메뉴 건너뛰기




Volumn 117, Issue 1, 2009, Pages 19-29

Cytoskeletal alterations differentiate presenilin-1 and sporadic Alzheimer's disease

Author keywords

Cotton wool plaques; Dystrophic neurites; Familial Alzheimer's disease; Neurofibrillary tangles; Presenilin 1

Indexed keywords

AMYLOID BETA PROTEIN; DIRECT YELLOW 7; PRESENILIN 1; THIOFLAVINE; UNCLASSIFIED DRUG;

EID: 57049098091     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-008-0458-z     Document Type: Article
Times cited : (23)

References (54)
  • 1
    • 0036946621 scopus 로고    scopus 로고
    • Morphologically distinct plaque types differentially affect dendritic structure and organization in the early and late stages of Alzheimer's disease
    • Akiyama H, Schwab C, Kondo H et al (2002) Morphologically distinct plaque types differentially affect dendritic structure and organization in the early and late stages of Alzheimer's disease. Acta Neuropathol 103:377-383
    • (2002) Acta Neuropathol , vol.103 , pp. 377-383
    • Akiyama, H.1    Schwab, C.2    Kondo, H.3
  • 2
    • 0031811820 scopus 로고    scopus 로고
    • β-Amyloid plaques: Stages in life history or independent origin?
    • Armstrong RA (1998) β-Amyloid plaques: Stages in life history or independent origin? Dement Geriatr Cogn Disord 9:227-238
    • (1998) Dement Geriatr Cogn Disord , vol.9 , pp. 227-238
    • Armstrong, R.A.1
  • 3
    • 0036854327 scopus 로고    scopus 로고
    • Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity
    • Biernat J, Wu Y-Z, Timm T et al (2002) Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity. Mol Biol Cell 13:4013-4028
    • (2002) Mol Biol Cell , vol.13 , pp. 4013-4028
    • Biernat, J.1    Wu, Y.-Z.2    Timm, T.3
  • 4
    • 0344826476 scopus 로고    scopus 로고
    • Time sequence of maturation of dystrophic neurites associated with Aβ deposits in APP/PS1 transgenic mice
    • Blanchard V, Moussaoui S, Czech C et al (2003) Time sequence of maturation of dystrophic neurites associated with Aβ deposits in APP/PS1 transgenic mice. Exp Neurol 184:247-263
    • (2003) Exp Neurol , vol.184 , pp. 247-263
    • Blanchard, V.1    Moussaoui, S.2    Czech, C.3
  • 5
    • 0030293676 scopus 로고    scopus 로고
    • Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo
    • Borchelt DR, Thinakaran G, Eckman CB et al (1996) Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo. Neuron 17:1005-1013
    • (1996) Neuron , vol.17 , pp. 1005-1013
    • Borchelt, D.R.1    Thinakaran, G.2    Eckman, C.B.3
  • 6
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82:239-259
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 7
    • 0028986916 scopus 로고
    • β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding
    • Busciglio J, Lorenzo A, Yeh J, Yanker BA (1995) β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron 14:879-888
    • (1995) Neuron , vol.14 , pp. 879-888
    • Busciglio, J.1    Lorenzo, A.2    Yeh, J.3    Yanker, B.A.4
  • 8
    • 0033358671 scopus 로고    scopus 로고
    • Early-onset autosomal dominant Alzheimer disease: Prevalence, genetic heterogeneity, and mutation spectrum
    • Campion D, Dumanchin C, Hannequin D et al (1999) Early-onset autosomal dominant Alzheimer disease: Prevalence, genetic heterogeneity, and mutation spectrum. Am J Hum Genet 65:664-670
    • (1999) Am J Hum Genet , vol.65 , pp. 664-670
    • Campion, D.1    Dumanchin, C.2    Hannequin, D.3
  • 9
    • 43149088503 scopus 로고    scopus 로고
    • Loss of presenilin function causes Alzheimer's disease-like neurodegeneration in the mouse
    • Chen Q, Nakajima A, Choi SH, Xiong X, Tang YP (2008) Loss of presenilin function causes Alzheimer's disease-like neurodegeneration in the mouse. J Neurosci Res 86:1615-1626
    • (2008) J Neurosci Res , vol.86 , pp. 1615-1626
    • Chen, Q.1    Nakajima, A.2    Choi, S.H.3    Xiong, X.4    Tang, Y.P.5
  • 10
