메뉴 건너뛰기




Volumn 45, Issue 2, 2012, Pages 314-326

The role of clusterin in Alzheimer's disease: Pathways, pathogenesis, and therapy

Author keywords

Alzheimer's disease; Amyloid ; Clusterin; Genetics; Pathogenesis; Therapy

Indexed keywords

AMYLOID BETA PROTEIN; CLUSTERIN; CLUSTERIN PEPTIDE; UNCLASSIFIED DRUG;

EID: 84862777328     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-012-8237-1     Document Type: Review
Times cited : (137)

References (104)
  • 1
    • 33845892752 scopus 로고    scopus 로고
    • Systematic meta-analyses of Alzheimer disease genetic association studies: The AlzGene database
    • Bertram L et al (2007) Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet 39:17-23
    • (2007) Nat Genet , vol.39 , pp. 17-23
    • Bertram, L.1
  • 2
    • 77954510398 scopus 로고    scopus 로고
    • Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease
    • Thambisetty M et al (2010) Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry 67:739-748
    • (2010) Arch Gen Psychiatry , vol.67 , pp. 739-748
    • Thambisetty, M.1
  • 3
    • 79953747266 scopus 로고    scopus 로고
    • Plasma clusterin and the risk of Alzheimer disease
    • Schrijvers EM et al (2011) Plasma clusterin and the risk of Alzheimer disease. JAMA 305:1322-1326
    • (2011) JAMA , vol.305 , pp. 1322-1326
    • Schrijvers, E.M.1
  • 4
    • 73949094931 scopus 로고    scopus 로고
    • Chapter 2: Clusterin (CLU): From one gene and two transcripts to many proteins
    • Rizzi F et al (2009) Chapter 2: clusterin (CLU): from one gene and two transcripts to many proteins. Adv Cancer Res 104:9-23
    • (2009) Adv Cancer Res , vol.104 , pp. 9-23
    • Rizzi, F.1
  • 5
    • 0025301469 scopus 로고
    • Apolipoprotein J: Structure and tissue distribution
    • de Silva HV et al (1990) Apolipoprotein J: structure and tissue distribution. Biochemistry 29:5380-5389
    • (1990) Biochemistry , vol.29 , pp. 5380-5389
    • De Silva, H.V.1
  • 7
    • 70349557788 scopus 로고    scopus 로고
    • Clusterin: A forgotten player in Alzheimer's disease
    • Nuutinen T et al (2009) Clusterin: a forgotten player in Alzheimer's disease. Brain Res Rev 61:89-104
    • (2009) Brain Res Rev , vol.61 , pp. 89-104
    • Nuutinen, T.1
  • 8
    • 7744226396 scopus 로고    scopus 로고
    • Immunolocalization of cubilin, megalin, apolipoprotein J, and apolipoprotein A-I in the uterus and oviduct
    • Argraves WS, Morales CR (2004) Immunolocalization of cubilin, megalin, apolipoprotein J, and apolipoprotein A-I in the uterus and oviduct. Mol Reprod Dev 69:419-427
    • (2004) Mol Reprod Dev , vol.69 , pp. 419-427
    • Argraves, W.S.1    Morales, C.R.2
  • 9
    • 0023657717 scopus 로고
    • Biosynthesis and molecular cloning of sulfated glycoprotein 2 secreted by rat Sertoli cells
    • Collard MW, Griswold MD (1987) Biosynthesis and molecular cloning of sulfated glycoprotein 2 secreted by rat Sertoli cells. Biochemistry 26:3297-3303
    • (1987) Biochemistry , vol.26 , pp. 3297-3303
    • Collard, M.W.1    Griswold, M.D.2
  • 10
    • 67349127527 scopus 로고    scopus 로고
    • Meta-analysis of linkage studies for Alzheimer's disease - A web resource
    • Butler AW et al (2009) Meta-analysis of linkage studies for Alzheimer's disease - a web resource. Neurobiol Aging 30:1037-1047
    • (2009) Neurobiol Aging , vol.30 , pp. 1037-1047
    • Butler, A.W.1
  • 11
    • 70349558522 scopus 로고    scopus 로고
    • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease
    • Harold D et al (2009) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nat Genet 41:1088-1093
    • (2009) Nat Genet , vol.41 , pp. 1088-1093
    • Harold, D.1
  • 12
    • 78549264026 scopus 로고    scopus 로고
    • Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
    • Lambert JC et al (2009) Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat Genet 41:1094-1099
    • (2009) Nat Genet , vol.41 , pp. 1094-1099
    • Lambert, J.C.1
  • 13
    • 77952307991 scopus 로고    scopus 로고
