Smad3 mediates cardiac inflammation and fibrosis in angiotensin II-induced hypertensive cardiac remodeling

Hypertension

Volumn 55, Issue 5, 2010, Pages 1165-1171

  Huang, Xiao R ^a   Chung, Arthur C K ^a   Yang, Fuye ^b   Yue, Wensheng ^b   Deng, Chuxia ^c   Lau, Chu Pak ^b   Tse, Hung Fat ^b   Lan, Hui Y ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Angiotensin II; Cardiac remodeling; Hypertension; Smad3; TGF

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANGIOTENSIN II; COLLAGEN TYPE 1; COLLAGEN TYPE 3; CONNECTIVE TISSUE GROWTH FACTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDITIS; CONTROLLED STUDY; HEART MUSCLE FIBROSIS; HEART VENTRICLE REMODELING; HYPERTENSION; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANGIOTENSIN II; ANIMALS; CHEMOKINE CCL2; ECHOCARDIOGRAPHY; GENE DELETION; HYPERTENSION; INFLAMMATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NF-KAPPA B; SMAD3 PROTEIN; STROKE VOLUME; TUMOR NECROSIS FACTOR-ALPHA; VENTRICULAR REMODELING;

EID: 77951499390     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.109.147611     Document Type: Article

References (33)

