Chromodomain helicase DNA-binding protein 4 (CHD4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly(ADP-ribose) polymerase (PARP) inhibitor treatment

Journal of Biological Chemistry

Volumn 287, Issue 9, 2012, Pages 6764-6772

  Pan, Mei Ren ^a,b   Hsieh, Hui Ju ^a   Dai, Hui ^a   Hung, Wen Chun ^b   Li, Kaiyi ^c   Peng, Guang ^a   Lin, Shiaw Yih ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PARTNERS; BRCA1 C-TERMINAL DOMAINS; CHROMODOMAINS; DEFENSE MECHANISM; DNA DAMAGES; DNA DOUBLE STRAND BREAKS; DNA REPAIR; DNA REPAIR PROTEINS; DNA REPLICATIONS; DNA-BINDING PROTEIN; DOUBLE STRANDS; GENOME STABILITY; GENOMIC INTEGRITY; HELICASES; HOMOLOGOUS RECOMBINATION; KEY REGULATORS; OVER-EXPRESSION; PHYSIOLOGICAL PROCESS; POLY POLYMERASE; POLY(ADP-RIBOSE) POLYMERASE; REPAIR PROCESS; REPLICATION PROTEIN A;

CELLS; CYTOLOGY; DNA; EMPLOYMENT; FREE RADICALS; GENES; IONIZING RADIATION; PLANTS (BOTANY); POLYMERS; PROTEINS;

REPAIR;

BRCA1 PROTEIN; DNA; DNA BINDING PROTEIN; FREE RADICAL; HELICASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN A;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CHROMATIN; DNA BINDING; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; GENOMIC INSTABILITY; HUMAN; IONIZING RADIATION; LETHALITY; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECOMBINATION REPAIR;

AUTOANTIGENS; BRCA1 PROTEIN; BREAST; BREAST NEOPLASMS; CELL LINE; CHROMATIN; DNA DAMAGE; DNA REPAIR; FEMALE; HOMOLOGOUS RECOMBINATION; HUMANS; MI-2 NUCLEOSOME REMODELING AND DEACETYLASE COMPLEX; NERVE TISSUE PROTEINS; PHTHALAZINES; PIPERAZINES; POLY ADENOSINE DIPHOSPHATE RIBOSE; POLY(ADP-RIBOSE) POLYMERASES; REPLICATION PROTEIN A; RNA, SMALL INTERFERING;

EID: 84863166648     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.287037     Document Type: Article

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