    • Genome-wide analysis of genetic loci associated with Alzheimer disease
    • Seshadri S et al (2010) Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 303:1832-1840
    • (2010) JAMA , vol.303 , pp. 1832-1840
    • Seshadri, S.1
  • 14
    • 79955464911 scopus 로고    scopus 로고
    • Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
    • Naj AC et al (2011) Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet 43:436-441
    • (2011) Nat Genet , vol.43 , pp. 436-441
    • Naj, A.C.1
  • 15
    • 79951499355 scopus 로고    scopus 로고
    • The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels
    • Schjeide BM et al (2011) The role of clusterin, complement receptor 1, and phosphatidylinositol binding clathrin assembly protein in Alzheimer disease risk and cerebrospinal fluid biomarker levels. Arch Gen Psychiatry 68:207-213
    • (2011) Arch Gen Psychiatry , vol.68 , pp. 207-213
    • Schjeide, B.M.1
  • 16
    • 77955036445 scopus 로고    scopus 로고
    • Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals
    • Corneveaux JJ et al (2010) Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Hum Mol Genet 19:3295-3301
    • (2010) Hum Mol Genet , vol.19 , pp. 3295-3301
    • Corneveaux, J.J.1
  • 17
    • 79952592605 scopus 로고    scopus 로고
    • Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals
    • Lee JH et al (2009) Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals. Arch Neurol 68:320-328
    • (2009) Arch Neurol , vol.68 , pp. 320-328
    • Lee, J.H.1
  • 18
    • 77955463899 scopus 로고    scopus 로고
    • Replication of CLU, CR1, and PICALM associations with Alzheimer disease
    • Carrasquillo MM et al (2010) Replication of CLU, CR1, and PICALM associations with Alzheimer disease. Arch Neurol 67:961-964
    • (2010) Arch Neurol , vol.67 , pp. 961-964
    • Carrasquillo, M.M.1
  • 19
    • 84855801442 scopus 로고    scopus 로고
    • Association of CLU and PICALM variants with Alzheimer's disease
    • Kamboh MI et al (2010) Association of CLU and PICALM variants with Alzheimer's disease. Neurobiol Aging 33:518-521
    • (2010) Neurobiol Aging , vol.33 , pp. 518-521
    • Kamboh, M.I.1
  • 20
    • 77955049825 scopus 로고    scopus 로고
    • Implication of CLU gene polymorphisms in Chinese patients with Alzheimer's disease
    • Yu JT et al (2010) Implication of CLU gene polymorphisms in Chinese patients with Alzheimer's disease. Clin Chim Acta 411:1516-1519
    • (2010) Clin Chim Acta , vol.411 , pp. 1516-1519
    • Yu, J.T.1
  • 21
    • 77957909886 scopus 로고    scopus 로고
    • Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer disease risk loci and reveals interactions with APOE genotypes
    • Jun G et al (2010) Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer disease risk loci and reveals interactions with APOE genotypes. Arch Neurol 67:1473-1484
    • (2010) Arch Neurol , vol.67 , pp. 1473-1484
    • Jun, G.1
  • 22
    • 79952256613 scopus 로고    scopus 로고
    • Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE
    • Wijsman EM et al (2011) Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE. PLoS Genet 7:e1001308
    • (2011) PLoS Genet , vol.7
    • Wijsman, E.M.1
  • 23
    • 77949784437 scopus 로고    scopus 로고
    • Genetic variability in CLU and its association with Alzheimer's disease
    • Guerreiro RJ et al (2010) Genetic variability in CLU and its association with Alzheimer's disease. PLoS One 5:e9510
    • (2010) PLoS One , vol.5
    • Guerreiro, R.J.1
  • 24
    • 79960363619 scopus 로고    scopus 로고
    • Alzheimer's risk variants in the Clusterin gene are associated with alternative splicing
    • Szymanski M et al (2011) Alzheimer's risk variants in the Clusterin gene are associated with alternative splicing. Transl Psychiatr 1:e18
    • (2011) Transl Psychiatr , vol.1
    • Szymanski, M.1
  • 25
    • 79960826290 scopus 로고    scopus 로고
    • Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration
    • Schürmann B et al (2011) Association of the Alzheimer's disease clusterin risk allele with plasma clusterin concentration. J Alzheimers Dis 25:421-424
