Glycoproteomics in health and disease

Functional and Structural Proteomics of Glycoproteins

Volumn 9789048193554, Issue , 2011, Pages 1-38

  Struwe, Weston B ^a   Cosgrave, Eoin F J ^a   Byrne, Jennifer C ^a   Saldova, Radka ^a   Rudd, Pauline M ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

Author keywords

Biotherapeutics; Cancer; Glycoproteomics; Glycosylation; Systems biology

Indexed keywords

EID: 84862841883     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-90-481-9355-4_1     Document Type: Chapter

References (158)

1. Varki A (1993) Biological roles of oligosaccharides: all of the theories are correct. Glycobiology 3:97-130
2. Griffitts JS et al (2005) Glycolipids as receptors for Bacillus thuringiensis crystal toxin. Science 307:922-925
3. Fuster MM, Esko JD (2005) The sweet and sour of cancer: glycans as novel therapeutic targets. Nat Rev Cancer 5:526-542
4. Marek KW, Vijay IK, Marth JD (1999) A recessive deletion in the GlcNAc-1-phosphotransferase gene results in peri-implantation embryonic lethality. Glycobiology 9:1263-1271
5. Matthijs G, Schollen E, Van Schaftingen E, Cassiman JJ, Jaeken J (1998) Lack of homozygotes for the most frequent disease allele in carbohydrate-deficient glycoprotein syndrome type 1A. Am J Hum Genet 62:542-550
6. Apweiler R, Hermjakob H, Sharon N (1999) On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database. Biochim Biophys Acta 1473:4-8
7. Laine RA (1994) A calculation of all possible oligosaccharide isomers both branched and linear yields 1.05×10 (12) structures for a reducing hexasaccharide: the Isomer Barrier to development of single-method saccharide sequencing or synthesis systems. Glycobiology 4:759-767
8. Opat AS, van Vliet C, Gleeson PA (2001) Trafficking and localisation of resident Golgi glycosylation enzymes. Biochimie 83:763-773
9. Hossler P, Mulukutla BC, Hu WS (2007) Systems analysis of N-glycan processing in mammalian cells. PLoS ONE 2:e713
10. Srivastava S (2008) Move over proteomics, here comes glycomics. J Proteome Res 7:1799
11. Dove A (2001) The bittersweet promise of glycobiology. Nat Biotechnol 19:913-917
12. Schachter H et al (2002) Functional post-translational proteomics approach to study the role of N-glycans in the development of Caenorhabditis elegans. Biochem Soc Symp (69): 1-21
13. Raman R, Raguram S, Venkataraman G, Paulson JC, Sasisekharan R (2005) Glycomics: an integrated systems approach to structure-function relationships of glycans. Nat Methods 2:817-824
14. Varki A (1999) Essentials of glycobiology. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
15. North SJ et al (2010) Glycomics profiling of Chinese hamster ovary (CHO) cell glycosylation mutants reveals N-glycans of a novel size and complexity. J Biol Chem 285:5759-5775
16. Schroder M, Kaufman RJ (2005) The mammalian unfolded protein response. Annu Rev Biochem 74:739-789
17. Menon KM, Jaffe RB (1973) Chorionic gonadotropin sensitive adenylate cyclase in human term placenta. J Clin Endocrinol Metab 36:1104-1109
18. Erbayraktar S et al (2003) Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo. Proc Natl Acad Sci USA 100:6741-6746
19. Takeuchi M, Kobata A (1991) Structures and functional roles of the sugar chains of human erythropoietins. Glycobiology 1:337-346
20. Chandrasekaran A, Srinivasan A, Raman R, Viswanathan K, Raguram S, Tumpey TM, Sasisekharan V, Sasisekharan R (2008) Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin. Nat Biotechnol 26:107-113
