R. T., D. F. McDonald, M. A. Kehoe, and J. E. Calvert. 1994. Influence of Gm allotype subclass response to streptococcal M protein and membrane proteins of Moraxella catarrhalis. Immunology 83:107-113.
22. Chong, P., Y.-P. Yan, D. Persaud, M. Haer, B. Tripet, E. Tam, C. Sia, and M. Klein. 1995. Immunogenicity of synthetic peptides of Haemophilus influenzae type b outer membrane protein P1. Infect. Immun. 63:3751-3758.
23. Clancy, R., A. Cripps, K. Murree-Allen, S. Yeung, and M. Engel. 1985. Oral immunisation with killed Haemophilus influenzae for protection against acute bronchitis in chronic obstructive lung disease. Lancet ii:1395-1397.
24. Clancy, R. L., and A. W. Cripps. 1992. Specific protection against acute bronchitis associated with nontypeable Haemophilus influenzae. J. Infect. Dis. 165(Suppl. 1):S194-S195.
25. Clancy, R. L., A. W. Cripps, A. J. Husband, and D. Buckley. 1983. Specific immune response in the respiratory tract after administration of an oral polyvalent bacterial vaccine. Infect. Immun. 39:491-496.
26. Cohen, M. S., J. Mao, G. T. Rasmussen, J. S. Serody, and B. E. Britigan. 1992. Interaction of lactoferrin and lipopolysaccharide (LPS): effects on the antioxidant property of lactoferrin and the ability of LPS to prime human neutrophils for enhanced superoxide formation. J. Infect. Dis. 166:1375-1378.
27. Cope, L. D., S. E. Pelzel, J. L. Latimer, and E. J. Hansen. 1990. Characterization of Haemophilus influenzae type b lacking the P2 major outer membrane protein. Infect. Immun. 58:3312-3318.
28. Cope, L. D., S. E. Thomas, J. L. Latimer, C. A. Slaughter, U. Müller-Eberhard, and E. J. Hansen. 1994. The 100 kDa haem:haemopexin-binding protein of Haemophilus influenzae: structure and localization. Mol. Microbiol. 13:863-873.
29. Costerton, J. W., J. M. Ingram, and K. J. Cheng. 1974. Structure and function of the cell envelope of gram-negative bacteria. Bacteriol. Rev. 38:87-110.
30. Coulton, J. W., A. C. Chin, and V. Vachon. 1992. Recombinant porin of Haemophilus influenzae type b. J. Infect. Dis. 165(Suppl. 1):S188-S191.
31. Cripps, A. W., D. C. Taylor, F. J. Wallace, and R. L. Clancy. 1992. Respiratory immunity stimulated by intestinal immunization with purified nontypeable Haemophilus influenzae antigens. J. Infect. Dis. 165(Suppl. 1): S199-S201.
32. Davies, J., I. Carlstedt, A.-K. Nilsson, A. Håkansson, H. Sabharwal, L. van Alphen, M. van Ham, and C. Svanborg. 1995. Binding of Haemophilus influenzae to purified mucins from the human respiratory tract. Infect. Immun. 63:2485-2492.
33. De Aizpuria, H. J., and G. J. Russell-Jones. 1988. Oral vaccination: identification of classes of proteins that provoke an immune response upon oral feeding. J. Exp. Med. 167:440-451.
34. Deich, R. A., A. Anilionis, J. Fulginiti, B. J. Metcalf, S. Quataert, T. Quinn-Dey, G. W. Zlotnick, and B. A. Green. 1990. Antigenic conservation of the 15,000-dalton outer membrane lipoprotein PCP of Haemophilus influenzae and biologic activity of anti-PCP antisera. Infect. Immun. 58: 3388-3393.
35. Delacroix, D. L., C. Dive, J. C. Rambaud, and J. P. Vaerman. 1982. IgA subclasses in various secretions and in serum. Immunology 47:383-385.
36. DeMaria, T. F., D. M. Murwin, and E. R. Leake. 1996. Immunization with outer membrane protein P6 from nontypeable Haemophilus influenzae induces bactericidal antibody and affords protection in the chinchilla model of otitis media. Infect. Immun. 64:5187-5192.
37. DeMaria, T. F., T. Yamaguchi, L. O. Bakaletz, and D. J. Lim. 1992. Serum and middle ear antibody response in the chinchilla during otitis media with effusion induced by nonviable nontypeable Haemophilus influenzae. J. Infect. Dis. 165(Suppl. 1):S196-S197.
38. Denny, F. W. 1974. Effect of a toxin produced by Haemophilus influenzae on ciliated respiratory epithelium. J. Infect. Dis. 129:93-100.
39. Donnelly, J. J., R. R. Deck, and M. A. Liu. 1990. Immunogenicity of a Haemophilus influenzae polysaccharide-Neisseria meningitidis outer membrane protein complex conjugate vaccine. J. Immunol. 145:3071-3079.
40. Duim, B., L. Vogel, W. Puijk, H. M. Jansen, R. H. Meloen, J. Dankert, and L. van Alphen. 1996. Fine mapping of outer membrane protein P2 antigenic sites which vary during persistent infection by Haemophilus influenzae. Infect. Immun. 64:4673-4679.
41. + T cells from orally immunized rats in enhanced clearance of Pseudomonas aeruginosa from the lung. Immunology 83:362-369.
42. Edén, C. S., R. Shahin, and D. Briles. 1988. Host resistance to mucosal gram-negative infection. J. Immunol. 140:3180-3185.
43. El Adhami, W., J. M. Kyd, and A. W. Cripps. Unpublished data.
44. Ellison, R. T., III, and T. J. Giehl. 1991. Killing of gram-negative bacteria by lactoferrin and lysozyme. J. Clin. Invest. 88:1080-1091.
45. Ellison, R. T., III, T. J. Giehl, and F. M. LaForce. 1988. Damage of the outer membrane of enteric gram-negative bacteria by lactoferrin and transferrin. Infect. Immun. 56:2774-2781.
46. Eskola, J., H. Käyhty, H. Peltola, V. Karanko, P. H. Mäkela, J. Samuelson, and L. K. Gordon. 1985. Antibody levels achieved in infants by course of Haemophilus influenzae type B polysaccharide/diphtheria toxoid conjugate vaccine. Lancet 1:1184-1186.
47. Faden, H., J. Bernstein, L. Brodsky, J. Stanievich, D. Krystofik, C. Shulf, J. J. Hong, and P. L. Ogra. 1989. Otitis media in children. I. The systemic immune response to nontypeable Haemophilus influenzae. J. Infect. Dis. 160:999-1004.
