Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes

Journal of Controlled Release

Volumn 119, Issue 2, 2007, Pages 236-244

  Wang, XinYu ^a   Ishida, Tatsuhiro ^a   Kiwada, Hiroshi ^a  

^a Institute of Health Biosciences   (Japan)

Author keywords

Accelerated blood clearance (ABC) phenomenon; Complement system; IgM; Liposomes; Polyethylene glycol (PEG); Repeated injection

Indexed keywords

ACCELERATED BLOOD CLEARANCE (ABC) PHENOMENON; COMPLEMENT SYSTEMS; IMMUNOGENICITY; REPEATED INJECTION;

ACTIVATION ANALYSIS; ANIMALS; BLOOD; IMMUNOLOGY; LIPIDS; POLYETHYLENE GLYCOLS;

LIPOSOMES;

ANTIBODY; LIPOSOME; POLYETHYLENE GLYCOL IMMUNOGLOBULIN M ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ARTICLE; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM; CONTROLLED STUDY; IMMUNOGENICITY; LIPID COMPOSITION; MALE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RAT;

ANIMALS; IMMUNOGLOBULIN M; INJECTIONS, INTRAVENOUS; LIPOSOMES; MALE; METABOLIC CLEARANCE RATE; PROPYLENE GLYCOL; RATS; RATS, WISTAR;

EID: 34248589255     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2007.02.010     Document Type: Article

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