21. Wada Y et al (2010) Comparison of methods for profiling O-glycosylation: HUPO Human Disease Glycomics/Proteome Initiative Multi-Institutional Study of IgA1. Mol Cell Proteomics 9:719-727
22. Tissot B et al (2009) Glycoproteomics: past, present and future. FEBS Lett 583:1728-1735
23. Tackenberg B, Jelcic I, Baerenwaldt A, Oertel WH, Sommer N, Nimmerjahn F, Lunemann JD (2009) Impaired inhibitory Fcgamma receptor IIB expression on B cells in chronic inflammatory demyelinating polyneuropathy. Proc Natl Acad Sci USA 106:4788-4792
24. An HJ, Froehlich JW, Lebrilla CB (2009) Determination of glycosylation sites and sitespecific heterogeneity in glycoproteins. Curr Opin Chem Biol 13:421-426
25. Saldova R et al (2007) Ovarian cancer is associated with changes in glycosylation in both acute-phase proteins and IgG. Glycobiology 17:1344-1356
26. Harvey DJ (2005) Fragmentation of negative ions from carbohydrates: part 1. Use of nitrate and other anionic adducts for the production of negative ion electrospray spectra from Nlinked carbohydrates. J Am Soc Mass Spectrom 16:622-630
27. Harvey DJ (2005) Fragmentation of negative ions from carbohydrates: part 2. Fragmentation of high-mannose N-linked glycans. J Am Soc Mass Spectrom 16:631-646
28. Harvey DJ (2005) Fragmentation of negative ions from carbohydrates: part 3. Fragmentation of hybrid and complex N-linked glycans. J Am Soc Mass Spectrom 16:647-659
29. Prien JM, Ashline DJ, Lapadula AJ, Zhang H, Reinhold VN (2009) The high mannose glycans from bovine ribonuclease B isomer characterization by ion trap MS. J Am Soc Mass Spectrom 20:539-556
30. Hanneman AJ, Rosa JC, Ashline D, Reinhold VN (2006) Isomer and glycomer complexities of core GlcNAcs in Caenorhabditis elegans. Glycobiology 16:874-890
31. Ashline D, Singh S, Hanneman A, Reinhold V (2005) Congruent strategies for carbohydrate sequencing. 1. Mining structural details by MSn. Anal Chem 77:6250-6262
32. Prien JM, Huysentruyt LC, Ashline DJ, Lapadula AJ, Seyfried TN, Reinhold VN (2008) Differentiating N-linked glycan structural isomers in metastatic and nonmetastatic tumour cells using sequential mass spectrometry. Glycobiology 18:353-366
33. Zaia J (2008) Mass spectrometry and the emerging field of glycomics. Chem Biol 15:881-892
34. Wheeler SF, Domann P, Harvey DJ (2009) Derivatization of sialic acids for stabilization in matrix-assisted laser desorption/ionization mass spectrometry and concomitant differentiation of alpha (2→ 3) - and alpha (2 → 6)-isomers. Rapid Commun Mass Spectrom 23:303-312
35. Ashline DJ, Lapadula AJ, Liu YH, Lin M, Grace M, Pramanik B, Reinhold VN (2007) Carbohydrate structural isomers analyzed by sequential mass spectrometry. Anal Chem 79:3830-3842
36. Royle L et al (2008) HPLC-based analysis of serum N-glycans on a 96-well plate platform with dedicated database software. Analytical Biochemistry 376:1-12
37. Guile GR, Rudd PM, Wing DR, Prime SB, Dwek RA (1996) A rapid high-resolution highperformance liquid chromatographic method for separating glycan mixtures and analyzing oligosaccharide profiles. Anal Biochem 240:210-226
38. Anumula KR (2006) Advances in fluorescence derivatization methods for high-performance liquid chromatographic analysis of glycoprotein carbohydrates. Anal Biochem 350:1-23
39. Anumula KR (2000) High-sensitivity and high-resolution methods for glycoprotein analysis. Anal Biochem 283:17-26
40. Nimmerjahn A (2009) Astrocytes going live: advances and challenges. J Physiol 587:1639-1647
41. Jacobs JM, Adkins JN, Qian WJ, Liu T, Shen Y, Camp DG 2nd, Smith RD (2005) Utilizing human blood plasma for proteomic biomarker discovery. J Proteome Res 4:1073-1085
