Induction of activation of the antioxidant response element and stabilization of Nrf2 by 3-(3-pyridylmethylidene)-2-indolinone (PMID) confers protection against oxidative stress-induced cell death

Toxicology and Applied Pharmacology

Volumn 259, Issue 2, 2012, Pages 227-235

  Yao, Jia Wei ^a,b   Liu, Jing ^b   Kong, Xiang Zhen ^a,b   Zhang, Shou Guo ^b   Wang, Xiao Hui ^b,c   Yu, Miao ^b   Zhan, Yi Qun ^b   Li, Wei ^b   Xu, Wang Xiang ^b   Tang, Liu Jun ^b,c   Ge, Chang Hui ^b   Wang, Lin ^b   Li, Chang Yan ^b,c   Yang, Xiao Ming ^a,b,c  

^a TIANJIN UNIVERSITY   (China)

^b BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^c State Key Laboratory of Proteomics   (China)

Author keywords

ARE; Nrf2; Oxidative stress; PMID

Indexed keywords

3 (3 PYRIDYLMETHYLIDENE) 2 INDOLINONE; CULLIN; CULLIN 3; CYCLOHEXIMIDE; HEME OXYGENASE 1; HYDROGEN PEROXIDE; INDOLE DERIVATIVE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; NAD(P)H:QUINONE OXIREDUCTASE 1; OXIDOPAMINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; GENE EXPRESSION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; TURNOVER TIME; UBIQUITINATION; UPREGULATION;

ANIMALS; ANTIOXIDANTS; CELL SURVIVAL; GLUTATHIONE; HEP G2 CELLS; HUMANS; INDOLES; MALE; MICE; MICE, INBRED BALB C; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; RESPONSE ELEMENTS; SUPEROXIDE DISMUTASE; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

MUS;

EID: 84862807930     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.12.027     Document Type: Article

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