Val97Leu mutant presenilin-1 induces tau hyperphosphorylation and spatial memory deficit in mice and the underlying mechanisms

Journal of Neurochemistry

Volumn 121, Issue 1, 2012, Pages 135-145

  Wang, Yue ^a,b   Cheng, Zhe ^a   Qin, Wei ^a,b   Jia, Jianping ^a,b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

glycogen synthase kinase 3; presenilin 1; spatial memory; tau hyperphosphorylation; Val97Leu mutation

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PRESENILIN 1; PROTEIN KINASE B; TAU PROTEIN;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DENTATE HILUS; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; FRONTAL CORTEX; HIPPOCAMPAL CA3 REGION; MALE; MOLECULAR PATHOLOGY; MOUSE; MUTATOR GENE; NERVE DEGENERATION; NONHUMAN; PRESENILIN 1 GENE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SPATIAL MEMORY; TRANSGENIC MOUSE;

ANIMALS; CELL LINE, TUMOR; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LEUCINE; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; MICE, TRANSGENIC; MUTATION; PHOSPHORYLATION; PRESENILIN-1; TAU PROTEINS; VALINE;

MUS; MUS MUSCULUS;

EID: 84862785200     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07489.x     Document Type: Article

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