42. Gorg A, Weiss W, Dunn MJ (2004) Current two-dimensional electrophoresis technology for proteomics. Proteomics 4:3665-3685
43. Unlu M, Morgan ME, Minden JS (1997) Difference gel electrophoresis: a single gel method for detecting changes in protein extracts. Electrophoresis 18:2071-2077
44. Byrne JC et al (2009) 2D-DIGE as a strategy to identify serum markers for the progression of prostate cancer. J Proteome Res 8:942-957
45. Hart C, Schulenberg B, Steinberg TH, Leung WY, Patton WF (2003) Detection of glycoproteins in polyacrylamide gels and on electroblots using Pro-Q Emerald 488 dye, a fluorescent periodate Schiff-base stain. Electrophoresis 24:588-598
46. Partridge EA et al (2004) Regulation of cytokine receptors by Golgi N-glycan processing and endocytosis. Science 306:120-124
47. Yoshimura M, Ihara Y, Matsuzawa Y, Taniguchi N (1996) Aberrant glycosylation of E-cadherin enhances cell-cell binding to suppress metastasis. J Biol Chem 271:13811-13815
48. Yamashita K, Ohkura T, Tachibana Y, Takasaki S, Kobata A (1984) Comparative study of the oligosaccharides released from baby hamster kidney cells and their polyoma transformant by hydrazinolysis. J Biol Chem 259:10834-10840
49. Pierce M, Arango J (1986) Rous sarcoma virus-transformed baby hamster kidney cells express higher levels of asparagine-linked tri- and tetraantennary glycopeptides containing [GlcNAc-beta (1, 6) Man-alpha (1, 6) Man] and poly-N-acetyllactosamine sequences than baby hamster kidney cells. J Biol Chem 261:10772-10777
50. Granovsky M, Fata J, Pawling J, Muller WJ, Khokha R, Dennis JW (2000) Suppression of tumour growth and metastasis in Mgat5-deficient mice. Nat Med 6:306-312
51. Tsui KH, Chang PL, Feng TH, Chung LC, Sung HC, Juang HH (2008) Evaluating the function of matriptase and N-acetylglucosaminyltransferase V in prostate cancer metastasis. Anticancer Res 28:1993-1999
52. Fernandes B, Sagman U, Auger M, Demetrio M, Dennis JW (1991) Beta 1-6 branched oligosaccharides as a marker of tumour progression in human breast and colon neoplasia. Cancer Res 51:718-723
53. Seelentag WK, Li WP, Schmitz SF, Metzger U, Aeberhard P, Heitz PU, Roth J (1998) Prognostic value of beta1, 6-branched oligosaccharides in human colorectal carcinoma. Cancer Res 58:5559-5564
54. Saito T, Miyoshi E, Sasai K, Nakano N, Eguchi H, Honke K, Taniguchi N (2002) A secreted type of beta 1, 6-N-acetylglucosaminyltransferase V (GnT-V) induces tumour angiogenesis without mediation of glycosylation: a novel function of GnT-V distinct from the original glycosyltransferase activity. J Biol Chem 277:17002-17008
55. Saito H et al (1994) cDNA cloning and chromosomal mapping of human Nacetylglucosaminyltransferase V+. Biochem Biophys Res Commun 198:318-327
56. Cornil I, Kerbel RS, Dennis JW (1990) Tumour cell surface beta 1-4-linked galactose binds to lectin (s) on microvascular endothelial cells and contributes to organ colonization. J Cell Biol 111:773-781
57. Sato Y et al (2001) Overexpression of N-acetylglucosaminyltransferase III enhances the epidermal growth factor-induced phosphorylation of ERK in HeLaS3 cells by up-regulation of the internalization rate of the receptors. J Biol Chem 276:11956-11962
58. Kumamoto K, Goto Y, Sekikawa K, Takenoshita S, Ishida N, Kawakita M, Kannagi R (2001) Increased expression of UDP-galactose transporter messenger RNA in human colon cancer tissues and its implication in synthesis of Thomsen-Friedenreich antigen and sialyl Lewis A/X determinants. Cancer Res 61:4620-4627