    • 0031949628 scopus 로고    scopus 로고
    • A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to the deletion of exon 9 of presenilin 1
    • Crook R, Verkkoniemi A, Perez-Tur J et al (1998) A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to the deletion of exon 9 of presenilin 1. Nat Med 4:452-455
    • (1998) Nat Med , vol.4 , pp. 452-455
    • Crook, R.1    Verkkoniemi, A.2    Perez-Tur, J.3
  • 11
    • 0033990169 scopus 로고    scopus 로고
    • Presenilins and Alzheimer's disease: Biological functions and pathogenic mechanisms
    • Czech C, Tremp G, Pradier L (2000) Presenilins and Alzheimer's disease: biological functions and pathogenic mechanisms. Prog Neurobiol 60:363-384
    • (2000) Prog Neurobiol , vol.60 , pp. 363-384
    • Czech, C.1    Tremp, G.2    Pradier, L.3
  • 12
    • 47049120422 scopus 로고    scopus 로고
    • Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Abeta oligomers
    • De Felice FG, Wu D, Lambert MP et al (2008) Alzheimer's disease-type neuronal tau hyperphosphorylation induced by Abeta oligomers. Neurobiol Aging 29:1334-1347
    • (2008) Neurobiol Aging , vol.29 , pp. 1334-1347
    • De Felice, F.G.1    Wu, D.2    Lambert, M.P.3
  • 13
    • 15944382705 scopus 로고    scopus 로고
    • Novel Alzheimer's disease pathology reflects variable neuronal vulnerability and demonstrates the role of β-amyloid plaques in neurodegeneration
    • Dickson TC, Chuckowree JA, Chuah MI, West AK, Vickers JC (2005) Novel Alzheimer's disease pathology reflects variable neuronal vulnerability and demonstrates the role of β-amyloid plaques in neurodegeneration. Neurobiol Dis 18:286-295
    • (2005) Neurobiol Dis , vol.18 , pp. 286-295
    • Dickson, T.C.1    Chuckowree, J.A.2    Chuah, M.I.3    West, A.K.4    Vickers, J.C.5
  • 14
    • 0035898257 scopus 로고    scopus 로고
    • The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease
    • Dickson TC, Vickers JC (2001) The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease. Neuroscience 105:99-107
    • (2001) Neuroscience , vol.105 , pp. 99-107
    • Dickson, T.C.1    Vickers, J.C.2
  • 15
    • 0033066239 scopus 로고    scopus 로고
    • Neurochemical diversity of dystrophic neurites in the early and late stages of Alzheimer's disease
    • Dickson TC, King CE, McCormack GH, Vickers JC (1999) Neurochemical diversity of dystrophic neurites in the early and late stages of Alzheimer's disease. Exp Neurol 156:100-110
    • (1999) Exp Neurol , vol.156 , pp. 100-110
    • Dickson, T.C.1    King, C.E.2    McCormack, G.H.3    Vickers, J.C.4
  • 16
    • 0035961218 scopus 로고    scopus 로고
    • Alzheimer's disease presenilin-1 expression modulates the assembly of neurofilaments
    • Dowjat WK, Wisniewski H, Wisniewski T (2001) Alzheimer's disease presenilin-1 expression modulates the assembly of neurofilaments. Neuroscience 103:1-8
    • (2001) Neuroscience , vol.103 , pp. 1-8
    • Dowjat, W.K.1    Wisniewski, H.2    Wisniewski, T.3
  • 17
    • 0036089779 scopus 로고    scopus 로고
    • Characterisation of mitotic neurons derived from adult rat hypothalamus and brain stem
    • Evans J, Sumners C, Moore J et al (2002) Characterisation of mitotic neurons derived from adult rat hypothalamus and brain stem. J Neurophysiol 87:1076-1085
    • (2002) J Neurophysiol , vol.87 , pp. 1076-1085
    • Evans, J.1    Sumners, C.2    Moore, J.3
  • 18
    • 0030879686 scopus 로고    scopus 로고
    • Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar Abeta
    • Ferreira A, Lu Q, Orecchio L, Kosik KS (1997) Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar Abeta. Mol Cell Neurosci 9:220-234
    • (1997) Mol Cell Neurosci , vol.9 , pp. 220-234
    • Ferreira, A.1    Lu, Q.2    Orecchio, L.3    Kosik, K.S.4
  • 19
    • 0029923520 scopus 로고    scopus 로고
    • Association of Aβ40-positive senile plaques with microglial cells in the brains of patients with Alzheimer's disease and in non-demented aged individuals