48. Faden, H., L. Duffy, R. Wasielewski, J. Wolf, D. Krystofik, Y. Tung, and Tonawanda/Williamsville Pediatrics. 1997. Relationship between nasopharyngeal colonization and the development of otitis media in children. J. Infect. Dis. 175:1440-1445.
49. Faden, H., L. Duffy, A. Williams, Tonawanda/Williamsville Pediatrics, D. A. Krystofik, and J. Wolf. 1995. Epidemiology of nasopharyngeal colonisation with nontypeable Haemophilus influenzae in the first 2 years of life. J. Infect. Dis. 172:132-135.
50. Faden, H., J. Stanievich, L. Brodsky, J. Bernstein, and P. L. Ogra. 1990. Changes in nasopharyngeal flora during otitis media of childhood. Pediatr. Infect. Dis. J. 9:623-626.
51. Falkow, S. 1991. Bacterial entry into eukaryotic cells. Cell 65:1099-1102.
52. Farley, M. M., D. S. Stephens, M. H. Mulks, M. D. Cooper, J. V. Bricker, S. Mirra, and A. Wright. 1986. Pathogenesis of IgA1 protease-producing and -nonproducing Haemophilus influenzae in human nasopharyngeal organ cultures. J. Infect. Dis. 154:752-759.
53. Ferrante, A., L. J. Beard, and R. G. Feldman. 1990. IgG subclass distribution of antibodies to bacterial and viral antigens. Pediatr. Infect. Dis. J. 9:S16-S24.
54. Finkelman, F. D., J. Holmes, I. M. Katona, J. F. Urban, Jr., M. P. Beckman, L. S. Park, K. A. Schooley, R. L. Coffman, T. R. Mosman, and W. E. Paul. 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8:303-333.
55. Flack, F. S., S. Loosmore, P. Chong, and W. R. Thomas. 1995. The sequencing of the 80-kDa D15 protective surface antigen of Haemophilus influenzae. Gene 156:97-99.
56. Flesher, A. R., and R. A. Insel. 1978. Characterisation of lipopolysaccharide of Haemophilus influenzae. J. Infect. Dis. 138:719-729.
57. Forney, L. J., C. F. Marrs, S. L. Bektesh, and J. R. Gilsdorf. 1991. Comparison and analysis of the nucleotide sequences of pilin genes from Haemophilus influenzae type b strains eagan and M43. Infect. Immun. 59:1991-1996.
58. Forsgren, J., A. Samuelson, A. Ahlin, J. Jonasson, B. Rynnel-Dagoo, and A. Lindberg. 1994. Haemophilus influenzae resides and multiplies intracellularly in human adenoid tissue as demonstrated by in situ hybridization and bacterial viability assay. Infect. Immun. 62:673-679.
59. Friesen, C. A., and C. T. Cho. 1986. Characteristic features of neonatal sepsis due to Haemophilus influenzae. Rev. Infect. Dis. 8:777-780.
60. Ghafoor, A., N. K. Nomani, Z. Ishaq, S. Z. Zaidi, F. Anwar, M. I. Burney, W. Qureshi and S. A. Ahmad. 1990. Diagnoses of acute lower respiratory tract infections in children in Rawalpindi and Islamabad, Pakistan. Rev. Infect. Dis. 12:S907-S914.
61. Gilsdorf, J. R., H. Y. Chang, K. W. MeCrea, and L. O. Bakaletz. 1992. Comparison of haemagglutinating pili of Haemophilus influenzae type b with similar structures of nontypeable H. influenzae. Infect. Immun. 60:374-379.
62. Gilsdorf, J. R., K. MeCrea, and L. Forney. 1990. Conserved and nonconserved epitopes among Haemophilus influenzae type b pill. Infect. Immun. 58:2252-2257.
63. Gnehm, H. E., S. I. Pelton, S. Gulati, and P. A. Rice. 1985. Characterization of antigens from nontypeable Haemophilus influenzae recognized by human bactericidal antibodies. J. Clin. Invest. 75:1645-1658.
64. Goetz, M. B., H. O'Brien, J. M. Musser, and J. I. Ward. 1994. Nosocomial transmission of disease caused by nontypeable strains of Haemophilus influenzae. Am. J. Med. 96:342-347.
65. Goldblatt, D., M. W. Turner, and R. J. Levinsky. 1989. Branhamella catarrhalis: antigenic determinants and the development of the IgG subclass response in childhood. J. Infect. Dis. 162:1128-1135.
66. Gorbach, S. L., T.-W. Chang, and B. Goldin. 1987. Successful treatment of relapsing Clostridium difficile colitis with Lactobacillus GG. Lancet ii:1519.
67. Granoff, D. M., K. Sheetz, J. P. Pandey, M. H. Nahm, J. H. Rambeck, J. L. Jacobs, J. Musser, R. K. Selander, M. Kabeer, T. V. Murphy and M. T. Osterholm. 1989. Host and bacterial factors associated with Haemophilus influenzae type b disease in Minnesota children vaccinated with type b polysaccharide vaccine. J. Infect. Dis. 159:908-916.
68. Granoff, D. M., B. K. Suarez, J. P. Pandey, and P. G. Shackelford. 1988. Genes associated with the G2m(23) immunoglobulin allotype regulate the IgG subclass responses to Haemophilus influenzae type b polysaccharide vaccine. J. Infect. Dis. 157:1142-1149.
69. Gray-Owen, S. D., S. Loosmore, and A. B. Schryvers. 1995. Identincation and characterization of genes encoding the human transferrin-binding proteins from Haemophilus influenzae. Infect. Immun. 63:1201-1210.
70. Green, B. A., J. E. Farley, T. Quinn-Dey, R. A. Deich, and G. W. Zlotnick. 1991. The e (P4) outer membrane protein of Haemophilus influenzae: biologic activity of anti-e serum and cloning and sequencing of the structural gene. Infect. Immun. 59:3191-3198.
71. Green, B. A., B. J. Metcalf, T. Quinn-Dey, D. H. Kirkley, S. A. Quartet, and R. A. Deich. 1990. A recombinant non-fatty acylated form of the Hi-PAL (P6) protein on Haemophilus influenzae elicits biologically active antibody against both nontypeable and type b H. influenzae. Infect. Immun. 58:3272-3278.
