Accelerated blood clearance phenomenon upon repeated injection of peg-modified pla-nanoparticles

Pharmaceutical Research

Volumn 26, Issue 10, 2009, Pages 2270-2279

  Ishihara, Tsutomu ^a,b   Takeda, Miho ^a   Sakamoto, Haruka ^a   Kimoto, Ayumi ^a   Kobayashi, Chisa ^a   Takasaki, Naoko ^a   Yuki, Kanae ^a   Tanaka, Ken Ichiro ^a   Takenaga, Mitsuko ^c   Igarashi, Rie ^c   Maeda, Taishi ^a   Yamakawa, Naoki ^a   Okamoto, Yoshinari ^a   Otsuka, Masami ^a   Ishida, Tatsuhiro ^d   Kiwada, Hiroshi ^d   Mizushima, Yutaka ^b   Mizushima, Tohru ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

ABC phenomenon; Anti PEG IgM antibody; Biodegradable nanoparticles; Encapsulation; Prostaglandin E1

Indexed keywords

COPOLYMER; IMMUNOGLOBULIN M ANTIBODY; MACROGOL DERIVATIVE; MONOMETHOXYPOLY(ETHYLENEGLYCOL)POLYLACTIDE; NANOPARTICLE; POLYLACTIDE; PROSTAGLANDIN E1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBODY PRODUCING CELL; AREA UNDER THE CURVE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; MOLECULAR WEIGHT; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT; SUSTAINED DRUG RELEASE;

ANIMALS; BLOOD CIRCULATION TIME; METABOLIC CLEARANCE RATE; NANOPARTICLES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; RATS; RATS, WISTAR; TIME FACTORS;

EID: 69949132111     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-009-9943-x     Document Type: Article

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