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Volumn 1015, Issue , 2004, Pages 250-260

Regulation of cell size and contractile function by AKT in cardiomyocytes

Author keywords

AKT; Heart failure; Hypertrophy; Inotropism; Signal transduction

Indexed keywords

BETA ADRENERGIC RECEPTOR; CALCIUM ION; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; S6 KINASE; SOMATOMEDIN C;

EID: 3042718647     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1302.021     Document Type: Conference Paper
Times cited : (111)

References (35)
  • 1
    • 0026095665 scopus 로고
    • A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
    • BELLACOSA, A., J.R. TESTA, S.P. STAAL & P.N. TSICHLIS. 1991. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science 254: 274-277.
    • (1991) Science , vol.254 , pp. 274-277
    • Bellacosa, A.1    Testa, J.R.2    Staal, S.P.3    Tsichlis, P.N.4
  • 2
    • 0034680838 scopus 로고    scopus 로고
    • Peptide and protein library screening defines optimal substrate motifs for AKT/PKB
    • OBATA, T., M.B. YAFFE, G.G. LEPARC, et al. 2000. Peptide and protein library screening defines optimal substrate motifs for AKT/PKB. J. Biol. Chem. 275: 36108-36115.
    • (2000) J. Biol. Chem. , vol.275 , pp. 36108-36115
    • Obata, T.1    Yaffe, M.B.2    Leparc, G.G.3
  • 3
    • 0027470177 scopus 로고
    • Structure, expression and chromosomal mapping of c-akt: Relationship to v-akt and its implications
    • BELLACOSA, A., T.F. FRANKE, M.E. GONZALEZ-PORTAL, et al. 1993. Structure, expression and chromosomal mapping of c-akt: relationship to v-akt and its implications. Oncogene 8: 745-754.
    • (1993) Oncogene , vol.8 , pp. 745-754
    • Bellacosa, A.1    Franke, T.F.2    Gonzalez-Portal, M.E.3
  • 4
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • DATTA, S.R., A. BRUNET & M.E. GREENBERG. 1999. Cellular survival: a play in three Akts. Genes Dev. 13: 2905-2927.
    • (1999) Genes Dev. , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 5
    • 0030943057 scopus 로고    scopus 로고
    • cAMP stimulates protein kinase B in a Wortmannin-insensitive manner
    • SABLE, C.L., N. FILIPPA, B. HEMMINGS, et al. 1997. cAMP stimulates protein kinase B in a Wortmannin-insensitive manner. FEBS Lett. 409: 253-257.
    • (1997) FEBS Lett. , vol.409 , pp. 253-257
    • Sable, C.L.1    Filippa, N.2    Hemmings, B.3
  • 6
    • 0032506514 scopus 로고    scopus 로고
    • Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway
    • YANO, S., H. TOKUMITSU & T.R. SODERLING. 1998. Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway. Nature 396: 584-587.
    • (1998) Nature , vol.396 , pp. 584-587
    • Yano, S.1    Tokumitsu, H.2    Soderling, T.R.3
  • 7
    • 0037205315 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta: A novel regulator of cardiac hypertrophy and development
    • HARDT, S.E. & J. SADOSHIMA. 2002. Glycogen synthase kinase-3beta: a novel regulator of cardiac hypertrophy and development. Circ. Res. 90: 1055-1063.
    • (2002) Circ. Res. , vol.90 , pp. 1055-1063
    • Hardt, S.E.1    Sadoshima, J.2
  • 8
    • 0032540252 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes
    • OH, H., Y. FUJIO, K. KUNISADA, et al. 1998. Activation of phosphatidylinositol 3-kinase through glycoprotein 130 induces protein kinase B and p70 S6 kinase phosphorylation in cardiac myocytes. J. Biol. Chem. 273: 9703-9710.
    • (1998) J. Biol. Chem. , vol.273 , pp. 9703-9710
    • Oh, H.1    Fujio, Y.2    Kunisada, K.3
  • 9
    • 0034651983 scopus 로고    scopus 로고
    • AKT promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart
    • FUJIO, Y., T. NGUYEN, D. WENCKER, et al. 2000. AKT promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 101: 660-667.
    • (2000) Circulation , vol.101 , pp. 660-667
    • Fujio, Y.1    Nguyen, T.2    Wencker, D.3
  • 10
    • 0034640299 scopus 로고    scopus 로고
    • The Akt-glycogen synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor stimulation in cardiac myocytes
    • MORISCO, C., D. ZEBROWSKI, G. CONDORELLI, et al. 2000. The Akt-glycogen synthase kinase 3beta pathway regulates transcription of atrial natriuretic factor induced by beta-adrenergic receptor stimulation in cardiac myocytes. J. Biol. Chem. 275: 14466-14475.
    • (2000) J. Biol. Chem. , vol.275 , pp. 14466-14475
    • Morisco, C.1    Zebrowski, D.2    Condorelli, G.3
  • 11
    • 0035958845 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes
    • MORISCO, C., K. SETA, S.E. HARDT, et al. 2001. Glycogen synthase kinase 3beta regulates GATA4 in cardiac myocytes. J. Biol. Chem. 276: 28586-28597.
    • (2001) J. Biol. Chem. , vol.276 , pp. 28586-28597
    • Morisco, C.1    Seta, K.2    Hardt, S.E.3
  • 12
    • 0035852634 scopus 로고    scopus 로고
    • Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes
    • ZHU, W.Z., M. ZHENG, W.J. KOCH, et al. 2001. Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. Proc. Natl. Acad. Sci. USA 98: 1607-1612.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 1607-1612
    • Zhu, W.Z.1    Zheng, M.2    Koch, W.J.3
  • 13
    • 0031854870 scopus 로고    scopus 로고
    • Effects of growth hormone and IGF-I on cardiac hypertrophy and gene expression in mice
    • TANAKA, N., T. RYOKE, M. HONGO, et al. 1998. Effects of growth hormone and IGF-I on cardiac hypertrophy and gene expression in mice. Am. J. Physiol. 275: H393-H399.
    • (1998) Am. J. Physiol. , vol.275
    • Tanaka, N.1    Ryoke, T.2    Hongo, M.3
  • 14
    • 0037020157 scopus 로고    scopus 로고
    • Akt signaling mediates postnatal heart growth in response to insulin and nutritional status
    • SHIOJIMA, I., M. YEFREMASHVILI, Z. LUO, et al. 2002. Akt signaling mediates postnatal heart growth in response to insulin and nutritional status. J. Biol. Chem. 277: 37670-37677.
    • (2002) J. Biol. Chem. , vol.277 , pp. 37670-37677
    • Shiojima, I.1    Yefremashvili, M.2    Luo, Z.3
  • 15
    • 0034213075 scopus 로고    scopus 로고
    • The conserved phosphoinositide 3-kinase pathway determines heart size in mice
    • SHIOI, T., P.M. KANG, P.S. DOUGLAS, et al. 2000. The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J. 19: 2537-2548.
    • (2000) EMBO J. , vol.19 , pp. 2537-2548
    • Shioi, T.1    Kang, P.M.2    Douglas, P.S.3
  • 16
    • 18644372367 scopus 로고    scopus 로고
    • Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways
    • CRACKOWER, M.A., G.Y. OUDIT, I. KOZIERADZKI, et al. 2002. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 110: 737-749.
    • (2002) Cell , vol.110 , pp. 737-749
    • Crackower, M.A.1    Oudit, G.Y.2    Kozieradzki, I.3
  • 17
    • 0036327388 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex
    • NAGA PRASAD, S.V., S.A. LAPORTE, D. CHAMBERLAIN, et al. 2002. Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. J. Cell Biol. 158: 563-575.
    • (2002) J. Cell Biol. , vol.158 , pp. 563-575
    • Naga Prasad, S.V.1    Laporte, S.A.2    Chamberlain, D.3
  • 18
    • 0035929596 scopus 로고    scopus 로고
    • The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival
    • SCHWARTZBAUER, G. & J. ROBBINS. 2001. The tumor suppressor gene PTEN can regulate cardiac hypertrophy and survival. J. Biol. Chem. 276: 35786-35793.