72. Green, B. A., M. E. Vazquez, G. W. Zoltnick, G. Quigley-Reape, J. D. Swarts, I. Green, J. L. Cowell, C. D. Bluestone, and W. J. Doyle. 1993. Evaluation of mixtures of purified Haemophilus influenzae outer membrane proteins in protection against challenge with nontypeable Haemophilus influenzae in the chinchilla otitis media model. Infect. Immun. 61:1950-1957.
73. Groeneveld, K., P. P. Eijk, L. van Alphen, H. M. Jansen, and H. C. Zanen. 1990. Haemophilus influenzae infections in patients with chronic obstructive pulmonary disease despite specific antibodies in serum and sputum. Am. J. Respir. Crit. Care Med. 141:1316-1321.
74. Groeneveld, K., L. van Alphen, P. E. Eijk, H. M. Jansen, and H. C. Zanen. 1988. Changes in outer membrane proteins of nontypable Haemophilus influenzae in patients with chronic obstructive pulmonary disease. J. Infect. Dis. 158:360-365.
75. Groeneveld, K., L. van Alphen, C. Voorter, P. P. Eijk, H. M. Jansen and H. C. Zanen. 1989. Antigenic drift of Haemophilus influenzae inpatients with chronic obstructive pulmonary disease. Infect. Immun. 57:3038-3044.
76. Gu, X.-X., C.-M. Tsai, T. Ueyama, S. J. Barenkamp, J. B. Robbins, and D. J. Lim. 1996. Synthesis, characterization, and immunologic properties of detoxified lipooligosaccharide from nontypeable Haemophilus influenzae conjugated to proteins. Infect. Immun. 64:4047-4053.
77. Gulig, P. A., G. H. McCracken, Jr., P. L. Holmans, and E. J. Hansen. 1984. Immunogenic proteins in cell-free culture supernatants of Haemophilus influenzae type b. Infect. Immun. 44:41-48.
78. Guthrie, L. A., L. C. McPhail, P. M. Henson, and R. B. Johnston, Jr. 1984. Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. J. Exp. Med. 160:1656-1671.
79. Hajishengallis, G., S. M. Michalek, and M. W. Russell. 1996. Persistence of serum and salivary antibody responses after oral immunization with a bacterial protein antigen genetically linked to the A2/B subunits of cholera toxin. Infect. Immun. 64:665-667.
80. Hammerström, L., M. A. A. Persson, and C. I. E. Smith. 1984. Subclass distribution of human anti-Staphylococcus aureus alpha toxin antibodies: suggestion of an IgG1, IgA1, IgG4 switch pattern. Scand. J. Immunol. 20:247-250.
81. Hammerström, L., M. Granström, V. Oxelius, M. A. A. Persson, and C. I. E. Smith. 1984. IgG subclass distribution of antibodies against S. aureus teichoic acid and α-toxin in normal and immunodeficient donors. Clin. Exp. Immunol. 55:593-601.
82. Hammerström, L., and C. I. E. Smith. 1986. IgG subclass changes in response to vaccination. Monogr. Allergy 19:241-252.
83. Hammerström, L., and C. I. E. Smith. 1986. IgG subclasses in bacterial infections. Monogr. Allergy 19:122-133.
84. Hansen, E. J., D. A. Hart, J. L. McGehee, and G. B. Toews. 1988. Immune enhancement of pulmonary clearance of nontypable Haemophilus influenzae. Infect. Immun. 56:182-190.
85. Hansen E. J., and G. B. Toews. 1992. Animal models for the study of noninvasive Haemophilus influenzae disease: pulmonary clearance systems. J. Infect. Dis. 165(Suppl. 1):S185-S187.
86. Hansen, M. V., D. M. Musher, and R. E. Baughn. 1985. Outer membrane proteins of nontypeable Haemophilus influenzae and reactivity of paired sera from infected patients with their homologous isolates. Infect. Immun. 47:843-846.
87. Harabuchi, Y., H. Fadden, L. Duffy, J. Wolf, and D. Krystofik. 1994. Human milk secretory IgA antibody to nontypeable Haemophilus influenzae: possible protective effects against nasopharyngeal colonization. J. Pediatr. 124: 193-198.
88. Harabuchi, Y., H. Faden, N. Yamanaka, L. Duffy, J. Wolf, D. Krystofik, and Tonawanda/Williamsville Pediatrics. 1994. Nasopharyngeal colonization with nontypeable Haemophilus influenzae and recurrent otitis media. J. Infect. Dis. 170:862-866.
89. Hardie, K. R., R. A. Adams, and K. J. Towner. 1993. Transferrin-binding ability of invasive and commensal isolates of Haemophilus spp. J. Med. Microbiol. 39:218-224.
90. Holland, J., P. R. Langford, K. J. Towner, and P. Williams. 1992. Evidence for in vivo expression of transferrin-binding proteins in Haemophilus influenzae type b. Infect. Immun. 60:2986-2991.
91. Holland, J., T. R. Parsons, A. A. Hasan, S. M. Cook, P. Stevenson, E. Griffiths, and P. Williams. 1996. Conservation and antigenic cross-reactivity of the transferrin-binding proteins of Haemophilus influenzae, Actinobacillus pleuropneumoniae and Neisseria meningitidis. Microbiology 142:3505-3513.
92. Howard, J. G., and C. Hale. 1976. Lack of neonatal susceptibility to induction of tolerance by polysaccharide antigens. Eur. J. Immunol. 6:486-492.
93. Hultgren, S. J., S. Abraham, M. Caparon, P. Falk, J. W. St. Geme III, and S. Normark. 1993. Pilus and nonpilus bacterial adhesins; assembly and function in cell recognition. Cell 73:887-901.
94. Isberg, R. R., and G. Tran Van Nhieu. 1994. Two mammalian cell internalization strategies used by pathogenic bacteria. Annu. Rev. Genet. 27: 395-422.
95. Jacques, M. 1996. Role of lipo-oligosaccharides and lipopolysaccharides in bacterial adherence. Trends Microbiol. 4:408-410.
96. Jauris-Heipke, S., E. R. Leake, J. M. Billy, and T. F. DeMaria. 1997. The effect of antibiotic treatment on the release of endotoxin during nontypeable Haemophilus influenzae-induced otitis media in the chinchilla. Acta Otolaryngol. 117:109-112.
97. Jertborn, M., A. M. Svennerholm, and J. Holmgren. 1988. IgG and IgA subclass distribution of antitoxin antibody responses after oral cholera vaccination or cholera disease. Int. Arch. Allergy Immunol. 85:358-363.
