-
1
-
-
0035093737
-
DNA double-strand breaks: signaling, repair and the cancer connection
-
10.1038/85798, 11242102
-
Khanna KK, Jackson SP. DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 2001, 27:247-254. 10.1038/85798, 11242102.
-
(2001)
Nat Genet
, vol.27
, pp. 247-254
-
-
Khanna, K.K.1
Jackson, S.P.2
-
2
-
-
62849083222
-
The emerging role of nuclear architecture in DNA repair and genome maintenance
-
10.1038/nrm2651, 19277046
-
Misteli T, Soutoglou E. The emerging role of nuclear architecture in DNA repair and genome maintenance. Nat Rev Mol Cell Biol 2009, 10:243-254. 10.1038/nrm2651, 19277046.
-
(2009)
Nat Rev Mol Cell Biol
, vol.10
, pp. 243-254
-
-
Misteli, T.1
Soutoglou, E.2
-
3
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
10.1101/gad.914401, 11544175
-
Abraham RT. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 2001, 15:2177-2196. 10.1101/gad.914401, 11544175.
-
(2001)
Genes Dev
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
4
-
-
36249031962
-
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
-
10.1016/j.cell.2007.09.041, 2149842, 18001825
-
Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell 2007, 131:901-914. 10.1016/j.cell.2007.09.041, 2149842, 18001825.
-
(2007)
Cell
, vol.131
, pp. 901-914
-
-
Huen, M.S.1
Grant, R.2
Manke, I.3
Minn, K.4
Yu, X.5
Yaffe, M.B.6
Chen, J.7
-
5
-
-
36749084931
-
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase
-
10.1126/science.1150034, 2430610, 18006705
-
Kolas NK, Chapman JR, Nakada S, Ylanko J, Chahwan R, Sweeney FD, Panier S, Mendez M, Wildenhain J, Thomson TM, et al. Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science 2007, 318:1637-1640. 10.1126/science.1150034, 2430610, 18006705.
-
(2007)
Science
, vol.318
, pp. 1637-1640
-
-
Kolas, N.K.1
Chapman, J.R.2
Nakada, S.3
Ylanko, J.4
Chahwan, R.5
Sweeney, F.D.6
Panier, S.7
Mendez, M.8
Wildenhain, J.9
Thomson, T.M.10
-
6
-
-
36248966246
-
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
-
10.1016/j.cell.2007.09.040, 18001824
-
Mailand N, Bekker-Jensen S, Faustrup H, Melander F, Bartek J, Lukas C, Lukas J. RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell 2007, 131:887-900. 10.1016/j.cell.2007.09.040, 18001824.
-
(2007)
Cell
, vol.131
, pp. 887-900
-
-
Mailand, N.1
Bekker-Jensen, S.2
Faustrup, H.3
Melander, F.4
Bartek, J.5
Lukas, C.6
Lukas, J.7
-
7
-
-
36749025467
-
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage
-
10.1073/pnas.0710061104, 2410075, 18077395
-
Wang B, Elledge SJ. Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc Natl Acad Sci USA 2007, 104:20759-20763. 10.1073/pnas.0710061104, 2410075, 18077395.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 20759-20763
-
-
Wang, B.1
Elledge, S.J.2
-
8
-
-
59049091728
-
RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins
-
10.1016/j.cell.2008.12.041, 19203579
-
Doil C, Mailand N, Bekker-Jensen S, Menard P, Larsen DH, Pepperkok R, Ellenberg J, Panier S, Durocher D, Bartek J, et al. RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins. Cell 2009, 136:435-446. 10.1016/j.cell.2008.12.041, 19203579.
-
(2009)
Cell
, vol.136
, pp. 435-446
-
-
Doil, C.1
Mailand, N.2
Bekker-Jensen, S.3
Menard, P.4
Larsen, D.H.5
Pepperkok, R.6
Ellenberg, J.7
Panier, S.8
Durocher, D.9
Bartek, J.10
-
9
-
-
66849138419
-
Solving the RIDDLE of 53BP1 recruitment to sites of damage
-
10.4161/cc.8.10.8351, 19372751
-
Stewart GS. Solving the RIDDLE of 53BP1 recruitment to sites of damage. Cell Cycle 2009, 8:1532-1538. 10.4161/cc.8.10.8351, 19372751.