    • (2011) J Alzheimers Dis , vol.25 , pp. 421-424
    • Schürmann, B.1
  • 26
    • 84859396133 scopus 로고    scopus 로고
    • Blood clusterin levels, rs9331888 polymorphism, and the risk of Alzheimer's disease
    • doi:10.3233/JAD-2011-111844
    • Xing YY et al (2012) Blood clusterin levels, rs9331888 polymorphism, and the risk of Alzheimer's disease. J Alzheimers Dis. doi:10.3233/JAD-2011-111844
    • J Alzheimers Dis , vol.2012
    • Xing, Y.Y.1
  • 27
    • 9144224765 scopus 로고    scopus 로고
    • ApoE and clusterin cooperatively suppress Abeta levels and deposition: Evidence that ApoE regulates extracellular Abeta metabolism in vivo
    • DeMattos RB et al (2004) ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo. Neuron 41:193-202
    • (2004) Neuron , vol.41 , pp. 193-202
    • DeMattos, R.B.1
  • 28
    • 78651372043 scopus 로고    scopus 로고
    • Proteome-based plasma markers of brain amyloid-β deposition in non-demented older individuals
    • Thambisetty M et al (2010) Proteome-based plasma markers of brain amyloid-β deposition in non-demented older individuals. J Alzheimers Dis 22:1099-1109
    • (2010) J Alzheimers Dis , vol.22 , pp. 1099-1109
    • Thambisetty, M.1
  • 29
    • 77950866465 scopus 로고    scopus 로고
    • Epigenetic regulation in the pathophysiology of Alzheimer's disease
    • Chouliaras L et al (2010) Epigenetic regulation in the pathophysiology of Alzheimer's disease. Prog Neurobiol 90:498-510
    • (2010) Prog Neurobiol , vol.90 , pp. 498-510
    • Chouliaras, L.1
  • 30
    • 33645578890 scopus 로고    scopus 로고
    • Up-regulation of the clusterin gene after proteotoxic stress: Implication of HSF1-HSF2 heterocomplexes
    • Loison F et al (2006) Up-regulation of the clusterin gene after proteotoxic stress: implication of HSF1-HSF2 heterocomplexes. Biochem J 395:223-231
    • (2006) Biochem J , vol.395 , pp. 223-231
    • Loison, F.1
  • 31
    • 50549086305 scopus 로고    scopus 로고
    • Clusterin is epigenetically regulated in prostate cancer
    • Rauhala HE et al (2008) Clusterin is epigenetically regulated in prostate cancer. Int J Cancer 123:1601-1609
    • (2008) Int J Cancer , vol.123 , pp. 1601-1609
    • Rauhala, H.E.1
  • 32
    • 26444444252 scopus 로고    scopus 로고
    • Induction of clusterin/apoJ expression by histone deacetylase inhibitors in neural cells
    • Nuutinen T et al (2005) Induction of clusterin/apoJ expression by histone deacetylase inhibitors in neural cells. Neurochem Int 47:528-538
    • (2005) Neurochem Int , vol.47 , pp. 528-538
    • Nuutinen, T.1
  • 33
    • 34247118445 scopus 로고    scopus 로고
    • Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells
    • Suuronen T et al (2007) Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells. Biochem Biophys Res Commun 357:397-401
    • (2007) Biochem Biophys Res Commun , vol.357 , pp. 397-401
    • Suuronen, T.1
  • 34
    • 34249323034 scopus 로고    scopus 로고
    • Identification of epigenetically silenced genes in tumor endothelial cells
    • Hellebrekers et al (2007) Identification of epigenetically silenced genes in tumor endothelial cells. Cancer Res 67:4138-4148
    • (2007) Cancer Res , vol.67 , pp. 4138-4148
    • Hellebrekers1
  • 35
    • 68149100569 scopus 로고    scopus 로고
    • The role of epigenetics in aging and age-related diseases
    • Calvanese Vet al (2009) The role of epigenetics in aging and age-related diseases. Ageing Res Rev 8:268-276
    • (2009) Ageing Res Rev , vol.8 , pp. 268-276
    • Calvanese, V.1
  • 36
    • 49949108971 scopus 로고    scopus 로고
    • Age-specific epigenetic drift in late-onset Alzheimer's disease
    • Wang SC et al (2008) Age-specific epigenetic drift in late-onset Alzheimer's disease. PLoS One 3:e2698
    • (2008) PLoS One , vol.3
    • Wang, S.C.1
  • 37
    • 40749117651 scopus 로고    scopus 로고
    • The environment, epigenetics and amyloidogenesis