98. Johnson, A. P., and T. J. Inzana. 1986. Loss of ciliary activity in organ cultures of rat trachea treated with lipo-oligosaccharide from Haemophilus influenzae. J. Med. Microbiol. 22:265-268.
99. Karasic, R. B., C. E. Trumpp, H. E. Gnehm, P. A. Rice, and S. I. Pelton. 1985. Modification of otitis media in chinchillas rechallenged with nontypeable Haemophilus influenzae and serological response to outer membrane antigens. J. Infect. Dis. 151:273-279.
100. Karlsson, K.-A. 1989. Animal glycosphingolipids as membrane attachment sites for bacteria. Annu. Rev. Biochem. 58:309-350.
101. Kett, K., P. Brandtzaeg, J. Radl, and J. J. Haaijman. 1986. Different subclass distribution of IgA-producing cells in human lymphoid organs and various secretory tissues. J. Immunol. 136:3631-3635.
102. Kilian, M. 1991. Haemophilus, p. 463-470. In A. Balows, W. J. Hausler, Jr., K. L. Herrmann, H. D. Isenberg, H. J. Shadomy (ed.), Manual of clinical microbiology, 5th ed. American Society for Microbiology, Washington, D.C.
103. Kilian, M., and E. L. Biberstein. 1984. Facultatively anaerobic gram-negative rods, p. 558-568. In N. R. Krieg and J. G. Holt (ed.), Bergey's manual of systematic bacteriology, vol. 1. The Williams & Wilkins Co., Baltimore, Md.
104. Kilian, M., S. Husby, A. Host, and S. Halken. 1995. Increased proportions of bacteria capable of cleaving IgA1 in the pharynx of infants with atopic disease. Pediatr. Res. 38:182-186.
105. Kilian, M., and K. Poulsen. 1992. Enzymatic, serologic, and genetic polymorphism of Haemophilus influenzae IgA1 proteases. J. Infect. Dis. 165(Suppl. 1):S192-S193.
106. Kimura, A., and E. J. Hansen. 1986. Antigenic and phenotypic variations of Haemophilus influenzae type b lipopolysaccharide and their relationship to virulence. Infect. Immun. 51:69-79.
107. Krivan, H. C., D. D. Roberts, and V. Ginsburg. 1988. Many pulmonary pathogenic bacteria bind specifically to the carbohydrate sequence Gal-NAcβ1-4Gal found in some glycolipids. Proc. Natl. Acad. Sci. USA 85: 6157-6161.
108. Kubiet, M., and R. Ramphal. 1995. Adhesion of nontypeable Haemophilus influenzae from blood and sputum to human tracheobronchial mucins and lactoferrin. Infect. Immun. 63:899-902.
109. Kyd, J. M. 1995. Purification of antigens from nontypeable Haemophilus influenzae and immune mechanisms induced in the lung. Ph.D. thesis. University of Newcastle, Newcastle, Australia.
110. Kyd, J. M., and A. W. Cripps. 1996. Modulation of antigen-specific T and B cell responses influence bacterial clearance of non-typeable Haemophilus influenzae from the lung in a rat model. Vaccine 14:1471-1478.
111. Kyd, J. M., and A. W. Cripps. 1998. Potential of a novel protein, OMP 26, from nontypeable Haemophilus influenzae to enhance pulmonary clearance in a rat model. Infect. Immun. 66:2272-2278.
112. Kyd, J. M., M. L. Dunkley, and A. W. Cripps. 1995. Enhanced respiratory clearance of nontypeable Haemophilus influenzae following mucosal immunization with P6 in a rat model. Infect. Immun. 63:2931-2940.
113. Leake, E. R., K. Holmes, D. J. Lim, and T. F. DeMaria. 1994. Peptidoglycan isolated from nontypeable Haemophilus influenzae induces experimental otitis media in the chinchilla. J. Infect. Dis. 170:1532-1538.
114. Lehmann, D., K. J. Coakley, C. A. Croakley, V. Spooner, J. M. Montgomery, A. Michael, I. D. Riley, T. Smith, R. L. Clancy, A. W. Cripps, and M. P. Alpers. 1991. Reduction in the incidence of acute bronchitis by an oral Haemophilus influenzae vaccine in patients with chronic bronchitis in the highlands of Papua New Guinea. Am. Rev. Respir. Dis. 144:324-330.
115. Loeb, M. R., and D. H. Smith. 1980. Outer membrane protein composition in disease isolates of Haemophilus influenzae: pathogenic and epidemiological implications. Infect. Immun. 30:709-717.
116. Lomholt, H., L. van Alphen, and M. Kilian. 1993. Antigenic variation of immunoglobulin A1 proteases among sequential isolates of Haemophilus influenzae from healthy children and patients with chronic obstructive pulmonary disease. Infect. Immun. 61:4575-4581.
117. Loos, B. G., J. M. Bernstein, D. M. Dryja, T. F. Murphy, and D. P. Dickinson. 1989. Determination of the epidemiology and transmission of nontypeable Haemophilus influenzae in children with otitis media by comparison of total genomic DNA restriction fingerprints. Infect. Immun. 57: 2751-2757.
118. Loosmore, S. M., Y.-P. Yang, D. C. Coleman, J. M. Shortreed, D. M. England, R. E. Harkness, P. S.-C. Chong, and M. H. Klein. 1996. Cloning and expression of the Haemophilus influenzae transferrin receptor genes. Mol. Microbiol. 19:575-586.
119. Loosmore, S. M., Y.-P. Yang, D. C. Coleman, J. M. Shortreed, D. M. England, and M. H. Klein. 1997. Outer membrane protein D15 is conserved among Haemophilus influenzae species and may represent a universal protective antigen against invasive disease. Infect. Immun. 65:3701-3707.
120. Magnuson, K., A. Hermansson, Å. Melhus, and S. Hellström. 1997. The typmpanic membrane and middle ear mucosa during non-typeable Haemophilus influenzae and Haemophilus influenzae type b acute otitis media: a study in the rat. Acta Otolaryngol. 117:396-405.
121. Mäkelä, P. H. 1988. Unencapsulated Haemophilus influenzae - what kind of pathogen? Eur J. Clin. Microbiol. Infect. Dis. 7:606-609.
122. Mandrell, R. E., R. McLaughlin, Y. A. Kwaik, A. Lesse, R. Yamasaki, B. Gibson, S. M. Spinola, and M. A. Apicella. 1992. Lipooligosaccharides (LOS) of some Haemophilus species mimic human glycosphingolipids, and some LOS are sialylated. Infect. Immun. 60:1322-1328.