59. Zipin A et al (2004) Tumour-microenvironment interactions: the fucose-generating FX enzyme controls adhesive properties of colorectal cancer cells. Cancer Res 64:6571-6578
60. Moriwaki K, Noda K, Nakagawa T, Asahi M, Yoshihara H, Taniguchi N, Hayashi N, Miyoshi E (2007) A high expression of GDP-fucose transporter in hepatocellular carcinoma is a key factor for increases in fucosylation. Glycobiology 17:1311-1320
61. Shields RL, Lai J, Keck R, O'Connell LY, Hong K, Meng YG, Weikert SH, Presta LG (2002) Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human Fcgamma RIII and antibody-dependent cellular toxicity. J Biol Chem 277:26733-26740
62. Taketa K et al (1993) A collaborative study for the evaluation of lectin-reactive alpha-fetoproteins in early detection of hepatocellular carcinoma. Cancer Res 53:5419-5423
63. Wang X, Gu J, Ihara H, Miyoshi E, Honke K, Taniguchi N (2006) Core fucosylation regulates epidermal growth factor receptor-mediated intracellular signaling. J Biol Chem 281:2572-2577
64. Osumi D et al (2009) Core fucosylation of E-cadherin enhances cell-cell adhesion in human colon carcinoma WiDr cells. Cancer Sci 100:888-895
65. Crocker PR, Varki A (2001) Siglecs, sialic acids and innate immunity. Trends Immunol 22:337-342
66. Feizi T (2000) Carbohydrate-mediated recognition systems in innate immunity. Immunol Rev 173:79-88
67. Kudo T, Ikehara Y, Togayachi A, Morozumi K, Watanabe M, Nakamura M, Nishihara S, Narimatsu H (1998) Up-regulation of a set of glycosyltransferase genes in human colorectal cancer. Lab Invest 78:797-811
68. Imai Y, Lasky LA, Rosen SD (1992) Further characterization of the interaction between L-selectin and its endothelial ligands. Glycobiology 2:373-381
69. Sperandio M, Gleissner CA, Ley K (2009) Glycosylation in immune cell trafficking. Immunol Rev 230:97-113
70. Kannagi R (2001) Transcriptional regulation of expression of carbohydrate ligands for cell adhesion molecules in the selectin family. Adv Exp Med Biol 491:267-278
71. Miyahara R, Tanaka F, Nakagawa T, Matsuoka K, Isii K, Wada H (2001) Expression of neural cell adhesion molecules (polysialylated form of neural cell adhesion molecule and L1-cell adhesion molecule) on resected small cell lung cancer specimens: in relation to proliferation state. J Surg Oncol 77:49-54
72. Tanaka F et al (2000) Expression of polysialic acid and STX, a human polysialyltransferase, is correlated with tumour progression in non-small cell lung cancer. Cancer Res 60:3072-3080
73. Narita T, Funahashi H, Satoh Y, Watanabe T, Sakamoto J, Takagi H (1993) Association of expression of blood group-related carbohydrate antigens with prognosis in breast cancer. Cancer 71:3044-3053
74. Nakagoe T et al (2000) Expression of Lewis (a), sialyl Lewis (a), Lewis (x) and sialyl Lewis (x) antigens as prognostic factors in patients with colorectal cancer. Can J Gastroenterol 14:753-760
75. Ogawa J-I, Sano A, Inoue H, Koide S (1995) Expression of Lewis-related antigen and prognosis in stage I non - small cell lung cancer. Ann Thorac Surg 59:412-415
76. Saldova R, Wormald MR, Dwek RA, Rudd PM (2008) Glycosylation changes on serum glycoproteins in ovarian cancer may contribute to disease pathogenesis. Dis Markers 25:219-232
77. Arnold JN, Saldova R, Abd Hamid UM, Rudd PM (2008) Evaluation of the serum Nlinked glycome for the diagnosis of cancer and chronic inflammation. Proteomics 8:3284-3293
78. Gornik O, Lauc G (2008) Glycosylation of serum proteins in inflammatory diseases. Dis Markers 25:267-278