    • Wu J et al (2008) The environment, epigenetics and amyloidogenesis. J Mol Neurosci 34:1-7
    • (2008) J Mol Neurosci , vol.34 , pp. 1-7
    • Wu, J.1
  • 38
    • 70350018325 scopus 로고    scopus 로고
    • Multiple roles of HDAC inhibition in neurodegenerative conditions
    • Chuang DM et al (2009) Multiple roles of HDAC inhibition in neurodegenerative conditions. Trends Neurosci 32:591-601
    • (2009) Trends Neurosci , vol.32 , pp. 591-601
    • Chuang, D.M.1
  • 39
    • 67649310030 scopus 로고    scopus 로고
    • Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease
    • Francis YI et al (2009) Dysregulation of histone acetylation in the APP/PS1 mouse model of Alzheimer's disease. J Alzheimers Dis 18:131-139
    • (2009) J Alzheimers Dis , vol.18 , pp. 131-139
    • Francis, Y.I.1
  • 40
    • 67650090545 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Potential in cancer therapy
    • Marks PA, Xu WS (2009) Histone deacetylase inhibitors: potential in cancer therapy. J Cell Biochem 107:600-608
    • (2009) J Cell Biochem , vol.107 , pp. 600-608
    • Marks, P.A.1    Xu, W.S.2
  • 41
    • 0025642562 scopus 로고
    • Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat
    • May PC et al (1990) Dynamics of gene expression for a hippocampal glycoprotein elevated in Alzheimer's disease and in response to experimental lesions in rat. Neuron 5:831-839
    • (1990) Neuron , vol.5 , pp. 831-839
    • May, P.C.1
  • 42
    • 0032411158 scopus 로고    scopus 로고
    • Clusterin (apolipoprotein J) protein levels are increased in hippocampus and in frontal cortex in Alzheimer's disease
    • Lidström AM et al (1998) Clusterin (apolipoprotein J) protein levels are increased in hippocampus and in frontal cortex in Alzheimer's disease. Exp Neurol 154:511-521
    • (1998) Exp Neurol , vol.154 , pp. 511-521
    • Lidström, A.M.1
  • 43
    • 2642684569 scopus 로고    scopus 로고
    • Possible neuroprotective role of clusterin in Alzheimer's disease: A quantitative immunocytochemical study
    • Giannakopoulos P et al (1998) Possible neuroprotective role of clusterin in Alzheimer's disease: a quantitative immunocytochemical study. Acta Neuropathol 95:387-394
    • (1998) Acta Neuropathol , vol.95 , pp. 387-394
    • Giannakopoulos, P.1
  • 44
    • 0029119753 scopus 로고
    • Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease
    • Bertrand P et al (1995) Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease. Brain Res Mol Brain Res 33:174-178
    • (1995) Brain Res Mol Brain Res , vol.33 , pp. 174-178
    • Bertrand, P.1
  • 45
    • 0030001328 scopus 로고    scopus 로고
    • Brain expression of apolipoproteins E, J, and A-I in Alzheimer's disease
    • Harr SD et al (1996) Brain expression of apolipoproteins E, J, and A-I in Alzheimer's disease. J Neurochem 66:2429-2435
    • (1996) J Neurochem , vol.66 , pp. 2429-2435
    • Harr, S.D.1
  • 46
    • 0036756538 scopus 로고    scopus 로고
    • Predominant apolipoprotein J exists as lipid-poor mixtures in cerebrospinal fluid
    • Suzuki T et al (2002) Predominant apolipoprotein J exists as lipid-poor mixtures in cerebrospinal fluid. Ann Clin Lab Sci 32:369-376
    • (2002) Ann Clin Lab Sci , vol.32 , pp. 369-376
    • Suzuki, T.1
  • 47
    • 33646492644 scopus 로고    scopus 로고
    • Clusterin in cerebrospinal fluid: Analysis of carbohydrates and quantification of native and glycosylated forms
    • Nilselid AM et al (2006) Clusterin in cerebrospinal fluid: analysis of carbohydrates and quantification of native and glycosylated forms. Neurochem Int 48:718-728
    • (2006) Neurochem Int , vol.48 , pp. 718-728
    • Nilselid, A.M.1
  • 48
    • 0027186334 scopus 로고
    • The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex
    • Ghiso J et al (1993) The cerebrospinal-fluid soluble form of Alzheimer's amyloid beta is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex. Biochem J 293:27-30
    • (1993) Biochem J , vol.293 , pp. 27-30
    • Ghiso, J.1
  • 49
    • 44549087658 scopus 로고    scopus 로고