123. McGhee, J. R., and H. Kiyono. 1993. New perspectives in vaccine development: mucosal immunity to infections. Infect. Agents Dis. 2:55-73.
124. Melhus, Å., A. Hermansson, A. Forsgren, and K. Prellner. 1997. A resolved pneumococcal infection protects against nontypeable Haemophilus influenzae: an evaluation of different routes of whole cell immunization in protection against experimental acute otitis media. Int. J. Pediatr. Otorhinolaryngol. 39:119-131.
125. Mencarelli, M., C. Marsili, A. Zanchi, C. Pantini, and C. Cellesi. 1993. Genomic DNA fingerprints and phenotypic characteristics of serotype b Haemophilus influenzae isolates from Italy. Eur. J. Epidemiol. 9:353-360.
126. Mestecky, J., and J. R. McGhee. 1987. Immunoglobulin A (IgA): molecular and cellular interactions involved in IgA biosynthesis and immune response. Adv. Immunol. 40:153-245.
127. Mestecky, J., and M. W. Russell. 1986. IgA subclasses. Monogr. Allergy 19:277-301.
128. Miyamoto, N., and L. O. Bakaletz. 1997. Kinetics of the ascension of NTHi from the nasopharynx to the middle ear coincident with adenovirus-induced compromise in the chinchilla. Microb. Pathog. 23:119-126.
129. Möller, L. V. M., A. G. Regelink, H. Grasselier, J. E. Dankert-Roelse, J. Dankert, and L. van Alphen. 1995. Multiple Haemophilus influenzae strains and strain variants coexist in the respiratory tract of patients with cystic fibrosis. J. Infect. Dis. 172:1388-1392.
130. Moran, A. P., M. M. Prendergast, and B. J. Appelmelk. 1996. Molecular mimicry of host structures by bacterial lipopolysaccharides and its contribution to disease. FEMS Immunol. Med. Microbiol. 16:105-115.
131. Morell, A., F. Skvaril, A. G. Steinberg, E. van Loghem, and W. D. Terry. 1972. Correlations between the concentrations of the four sub-classes of IgG and Gm allotypes in normal human sera. J. Immunol. 108:195-206.
132. Morton, D. J., and P. Williams. 1990. Siderophore-independent acquisition of transferrin-bound iron by Haemophilus influenzae type b. J. Gen. Microbiol. 136:927-933.
133. Mulks, M. H., S. J. Kornfeld, B. Frangione, and A. G. Plaut. 1982. Relationship between the specificity of IgA proteases and serotypes in Haemophilus influenzae. J. Infect. Dis. 144:266-273.
134. Munson, R., Jr., S. Grass, M. Einhorn, C. Bailey, and C. Newell. 1989. Comparative analysis of the structures of the outer membrane protein P1 genes from major clones of Haemophilus influenzae type b. Infect. Immun. 57:3300-3305.
135. Munson, R. S., Jr., and D. M. Granoff. 1985. Purification and partial characterization of outer membrane proteins P5 and P6 from Haemophilus influenzae type b. Infect. Immun. 49:544-549.
136. Munson, R. S., Jr., J. L. Shenep, and S. J. Barenkamp. 1983. Purification and comparison of outer membrane protein P2 from Haemophilus influenzae type b isolates. J. Clin. Invest. 72:677-684.
137. 136a. Murphy, T. F. Personal communication.
138. Murphy, T. F., and M. A. Apicella. 1985. Antigenic heterogeneity of outer membrane proteins of nontypeable Haemophilus influenzae as a basis for a serotyping system. Infect. Immun. 50:15-21.
139. Murphy, T. F., and M. A. Apicella. 1987. Nontypable Haemophilus influenzae: a review of clinical aspects, surface antigens, and the human immune response to infection. Rev. Infect. Dis. 9:1-15.
140. Murphy, T. F., and L. C. Bartos. 1988. Human bactericidal antibody response to outer membrane protein P2 of nontypeable Haemophilus influenzae. Infect. Immun. 56:2673-2679.
141. Murphy, T. F., L. C. Bartos, A. A. Campagnari, M. B. Nelson, and M. A. Apicella. 1986. Antigenic characterization of the P6 protein of nontypeable Haemophilus influenzae. Infect. Immun. 54:774-779.
142. Murphy, T. F., L. C. Bartos, P. A. Rice, M. B. Nelson, K. C. Dudas, and M. A. Apicella. 1986. Identification of a 16,000-dalton outer membrane protein on nontypeable Haemophilus influenzae as a target for human serum bactericidal antibody. J. Clin. Invest. 78:1020-1027.
143. Murphy, T. F., J. M. Bernstein, D. M. Dryja, A. A. Camagnari, and M. A. Apicella. 1987. Outer membrane protein and lipooligosaccharide analysis of paired nasopharyngeal and middle ear isolates in otitis media due to nontypeable Haemophilus influenzae: pathogenetic and epidemiological observations. J. Infect. Dis. 156:723-731.
144. Murphy, T. F., K. C. Dudas, J. M. Mylotte, and M. A. Apicella. 1983. A subtyping system for nontypable Haemophilus influenzae based on outer-membrane proteins. J. Infect. Dis. 147:838-846.
145. Murphy, T. F., M. B. Nelson, and M. A. Apicella. 1992. The P6 outer membrane protein of nontypeable Haemophilus influenzae as a vaccine antigen. J. Infect. Dis. 165(Suppl. 1):S203-S205.
146. Murphy, T. F., M. B. Nelson, K. C. Dudas, J. M. Mylotte, and M. A. Apicella. 1985. Identification of a specific epitope of Haemophilus influenzae on a 16,600-dalton outer membrane protein. J. Infect. Dis. 152:1300-1307.
147. Murphy, T. F., and S. Sethi. 1992. Bacterial infection in chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 146:1067-1083.
148. Musser, J. M., S. J. Barenkamp, D. M. Granoff, and R. K. Selander. 1986. Genetic relationships of serologically nontypeable and serotype b strains of Haemophilus influenzae. Infect. Immun. 52:183-191.
149. Nelson, M. B., R. S. Munson, Jr., M. A. Apicella, D. J. Sikkema, J. P. Molleston, and T. F. Murphy. 1991. Molecular conservation of the P6 outer membrane protein amoung strains of Haemophilus influenzae: analysis of antigenic determinants, gene sequences, and restriction fragment length polymorphisms. Infect. Immun. 59:2658-2663.