-
(2009)
Cell Cycle
, vol.8
, pp. 1532-1538
-
-
Stewart, G.S.1
-
10
-
-
59049103900
-
The RIDDLE syndrome protein mediates a ubiquitindependent signaling cascade at sites of DNA damage
-
10.1016/j.cell.2008.12.042, 19203578
-
Stewart GS, Panier S, Townsend K, Al-Hakim AK, Kolas NK, Miller ES, Nakada S, Ylanko J, Olivarius S, Mendez M, et al. The RIDDLE syndrome protein mediates a ubiquitindependent signaling cascade at sites of DNA damage. Cell 2009, 136:420-434. 10.1016/j.cell.2008.12.042, 19203578.
-
(2009)
Cell
, vol.136
, pp. 420-434
-
-
Stewart, G.S.1
Panier, S.2
Townsend, K.3
Al-Hakim, A.K.4
Kolas, N.K.5
Miller, E.S.6
Nakada, S.7
Ylanko, J.8
Olivarius, S.9
Mendez, M.10
-
11
-
-
77953720192
-
ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks
-
10.1016/j.cell.2010.04.038, 20550933
-
Shanbhag NM, Rafalska-Metcalf IU, Balane-Bolivar C, Janicki SM, Greenberg RA. ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks. Cell 2010, 141:970-981. 10.1016/j.cell.2010.04.038, 20550933.
-
(2010)
Cell
, vol.141
, pp. 970-981
-
-
Shanbhag, N.M.1
Rafalska-Metcalf, I.U.2
Balane-Bolivar, C.3
Janicki, S.M.4
Greenberg, R.A.5
-
12
-
-
70350115247
-
Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications
-
10.1042/BJ20090870, 2885444, 19624289
-
Musselman CA, Mansfield RE, Garske AL, Davrazou F, Kwan AH, Oliver SS, O'Leary H, Denu JM, Mackay JP, Kutateladze TG. Binding of the CHD4 PHD2 finger to histone H3 is modulated by covalent modifications. Biochem J 2009, 423:179-187. 10.1042/BJ20090870, 2885444, 19624289.
-
(2009)
Biochem J
, vol.423
, pp. 179-187
-
-
Musselman, C.A.1
Mansfield, R.E.2
Garske, A.L.3
Davrazou, F.4
Kwan, A.H.5
Oliver, S.S.6
O'Leary, H.7
Denu, J.M.8
Mackay, J.P.9
Kutateladze, T.G.10
-
13
-
-
77956870690
-
Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4
-
10.1038/emboj.2010.188, 2944064, 20693977
-
Polo S, Kaidi A, Baskcomb L, Galanty Y, Jackson S. Regulation of DNA-damage responses and cell-cycle progression by the chromatin remodelling factor CHD4. The EMBO Journal 2010, 29:3130-3139. 10.1038/emboj.2010.188, 2944064, 20693977.
-
(2010)
The EMBO Journal
, vol.29
, pp. 3130-3139
-
-
Polo, S.1
Kaidi, A.2
Baskcomb, L.3
Galanty, Y.4
Jackson, S.5
-
14
-
-
0037093537
-
The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization
-
10.1093/emboj/21.10.2430, 125999, 12006495
-
Bouazoune K, Mitterweger A, Langst G, Imhof A, Akhtar A, Becker PB, Brehm A. The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization. EMBO J 2002, 21:2430-2440. 10.1093/emboj/21.10.2430, 125999, 12006495.