    • Structural and quantitative comparison of cerebrospinal fluid glycoproteins in Alzheimer's disease patients and healthy individuals
    • Sihlbom C et al (2008) Structural and quantitative comparison of cerebrospinal fluid glycoproteins in Alzheimer's disease patients and healthy individuals. Neurochem Res 33:1332-1340
    • (2008) Neurochem Res , vol.33 , pp. 1332-1340
    • Sihlbom, C.1
  • 50
    • 80054107095 scopus 로고    scopus 로고
    • Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment
    • Thambisetty M et al (2012) Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment. NeuroImage 59:212-217
    • (2012) NeuroImage , vol.59 , pp. 212-217
    • Thambisetty, M.1
  • 51
    • 79953695980 scopus 로고    scopus 로고
    • Serum clusterin levels are not increased in presymptomatic Alzheimer's disease
    • IJsselstijn L et al (2011) Serum clusterin levels are not increased in presymptomatic Alzheimer's disease. J Proteome Res 10:2006-2010
    • (2011) J Proteome Res , vol.10 , pp. 2006-2010
    • IJsselstijn, L.1
  • 52
    • 0036829661 scopus 로고    scopus 로고
    • Clusterin/apolipoprotein J in human aging and cancer
    • Trougakos IP, Gonos ES (2002) Clusterin/apolipoprotein J in human aging and cancer. Int J Biochem Cell Biol 34:1430-1448
    • (2002) Int J Biochem Cell Biol , vol.34 , pp. 1430-1448
    • Trougakos, I.P.1    Gonos, E.S.2
  • 53
    • 0030014990 scopus 로고    scopus 로고
    • Apolipoprotein J and Alzheimer's amyloid beta solubility
    • Matsubara E et al (1996) Apolipoprotein J and Alzheimer's amyloid beta solubility. Biochem J 316:671-679
    • (1996) Biochem J , vol.316 , pp. 671-679
    • Matsubara, E.1
  • 54
    • 34547823043 scopus 로고    scopus 로고
    • The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures
    • Yerbury JJ et al (2007) The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures. FASEB J 21:2312-2322
    • (2007) FASEB J , vol.21 , pp. 2312-2322
    • Yerbury, J.J.1
  • 55
    • 0028828044 scopus 로고
    • Clusterin (apoJ) alters the aggregation of amyloid beta-peptide (A beta 1-42) and forms slowly sedimenting A beta complexes that cause oxidative stress
    • Oda T et al (1995) Clusterin (apoJ) alters the aggregation of amyloid beta-peptide (A beta 1-42) and forms slowly sedimenting A beta complexes that cause oxidative stress. Exp Neurol 136:22-31
    • (1995) Exp Neurol , vol.136 , pp. 22-31
    • Oda, T.1
  • 56
    • 11544279355 scopus 로고    scopus 로고
    • Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins
    • Lambert MP et al (1998) Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proc Natl Acad Sci U S A 95:6448-6453
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 6448-6453
    • Lambert, M.P.1
  • 57
    • 84855450514 scopus 로고    scopus 로고
    • The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide
    • Narayan P et al (2011) The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β(1-40) peptide. Nat Struct Mol Biol 19:79-83
    • (2011) Nat Struct Mol Biol , vol.19 , pp. 79-83
    • Narayan, P.1
  • 58
    • 0036678856 scopus 로고    scopus 로고
    • Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease
    • DeMattos RB et al (2002) Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 99:10843-10848
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 10843-10848
    • DeMattos, R.B.1
  • 59
    • 33748753481 scopus 로고    scopus 로고
    • Clearance of amyloid-beta in Alzheimer's disease: Progress, problems and perspectives
    • Wang YJ et al (2006) Clearance of amyloid-beta in Alzheimer's disease: progress, problems and perspectives. Drug Discov Today 11:931-938
    • (2006) Drug Discov Today , vol.11 , pp. 931-938
    • Wang, Y.J.1
  • 60
    • 0141529993 scopus 로고    scopus 로고
    • In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life
    • Cirrito JR et al (2003) In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life. J Neurosci 23:8844-8853
    • (2003) J Neurosci , vol.23 , pp. 8844-8853