150. Nelson, S., G. J. Bagby, B. G. Bainton, L. A. Wilson, J. J. Thompson, and W. R. Summer. 1989. Compartmentalization of intraalveolar and systemic lipopolysaccharide-induced tumor necrosis factor and the pulmonary inflammatory response. J. Infect. Dis. 159:189-194.
151. Neutra, M., and J.-P. Kraehenbuhl. 1994. Mucosal immunization via M cells for the production of protective secretory IgA antibodies. Am. J. Trop. Med. Hyg. 50(Suppl.):10-13.
152. Noel, G. J., S. J. Barenkamp, J. W. St. Geme III, N. Haining, and D. M. Mosser. 1994. High-molecular-weight surface-exposed proteins of Haemophilus influenzae mediate binding to macrophages. J. Infect. Dis. 169: 425-429.
153. Noel, G. J., D. C. Love, and D. M. Mosser. 1994. High-molecular-weight proteins of nontypeable Haemophilus influenzae mediate bacterial adhesion to cellular proteoglycans. Infect. Immun. 62:4028-4033.
154. O'Reilly, T. 1995. Relevance of animal models for chronic bacterial airway infections in humans. Am. Rev. Respir. Dis. 151:2101-2108.
155. Papadea, C., and I. J. Check. 1989. Human immunoglobulin G and immunoglobin G subclasses: biochemical, genetic, and clinical aspects. Crit. Rev. Clin. Lab. Sci. 27:27-58.
156. Patrick, C. C., A. Kimura, M. A. Jackson, L. Hermanstorfer, A. Hood, G. H. McCracken, Jr., and E. J. Hansen. 1987. Antigenic characterization of the oligosaccharide portion of the lipooligosaccharide of nontypeable Haemophilus influenzae. Infect. Immun. 55:2902-2911.
157. Patrick, C. C., S. E. Pelzel, E. E. Miller, E. Haanes-Fritz, J. D. Radolf, P. A. Gulig, G. H. McCracken, Jr., and E. J. Hansen. 1989. Antigenic evidence for simultaneous expression of two different lipooligosaccharides by some strains of Haemophilus influenzae type b. Infect. Immun. 57:1971-1978.
158. Phillips, N. J., M. A. Apicella, J. M. Griffiss, and B. W. Gibson. 1992. Structural characterization of the cell surface lipooligosaccharides from a nontypable strain of Haemophilus influenzae. Biochem. J. 31:4515-4526.
159. Pierce, N. F., J. B. Kaper, J. J. Mekalanos, and W. C. Cray, Jr. 1987. Determinants of the immunogenicity of live virulent and mutant Vibrio cholerae O1 in rabbit intestine. Infect. Immun. 55:477-481.
160. Pittman, M. 1931. Variation and type specificity of the bacterial species Haemophilus influenzae. J. Exp. Med. 53:471-492.
161. Porras, O., D. A. Caugant, B. Gray, T. Lagergård, B. R. Levin, and C. Svanborg-Edén. 1986. Difference in structure between type b and nontypeable Haemophilus influenzae populations. Infect. Immun. 53:79-89.
162. Porras, O., D. A. Caugant, T. Lagergard, and C. Svanborg-Eden. 1986. Application of multilocus enzyme gel electrophoresis to Haemophilus influenzae. Infect. Immun. 53:71-78.
163. Poulson, K., J. Reinholdt, and M. Kilian. 1992. A comparative genetic study of serologically distinct Haemophilus influenzae type 1 immunoglobulin A1 proteases. J. Bacteriol. 174:2913-2921.
164. Provence, D. L., and R. Curtiss III. 1994. Isolation and characterization of a gene involved in hemagglutination by an avian pathogenic Escherichia coli strain. Infect. Immun. 62:1369-1380.
165. Rautonen, N., H. Sarvas, I. Julkunen, R. Pyhälä, and O. Mäkelä. 1991. Gm allotypes influence the production of IgG3 but the effect is not age dependent. Hum. Immunol. 32:72-77.
166. Read, R. C., R. Wilson, A. Rutman, V. Lund, H. C. Todd, A. P. R. Brain, P. K. Jeffery, and P. J. Cole. 1991. Interaction of nontypable Haemophilus influenzae with human respiratory mucosa in vitro. J. Infect. Dis. 163:549-558.
167. Reddy, M. S., J. M. Bernstein, T. F. Murphy, and H. S. Faden. 1996. Binding between outer membrane proteins of nontypeable Haemophilus influenzae and human nasopharyngeal mucin. Infect. Immun. 64:1477-1479.
168. Reddy, M. S., F. A. Scannapieco, and M. J. Levine. 1988. Tracheobronchial mucin: interaction with non-typeable Haemophilus influenzae. Am. Rev. Respir. Dis. 137:A317.
169. Regoli, M., E. Bertelli, C. Borghesi, and C. Nicoletti. 1995. Three-dimensional (3D-) reconstruction of M cells in rabbit Peyer's patches: definition of the intraepithelial compartment of the follicle-associated epithelium. Anat. Rec. 243:19-26.
170. Reidl, J., and J. J. Mekalanos. 1996. Lipoprotein e(P4) essential for hemin uptake by Haemophilus influenzae. J. Exp. Med. 183:621-629.
171. Rivier, D. A., P. E. Trefts, and M. F. Kagnoff. 1983. Age-dependence of the IgA anti-α(1→3)dextran B1355 response in vitro. Scand. J. Immunol. 17: 115-121.
172. Roberts, D. E., A. Ingold, S. V. Want, and J. R. May. 1974. Osmotically stable L forms of Haemophilus influenzae and their significance in testing sensitivity to penicillins. J. Clin. Pathol. 27:560-564.
173. Samuelson, A., S. Borrelli, R. Gustafson, L. Hammarström, C. I. E. Smith, J. Jonasson, and A. A. Lindberg. 1995. Characterization of Haemophilus influenzae isolates from the respiratory tract of patients with primary antibody deficiencies: evidence for persistent colonizations. Scand. J. Infect. Dis. 27:303-313.
174. Sarvas, H., N. Rautonen, H. Kayhty, M. Kallio, and O. Makela. 1990. Effect of Gm allotypes on IgG2 antibody responses and IgG2 concentrations in children and adults. Int. Immunol. 2:317-322.
175. Scheifele, D. W., T. P. Jadavji, B. J. Law, R. Gold, N. E. Macdonald, M. H. Lebel, E. L. Mills, P. Dery, S. A. Halperin, R. F. Morris, V. Marchessault, and P. J. Duclos. 1996. Recent trends in pediatric Haemophilus influenzae type b infections in Canada. Can. Med. Assoc. J. 154:1041-1047.
