Discovery of potent and selective covalent inhibitors of JNK

Chemistry and Biology

Volumn 19, Issue 1, 2012, Pages 140-154

  Zhang, Tinghu ^a   Inesta Vaquera, Francisco ^b   Niepel, Mario ^a   Zhang, Jianming ^a   Ficarro, Scott B ^a   MacHleidt, Thomas ^c   Xie, Ting ^a   Marto, Jarrod A ^a   Kim, Namdoo ^d   Sim, Taebo ^d   Laughlin, John D ^e   Park, Hajeung ^e   Lograsso, Philip V ^e   Patricelli, Matt ^f   Nomanbhoy, Tyzoon K ^f   Sorger, Peter K ^a   Alessi, Dario R ^b   Gray, Nathanael S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c Primary and Stem Cell Systems Life Technologies   (United States)

^d Korea Institute of Science and Technology   (South Korea)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

^f ACTIVX BIOSCIENCES INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; MITOGEN ACTIVATED PROTEIN KINASE 12; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN C JUN; PROTEIN KINASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE 1; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; STRESS ACTIVATED PROTEIN KINASE INHIBITOR 1; STRESS ACTIVATED PROTEIN KINASE INHIBITOR 10; STRESS ACTIVATED PROTEIN KINASE INHIBITOR 11; STRESS ACTIVATED PROTEIN KINASE INHIBITOR 12; STRESS ACTIVATED PROTEIN KINASE INHIBITOR 2; STRESS ACTIVATED PROTEIN KINASE INHIBITOR 3; STRESS ACTIVATED PROTEIN KINASE INHIBITOR 4; STRESS ACTIVATED PROTEIN KINASE INHIBITOR 5; STRESS ACTIVATED PROTEIN KINASE INHIBITOR 6; STRESS ACTIVATED PROTEIN KINASE INHIBITOR 7; STRESS ACTIVATED PROTEIN KINASE INHIBITOR 8; STRESS ACTIVATED PROTEIN KINASE INHIBITOR 9; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CHEMISTRY; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME STRUCTURE; HUMAN; IC 50; METABOLISM; PHOSPHORYLATION; PROTEIN PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY;

EID: 84863056297     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2011.11.010     Document Type: Article

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