-
(2002)
EMBO J
, vol.21
, pp. 2430-2440
-
-
Bouazoune, K.1
Mitterweger, A.2
Langst, G.3
Imhof, A.4
Akhtar, A.5
Becker, P.B.6
Brehm, A.7
-
15
-
-
0032252209
-
NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities
-
10.1016/S1097-2765(00)80299-3, 9885572
-
Xue Y, Wong J, Moreno G, Young M, CÙtÈ J, Wang W. NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities. Molecular cell 1998, 2:851-861. 10.1016/S1097-2765(00)80299-3, 9885572.
-
(1998)
Molecular cell
, vol.2
, pp. 851-861
-
-
Xue, Y.1
Wong, J.2
Moreno, G.3
Young, M.4
CÙtÈ, J.5
Wang, W.6
-
16
-
-
70349645266
-
Ageing-related chromatin defects through loss of the NURD complex
-
10.1038/ncb1971, 2779731, 19734887
-
Pegoraro G, Kubben N, Wickert U, Ĝ hler H, Hoffmann K, Misteli T. Ageing-related chromatin defects through loss of the NURD complex. Nature cell biology 2009, 11:1261-1267. 10.1038/ncb1971, 2779731, 19734887.
-
(2009)
Nature cell biology
, vol.11
, pp. 1261-1267
-
-
Pegoraro, G.1
Kubben, N.2
Wickert, U.3
Ĝhler, H.4
Hoffmann, K.5
Misteli, T.6
-
17
-
-
77956379478
-
The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage
-
10.1083/jcb.200912135, 20805324
-
Larsen DH, Poinsignon C, Gudjonsson T, Dinant C, Payne MR, Hari FJ, Danielsen JM, Menard P, Sand JC, Stucki M, et al. The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage. J Cell Biol 2010, 190:731-740. 10.1083/jcb.200912135, 20805324.
-
(2010)
J Cell Biol
, vol.190
, pp. 731-740
-
-
Larsen, D.H.1
Poinsignon, C.2
Gudjonsson, T.3
Dinant, C.4
Payne, M.R.5
Hari, F.J.6
Danielsen, J.M.7
Menard, P.8
Sand, J.C.9
Stucki, M.10
-
18
-
-
0032578762
-
Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex
-
10.1038/27699, 9804427
-
Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL. Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. Nature 1998, 395:917-921. 10.1038/27699, 9804427.
-
(1998)
Nature
, vol.395
, pp. 917-921
-
-
Tong, J.K.1
Hassig, C.A.2
Schnitzler, G.R.3
Kingston, R.E.4
Schreiber, S.L.5
-
19
-
-
77956387556
-
The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage
-
10.1083/jcb.201001048, 20805320
-
Smeenk G, Wiegant WW, Vrolijk H, Solari AP, Pastink A, van Attikum H. The NuRD chromatin-remodeling complex regulates signaling and repair of DNA damage. J Cell Biol 2010, 190:741-749. 10.1083/jcb.201001048, 20805320.
-
(2010)
J Cell Biol
, vol.190
, pp. 741-749
-
-
Smeenk, G.1
Wiegant, W.W.2
Vrolijk, H.3
Solari, A.P.4
Pastink, A.5
van Attikum, H.6
-
20
-
-
0034106722
-
ATM-dependent phosphorylation of nibrin in response to radiation exposure
-
10.1038/75508, 10802669
-
Gatei M, Young D, Cerosaletti KM, Desai-Mehta A, Spring K, Kozlov S, Lavin MF, Gatti RA, Concannon P, Khanna K. ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat Genet 2000, 25:115-119. 10.1038/75508, 10802669.
-
(2000)
Nat Genet
, vol.25
, pp. 115-119
-
-
Gatei, M.1
Young, D.2
Cerosaletti, K.M.3
Desai-Mehta, A.4
Spring, K.5
Kozlov, S.6
Lavin, M.F.7
Gatti, R.A.8
Concannon, P.9
Khanna, K.10
-
21
-
-
0032508608
-
Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
-
10.1126/science.281.5383.1677, 9733515
-
Canman CE, Lim DS, Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD. Activation of the ATM kinase by ionizing radiation and phosphorylation of p53. Science 1998, 281:1677-1679. 10.1126/science.281.5383.1677, 9733515.
