A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase

Journal of Biological Chemistry

Volumn 279, Issue 53, 2004, Pages 55827-55832

  Atwell, Shane ^a,c   Adams, Jason M ^a   Badger, John ^a   Buchanan, Michelle D ^a   Feil, Ingeborg K ^a   Froning, Karen J ^a   Gao, Xia ^a   Hendle, Jörg ^a   Keegan, Kevin ^a   Leon, Barbara C ^a   Müller Dieckmann, Hans J ^b   Nienaber, Vicki L ^a   Noland, Brian W ^a   Post, Kai ^a   Rajashankar, K R ^c   Ramos, Aurora ^a   Russell, Marijane ^a   Burley, Stephen K ^a   Buchanan, Sean G ^a  

^a ELI LILLY AND COMPANY   (United States)

^b DESY   (Germany)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CELLS; CONFORMATIONS; IMMUNOLOGY; REACTION KINETICS; STRUCTURE (COMPOSITION); X RAY ANALYSIS;

GLEEVEC BINDING; IMMUNORECEPTORS; PHOSPHORYLATION; SPLEEN TYROSINE KINASE (SYK);

ENZYMES;

ABELSON KINASE; IMATINIB; PHENYLALANINE; PROTEIN KINASE; PROTEIN KINASE SYK; STAUROSPORINE; TYROSINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CATALYSIS; DRUG CONFORMATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME STRUCTURE; HEMATOPOIETIC CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; X RAY ANALYSIS;

ANIMALS; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME PRECURSORS; HEMATOPOIETIC STEM CELLS; HUMANS; HYDROGEN BONDING; INSECTS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MODELS, MOLECULAR; MUTATION; PHOSPHORYLATION; PIPERAZINES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE KINASES; PYRIMIDINES; SIGNAL TRANSDUCTION; STAUROSPORINE; X-RAYS;

ANIMALIA;

EID: 19944429284     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M409792200     Document Type: Article

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