Cleavage and inactivation of antiapoptotic Akt/PKB by caspases during apoptosis

Journal of Cellular Physiology

Volumn 182, Issue 2, 2000, Pages 290-296

  Rokudai, Susumu ^a   Fujita, Naoya ^a   Hashimoto, Yuichi ^a   Tsuruo, Takashi ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b CANCER CHEMOTHERAPY CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE INHIBITOR; PLECKSTRIN; PROTEIN SERINE THREONINE KINASE;

APOPTOSIS; ARTICLE; CELL DEATH; CELL METABOLISM; CELL STRAIN U937; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INACTIVATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL;

APOPTOSIS; CASPASES; CELL LINE; DOWN-REGULATION; HUMANS; PEPTIDE FRAGMENTS; PHOSPHOTRANSFERASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 0033975366     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4652(200002)182:2<290::AID-JCP18>3.0.CO;2-8     Document Type: Article

References (57)

1. Ahmed NN, Grimes HL, Bellacosa A, Chan TO, Tsichlis PN. 1997. Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase. Proc Natl Acad Sci USA 94:3627-3632.
2. Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA. 1996. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15:6541-6551.
3. Alessi DR, Deak M, Casamayor A, Caudwell FB, Morrice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D, Ashworth A, Bownes M. 1997a. 3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase. Curr Biol 7:776-789.
4. Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PR, Reese CB, Cohen P. 1997b. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha. Curr Biol 7:261-269.
5. Andjelkovic M, Jakubowicz T, Cron P, Ming XF, Han JW, Hemmings BA. 1996. Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc Natl Acad Sci USA 93:5699-5704.
6. Ataliotis P, Mercola M. 1997. Distribution and functions of platelet-derived growth factors and their receptors during embryogenesis. Int Rev Cytol 172:95-127.
7. Bos JL. 1995. A target for phosphoinositide 3-kinase: Akt/PKB. Trends Biochem Sci 20:441-442.
8. Burgering BM, Coffer PJ. 1995. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:599-602.
9. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke T, Stanbridge E, Frisch S, Reed JC. 1998. Regulation of cell death protease caspase-9 by phosphorylation. Science 282:1318-1321.
10. Carpenter CL, Cantley LC. 1996. Phosphoinositide kinases. Curr Opin Cell Biol 8:153-158.
11. Cheng EH-Y, Kirsch DG, Clem RJ, Ravi R, Kastan MB, Bedi A, Ueno K, Hardwick JM. 1997. Conversion of bcl-2 to a bax-like death effector by caspases. Science 278:1966-1968.
12. L through caspase interaction. Proc Natl Acad Sci USA 95:554-559.
13. Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. 1995. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-789.
14. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME. 1997. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241.
15. del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nunez G. 1997. Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278:687-689.
16. Delcommenne M, Tan C, Gray V, Rue L, Woodgett J, Dedhar S. 1998. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci USA 95:11211-11216.
17. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME. 1997. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275:661-665.
18. Duke RC, Cohen JJ. 1986. IL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T cells. Lymphokine Res 5:289-299.
19. Enari M, Talanian RV, Wong WW, Nagata S. 1996. Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis. Nature 380:723-726.
20. Enari M, Sakahira H, Yokoyama H, Okawa K, Iwamatsu A, Nagata S. 1998. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391:43-50.
21. Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN. 1995. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81:727-736.
22. Franke TF, Kaplan DR, Cantley LC. 1997a. P13K: downstream AKTion blocks apoptosis. Cell 88:435-437.
23. Franke TF, Kaplan DR, Cantley LC, Toker A. 1997b. Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275:665-668.
24. Fujita N, Tsuruo T. 1998. Involvement of Bcl-2 cleavage in the acceleration of VP-16-induced U937 cell apoptosis. Biochem Biophys Res Commun 246:484-488.
25. Fujita N, Nagahashi A, Nagashima K, Rokudai S, Tsuruo T. 1998. Acceleration of apoptotic cell death after the cleavage of Bcl-XL protein by caspase-3-like proteases. Oncogene 17:1295-1304.
26. Cip1/Waf1 by caspases is an early event during DNA damage-induced apoptosis. J Biol Chem 273:19207-19212.
27. Grandgirard D, Studer E, Moonney L, Belser T, Fellay I, Borner C, Michel MR. 1998. Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: evidence for a caspase-mediated, proteolytic inactivation of Bcl-2. EMBO J 17:1268-1278.