-
(1998)
Science
, vol.281
, pp. 1677-1679
-
-
Canman, C.E.1
Lim, D.S.2
Cimprich, K.A.3
Taya, Y.4
Tamai, K.5
Sakaguchi, K.6
Appella, E.7
Kastan, M.B.8
Siliciano, J.D.9
-
22
-
-
79952233616
-
HSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex
-
Richard DJ, Savage K, Bolderson E, Cubeddu L, So S, Ghita M, Chen DJ, White MF, Richard K, Prise KM, et al. hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex. Nucleic Acids Res 2010,
-
(2010)
Nucleic Acids Res
-
-
Richard, D.J.1
Savage, K.2
Bolderson, E.3
Cubeddu, L.4
So, S.5
Ghita, M.6
Chen, D.J.7
White, M.F.8
Richard, K.9
Prise, K.M.10
-
23
-
-
0035155661
-
ATM, a central controller of cellular responses to DNA damage
-
10.1038/sj.cdd.4400874, 11687884
-
Khanna KK, Lavin MF, Jackson SP, Mulhern TD. ATM, a central controller of cellular responses to DNA damage. Cell Death Differ 2001, 8:1052-1065. 10.1038/sj.cdd.4400874, 11687884.
-
(2001)
Cell Death Differ
, vol.8
, pp. 1052-1065
-
-
Khanna, K.K.1
Lavin, M.F.2
Jackson, S.P.3
Mulhern, T.D.4
-
24
-
-
44449118949
-
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability
-
10.1038/nature06883, 18449195
-
Richard DJ, Bolderson E, Cubeddu L, Wadsworth RI, Savage K, Sharma GG, Nicolette ML, Tsvetanov S, McIlwraith MJ, Pandita RK, et al. Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature 2008, 453:677-681. 10.1038/nature06883, 18449195.
-
(2008)
Nature
, vol.453
, pp. 677-681
-
-
Richard, D.J.1
Bolderson, E.2
Cubeddu, L.3
Wadsworth, R.I.4
Savage, K.5
Sharma, G.G.6
Nicolette, M.L.7
Tsvetanov, S.8
McIlwraith, M.J.9
Pandita, R.K.10
-
25
-
-
0032508504
-
Enhanced phosphorylation of p53 by ATM in response to DNA damage
-
10.1126/science.281.5383.1674, 9733514
-
Banin S, Moyal L, Shieh S, Taya Y, Anderson C, Chessa L, Smorodinsky N, Prives C, Reiss Y, Shiloh Y. Enhanced phosphorylation of p53 by ATM in response to DNA damage. Science 1998, 281:1674. 10.1126/science.281.5383.1674, 9733514.
-
(1998)
Science
, vol.281
, pp. 1674
-
-
Banin, S.1
Moyal, L.2
Shieh, S.3
Taya, Y.4
Anderson, C.5
Chessa, L.6
Smorodinsky, N.7
Prives, C.8
Reiss, Y.9
Shiloh, Y.10
-
26
-
-
0032484084
-
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
-
10.1126/science.282.5395.1893, 9836640
-
Matsuoka S, Huang M, Elledge S. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 1998, 282:1893. 10.1126/science.282.5395.1893, 9836640.
-
(1998)
Science
, vol.282
, pp. 1893
-
-
Matsuoka, S.1
Huang, M.2
Elledge, S.3
-
27
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
-
10.1126/science.1140321, 17525332
-
Matsuoka S, Ballif B, Smogorzewska A, McDonald III E, Hurov K, Luo J, Bakalarski C, Zhao Z, Solimini N, Lerenthal Y. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007, 316:1160. 10.1126/science.1140321, 17525332.
-
(2007)
Science
, vol.316
, pp. 1160
-
-
Matsuoka, S.1
Ballif, B.2
Smogorzewska, A.3
McDonald III, E.4
Hurov, K.5
Luo, J.6
Bakalarski, C.7
Zhao, Z.8
Solimini, N.9
Lerenthal, Y.10
-
28
-
-
34948899943
-
Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template
-
10.1139/O07-069, 17713585
-
Williams R, Williams J, Tainer J. Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template. Biochemistry and Cell Biology 2007, 85:509-520. 10.1139/O07-069, 17713585.