79. Schmid K, Nimerg RB, Kimura A, Yamaguchi H, Binette JP (1977) The carbohydrate units of human plasma alpha1-acid glycoprotein. Biochim Biophys Acta 492:291-302
80. Laine A, Hayem A (1981) Purification and characterization of alpha 1-antichymotrypsin from human pleural fluid and human serum. Biochim Biophys Acta 668:429-438
81. Malhotra R, Wormald MR, Rudd PM, Fischer PB, Dwek RA, Sim RB (1995) Glycosylation changes of IgG associated with rheumatoid arthritis can activate complement via the mannose-binding protein. Nat Med 1:237-243
82. Umana P, Jean-Mairet J, Moudry R, Amstutz H, Bailey JE (1999) Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity. Nat Biotechnol 17:176-180
83. Kaneko Y, Nimmerjahn F, Ravetch JV (2006) Anti-inflammatory activity of immunoglobulin G resulting from Fc sialylation. Science 313:670-673
84. Axford JS, Sumar N, Alavi A, Isenberg DA, Young A, Bodman KB, Roitt IM (1992) Changes in normal glycosylation mechanisms in autoimmune rheumatic disease. J Clin Invest 89:1021-1031
85. Omtvedt LA, Royle L, Husby G, Sletten K, Radcliffe CM, Harvey DJ, Dwek RA, Rudd PM (2006) Glycan analysis of monoclonal antibodies secreted in deposition disorders indicates that subsets of plasma cells differentially process IgG glycans. Arthritis Rheum 54:3433-3440
86. Kanoh Y, Mashiko T, Danbara M, Takayama Y, Ohtani S, Egawa S, Baba S, Akahoshi T (2004) Changes in serum IgG oligosaccharide chains with prostate cancer progression. Anticancer Res 24:3135-3139
87. Kanoh Y, Mashiko T, Danbara M, Takayama Y, Ohtani S, Imasaki T, Abe T, Akahoshi T (2004) Analysis of the oligosaccharide chain of human serum immunoglobulin g in patients with localized or metastatic cancer. Oncology 66:365-370
88. Parekh RB et al (1985) Association of rheumatoid arthritis and primary osteoarthritis with changes in the glycosylation pattern of total serum IgG. Nature 316:452-457
89. Holland M et al (2002) Hypogalactosylation of serum IgG in patients with ANCA-associated systemic vasculitis. Clin Exp Immunol 129:183-190
90. Matsumoto A, Shikata K, Takeuchi F, Kojima N, Mizuochi T (2000) Autoantibody activity of IgG rheumatoid factor increases with decreasing levels of galactosylation and sialylation. J Biochem 128:621-628
91. Jacobs JM, Adkins JN, Qian W-J, Liu T, Shen Y, Camp DG, Smith RD (2005) Utilizing human blood plasma for proteomic biomarker discovery. J Proteome Res 4:1073-1085
92. Oesterling JE (1991) Prostate specific antigen: a critical assessment of the most useful tumour marker for adenocarcinoma of the prostate. J Urol 145:907-923
93. Peracaula R, Tabares G, Royle L, Harvey DJ, Dwek RA, Rudd PM, de Llorens R (2003) Altered glycosylation pattern allows the distinction between prostate-specific antigen (PSA) from normal and tumour origins. Glycobiology 13:457-470
94. Ohyama C, Hosono M, Nitta K, Oh-eda M, Yoshikawa K, Habuchi T, Arai Y, Fukuda M (2004) Carbohydrate structure and differential binding of prostate specific antigen to Maackia amurensis lectin between prostate cancer and benign prostate hypertrophy. Glycobiology 14:671-679
95. Meany DL, Zhang Z, Sokoll LJ, Zhang H, Chan DW (2008) Glycoproteomics for prostate cancer detection: changes in serum PSA glycosylation patterns. J Proteome Res 8:613-619
96. Weickmann JL, Olson EM, Glitz DG (1984) Immunological assay of pancreatic ribonuclease in serum as an indicator of pancreatic cancer. Cancer Res 44:1682-1687
97. Barrabes S et al (2007) Glycosylation of serum ribonuclease 1 indicates a major endothelial origin and reveals an increase in core fucosylation in pancreatic cancer. Glycobiology 17:388-400
