Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: Impact on cell motility

Clinical Cancer Research

Volumn 11, Issue 8, 2005, Pages 2840-2852

  Gesierich, Sabine ^a   Paret, Claudia ^a   Hildebrand, Dagmar ^a   Weitz, Jürgen ^b   Zgraggen, Kaspar ^b   Schmitz Winnenthal, Friedrich H ^b   Horejsi, Vaclav ^d   Yoshie, Osamu ^e   Herlyn, Dorothee ^f   Ashman, Leonie K ^g   Zöller, Margot ^a,c  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF KARLSRUHE   (Germany)

^d INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^e KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^f WISTAR INSTITUTE   (United States)

^g UNIVERSITY OF NEWCASTLE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2 INTEGRIN; ALPHA3 INTEGRIN; ALPHA6 INTEGRIN; ALPHA6BETA4 INTEGRIN; ANTIGEN; BETA1 INTEGRIN; BETA4 INTEGRIN; CD 151 ANTIGEN; CD63 ANTIGEN; CD81 ANTIGEN; CD9 ANTIGEN; INTEGRIN; KALININ; PROTEIN KINASE C; TETRASPANIN; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 3;

ARTICLE; CELL MEMBRANE TRANSPORT; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN TISSUE; IMMUNOPRECIPITATION; INTERNALIZATION; PANCREAS ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STROMA; TUMOR CELL;

ADENOCARCINOMA; ANTIGENS, CD; ANTIGENS, NEOPLASM; CELL LINE, TUMOR; CELL MOVEMENT; FLOW CYTOMETRY; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INTEGRINS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; PANCREATIC NEOPLASMS;

EID: 20244362928     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-04-1935     Document Type: Article

References (51)

