Aberrant methylation of the Pleckstrin and Sec7 domain-containing gene is implicated in ulcerative colitis-associated carcinogenesis through its inhibitory effect on apoptosis

International Journal of Oncology

Volumn 40, Issue 3, 2012, Pages 686-694

  Okada, Shinichiro ^a   Suzuki, Koichi ^a   Takaharu, Kato ^a   Noda, Hiroshi ^a   Kamiyama, Hidenori ^a   Maeda, Takafumi ^a   Saito, Masaaki ^a   Koizumi, Kei ^b   Miyaki, Yuichiro ^b   Konishi, Fumio ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Apoptosis; Filamentous actin; Neutrophils; Pleckstrin and Sec7 domain containing gene; Promoter methylation; Ulcerative colitis associated colorectal carcinogenesis

Indexed keywords

APOPTOSIS INHIBITOR; CASPASE 3; CASPASE 7; F ACTIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MESSENGER RNA; PLECKSTRIN; PLECKSTRIN AND SEC 7 DOMAIN PROTEIN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ADULT; AGED; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL AGING; CELL PROLIFERATION; COLON MUCOSA; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE DURATION; FEMALE; FIBROBLAST CULTURE; GENE SEQUENCE; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; NEUTROPHIL; NICK END LABELING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METHYLATION; ULCERATIVE COLITIS;

ACTINS; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; APOPTOSIS; CELL AGING; CELL GROWTH PROCESSES; CELL LINE; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; COLITIS, ULCERATIVE; COLORECTAL NEOPLASMS; DNA METHYLATION; DOWN-REGULATION; FEMALE; FIBROBLASTS; GENE KNOCKDOWN TECHNIQUES; GENE SILENCING; HL-60 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; NEUTROPHILS; REACTIVE OXYGEN SPECIES; YOUNG ADULT;

EID: 84863115648     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2011.1231     Document Type: Article

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