    • Cirrito, J.R.1
  • 61
    • 33745920161 scopus 로고    scopus 로고
    • Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo
    • Bateman RJ et al (2006) Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo. Nat Med 12:856-861
    • (2006) Nat Med , vol.12 , pp. 856-861
    • Bateman, R.J.1
  • 62
    • 67349270965 scopus 로고    scopus 로고
    • Apolipoprotein E and its receptors in Alzheimer's disease: Pathways, pathogenesis and therapy
    • Bu G (2009) Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy. Nat Rev Neurosci 10:333-344
    • (2009) Nat Rev Neurosci , vol.10 , pp. 333-344
    • Bu, G.1
  • 63
    • 34247506244 scopus 로고    scopus 로고
    • Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system
    • Bell RD et al (2007) Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system. J Cereb Blood Flow Metab 27:909-918
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 909-918
    • Bell, R.D.1
  • 64
    • 34248181862 scopus 로고    scopus 로고
    • Role of ischemic blood-brain barrier on amyloid plaques development in Alzheimer's disease brain
    • Pluta R (2007) Role of ischemic blood-brain barrier on amyloid plaques development in Alzheimer's disease brain. Curr Neurovasc Res 4:121-129
    • (2007) Curr Neurovasc Res , vol.4 , pp. 121-129
    • Pluta, R.1
  • 65
    • 0029920929 scopus 로고    scopus 로고
    • Glycoprotein 330/megalin: Probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers
    • Zlokovic BV et al (1996) Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers. Proc Natl Acad Sci USA 93:4229-4234
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4229-4234
    • Zlokovic, B.V.1
  • 66
    • 0034663183 scopus 로고    scopus 로고
    • Apolipoprotein J (clusterin) and Alzheimer's disease
    • Calero M et al (2000) Apolipoprotein J (clusterin) and Alzheimer's disease. Microsc Res Tech 50:305-315
    • (2000) Microsc Res Tech , vol.50 , pp. 305-315
    • Calero, M.1
  • 67
    • 0030753654 scopus 로고    scopus 로고
    • Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide
    • Hammad SM et al (1997) Interaction of apolipoprotein J-amyloid beta-peptide complex with low density lipoprotein receptor-related protein-2/megalin. A mechanism to prevent pathological accumulation of amyloid beta-peptide. J Biol Chem 272:18644-18649
    • (1997) J Biol Chem , vol.272 , pp. 18644-18649
    • Hammad, S.M.1
  • 68
    • 0034721849 scopus 로고    scopus 로고
    • Apolipoprotein e receptors mediate the effects of beta-amyloid on astrocyte cultures
    • LaDu MJ et al (2000) Apolipoprotein E receptors mediate the effects of beta-amyloid on astrocyte cultures. J Biol Chem 275:33974-33980
    • (2000) J Biol Chem , vol.275 , pp. 33974-33980
    • LaDu, M.J.1
  • 69
    • 33846592417 scopus 로고    scopus 로고
    • Amyloid-beta 1-42 induced endocytosis and clusterin/apoJ protein accumulation in cultured human astrocytes
    • Nuutinen T et al (2007) Amyloid-beta 1-42 induced endocytosis and clusterin/apoJ protein accumulation in cultured human astrocytes. Neurochem Int 50:540-547
    • (2007) Neurochem Int , vol.50 , pp. 540-547
    • Nuutinen, T.1
  • 70
    • 0033452142 scopus 로고    scopus 로고
    • Functional and structural properties of lipid-associated apolipoprotein J (clusterin)
    • Calero M et al (1999) Functional and structural properties of lipid-associated apolipoprotein J (clusterin). Biochem J 344:375-383
    • (1999) Biochem J , vol.344 , pp. 375-383
    • Calero, M.1
  • 71
    • 0031976656 scopus 로고    scopus 로고
    • Distribution and synthesis of apolipoprotein J in the atherosclerotic aorta
    • Ishikawa Yet al (1998) Distribution and synthesis of apolipoprotein J in the atherosclerotic aorta. Arterioscler Thromb Vasc Biol 18:665-672
    • (1998) Arterioscler Thromb Vasc Biol , vol.18 , pp. 665-672
    • Ishikawa, Y.1
  • 72
    • 0032055127 scopus 로고    scopus 로고
    • Apolipoprotein J (clusterin) induces cholesterol export from macrophage-foam cells: A potential anti-atherogenic function?