    • (2001) J. Biol. Chem. , vol.276 , pp. 35786-35793
    • Schwartzbauer, G.1    Robbins, J.2
  • 19
    • 0035902451 scopus 로고    scopus 로고
    • Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo
    • MATSUI, T., J. TAO, F. DEL MONTE, et al. 2001. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation 104: 330-335.
    • (2001) Circulation , vol.104 , pp. 330-335
    • Matsui, T.1    Tao, J.2    Del Monte, F.3
  • 20
    • 0036200937 scopus 로고    scopus 로고
    • Akt/protein kinase B promotes organ growth in transgenic mice
    • SHIOI, T., J.R. MCMULLEN, P.M. KANG, et al. 2002. Akt/protein kinase B promotes organ growth in transgenic mice. Mol. Cell. Biol. 22: 2799-2809.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 2799-2809
    • Shioi, T.1    McMullen, J.R.2    Kang, P.M.3
  • 21
    • 0037151104 scopus 로고    scopus 로고
    • Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart
    • MATSUI, T., L. LI, J.C. WU, et al. 2002. Phenotypic spectrum caused by transgenic overexpression of activated Akt in the heart. J. Biol. Chem. 277: 22896-22901.
    • (2002) J. Biol. Chem. , vol.277 , pp. 22896-22901
    • Matsui, T.1    Li, L.2    Wu, J.C.3
  • 22
    • 0037125980 scopus 로고    scopus 로고
    • Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice
    • CONDORELLI, G., A. DRUSCO, G. STASSI, et al. 2002. Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice. Proc. Natl. Acad. Sci. USA 99: 12333-12338.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 12333-12338
    • Condorelli, G.1    Drusco, A.2    Stassi, G.3
  • 23
    • 0033584710 scopus 로고    scopus 로고
    • Progressive cardiac dysfunction and fibrosis in the cardiomyopathic hamster and effects of growth hormone and angiotensin-converting enzyme inhibition
    • RYOKE, T., Y. GU, L. MAO, et al. 1999. Progressive cardiac dysfunction and fibrosis in the cardiomyopathic hamster and effects of growth hormone and angiotensin-converting enzyme inhibition. Circulation 100: 1734-1743.
    • (1999) Circulation , vol.100 , pp. 1734-1743
    • Ryoke, T.1    Gu, Y.2    Mao, L.3
  • 24
    • 0032533225 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization
    • DIEHL, J.A., M. CHENG, M.F. ROUSSEL & C.J. SHERR. 1998. Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization. Genes Dev. 12: 3499-3511.
    • (1998) Genes Dev. , vol.12 , pp. 3499-3511
    • Diehl, J.A.1    Cheng, M.2    Roussel, M.F.3    Sherr, C.J.4
  • 25
    • 0037154168 scopus 로고    scopus 로고
    • Activated glycogen synthase-3beta suppresses cardiac hypertrophy in vivo
    • ANTOS, C.L., T.A. MCKINSEY, N. FREY, et al. 2002. Activated glycogen synthase-3beta suppresses cardiac hypertrophy in vivo. Proc. Natl. Acad. Sci. USA 99: 907-912.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 907-912
    • Antos, C.L.1    McKinsey, T.A.2    Frey, N.3
  • 26
    • 0037382861 scopus 로고    scopus 로고
    • Rapamycin attenuates load-induced cardiac hypertrophy in mice
    • SHIOI, T., J.R. MCMULLEN, O. TARNAVSKI, et al. 2003. Rapamycin attenuates load-induced cardiac hypertrophy in mice. Circulation 107: 1664-1670.
    • (2003) Circulation , vol.107 , pp. 1664-1670
    • Shioi, T.1    McMullen, J.R.2    Tarnavski, O.3
  • 27
    • 0141925771 scopus 로고    scopus 로고
    • Akt activity negatively regulates phosphorylation of AMPK in the heart
    • KOVACIC, S., C.L. SOLTYS, A.J. BARR, et al. 2003. Akt activity negatively regulates phosphorylation of AMPK in the heart. J. Biol. Chem. 278: 39422-39427.
    • (2003) J. Biol. Chem. , vol.278 , pp. 39422-39427
    • Kovacic, S.1    Soltys, C.L.2    Barr, A.J.3
  • 28