176. Schmitt, W., and R. Haas. 1994. Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: structural similarities with the IgA protease type exported protein. Mol. Microbiol. 12:307-319.
177. Schryvers, A. B. 1989. Identification of the transferrin- and lactoferrin-binding proteins in Haemophilus influenzae. J. Med. Microbiol. 29:121-130.
178. Schryvers, A. B., and S. Gray-Owen. 1992. Iron acquisition in Haemophilus influenzae: receptors for human transferrin. J. Infect. Dis. 165(Suppl. 1): S103-S104.
179. Schulte, E. E., G. S. Birkhead, S. F. Kondracki, and D. L. Morse. 1994. Patterns of Haemophilus influenzae type b invasive disease in New York State, 1987-1991: the role of vaccination requirements for day-care attendance. Pediatrics 94(6 pt 2):1014-1016.
180. Shann, F., M. Gratten, S. Germer, V. Linnemann, D. Hazlett, and R. Payne. 1984. Aetiology of pneumonia in children in Goroka hospital, Papua New Guinea. Lancet ii:537-541.
181. Shenep, J. L., R. S. Munson, Jr., and D. M. Granoff. 1982. Human antibody responses to lipopolysaccharide after meningitis due to Haemophilus influenzae type b. J. Infect. Dis. 145:181-190.
182. Sirakova, T., P. E. Kolattukudy, D. Murwin, J. Billy, E. Leake, D. Lim, T. DeMaria, and L. Bakaletz. 1994. Role of fimbriae expressed by nontypeable Haemophilus influenzae in pathogenesis of and protection against otitis media and relatedness of the fimbrin subunit to outer membrane protein A. Infect. Immun. 62:2002-2020.
183. Slater, L. N. 1990. A rat model of prolonged pulmonary infection due to nontypable Haemophilus influenzae. Am. Rev. Respir. Dis. 142:1429-1435.
184. Smith-Vaughan, H. C., A. J. Leach, T. M. Shelby-James, K. Kemp, D. J. Kemp, and J. D. Mathews. 1996. Carriage of multiple ribotypes of nonencapsulated Haemophilus influenzae in aboriginal infants with otitis media. Epidemiol. Infect. 116:177-183.
185. Smith-Vaughan, H. C., K. S. Sriprakash, J. D. Mathews, and D. J. Kemp. 1997. Nonencapsulated Haemophilus influenzae in aboriginal infants with otitis media: prolonged carriage of P2 porin variants and evidence for horizontal P2 gene transfer. Infect. Immun. 65:1468-1474.
186. Spinola, S. M., J. Peacock, F. W. Denny, D. L. Smith, and J. G. Cannon. 1986. Epidemiology of colonization by nontypable Haemophilus influenzae in children: a longitudinal study. J. Infect. Dis. 154:100-109.
187. St. Geme, J. W., III. 1993. Nontypeable Haemophilus influenzae disease: epidemiology, pathogenesis, and prospects for prevention. Infect. Agents Dis. 2:1-16.
188. St. Geme, J. W., III. 1994. The HMW1 adhesin of nontypeable Haemophilus influenzae recognizes sialylated glycoprotein receptors on cultured human epithelial cells. Infect. Immun. 62:3881-3889.
189. St. Geme, J. W., III. 1996. Progress towards a vaccine for nontypable Haemophilus influenzae. Ann. Med. 28:31-37.
190. St. Geme, J. W., III, M. L. de la Morena, and S. Falkow. 1994. A Haemophilus influenzae IgA protease-like protein promotes intimate interaction with human epithelial cells. Mol. Microbiol. 14:217-233.
191. St. Geme, J. W., III, and S. Falkow. 1990. Haemophilia influenzae adheres to and enters cultured human epithelial cells. Infect. Immun. 58:4036-4044.
192. Street, N. E., and T. R. Mosmann. 1991. Functional diversity of T lymphocytes due to secretion of different cytokine patterns. FASEB J. 5:171-177.
193. Tandon, M. K., and V. Gebski. 1991. A controlled trial of a killed Haemophilus influenzae vaccine for the prevention of acute exacerbations of chronic bronchitis. Aust. N. Z. J. Med. 21:427-432.
194. Teele, D. W., J. O. Klein, C. Chase, P. Menyuk, B. A. Rosner, and the Greater Boston Otitis Media Study Group. 1990. Otitis media in infancy and intellectual ability, school achievement, speech, and language at age 7 years. J. Infect. Dis. 162:685-694.
195. Teele, D. W., J. O. Klein, B. Rosner, and Greater Boston Otitis Media Study Group. 1989. Epidemiology of otitis media during the first seven years of life in children in Greater Boston: a prospective, cohort study. J. Infect. Dis. 160:83-94.
196. Thomas, W. R., M. G. Callow, R. J. Dilworth, and A. A. Audesho. 1990. Expression in Escherichia coli of a high-molecular-weight protective surface antigen found in nontypeable and type b Haemophilus influenzae. Infect. Immun. 58:1909-1913.
197. Toews, G. B., W. C. Vial, and E. J. Hansen. 1985. Role of C5 and recruited neutrophils in early clearance of nontypeable Haemophilus influenzae from murine lungs. Infect. Immun. 50:207-212.
198. Toews, G. B., S. Viroslav, D. A. Hart, and E. J. Hansen. 1984. Pulmonary clearance of encapsulated and unencapsulated Haemophilus influenzae strains. Infect. Immun. 45:437-442.
199. Turk, D. C. 1984. The pathogenicity of Haemophilus influenzae. J. Med. Microbiol. 18:1-16.
200. van Alphen, L., D. A. Caugant, B. Duim, M. O'Rourke, and L. D. Bowler. 1997. Differences in genetic diversity of nonencapsulated Haemophilus influenzae from various diseases. Microbiology 143:1423-1431.
201. van Alphen, L., T. Riemens, J. Poolman, and H. C. Zanen. 1983. Characteristics of major outer membrane proteins of Haemophilus influenzae. J. Bacteriol. 155:878-885.
202. van Alphen, L., L. G. van den Broek, L. Blaas, and M. van Ham. 1991. Blocking of fimbria-mediated adherence of Haemophilus influenzae by sialyl gangliosides. Infect. Immun. 59:4473-4477.