-
(2007)
Biochemistry and Cell Biology
, vol.85
, pp. 509-520
-
-
Williams, R.1
Williams, J.2
Tainer, J.3
-
29
-
-
0142136826
-
Requirement of the MRN complex for ATM activation by DNA damage
-
10.1093/emboj/cdg541, 213795, 14532133
-
Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y. Requirement of the MRN complex for ATM activation by DNA damage. The EMBO Journal 2003, 22:5612. 10.1093/emboj/cdg541, 213795, 14532133.
-
(2003)
The EMBO Journal
, vol.22
, pp. 5612
-
-
Uziel, T.1
Lerenthal, Y.2
Moyal, L.3
Andegeko, Y.4
Mittelman, L.5
Shiloh, Y.6
-
30
-
-
0032474826
-
A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase
-
10.1016/S0960-9822(98)70328-8, 9663395
-
Wade P, Jones P, Vermaak D, Wolffe A. A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase. Current Biology 1998, 8:843-848. 10.1016/S0960-9822(98)70328-8, 9663395.
-
(1998)
Current Biology
, vol.8
, pp. 843-848
-
-
Wade, P.1
Jones, P.2
Vermaak, D.3
Wolffe, A.4
-
31
-
-
0033517797
-
Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4
-
10.1021/bi991614n, 10545197
-
Schmidt DR, Schreiber SL. Molecular association between ATR and two components of the nucleosome remodeling and deacetylating complex, HDAC2 and CHD4. Biochemistry 1999, 38:14711-14717. 10.1021/bi991614n, 10545197.
-
(1999)
Biochemistry
, vol.38
, pp. 14711-14717
-
-
Schmidt, D.R.1
Schreiber, S.L.2
-
32
-
-
0035851090
-
Nuclear retention of ATM at sites of DNA double strand breaks
-
Andegeko Y, Moyal L, Mittelman L, Tsarfaty I, Shiloh Y, Rotman G. Nuclear retention of ATM at sites of DNA double strand breaks. J Biol Chem 2001, 276:38224-38230.
-
(2001)
J Biol Chem
, vol.276
, pp. 38224-38230
-
-
Andegeko, Y.1
Moyal, L.2
Mittelman, L.3
Tsarfaty, I.4
Shiloh, Y.5
Rotman, G.6
-
33
-
-
17444368701
-
Histone modifying and chromatin remodelling enzymes in cancer and dysplastic syndromes
-
10.1093/hmg/ddi106, 15809277
-
Gibbons R. Histone modifying and chromatin remodelling enzymes in cancer and dysplastic syndromes. Human molecular genetics 2005, 14:R85. 10.1093/hmg/ddi106, 15809277.
-
(2005)
Human molecular genetics
, vol.14
-
-
Gibbons, R.1
-
34
-
-
67649305191
-
Epigenetics in cancer: targeting chromatin modifications
-
10.1158/1535-7163.MCT-08-0860, 19509247
-
Ellis L, Atadja PW, Johnstone RW. Epigenetics in cancer: targeting chromatin modifications. Mol Cancer Ther 2009, 8:1409-1420. 10.1158/1535-7163.MCT-08-0860, 19509247.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 1409-1420
-
-
Ellis, L.1
Atadja, P.W.2
Johnstone, R.W.3
-
35
-
-
4143140016
-
Histone deacetylase inhibitors open new doors in cancer therapy
-
10.1016/j.bcp.2004.05.034, 15313411
-
McLaughlin F, La Thangue N. Histone deacetylase inhibitors open new doors in cancer therapy. Biochemical pharmacology 2004, 68:1139-1144. 10.1016/j.bcp.2004.05.034, 15313411.
-
(2004)
Biochemical pharmacology
, vol.68
, pp. 1139-1144
-
-
McLaughlin, F.1
La Thangue, N.2
|