98. Varma R, Hoshino AY (1980) Serum glycoproteins in schizophrenia. Carbohydr Res 82:343-351
99. Delves PJ (1998) The role of glycosylation in autoimmune disease. Autoimmunity 27:239-253
100. Raju TS (2008) Terminal sugars of Fc glycans influence antibody effector functions of IgGs. Curr Opin Immunol 20:471-478
101. Nezlin R, Ghetie V (2004) Interactions of immunoglobulins outside the antigen-combining site. Adv Immunol 82:155-215
102. Mullinax F, Mullinax GL (1975) Abnormality of Igg structure in rheumatoid-arthritis and systemic lupus-erythematosus. Arthritis Rheum 18:417-418
103. van Zeben D, Rook GA, Hazes JM, Zwinderman AH, Zhang Y, Ghelani S, Rademacher TW, Breedveld FC (1994) Early agalactosylation of IgG is associated with a more progressive disease course in patients with rheumatoid arthritis: results of a follow-up study. Br J Rheumatol 33:36-43
104. Bauer D, Haroutunian V, Meador-Woodruff JH, McCullumsmith RE (2009) Abnormal glycosylation of EAAT1 and EAAT2 in prefrontal cortex of elderly patients with schizophrenia. Schizophr Res 117:92-98
105. Yazawa S, Tanaka S, Nishimura T, Miyanaga K, Kochibe N (1999) Plasma alpha1, 3-fucosyltransferase deficiency in schizophrenia. Exp Clin Immunogenet 16:125-130
106. Maguire TM, Thakore J, Dinan TG, Hopwood S, Breen KC (1997) Plasma sialyltransferase levels in psychiatric disorders as a possible indicator of HPA axis function. Biol Psychiatry 41:1131-1136
107. Haeuptle MA, Hennet T (2009) Congenital disorders of glycosylation: an update on defects affecting the biosynthesis of dolichol-linked oligosaccharides. Hum Mutat 30:1628-1641
108. Freeze HH, Westphal V (2001) Balancing N-linked glycosylation to avoid disease. Biochimie 83:791-799
109. Eklund EA, Freeze HH (2006) The congenital disorders of glycosylation: a multifaceted group of syndromes. NeuroRx 3:254-263
110. Prietsch V et al (2002) A new case of CDG-x with stereotyped dystonic hand movements and optic atrophy. J Inherit Metab Dis 25:126-130
111. Mahant S, Feigenbaum A (2006) A child with an underrecognized form of developmental delay: a congenital disorder of glycosylation. CMAJ 175:1369
112. Kjaergaard S, Schwartz M, Skovby F (2001) Congenital disorder of glycosylation type Ia (CDG-Ia): phenotypic spectrum of the R141H/F119L genotype. Arch Dis Child 85:236-239
113. Schollen E, Kjaergaard S, Martinsson T, Vuillaumier-Barrot S, Dunoe M, Keldermans L, Seta N, Matthijs G (2004) Increased recurrence risk in congenital disorders of glycosylation type Ia (CDG-Ia) due to a transmission ratio distortion. J Med Genet 41:877-880
114. Schollen E, Kjaergaard S, Legius E, Schwartz M, Matthijs G (2000) Lack of Hardy-Weinberg equilibrium for the most prevalent PMM2 mutation in CDG-Ia (congenital disorders of glycosylation type Ia). Eur J Hum Genet 8:367-371
115. Matthijs G et al (2000) Mutations in PMM2 that cause congenital disorders of glycosylation, type Ia (CDG-Ia). Hum Mutat 16:386-394
116. de Lonlay P et al (2001) A broad spectrum of clinical presentations in congenital disorders of glycosylation I: a series of 26 cases. J Med Genet 38:14-19
117. Fletcher JM (2006) Screening for lysosomal storage disorders - a clinical perspective. J Inherit Metab Dis 29:405-408
118. Beck M (2007) New therapeutic options for lysosomal storage disorders: enzyme replacement, small molecules and gene therapy. Hum Genet 121:1-22
119. Elstein D, Zimran A (2009) Review of the safety and efficacy of imiglucerase treatment of Gaucher disease. Biologics 3:407-417