203. van Belkum, A., B. Duim, A. Regelink, L. Möller, W. Quint, and L. van Alphen. 1994. Genomic DNA fingerprinting of clinical Haemophilus influenzae isolates by polymerase chain reaction amplification: comparison with major outer-membrane protein and restriction fragment length polymorphism analysis. J. Med. Microbiol. 41:63-68.
204. van Loghem, E., and J. Biewenga. 1983. Allotypic and isotypic aspects of human immunoglobulin A. Mol. Immunol. 20:1001-1007.
205. van Schilfgaarde, M., L. van Alphen, P. Eijk, V. Everts, and J. Dankert. 1995. Paracytosis of Haemophilus influenzae through cell layers of NCI-H292 lung epithelial cells. Infect. Immun. 63:4729-4737.
206. Virji, M., H. Käyhty, D. J. P. Ferguson, C. Alexandrescu, and E. R. Moxon. 1992. Interactions of Haemophilus influenzae with human endothelial cells in vitro. J. Infect. Dis. 165(Suppl. 1):S115-S116.
207. Vogel, L., B. Duim, F. Geluk, P. Eijk, H. Jansen, J. Dankert, and L. van Alphen. 1996. Immune selection for antigenic drift of major outer membrane protein P2 of Haemophilus influenzae during persistence in subcutaneous tissue cages in rabbits. Infect. Immun. 64:980-986.
208. Vosbeck, K., P. Tobias, H. Mueller, R. A. Allen, K.-E. Arfors, R. J. Ulevitch, and L. A. Sklar. 1990. Priming of polymorphonuclear granulocytes by lipopolysaccharides and its complexes with lipopolysaccharide binding protein and high density lipoprotein. J. Leukocyte Biol. 47:97-104.
209. Wallace, F. J., R. L. Clancy, and A. W. Cripps. 1989. An animal model demonstration of enhanced clearance of nontypeable Haemophilus influenzae from the respiratory tract after antigen stimulation of gut-associated lymphoid tissue. Am. Rev. Respir. Dis. 140:311-316.
210. Wallace, F. J., A. W. Cripps, R. L. Clancy, A. J. Husband, and C. S. Witt. 1991. A role for intestinal T lymphocytes in bronchus mucosal immunity. Immunology 74:68-73.
211. Wallace, F. J., C. S. Witt, R. L. Clancy, and A. W. Cripps. 1995. Protection against non-typable Haemophilia influenzae following sensitization of gut associated lymphoid tissue: role of specific antibody and phagocytes. Immunol. Cell Biol. 73:258-265.
212. Wallace, R. J., Jr., C. J. Baker, F. J. Quinones, D. G. Hollis, R. E. Weaver, and K. Wiss. 1983. Nontypable Haemophilus influenzae (biotype 4) as a neonatal, maternal, and genital pathogen. Rev. Infect. Dis. 5:123-136.
213. Wallace, R. J., Jr., D. M. Musher, E. J. Septimus, J. E. McGowan, Jr., F. J. Quinones, K. Wiss, P. H. Vance, and P. A. Trier. 1981. Haemophilus influenzae infections in adults: characterization of strains by serotypes, biotypes, and β-lactamase production. J. Infect. Dis. 144:101-106.
214. Weinberg, G. A., A. Ghafoor, Z. Ishaq, N. K. Nomani, M. Kabeer, F. Anwar, M. I. Burney, A. W. Qureshi, J. M. Musser, R. K. Selander, and D. M. Granoff. 1989. Clonal analysis of Haemophilus influenzae isolated from children from Pakistan with lower respiratory tract infections. J. Infect. Dis. 160:634-643.
215. Weiser, J. N. 1992. The oligosaccharide of Haemophilus influenzae. Microb. Pathog. 13:335-342.
216. Weiser, J. N. 1993. Relationship between colony morphology and the life cycle of Haemophilus influenzae: the contribution of lipopolysaccharide phase variation to pathogenesis. J. Infect. Dis. 168:672-680.
217. Weiser, J. N., M. Shchepetov, and S. T. H. Chong. 1997. Decoration of lipopolysaccharide with phosphorylcholine: a phase-variable characteristic of Haemophilus influenzae. Infect. Immun. 65:943-950.
218. Weiser, J. N., A. Williams, and E. R. Moxon. 1990. Phase-variable lipopolysaccharide structures enhance the invasive capacity of Haemophilus influenzae. Infect. Immun. 58:3455-3457.
219. Weissfeld, A. S., A. M. McNamara, V. L. Tesh, and B. J. Howard. 1994. Enterobacteriaceae, p. 322. In B. J. Howard (ed.), Clinical and pathogenic microbiology, 2nd ed. The C. V. Mosby Co., St. Louis, Mo.
220. Westerlund, B., and T. K. Korhonen. 1993. Bacterial proteins binding to the mammalian extracellular matrix. Mol. Microbiol. 9:687-694.
221. Yamanaka, N., and H. Faden. 1993. Antibody response to outer membrane protein of nontypeable Haemophilus influenzae in otitis-prone children. J. Pediatr. 122:212-218.
222. Yamanaka, N., and H. Faden. 1993. Local antibody response to P6 of nontypable Haemophilus influenzae in otitis-prone and normal children. Acta Otolaryngol. 113:524-529.
223. Yang, Y.-P., R. S. Munson, Jr., S. Grass, P. Chong, R. E. Harkness, L. Gisonni, O. James, Y. Kwok, and M. H. Klein. 1997. Effect of lipid modification on the physicochemical, structural, antigenic and immunoprotective properties of Haemophilus influenzae outer membrane protein P6. Vaccine 15:976-987.
224. Yount, W. J., H. G. Kunkel, and S. D. Litwin. 1967. Studies of the Vi (gamma 2c) subgroup of gammaglobulin. A relationship between concentration and genetic type amoung normal individuals. J. Exp. Med. 125:177-190.
225. Zhang, Y.-H., K. Takahashi, G.-Z. Jiang, X.-M. Zhang, M. Kawai, M. Fukada, and T. Yokochi. 1994. In vivo production of heat shock protein in mouse peritoneal macrophages by administration of lipopolysaccharide. Infect. Immun. 62:4140-4144.
226. Zoon, K. C., and J. J. Socca. 1975. Constitution of the cell envelope of Haemophilus influenzae in relation to competence for genetic transformation. J. Bacteriol. 123:666-677.
227. Zwahlen, A., J. A. Winkelstein, and E. R. Moxon. 1983. Surface determinants of Haemophilus influenzae pathogenicity: comparative virulence of capsular transformants in normal and complement-depleted rats. J. Infect. Dis. 148:385-393.