1. Rosenberg L, Lipsett M. Biotherapeutic approaches to pancreatic cancer. Expert Opin Biol Ther 2003;3:319-7.
2. Brand R. The diagnosis of pancreatic cancer. Cancer J 2001;7:287-97.
3. Kleeff J, Friess H, Berberat PO, Martignoni ME, Z'graggen K, Buchler MW. Pancreatic cancer - new aspects of molecular biology research. Swiss Surg 2000;6:231-4.
4. Perugini RA, McDade TP, Vittimberga FJ Jr, Callery MP. The molecular and cellular biology of pancreatic cancer. Crit Rev Eukaryot Gene Expr 1998;8:377-93.
5. Hood JD, Cheresh DA. Role of integrins in cell invasion and migration. Nat Rev Cancer 2002;2:91-100.
6. Mercurio AM, Rabinovitz I. Towards a mechanistic understanding of tumor invasion-lessons from the α6β4 integrin. Semin Cancer Biol 2001;11:129-41.
7. Lohr M, Trautmann B, Gottler M, et al. Expression and function of receptors for extracellular matrix proteins in human ductal adenocarcinomas of the pancreas. Pancreas 1996;12:248-59.
8. Sawai H, Funahashi H, Matsuo Y, et al. Expression and prognostic roles of integrins and interleukin-1 receptor type I in patients with ductal adenocarcinoma of the pancreas. Dig Dis Sci 2003;48:1241-50.
9. Katayama M, Sanzen N, Funakoshi A, Sekiguchi K. Laminin 72-chain fragment in the circulation: a prognostic indicator of epithelial tumor invasion. Cancer Res 2003;63:222-9.
10. Nishimori H, Yasoshima T, Denno R, et al. A new peritoneal dissemination model established from the human pancreatic cancer cell line. Pancreas 2001;22:348-56.
11. Linder S, Castanos-Velez E, von Rosen A, Biberfeld P. Immunohistochemical expression of extracellular matrix proteins and adhesion molecules in pancreatic carcinoma. Hepatogastroenterology 2001;48:1321-7.
12. Weinel RJ, Rosendahl A, Neumann K, et al. Expression and function of VLA-α2, -α3, -α5 and -α6-integrin receptors in pancreatic carcinoma. Int J Cancer 1992;52:827-33.
13. Logsdon CD, Simeone DM, Binkley C, et al. Molecular profiling of pancreatic adenocarcinoma and chronic pancreatitis identifies multiple genes differentially regulated in pancreatic cancer. Cancer Res 2003;63:2649-57.
14. Claas C, Seiter S, Claas A, Savelyeva L, Schwab M, Zöller M. Association between the rat homologue of CO-029, a metastasis-associated tetraspanin molecule and consumption coagulopathy. J Cell Biol 1998;141:267-80.
15. Odintsova E, Sugiura T, Berditchevski F. Attenuation of EGF receptor signaling by a metastasis suppressor, the tetraspanin CD82/KAI-1. Curr Biol 2000;10:1009-12.
16. Testa JE, Brooks PC, Lin JM, Quigle JP. Eukaryotic expression cloning with an antimetastatic monoclonal antibody identifies a tetraspanin (PETA-3/CD151) as an effector of human tumor cell migration and metastasis. Cancer Res 1999;59:3812-20.
17. Sordat I, Decraene C, Silvestre T, et al. Complementary DNA arrays identify CD63 tetraspanin and α3 integrin chain as differentially expressed in low and high metastatic human colon carcinoma cells. Lab Invest 2002;82:1715-24.
18. Hashida H, Takabayashi A, Tokuhara T, et al. Clinical significance of transmembrane 4 superfamily in colon cancer. Br J Cancer 2003;89:158-67.
19. Ono M, Handa K, Withers DA, Hakomori S. Motility inhibition and apoptosis are induced by metastasis-suppressing gene product CD82 and its analogue CD9, with concurrent glycosylation. Cancer Res 1999;59:2335-9.
20. Sho M, Adachi M, Taki T, et al. Transmembrane 4 superfamily as a prognostic factor in pancreatic cancer. Int J Cancer 1998;79:509-16.
21. Mori M, Mimori K, Shiraishi T, et al. Motility related protein 1 (MRP1/CD9) expression in colon cancer. Clin Cancer Res 1998;4:1507-10.
22. White A, Lamb PW, Barrett JC. Frequent downregulation of the KAI1 (CD82) metastasis suppressor protein in human cancer cell lines. Oncogene 1998;16:3143-9.
23. Liu L, Wu DH, Li ZG, Yang GZ, Ding YQ. Effects of KAI1/CD82 on biological behavior of human colorectal carcinoma cell line. World J Gastroenterol 2003;9:1231-6.
24. Kanetaka K, Sakamoto M, Yamamoto Y, et al. Overexpression of tetraspanin CO-029 in hepatocellular carcinoma. J Hepatol 2001;35:637-42.
25. Maecker HT, Todd SC, Levy S. The tetraspanin superfamily: molecular facilitators. FASEB J 1997;11:428-42.
26. Sincock PM, Fitter S, Parton RG, Berndt MC, Gamble JR, Ashman LK. PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function. J Cell Sci 1999;112:833-44.