120. Schiffmann R et al (2000) Infusion of alpha-galactosidase A reduces tissue globotriaosylceramide storage in patients with Fabry disease. Proc Natl Acad Sci U S A 97:365-370
121. Van den Hout JM et al (2004) Long-term intravenous treatment of Pompe disease with recombinant human alpha-glucosidase from milk. Pediatrics 113:e448-e457
122. Pastores GM (2008) Laronidase (Aldurazyme): enzyme replacement therapy for mucopolysaccharidosis type I. Expert Opin Biol Ther 8:1003-1009
123. Clarke LA (2008) Idursulfase for the treatment of mucopolysaccharidosis II. Expert Opin Pharmacother 9:311-317
124. Hopwood JJ, Bate G, Kirkpatrick P (2006) Galsulfase. Nat Rev Drug Discov 5:101-102
125. Aggarwal S (2009) What's fueling the biotech engine-2008. Nat Biotech 27:987-993
126. Dennis L et al (2005) Functional analysis of the Campylobacter jejuni N-linked protein glycosylation pathway. Mol Microbiol 55:1695-1703
127. Hossler P, Khattak SF, Li ZJ (2009) Optimal and consistent protein glycosylation in mammalian cell culture. Glycobiology 19:936-949
128. Figueroa B Jr, Ailor E, Osborne D, Hardwick JM, Reff M, Betenbaugh MJ (2007) Enhanced cell culture performance using inducible anti-apoptotic genes E1B-19 K and Aven in the production of a monoclonal antibody with Chinese hamster ovary cells. Biotechnol Bioeng 97:877-892
129. Lee YY, Wong KT, Tan J, Toh PC, Mao Y, Brusic V, Yap MG (2009) Overexpression of heat shock proteins (HSPs) in CHO cells for extended culture viability and improved recombinant protein production. J Biotechnol 143:34-43
130. Peng RW, Fussenegger M (2009) Molecular engineering of exocytic vesicle traffic enhances the productivity of Chinese hamster ovary cells. Biotechnol Bioeng 102:1170-1181
131. Peng RW, Guetg C, Tigges M, Fussenegger M (2010) The vesicle-trafficking protein munc18b increases the secretory capacity of mammalian cells. Metab Eng 12:18-25
132. Muchmore EA, Milewski M, Varki A, Diaz S (1989) Biosynthesis of N-glycolyneuraminic acid. The primary site of hydroxylation of N-acetylneuraminic acid is the cytosolic sugar nucleotide pool. J Biol Chem 264:20216-20223
133. Tangvoranuntakul P, Gagneux P, Diaz S, Bardor M, Varki N, Varki A, Muchmore E (2003) Human uptake and incorporation of an immunogenic nonhuman dietary sialic acid. PNAS 100:12045-12050
134. Bergwerff AA, Stroop CJ, Murray B, Holtorf AP, Pluschke G, Van Oostrum J, Kamerling JP, Vliegenthart JF (1995) Variation in N-linked carbohydrate chains in different batches of two chimeric monoclonal IgG1 antibodies produced by different murine SP2/0 transfectoma cell subclones. Glycoconj J 12:318-330
135. Umana P, Jean-Mairet J, Moudry R, Amstutz H, Bailey JE (1999) Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity. Nat Biotech 17:176-180
136. Ferrara C, Brünker P, Suter T, Moser S, Püntener U, Umaña P (2006) Modulation of therapeutic antibody effector functions by glycosylation engineering: Influence of Golgi enzyme localization domain and co-expression of heterologous beta1, 4-Nacetylglucosaminyltransferase III and Golgi alpha-mannosidase II. Biotechnol Bioeng 93:851-861
137. Trinchieri G (1989) Biology of natural killer cells. Adv Immunol 47:187-376
138. Nimmerjahn F, Ravetch JV (2008) Fcgamma receptors as regulators of immune responses. Nat Rev Immunol 8:34-47
139. Galili U (1989) Abnormal expression of alpha-galactosyl epitopes in man. A trigger for autoimmune processes? Lancet 2:358-361
140. Bencurova M, Hemmer W, Focke-Tejkl M, Wilson IB, Altmann F (2004) Specificity of IgG and IgE antibodies against plant and insect glycoprotein glycans determined with artificial glycoforms of human transferrin. Glycobiology 14:457-466