28. Henkart PA. 1996. ICE family proteases: Mediators of all apoptotic cell death? Immunity 4:195-201.
29. 3K and PKB. Nature 385:544-548.
30. Kennedy SG, Wagner AJ, Conzen SD, Jordan J, Bellacosa A, Tsichlis PN, Hay N. 1997. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev 11:701-713.
31. Khwaja A, Rodriguez-Viciana P, Wennstrom S, Warne PH, Downward J. 1997. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J 16:2783-2793.
32. Klippel A, Reinhard C, Kavanaugh WM, Apell G, Escobedo MA, Williams LT. 1996. Membrane localization of phosphatidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol Cell Biol 16:4117-4127.
33. Kohn AD, Kovacina KS, Roth RA. 1995. Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/ thr kinase. EMBO J 14:4288-4295.
34. Konishi H, Matsuzaki H, Tanaka M, Ono Y, Tokunaga C, Kuroda S, Kikkawa U. 1996. Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase. Proc Natl Acad Sci USA 93:7639-7643.
35. Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H, Su M.S, Rakic P, Flavell RA. 1998. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94: 325-337.
36. Kulik G, Klippel A, Weber J. 1997. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol 17:1595-1606.
37. Kip1 mediates apoptosis in endothelial cells through activation o fCdk2: Role of a caspase cascade. Molecular Cell 1:553-563.
38. Marte BM, Rodriguez-Viciana P, Wennstrom S, Warne PH, Downward J. 1997. R-Ras can activate the phosphoinositide 3-kinase but not the MAP kinase arm of the Ras effector pathways. Curr Biol 7:63-70.
39. Mashima T, Naito M, Noguchi K, Miller DK, Nicholson DW, Tsuruo T. 1997. Actin cleavage by CPP-32/apopain during the development of apoptosis. Oncogene 14:1007-1012.
40. Miura M, Zhu H, Rotello R, Hartwieg EA, Yuan J. 1993. Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene, ced-3. Cell 75:653-660.
41. Nicholson DW, Thornberry NA. 1997. Caspases: killer proteases. Trends Biochem Sci 22:299-307.
42. Sakahira H, Enari M, Nagata S. 1998. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 391:96-99.
43. Scheid MP, Lauener RW, Duronio V. 1995. Role of phosphatidylinositol 3-OH-kinase activity in the inhibition of apoptosis in haemopoietic cells: phosphatidylinositol 3-OH-kinase inhibitors reveal a difference in signalling between interleukin-3 and granulocyte-macrophage colony stimulating factor. Biochem J 312:159-162.
44. Songyang Z, Baltimore D, Cantley LC, Kaplan DR, Franke TF. 1997. Interleukin 3-dependent survival by the Akt protein kinase. Proc Natl Acad Sci USA 94:11345-11350.
45. Srinivasula SM, Ahmad M, Fernandes-Alnemri T, Alnemri ES. 1998. Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization. Molecular Cell 1:949-957.
46. Staal SP. 1987. Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci USA 84:5034-5037.
47. Stewart CE, Rotwein P. 1996. Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors. Physiol Rev 76:1005-1026.
48. Talanian RV, Quinlan C, Trautz S, Hackett MC, Mankovich JA, Banach D, Ghayur T, Brady KD, Wong WW. 1997. Substrate specificities of caspase family proteases. J Biol Chem 272:9677-9682.
49. Thornberry NA, Rano TA, Peterson EP, Rasper DM, Timkey T, Garcia-Calvo M, Houtzager VM, Nordstrom PA, Roy S, Vaillancourt JP, Chapman KT, Nicholson DW. 1997. A combinatorial approach defines specificities of members of the caspase family and granzyme B: functional relationships established for key mediators of apoptosis. J Biol Chem 272:17907-17911.
50. Villa P, Kaufmann SH, Earnshaw WC. 1997. Caspases and caspase inhibitors. Trends Biochem Sci 22:388-393.
51. Widmann C, Gibson S, Johnson GL. 1998. Caspase-dependent cleavage of signaling proteins during apoptosis: a turn-off mechanism for anti-apoptotic signals. J Biol Chem 273:7141-7147.
52. Yang E, Zha J, Jockel J, Boise LH, Thompson CB, Korsmeyer SJ. 1995. A heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80:285-291.
53. Yao R, Cooper GM. 1995. Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor. Science 267:2003-2006.
54. Yao R, Cooper GM. 1996. Growth factor-dependent survival of rodent fibroblasts requires phosphatidylinositol 3-kinase but is independent of pp70S6K activity. Oncogene 13:343-351.
55. Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR. 1993. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme. Cell 75:641-652.
56. Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ. 1996. Serine phosphorylation of death agonist in response to survival factor results in binding to 14-3-3 not BCL-XL. Cell 87:619-628.
57. Waf/Cip1 converts cancer cells from growth arrest to undergoing apoptosis. Oncogene 18:1131-1138.