Bladder stromal loss of transforming growth factor receptor II decreases fibrosis after bladder obstruction

Journal of Urology

Volumn 182, Issue 4 SUPPL., 2009, Pages 1775-1780

  Anumanthan, Govindaraj ^a   Tanaka, Stacy T ^a   Adams, Cyrus M ^a   Thomas, John C ^a   Wills, Marcia L ^a   Adams, Mark C ^a   Hayward, Simon W ^a   Matusik, Robert J ^a   Bhowmick, Neil A ^a   Brock III, John W ^a   Pope IV, John C ^a  

^a MONROE CARELL JR CHILDREN S HOSPITAL AT VANDERBILT   (United States)

Author keywords

Collagen; Fibrosis; Receptors, transforming growth factor beta; Urinary bladder; Urinary bladder neck obstruction

Indexed keywords

PROTEIN SERINE THREONINE KINASE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA TYPE II RECEPTOR; TRANSFORMING GROWTH FACTOR-BETA TYPE II RECEPTOR;

ANIMAL; ARTICLE; BLADDER; BLADDER OBSTRUCTION; C57BL MOUSE; FEMALE; FIBROSIS; METABOLISM; MOUSE; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; FEMALE; FIBROSIS; MICE; MICE, INBRED C57BL; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA; URINARY BLADDER; URINARY BLADDER NECK OBSTRUCTION;

EID: 70350512321     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2009.05.126     Document Type: Conference Paper

References (20)

1. Runyan CE, Poncelet AC and Schnaper HW: TGF-beta receptor-binding proteins: complex interactions. Cell Signal 2006; 18: 2077.
2. Anumanthan G, Halder SK, Osada H et al: Restoration of TGF-beta signalling reduces tumorigenicity in human lung cancer cells. Br J Cancer 2005; 14: 157.
3. Roberts AB, Heine UI, Flanders KC et al: Transforming growth factor-beta. Major role in regulation of extracellular matrix. Ann N Y Acad Sci 1990; 580: 225.
4. Mauviel A: Transforming growth factor-beta: a key mediator of fibrosis. Methods Mol Med 2005; 117: 69.
5. Razzaque MS, Ahsan N and Taguchi T: Role of apoptosis in fibrogenesis. Nephron 2002; 90: 365.
6. Chytil A, Magnuson MA, Wright CV et al: Conditional inactivation of the TGF-beta type II receptor using Cre:Lox. Genesis 2002; 32: 73.
7. Feil R, Brocard J, Mascrez B et al: Ligand-activated site-specific recombination in mice. Proc Natl Acad Sci U S A 1996; 93: 10887.
8. Lemack GE, Zimmern PE, Vazquez D et al: Altered response to partial bladder outlet obstruction in mice lacking inducible nitric oxide synthase. J Urol 2000; 63: 1981.
9. Streng T, Launonen A, Salmi S et al: Nontraumatic urethral dyssynergia in neonatally estrogenized male rats. J Urol 2001; 165: 1305.
10. Austin JC, Chacko SK, DiSanto M et al: A male murine model of partial bladder outlet obstruction reveals changes in detrusor morphology, contractility and myosin isoform expression. J Urol 2004; 172: 1524.
11. Schröder A, Uvelius B, Newgreen D et al: Bladder overactivity in mice after 1 week of outlet obstruction. Mainly afferent dysfunction? J Urol 2003; 170: 1017.
12. Shapiro E, Becich MJ, Perlman E et al: Bladder wall abnormalities in myelodysplastic bladders: a computer assisted morphometric analysis. J Urol 1991; 145: 1024.
13. Lee CG, Homer RJ, Zhu Z et al: Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med 2001; 194: 809.
14. Martin M, Lefaix J and Delanian S, TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target? Int J Radiat Oncol Biol Phys 2000; 47: 277.
15. Kalluri R and Sukhatme VP: Fibrosis and angiogenesis. Curr Opin Nephrol Hypertens 2000; 9: 413.
16. Yehualaeshet T, O'Connor R, Begleiter A et al: CD36 synthetic peptide inhibits bleomycin-induced pulmonary inflammation and connective tissue synthesis in the rat. Am J Respir Cell Mol Biol 2000; 23: 204.
17. Kuhn C, Boldt J, King T et al: An immunohistochemical study of architectural fibrosis. Am Rev Respir Dis 1989; 140: 1693.
18. Chojkier M, Lyche K and Filip M: Increased production of collagen in vivo by hepatocytes and nonparenchymal cells in rats with carbon tetrachloride-induced hepatic fibrosis. Hepatology 1988; 8: 808.
19. Weber K, Sun Y, Guarda E et al: Myocardial fibrosis in hypertensive heart disease: an overview of potential regulatory mechanisms. Eur Heart J 1995; 16: 24.
20. Remy J, Wegrowski J, Crechet F et al: Long-term overproduction of collagen in radiation-induced fibrosis. Radiat Res 1991; 125: 14.