    • Fukumoto H, Asami-Odaka AS, Uzuki N, Iwatsubo T (1996) Association of Aβ40-positive senile plaques with microglial cells in the brains of patients with Alzheimer's disease and in non-demented aged individuals. Neurodegeneration 5:13-17
    • (1996) Neurodegeneration , vol.5 , pp. 13-17
    • Fukumoto, H.1    Asami-Odaka, A.S.2    Uzuki, N.3    Iwatsubo, T.4
  • 20
    • 0038708285 scopus 로고    scopus 로고
    • Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease
    • Giannakopoulos P, Herrmann FR, Bussiere T et al (2003) Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease. Neurology 60:1495-1500
    • (2003) Neurology , vol.60 , pp. 1495-1500
    • Giannakopoulos, P.1    Herrmann, F.R.2    Bussiere, T.3
  • 21
    • 2542509819 scopus 로고    scopus 로고
    • The impact of different presenilin 1 and presenilin 2 mutation on amyloid deposition neurofibrillary changes and neuronal loss in familial Alzheimer's disease brain: Evidence for other phenotype-modifying factors
    • Gomez-Isla T, Growdon WB, McNamara MJ et al (1999) The impact of different presenilin 1 and presenilin 2 mutation on amyloid deposition neurofibrillary changes and neuronal loss in familial Alzheimer's disease brain: Evidence for other phenotype-modifying factors. Brain 122:1709-1719
    • (1999) Brain , vol.122 , pp. 1709-1719
    • Gomez-Isla, T.1    Growdon, W.B.2    McNamara, M.J.3
  • 22
    • 0032150877 scopus 로고    scopus 로고
    • Genetic dissection of Alzheimer's disease and related dementias: Amyloid and its relationship to tau
    • Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M (1998) Genetic dissection of Alzheimer's disease and related dementias: Amyloid and its relationship to tau. Nat Neurosci 1:355-358
    • (1998) Nat Neurosci , vol.1 , pp. 355-358
    • Hardy, J.1    Duff, K.2    Hardy, K.G.3    Perez-Tur, J.4    Hutton, M.5
  • 23
    • 0033762710 scopus 로고    scopus 로고
    • Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations
    • Houlden H, Baker M, McGowan E et al (2000) Variant Alzheimer's disease with spastic paraparesis and cotton wool plaques is caused by PS-1 mutations that lead to exceptionally high amyloid-beta concentrations. Ann Neurol 48:806-808
    • (2000) Ann Neurol , vol.48 , pp. 806-808
    • Houlden, H.1    Baker, M.2    McGowan, E.3
  • 24
    • 0035882526 scopus 로고    scopus 로고
    • Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments
    • Ishihara T, Higuchi M, Zhang B et al (2001) Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments. J Neurosci 21:6026-6035
    • (2001) J Neurosci , vol.21 , pp. 6026-6035
    • Ishihara, T.1    Higuchi, M.2    Zhang, B.3
  • 25
    • 0030857182 scopus 로고    scopus 로고
    • Increased Abeta 42(43)-plaque deposition in early-onset familial Alzheimer's disease brains with the deletion of exon 9 and the missense point mutation (H163R) in the PS-1 gene
    • Ishii K, Ii K, Hasegawa T, Shoji S, Doi A, Mori H (1997) Increased Abeta 42(43)-plaque deposition in early-onset familial Alzheimer's disease brains with the deletion of exon 9 and the missense point mutation (H163R) in the PS-1 gene. Neurosci Lett 228:17-20
    • (1997) Neurosci Lett , vol.228 , pp. 17-20
    • Ishii, K.1    Ii, K.2    Hasegawa, T.3    Shoji, S.4    Doi, A.5    Mori, H.6
  • 26
    • 38049110977 scopus 로고    scopus 로고
    • Variable phenotype of Alzheimer's disease with spastic paraparesis
    • Karlstrom H, Brooks WS, Kwok JBJ et al (2008) Variable phenotype of Alzheimer's disease with spastic paraparesis. J Neurochem 104:573-583
    • (2008) J Neurochem , vol.104 , pp. 573-583
    • Karlstrom, H.1    Brooks, W.S.2    Kwok, J.B.J.3
  • 27
    • 0037470181 scopus 로고    scopus 로고
    • Presenilin-1 mutation L271V results in altered exon 8 splicing and Alzheimer's disease with non-cored plaques and no neuritic dystrophy