1. Díez J. Mechanisms of cardiac fibrosis in hypertension. J Clin Hypertens (Greenwich). 2007;9:546-550.
2. Mann DL. Inflammatory mediators and the failing heart: past, present, and the foreseeable future. Circ Res. 2002;91:988-998.
3. Ferrario CM, Strawn WB. Role of the renin-angiotensin-aldosterone system and proinflammatory mediators in cardiovascular disease. Am J Cardiol. 2006;98:121-128.
4. Werner CM, Bohm M. The therapeutic role of RAS blockade in chronic heart failure. Ther Adv Cardiovasc Dis. 2008;2:167-177. (Pubitemid 351863375)
5. Mehta PK, Griendling KK. Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system. Am J Physiol Cell Physiol. 2007;292:C82-C97.
6. Rosenkranz S. TGF-/31 and angiotensin networking in cardiac remodeling. Cardiovasc Res. 2004;63:423-432.
7. Yu CM, Tipoe GL, Wing-Hon Lai K, Lau CP. Effects of combination of angiotensin-converting enzyme inhibitor and angiotensin receptor antagonist on inflammatory cellular infiltration and myocardial interstitial fibrosis after acute myocardial infarction. J Am Coll Cardiol. 2001;38: 1207-1215. (Pubitemid 32912734)
8. Sun Y, Zhang JQ, Zhang J, Ramires FJ. Angiotensin II, transforming growth factor-/31 and repair in the infarcted heart. J Mol Cell Cardiol. 1998;30:1559-1569. (Pubitemid 28418646)
9. Bujak M, Frangogiannis NG. The role of TGF-/3 signaling in myocardial infarction and cardiac remodeling. Cardiovasc Res. 2007;74:184-195. (Pubitemid 46517504)
10. Kuwahara F, Kai H, Tokuda K, Kai M, Takeshita A, Egashira K, Imaizumi T. Transforming growth factor-/3 function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats. Circulation. 2002;106:130-135. (Pubitemid 34747453)
11. Okada H, Takemura G, Kosai K, Li Y, Takahashi T, Esaki M, Yuge K, Miyata S, Maruyama R, Mikami A, Minatoguchi S, Fujiwara T, Fujiwara H. Postinfarction gene therapy against transforming growth factor-/3 signal modulates infarct tissue dynamics and attenuates left ventricular remodeling and heart failure. Circulation. 2005;111:2430-2437. (Pubitemid 40696130)
12. Sakata Y, Chancey AL, Divakaran VG, Sekiguchi K, Sivasubramanian N, Mann DL. Transforming growth factor-/3 receptor antagonism attenuates myocardial fibrosis in mice with cardiac-restricted overexpression of tumor necrosis factor. Basic Res Cardiol. 2008;103:60-68. (Pubitemid 50005150)
13. Shi Y, Massague J. Mechanisms of TGF-/3 signaling from cell membrane to the nucleus. Cell. 2003;113:685-700. (Pubitemid 36724933)
14. Hao J, Ju H, Zhao S, Junaid A, Scammell-La Fleur T, Dixon IM. Elevation of expression of Smads 2, 3, and 4, decorin and TGF-/3 in the chronic phase of myocardial infarct scar healing. J Mol Cell Cardiol. 1999;31:667-678. (Pubitemid 29121651)
15. Wang B, Hao J, Jones SC, Yee MS, Roth JC, Dixon IM. Decreased Smad 7 expression contributes to cardiac fibrosis in the infarcted rat heart. Am J Physiol Heart Circ Physiol. 2002;282:H1685-H1696. (Pubitemid 34654836)
16. Hao J, Wang B, Jones SC, Jassal DS, Dixon IM. Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro. Am J Physiol Heart Circ Physiol. 2000;279:H3020-H3030. (Pubitemid 32005893)
17. Rodriguez-Vita J, Sanchez-Lopez E, Esteban V, Ruperez M, Egido J, Ruiz-Ortega M. Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-/3-independent mechanism. Circulation. 2005;111:2509-2517. (Pubitemid 40696140)
18. Wang W, Huang XR, Canlas E, Oka K, Truong LD, Deng C, Bhowmick NA, Ju W, Bottinger EP, Lan HY. Essential role of Smad3 in angiotensin II-induced vascular fibrosis. Circ Res. 2006;98:1032-1039. (Pubitemid 43755224)
19. Bujak M, Ren G, Kweon HJ, Dobaczewski M, Reddy A, Taffet G, Wang X-F, Frangogiannis NG. Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. Circulation. 2007;116:2127-2138. (Pubitemid 350060350)
20. Yang X, Letterio JJ, Lechleider RJ, Chen L, Hayman R, Gu H, Roberts AB, Deng C. Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-/3. EMBO J. 1999;18:1280-1291. (Pubitemid 29110312)
21. Sahn DJ, DeMaria A, Kisslo J, Weyman A. Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echo-cardiographic measurements. Circulation. 1978;58:1072-1083. (Pubitemid 9091990)
22. Lan HY, Mu W, Nikolic-Paterson DJ, Atkins RC. A novel, simple, reliable, and sensitive method for multiple immunoenzyme staining: use of microwave oven heating to block antibody crossreactivity and retrieve antigens. J Histochem Cytochem. 1995;43:97-102.
23. Huang XR, Chung AC, Zhou L, Wang XJ, Lan HY. Latent TGF-/31 protects against crescentic glomerulonephritis. J Am Soc Nephrol. 2008; 19:233-242. (Pubitemid 351240645)
24. Yang F, Chung AC, Ru Huang X, Lan HY. Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-{/3}-dependent and-independent smad pathways: the role of Smad3. Hypertension. 2009;54:877-884.
25. Wang F, Trial J, Diwan A, Gao F, Birdsall H, Entman M, Hornsby P, Sivasubramanian N, Mann D. Regulation of cardiac fibroblast cellular function by leukemia inhibitory factor. J Mol Cell Cardiol. 2002;34: 1309-1316. (Pubitemid 35244408)
26. Petrov VV, van Pelt JF, Vermeesch JR, Van Duppen VJ, Vekemans K, Fagard RH, Lijnen PJ. TGF-/31-induced cardiac myofibroblasts are non-proliferating functional cells carrying DNA damages. Exp Cell Res. 2008;314:1480-1494.
27. Olson ER, Naugle JE, Zhang X, Bomser JA, Meszaros JG. Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by res-veratrol. Am J Physiol Heart Circ Physiol. 2005;288:H1131-H1138. (Pubitemid 40270016)
28. Tsuchiya K, Yoshimoto T, Hirono Y, Tateno T, Sugiyama T, Hirata Y. Angiotensin II induces monocyte chemoattractant protein-1 expression via a nuclear factor-KB-dependent pathway in rat preadipocytes. Am J Physiol Endocrinol Metab. 2006;291:E771-E778. (Pubitemid 44484919)
29. Sarman B, Skoumal R, Leskinen H, Rysa J, Ilves M, Soini Y, Tuukkanen J, Pikkarainen S, Lako-Futo Z, Sarman B, Papp L, deChatel R, Toth M, Ruskoaho H, Szokodi I. Nuclear factor-KB signaling contributes to severe, but not moderate, angiotensin II-induced left ventricular remodeling. J Hypertens. 2007;25:1927-1939. (Pubitemid 47356635)
30. Zhang F, Tsai S, Kato K, Yamanouchi D, Wang C, Rafii S, Liu B, Kent KC. Transforming growth factor-/3 promotes recruitment of bone marrow cells and bone marrow-derived mesenchymal stem cells through stimulation of MCP-1 production in vascular smooth muscle cells. J Biol Chem. 2009;284:17564-17574.
31. Ng YY, Hou CC, Wang W, Huang XR, Lan HY. Blockade of NFKB activation and renal inflammation by ultrasound-mediated gene transfer of Smad7 in rat remnant kidney. Kidney Int. 2005;94(suppl):S83-S91. (Pubitemid 40446505)
32. Wang W, Huang XR, Li AG, Liu F, Li JH, Truong LD, Wang XJ, Lan HY. Signaling mechanism of TGF-{/3}1 in prevention of renal inflammation: role of Smad7. J Am Soc Nephrol. 2005;16:1371-1383. (Pubitemid 41716521)
33. Chung AC, Huang XR, Zhou L, Heuchel R, Lai KN, Lan HY. Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice. Nephrol Dial Transplant. 2009;24: 1443-1454.