    • Gelissen IC et al (1998) Apolipoprotein J (clusterin) induces cholesterol export from macrophage-foam cells: a potential anti-atherogenic function? Biochem J 331:231-237
    • (1998) Biochem J , vol.331 , pp. 231-237
    • Gelissen, I.C.1
  • 73
    • 21044454051 scopus 로고    scopus 로고
    • Insertion/deletion polymorphism in clusterin gene influences serum lipid levels and carotid intima-media thickness in hypertensive Japanese females
    • Miwa Yet al (2005) Insertion/deletion polymorphism in clusterin gene influences serum lipid levels and carotid intima-media thickness in hypertensive Japanese females. Biochem Biophys Res Commun 331:1587-1593
    • (2005) Biochem Biophys Res Commun , vol.331 , pp. 1587-1593
    • Miwa, Y.1
  • 74
    • 70450219539 scopus 로고    scopus 로고
    • Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease
    • Martins IJ et al (2009) Cholesterol metabolism and transport in the pathogenesis of Alzheimer's disease. J Neurochem 111:1275-1308
    • (2009) J Neurochem , vol.111 , pp. 1275-1308
    • Martins, I.J.1
  • 75
    • 61349088546 scopus 로고    scopus 로고
    • Inflammation in Alzheimer's disease: Amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors
    • Salminen A et al (2009) Inflammation in Alzheimer's disease: amyloid-beta oligomers trigger innate immunity defence via pattern recognition receptors. Prog Neurobiol 87:181-194
    • (2009) Prog Neurobiol , vol.87 , pp. 181-194
    • Salminen, A.1
  • 76
    • 84861183285 scopus 로고    scopus 로고
    • Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease
    • doi:10.1016/j.neurobiolaging.2011.01.007
    • Ferretti MT et al (2011) Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease. Neurobiol Aging. doi:10.1016/j.neurobiolaging.2011.01.007
    • (2011) Neurobiol Aging
    • Ferretti, M.T.1
  • 77
    • 0035936004 scopus 로고    scopus 로고
    • Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease
    • in t' Veld BA et al (2001) Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N Engl J Med 345:1515-1521
    • (2001) N Engl J Med , vol.345 , pp. 1515-1521
    • In T Veld, B.A.1
  • 78
    • 72849109858 scopus 로고    scopus 로고
    • NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease
    • Varvel NH et al (2009) NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. J Clin Invest 119:3692-3702
    • (2009) J Clin Invest , vol.119 , pp. 3692-3702
    • Varvel, N.H.1
  • 79
    • 11444256801 scopus 로고    scopus 로고
    • Glia and their cytokines in progression of neurodegeneration
    • Mrak RE, Griffin WS (2005) Glia and their cytokines in progression of neurodegeneration. Neurobiol Aging 26:349-354
    • (2005) Neurobiol Aging , vol.26 , pp. 349-354
    • Mrak, R.E.1    Griffin, W.S.2
  • 80
    • 18844379354 scopus 로고    scopus 로고
    • Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro
    • Xie Z et al (2005) Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro. J Neurochem 93:1038-1046
    • (2005) J Neurochem , vol.93 , pp. 1038-1046
    • Xie, Z.1
  • 81
    • 73949151645 scopus 로고    scopus 로고
    • Chapter 8: Clusterin: A multifacet protein at the crossroad of inflammation and autoimmunity
    • Falgarone G, Chiocchia G (2009) Chapter 8: clusterin: a multifacet protein at the crossroad of inflammation and autoimmunity. Adv Cancer Res 104:139-170
    • (2009) Adv Cancer Res , vol.104 , pp. 139-170