141. Geisler C, Aumiller JJ, Jarvis DL (2008) A fused lobes gene encodes the processing beta-Nacetylglucosaminidase in Sf9 cells. J Biol Chem 283:11330-11339
142. Lehle L, Strahl S, Tanner W (2006) Protein glycosylation, conserved from yeast to man: a model organism helps elucidate congenital human diseases. Angew Chem Int Ed Engl 45:6802-6818
143. Wildt S, Gerngross TU (2005) The humanization of N-glycosylation pathways in yeast. Nat Rev Microbiol 3:119-128
144. Varki A (2009) Essentials of glycobiology. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
145. Fitchette-Laine AC et al (1997) N-glycans harboring the Lewis a epitope are expressed at the surface of plant cells. Plant J 12:1411-1417
146. Chiba Y, Suzuki M, Yoshida S, Yoshida A, Ikenaga H, Takeuchi M, Jigami Y, Ichishima E (1998) Production of human compatible high mannose-type (Man5GlcNAc2) sugar chains in Saccharomyces cerevisiae. J Biol Chem 273:26298-26304
147. Herscovics A (2001) Structure and function of Class I alpha 1, 2-mannosidases involved in glycoprotein synthesis and endoplasmic reticulum quality control. Biochimie 83:757-762
148. Choi BK et al (2003) Use of combinatorial genetic libraries to humanize N-linked glycosylation in the yeast Pichia pastoris. PNAS 100:5022-5027
149. Bobrowicz P et al (2004) Engineering of an artificial glycosylation pathway blocked in core oligosaccharide assembly in the yeast Pichia pastoris: production of complex humanized glycoproteins with terminal galactose. Glycobiology 14:757-766
150. Hamilton SR et al (2006) Humanization of yeast to produce complex terminally sialylated glycoproteins. Science 313:1441-1443
151. Hollister JR, Jarvis DL (2001) Engineering lepidopteran insect cells for sialoglycoprotein production by genetic transformation with mammalian β1, 4-galactosyltransferase and α2, 6-sialyltransferase genes. Glycobiology 11:1-9
152. Hollister J, Grabenhorst E, Nimtz M, Conradt H, Jarvis DL (2002) Engineering the protein N-glycosylation pathway in insect cells for production of biantennary, complex N-glycans. Biochemistry 41:15093-15104
153. Bardor M, Faveeuw C, Fitchette AC, Gilbert D, Galas L, Trottein F, Faye L, Lerouge P (2003) Immunoreactivity in mammals of two typical plant glyco-epitopes, core alpha (1, 3) - fucose and core xylose. Glycobiology 13:427-434
154. Rayon C, Cabanes-Macheteau M, Loutelier-Bourhis C, Salliot-Maire I, Lemoine J, Reiter WD, Lerouge P, Faye L (1999) Characterization of N-glycans from Arabidopsis. Application to a fucose-deficient mutant. Plant Physiol 119:725-734
155. Frey AD, Karg SR, Kallio PT (2009) Expression of rat β (1, 4)-Nacetylglucosaminyltransferase III in Nicotiana tabacum remodels the plant-specific N-glycosylation. Plant Biotechnol J 7:33-48
156. Weise A, Altmann F, Rodriguez-Franco M, Sjoberg ER, Baumer W, Launhardt H, Kietzmann M, Gorr G (2007) High-level expression of secreted complex glycosylated recombinant human erythropoietin in the Physcomitrella Δfuc-t-Δxyl-t mutant. Plant Biotechnol J 5:389-401
157. Knezevic A et al (2009) Variability, heritability and environmental determinants of human plasma N-glycome. J Proteome Res 8:694-701
158. Lauc G, Huffman J, Hayward C, Knezevic A, Polasek O, Gornik O, Vitart V, Kolcic I, Biloglav Z, Zgaga L, Hastie N, Wright A, Campbell H, Rudd P, Rudan I (2009) Genomewide association study identifies FUT8 and ESR2 as co-regulators of a bi-antennary N-linked glycan A2 (GlcNAc2Man3GlcNAc2) in human plasma proteins. Available from Nature Precedings