    • Kwok JBJ, Halliday GM, Brooks WS et al (2003) Presenilin-1 mutation L271V results in altered exon 8 splicing and Alzheimer's disease with non-cored plaques and no neuritic dystrophy. J Biol Chem 278:6748-6754
    • (2003) J Biol Chem , vol.278 , pp. 6748-6754
    • Kwok, J.B.J.1    Halliday, G.M.2    Brooks, W.S.3
  • 28
    • 34347353311 scopus 로고    scopus 로고
    • Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's Disease-linked mutant presenilin 1
    • Lazarov O, Morfini GA, Pigino G et al (2007) Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's Disease-linked mutant presenilin 1. J Neurosci 27:7011-7020
    • (2007) J Neurosci , vol.27 , pp. 7011-7020
    • Lazarov, O.1    Morfini, G.A.2    Pigino, G.3
  • 29
    • 9044239670 scopus 로고    scopus 로고
    • Familial and sporadic Alzheimer's disease: Neuropathology cannot exclude a final common pathway
    • Lippa CF, Saunders AM, Smith TW et al (1996) Familial and sporadic Alzheimer's disease: Neuropathology cannot exclude a final common pathway. Neurology 46:406-412
    • (1996) Neurology , vol.46 , pp. 406-412
    • Lippa, C.F.1    Saunders, A.M.2    Smith, T.W.3
  • 30
    • 0034975365 scopus 로고    scopus 로고
    • Amyloid angiopathy and variability in amyloid-β deposition is determined by mutation position in presenilin-1-linked Alzheimer's disease
    • Familial Alzheimer's disease pathology study group
    • Mann DMA, Pickering-Brown SM, Takeuchi A, Iwatsubo T, Familial Alzheimer's disease pathology study group (2001) Amyloid angiopathy and variability in amyloid-β deposition is determined by mutation position in presenilin-1-linked Alzheimer's disease. Am J Pathol 158:2165-2175
    • (2001) Am J Pathol , vol.158 , pp. 2165-2175
    • Mann, D.M.A.1    Pickering-Brown, S.M.2    Takeuchi, A.3    Iwatsubo, T.4
  • 31
    • 0034917266 scopus 로고    scopus 로고
    • Cases of Alzheimer's disease due to deletion of exon 9 of the presenilin-1 gene show an unusual but characteristic β-amyloid pathology known as 'cotton wool' plaques
    • Mann DMA, Takeuchi A, Sato S et al (2001) Cases of Alzheimer's disease due to deletion of exon 9 of the presenilin-1 gene show an unusual but characteristic β-amyloid pathology known as 'cotton wool' plaques. Neuropathol Appl Neurobiol 27:189-196
    • (2001) Neuropathol Appl Neurobiol , vol.27 , pp. 189-196
    • Mann, D.M.A.1    Takeuchi, A.2    Sato, S.3
  • 32
    • 0027745766 scopus 로고
    • An antibody against phosphorylated neurofilaments identifies a subset of damaged association axons in Alzheimer's disease
    • Masliah E, Mallory M, Hansen L, Alford M, DeTeresa R, Terry R (1993) An antibody against phosphorylated neurofilaments identifies a subset of damaged association axons in Alzheimer's disease. Am J Pathol 142:871-881
    • (1993) Am J Pathol , vol.142 , pp. 871-881
    • Masliah, E.1    Mallory, M.2    Hansen, L.3    Alford, M.4    DeTeresa, R.5    Terry, R.6
  • 33
    • 0035057591 scopus 로고    scopus 로고
    • Neurofibrillary pathology in transgenic mice overexpressing V717F β-Amyloid precursor protein
    • Masliah E, Sisk A, Mallory M, Games D (2001) Neurofibrillary pathology in transgenic mice overexpressing V717F β-Amyloid precursor protein. J Neuropathol Exp Neurol 60:357-368
    • (2001) J Neuropathol Exp Neurol , vol.60 , pp. 357-368
    • Masliah, E.1    Sisk, A.2    Mallory, M.3    Games, D.4
  • 34
    • 38949123792 scopus 로고    scopus 로고
    • Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer's disease
    • Meyer-Luehmann M, Spires-Jones TL, Prada C et al (2008) Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer's disease. Nature 451:720-724
    • (2008) Nature , vol.451 , pp. 720-724
    • Meyer-Luehmann, M.1    Spires-Jones, T.L.2    Prada, C.3
  • 35
    • 0025908356 scopus 로고