    • 0030344977 scopus 로고    scopus 로고
    • The role of hypertrophy and growth factors in heart failure
    • ROSS, J., JR. & M. HONGO. 1996. The role of hypertrophy and growth factors in heart failure. J. Card. Fail. 2: S121-S128.
    • (1996) J. Card. Fail. , vol.2
    • Ross Jr., J.1    Hongo, M.2
  • 29
    • 0035941414 scopus 로고    scopus 로고
    • Increased cardiac sympathetic activity and insulin-like growth factor-I formation are associated with physiological hypertrophy in athletes
    • NERI SERNERI, G.G., M. BODDI, P.A. MODESTI, et al. 2001. Increased cardiac sympathetic activity and insulin-like growth factor-I formation are associated with physiological hypertrophy in athletes. Circ. Res. 89: 977-982.
    • (2001) Circ. Res. , vol.89 , pp. 977-982
    • Neri Serneri, G.G.1    Boddi, M.2    Modesti, P.A.3
  • 30
    • 0033538642 scopus 로고    scopus 로고
    • Cardiac growth factors in human hypertrophy. Relations with myocardial contractility and wall stress
    • NERI SERNERI, G.G., P.A. MODESTI, M. BODDI, et al. 1999. Cardiac growth factors in human hypertrophy. Relations with myocardial contractility and wall stress. Circ. Res. 85: 57-67.
    • (1999) Circ. Res. , vol.85 , pp. 57-67
    • Neri Serneri, G.G.1    Modesti, P.A.2    Boddi, M.3
  • 31
    • 0030069728 scopus 로고    scopus 로고
    • Differential cardiac effects of growth hormone and insulin-like growth factor-1 in the rat. A combined in vivo and in vitro evaluation
    • CITTADINI, A., H. STROMER, S.E. KATZ, et al. 1996. Differential cardiac effects of growth hormone and insulin-like growth factor-1 in the rat. A combined in vivo and in vitro evaluation. Circulation 93: 800-809.
    • (1996) Circulation , vol.93 , pp. 800-809
    • Cittadini, A.1    Stromer, H.2    Katz, S.E.3
  • 32
    • 0032559802 scopus 로고    scopus 로고
    • Effects of constitutive overexpression of insulin-like growth factor-1 on the mechanical characteristics and molecular properties of ventricular myocytes
    • REDAELLI, G., A. MALHOTRA, B. LI, et al. 1998. Effects of constitutive overexpression of insulin-like growth factor-1 on the mechanical characteristics and molecular properties of ventricular myocytes. Circ. Res. 82: 594-603.
    • (1998) Circ. Res. , vol.82 , pp. 594-603
    • Redaelli, G.1    Malhotra, A.2    Li, B.3
  • 33
    • 0037023643 scopus 로고    scopus 로고
    • Cardiac-specific IGF-1 expression attenuates dilated cardiomyopathy in tropomodulin-overexpressing transgenic mice
    • WELCH, S., D. PLANK, S. WITT, et al. 2002. Cardiac-specific IGF-1 expression attenuates dilated cardiomyopathy in tropomodulin-overexpressing transgenic mice. Circ. Res. 90: 641-648.
    • (2002) Circ. Res. , vol.90 , pp. 641-648
    • Welch, S.1    Plank, D.2    Witt, S.3
  • 34
    • 0028799490 scopus 로고
    • Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure
    • DUERR, R.L., S. HUANG, H.R. MIRALIAKBAR, et al. 1995. Insulin-like growth factor-1 enhances ventricular hypertrophy and function during the onset of experimental cardiac failure. J. Clin. Invest. 95: 619-627.
    • (1995) J. Clin. Invest. , vol.95 , pp. 619-627
    • Duerr, R.L.1    Huang, S.2    Miraliakbar, H.R.3
  • 35
    • 10744225737 scopus 로고    scopus 로고
    • Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt
    • KIM, Y., S-J. KIM, A. YATANI, et al. 2003. Mechanism of enhanced cardiac function in mice with hypertrophy induced by overexpressed Akt. J. Biol. Chem. 278(48): 47622-47628.
    • (2003) J. Biol. Chem. , vol.278 , Issue.48 , pp. 47622-47628
    • Kim, Y.1    Kim, S.-J.2    Yatani, A.3


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