27. Fitter S, Sincock PM, Jolliffe CN, Ashman LK. Transmembrane 4 superfamily protein CD151 (PETA-3) associates with β1 and αIIb β3 integrins in haemopoietic cell lines and modulates cell-cell adhesion. Biochem J 1999;338:61-70.
28. Yauch RL, Berditchevski F, Harler MB, Reichner J, Hemler ME. Highly stoichiometric, stable, and specific association of integrin α3β1 with CD151 provides a major link to phosphatidylinositol 4-kinase, and may regulate cell migration. Mol Biol Cell 1998;9:2751-65.
29. Hintermann E, Bilban M, Sharabi A, Quaranta V. Inhibitory rote of α6β4-associated erbB-2 and phosphoinositide 3-kinase in keratinocyte haptotactic migration dependent on α3β1 integrin. J Cell Biol 2001;153:465-78.
30. Yauch RL, Kazarov AR, Desai B, Lee RT, Hemler ME. Direct extracellular contact between integrin α(3)β(1) and TM4SF protein CD151. J Biol Chem 2000;275:9230-8.
31. Sterk LM, Geuijen CA, Oomen LC, Calafat J, Janssen H, Sonnenberg A. The tetraspan molecule CD151, a novel constituent of hemidesmosomes, associates with the integrin α6β4 and may regulate the spatial organization of hemidesmosomes. J Cell Biol 2000;149:969-82.
32. Jones PH, Bishop LA, Watt FM. Functional significance of CD9 association with β1 integrins in human epidermal keratinocytes. Cell Adhes Commun 1996;4:297-305.
33. Baudoux B, Castanares-Zapatero D, Leclercq-Smekens M, Berna N, Poumay Y. The tetraspanin CD9 associates with the integrin α6β4 in cultures human epidermal keratinocytes and is involved in cell motility. Eur J Cell Biol 2000;79:41-51.
34. Herlevsen M, Schmidt DS, Miyazaki K, Zöller M. The association of the tetraspanin D6.1A with the α6β4 integrin supports cell motility and liver metastasis formation. J Cell Sci 2003;116:4373-90.
35. Kariya Y, Ishida K, Tsubota Y, et al. Efficient expression system of human recombinant laminin-5. J Biochem (Tokyo) 2002;132:607-12.
36. Makary MA, Warshaw AL, Centeno BA, Willet CG, Rattner DW, Fernandez-del Castillo C. Implications of peritoneal cytology for pancreatic cancer management. Arch Surg 1998;133:361-5.
37. Penas PF, Garzia-Diez A, Sanchez-Madrid F, Yanez-Mo M. Tetraspanins are localized at motility-related structures and involved in normal human keratinocyte wound healing migration. J Invest Dermatol 2000;114:1126-35.
38. Berditchevski F. Complexes of tetraspanins with integrins: more than meets the eye. J Cell Sci 2001;114:4143-51.
39. Charrin S, LeNaour F, Oualid M, et al. The major CD9 and CD81 molecular partner. Identification and characterization of the complexes. J Biol Chem 2001;276:14329-37.
40. Belkin AM, Stepp MA. Integrins as receptors for laminins. Microsc Res Tech 2000;51:280-301.
41. Zhang XA, Bontrager AL, Hemler ME. Transmembrane-4 superfamily proteins associate with activated protein kinase C (PKC) and link PKC to specific β(1) integrins. J Biol Chem 2001;276:25005-13.
42. Bogenrieder T, Herlyn M. Axis of evil: molecular mechanisms of cancer metastasis. Oncogene 2003;22:6524-36.
43. Lombardi DP, Geradts J, Foley JF, Chiao C, Lamb PW, Barrett JC. Loss of KAI1 expression in the progression of colorectal cancer. Cancer Res 1999;59:5724-31.
44. Shinohara T, Nishimura N, Hanibuchi M, et al. Transduction of KAI1/CD82 cDNA promotes hematogenous spread of human lung-cancer cells in natural killer cell-depleted SCID mice. Int J Cancer 2001;94:16-23.
45. Crnogorac-Jurcevic T, Efthimiou E, Capelli P, et al. Gene expression profiles of pancreatic cancer and stromal desmoplasia. Oncogene 2001;20:7437-46.
46. Lijovic M, Somers G, Frauman AG. KAI1/CD82 protein expression in primary prostate cancer and in BPH associated with cancer. Cancer Detect Prev 2002;26:69-77.
47. Berditchevski F, Gilbert E, Griffiths MR, Fitter S, Ashman L, Jenner SJ. Analysis of the CD151-α3β1 integrin and CD151-tetraspanin interactions by mutagenesis. J Biol Chem 2001;276:41165-74.
48. Kawakami Y, Kawakami K, Steelant WF, et al. Tetraspanin CD9 is a "proteolipid", and its interaction with α3 integrin in microdomain is promoted by GM3 ganglioside, leading to inhibition of laminin-5-dependent cell motility. J Biol Chem 2002;277:34349-58.
49. Stipp CS, Hemler ME. Transmembrane-4-superfamily proteins CD151 and CD81 associate with α3β1 integrin, and selectively contribute to α3β1-dependent neurite outgrowth. J Cell Sci 2000;113:1871-82.
50. Hemler ME. Specific tetraspanin functions. J Cell Biol 2001;155:1103-7.
51. Yanez-Mo M, Mittelbrunn M, Sanchez-Madrid F. Tetraspanins and intercellular interactions. Microcirculation 2001;8:153-68.