    • The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathological assessment of Alzheimer's disease
    • Mirra SS, Heyman A, McKeel D et al (1991) The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathological assessment of Alzheimer's disease. Neurology 41:479-486
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3
  • 36
    • 51849126363 scopus 로고    scopus 로고
    • Phosphorylated tau in neuritic plaques of APP sw/Tau vlw transgenic mice and Alzheimer disease
    • Pérez M, Asunción Morán M, Ferrer I et al (2008) Phosphorylated tau in neuritic plaques of APP sw/Tau vlw transgenic mice and Alzheimer disease. Acta Neuropathol 116:409-418
    • (2008) Acta Neuropathol , vol.116 , pp. 409-418
    • Pérez, M.1    Asunción Morán, M.2    Ferrer, I.3
  • 37
    • 0035116513 scopus 로고    scopus 로고
    • Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation
    • Pigino G, Pelsman A, Mori H, Busciglio J (2001) Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation. J Neurosci 21:834-842
    • (2001) J Neurosci , vol.21 , pp. 834-842
    • Pigino, G.1    Pelsman, A.2    Mori, H.3    Busciglio, J.4
  • 38
    • 34248525053 scopus 로고    scopus 로고
    • Epitope mapping of mABs AT8 and Tau5 directed against hyperphosphoylated regions of the human tau protein
    • Porzig R, Singer D, Hoffmann R (2007) Epitope mapping of mABs AT8 and Tau5 directed against hyperphosphoylated regions of the human tau protein. Biochem Biophys Res Commun 358:644-649
    • (2007) Biochem Biophys Res Commun , vol.358 , pp. 644-649
    • Porzig, R.1    Singer, D.2    Hoffmann, R.3
  • 39
    • 0032989712 scopus 로고    scopus 로고
    • Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease
    • Price JL, Morris JC (1999) Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease. Ann Neurol 45:358-368
    • (1999) Ann Neurol , vol.45 , pp. 358-368
    • Price, J.L.1    Morris, J.C.2
  • 40
    • 0028301184 scopus 로고
    • Cathespin G: Localization in human cerebral cortex and generation of amyloidogenic fragments from the beta-amyloid precursor protein
    • Savage MJ, Iqbal M, Loh T et al (1994) Cathespin G: Localization in human cerebral cortex and generation of amyloidogenic fragments from the beta-amyloid precursor protein. Neuroscience 60:607-619
    • (1994) Neuroscience , vol.60 , pp. 607-619
    • Savage, M.J.1    Iqbal, M.2    Loh, T.3
  • 41
    • 16044373524 scopus 로고    scopus 로고
    • Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
    • Scheuner D, Eckman C, Jensen M et al (1996) Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 2:850-852
    • (1996) Nat Med , vol.2 , pp. 850-852
    • Scheuner, D.1    Eckman, C.2    Jensen, M.3
  • 42
    • 0024393482 scopus 로고
    • Analysis of epitopes shared by Hirano bodies and neurofilament proteins in normal and Alzheimer's disease hippocampus
    • Schmidt M, Lee VM, Trojanowski JQ (1989) Analysis of epitopes shared by Hirano bodies and neurofilament proteins in normal and Alzheimer's disease hippocampus. Lab Invest 60:513-522
    • (1989) Lab Invest , vol.60 , pp. 513-522
    • Schmidt, M.1    Lee, V.M.2    Trojanowski, J.Q.3
  • 43
    • 0029784838 scopus 로고    scopus 로고
    • Amyloid beta-protein and the genetics of Alzheimer's disease
    • Selkoe DJ (1996) (1996) Amyloid beta-protein and the genetics of Alzheimer's disease. J Biol Chem 271:18295-18298
    • (1996) J Biol Chem , vol.271 , pp. 18295-18298
    • Selkoe, D.J.1
  • 44
    • 1642456618 scopus 로고    scopus 로고
    • Positional effects of presenilin-1 mutations on tau phosphorylation in cortical plaques
    • Shepherd CE, Gregory GC, Vickers JC et al (2004) Positional effects of presenilin-1 mutations on tau phosphorylation in cortical plaques. Neurobiol Dis 15:115-119
    • (2004) Neurobiol Dis , vol.15 , pp. 115-119
    • Shepherd, C.E.1    Gregory, G.C.2    Vickers, J.C.3
  • 45
    • 0242317909 scopus 로고    scopus 로고
    • Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia
    • Stanford PM, Shepherd CE, Halliday GM et al (2003) Mutations in the tau gene that cause an increase in three repeat tau and frontotemporal dementia. Brain 126:814-826
    • (2003) Brain , vol.126 , pp. 814-826
    • Stanford, P.M.1    Shepherd, C.E.2    Halliday, G.M.3
  • 46
    • 0035831499 scopus 로고    scopus 로고
    • A pathogenic presenilin-1 deletion causes aberrant Aβ42 production in the absence of congophilic amyloid plaques
    • Steiner H, Revesz T, Neumann M et al (2001) A pathogenic presenilin-1 deletion causes aberrant Aβ42 production in the absence of congophilic amyloid plaques. J Biol Chem 276:7233-7239
    • (2001) J Biol Chem , vol.276 , pp. 7233-7239
    • Steiner, H.1    Revesz, T.2    Neumann, M.3
  • 47
    • 0030580439 scopus 로고    scopus 로고
    • Plaque biogenesis in brain aging and Alzheimer's disease. I. Progressive changes in phosphorylation states of paired helical filaments and neurofilaments
    • Su JH, Cummings BJ, Cotman CW (1996) Plaque biogenesis in brain aging and Alzheimer's disease. I. Progressive changes in phosphorylation states of paired helical filaments and neurofilaments. Brain Res 739:79-87
    • (1996) Brain Res , vol.739 , pp. 79-87
    • Su, J.H.1    Cummings, B.J.2    Cotman, C.W.3
  • 48
    • 0031716440 scopus 로고    scopus 로고
    • Plaque biogenesis in brain aging and Alzheimer's disease. II. Progressive transformation and developmental sequence of dystrophic neurites
    • Su JH, Cummings BJ, Cotman CW (1998) Plaque biogenesis in brain aging and Alzheimer's disease. II. Progressive transformation and developmental sequence of dystrophic neurites. Acta Neuropathol 96:463-471
    • (1998) Acta Neuropathol , vol.96 , pp. 463-471
    • Su, J.H.1    Cummings, B.J.2    Cotman, C.W.3
  • 49
    • 0036938641 scopus 로고    scopus 로고
    • A novel mutation (G217D) in the presenilin 1 gene (PSEN1) in a Japanese family: Presenile dementia and Parkinsonism are associated with cotton wool plaques in the cortex and striatum
    • Takao M, Ghetti B, Hayakawa I et al (2002) A novel mutation (G217D) in the presenilin 1 gene (PSEN1) in a Japanese family: Presenile dementia and Parkinsonism are associated with cotton wool plaques in the cortex and striatum. Acta Neuropathol 104:155-170
    • (2002) Acta Neuropathol , vol.104 , pp. 155-170
    • Takao, M.1    Ghetti, B.2    Hayakawa, I.3
  • 50
    • 13144265717 scopus 로고    scopus 로고
    • Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau
    • Takashima A, Murayama M, Murayama O et al (1998) Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau. Proc Natl Acad Sci USA 95:9637-9641
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9637-9641
    • Takashima, A.1    Murayama, M.2    Murayama, O.3
  • 52
    • 0028101798 scopus 로고
    • Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer's disease
    • Vickers JC, Riederer BM, Marugg R, Buée-Scherrer V, Buée L, Delacourtes A (1994) Alterations in neurofilament protein immunoreactivity in human hippocampal neurons related to normal aging and Alzheimer's disease. Neuroscience 62:1-13
    • (1994) Neuroscience , vol.62 , pp. 1-13
    • Vickers, J.C.1    Riederer, B.M.2    Marugg, R.3    Buée-Scherrer, V.4    Buée, L.5    Delacourtes, A.6
  • 54
    • 57049127294 scopus 로고    scopus 로고
    • Dystrophic neurites in TgCRND8 and Tg2576 mice mimic human pathological brain aging
    • (in press). 18 October 2007 [Epub ahead of print]
    • Woodhouse A, Vickers JC, Adlard PA, Dickson TC (2007) Dystrophic neurites in TgCRND8 and Tg2576 mice mimic human pathological brain aging. Neurobiol Aging (in press). 18 October 2007 [Epub ahead of print]
    • (2007) Neurobiol Aging
    • Woodhouse, A.1    Vickers, J.C.2    Adlard, P.A.3    DicksonT., C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.