6-shogaol induces apoptosis in human hepatocellular carcinoma cells and exhibits anti-tumor activity in vivo through endoplasmic reticulum stress

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Hu, Rong ^a   Zhou, Ping ^a   Peng, Yong Bo ^a   Xu, Xiaojun ^a   Ma, Jiang ^a   Liu, Qun ^a   Zhang, Lei ^a   Wen, Xiao Dong ^a   Qi, Lian Wen ^a   Gao, Ning ^b   Li, Ping ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; CASPASE; CASPASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN IRE1; SHOGAOL; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ELF 2 ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL DEATH; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN OVEREXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN UNFOLDING; PROTEINASE INHIBITION; PROTEOMICS; SIGNAL TRANSDUCTION; TUMOR XENOGRAFT; UPREGULATION; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CATECHOLS; CELL LINE, TUMOR; CELL SURVIVAL; CINNAMATES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG SYNERGISM; EIF-2 KINASE; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-2; HUMANS; LIVER NEOPLASMS; MICE; NEOPLASM PROTEINS; PHOSPHORYLATION; RNA, SMALL INTERFERING; THIOUREA; TIME FACTORS; TRANSCRIPTION FACTOR CHOP; UNFOLDED PROTEIN RESPONSE; UP-REGULATION; XENOGRAFT MODEL ANTITUMOR ASSAYS;

ZINGIBER OFFICINALE;

EID: 84863091501     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039664     Document Type: Article

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