    • Falgarone, G.1    Chiocchia, G.2
  • 82
    • 0034141470 scopus 로고    scopus 로고
    • Laminar shear stress upregulates the complement-inhibitory protein clusterin: A novel potent defense mechanism against complement-induced endothelial cell activation
    • Urbich C et al (2000) Laminar shear stress upregulates the complement-inhibitory protein clusterin: a novel potent defense mechanism against complement-induced endothelial cell activation. Circulation 101:352-355
    • (2000) Circulation , vol.101 , pp. 352-355
    • Urbich, C.1
  • 83
    • 0026518542 scopus 로고
    • SP-40,40, a protein involved in the control of the complement pathway, possesses a unique array of disulphide bridges
    • Kirszbaum L et al (1992) SP-40,40, a protein involved in the control of the complement pathway, possesses a unique array of disulphide bridges. FEBS Lett 297:70-76
    • (1992) FEBS Lett , vol.297 , pp. 70-76
    • Kirszbaum, L.1
  • 84
    • 77951188881 scopus 로고    scopus 로고
    • Identification of clusterin domain involved in NF-kappaB pathway regulation
    • Essabbani A et al (2010) Identification of clusterin domain involved in NF-kappaB pathway regulation. J Biol Chem 285:4273-4277
    • (2010) J Biol Chem , vol.285 , pp. 4273-4277
    • Essabbani, A.1
  • 85
    • 39349113582 scopus 로고    scopus 로고
    • Inhibition of NF-kappaB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis
    • Takase O et al (2008) Inhibition of NF-kappaB-dependent Bcl-xL expression by clusterin promotes albumin-induced tubular cell apoptosis. Kidney 73:567-577
    • (2008) Kidney , vol.73 , pp. 567-577
    • Takase, O.1
  • 86
    • 18844379354 scopus 로고    scopus 로고
    • Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro
    • Frautschy SA et al (2005) Apolipoprotein J (clusterin) activates rodent microglia in vivo and in vitro. J Neurochem 93:1038-1046
    • (2005) J Neurochem , vol.93 , pp. 1038-1046
    • Frautschy, S.A.1
  • 87
    • 0030685797 scopus 로고    scopus 로고
    • Regulation of clusterin gene expression by transforming growth factor β
    • Jin G, Howe PH (1997) Regulation of clusterin gene expression by transforming growth factor β. J Biol Chem 272:26620-26626
    • (1997) J Biol Chem , vol.272 , pp. 26620-26626
    • Jin, G.1    Howe, P.H.2
  • 88
    • 0141643351 scopus 로고    scopus 로고
    • Essential requirement of apolipoprotein J (clusterin) signaling for IkappaB expression and regulation of NF-kappaB activity
    • Santilli G et al (2003) Essential requirement of apolipoprotein J (clusterin) signaling for IkappaB expression and regulation of NF-kappaB activity. J Biol Chem 278:38214-38219
    • (2003) J Biol Chem , vol.278 , pp. 38214-38219
    • Santilli, G.1
  • 89
    • 37549041733 scopus 로고    scopus 로고
    • Clusterin, a novel modulator of TGF-beta signaling, is involved in Smad2/3 stability
    • Lee KB et al (2008) Clusterin, a novel modulator of TGF-beta signaling, is involved in Smad2/3 stability. Biochem Biophys Res Commun 366:905-909
    • (2008) Biochem Biophys Res Commun , vol.366 , pp. 905-909
    • Lee, K.B.1
  • 90
    • 0028946364 scopus 로고
    • Clusterin expression by astrocytes is influenced by transforming growth factor beta 1 and heterotypic cell interactions
    • Morgan TE et al (1995) Clusterin expression by astrocytes is influenced by transforming growth factor beta 1 and heterotypic cell interactions. J Neuroimmunol 58:101-110
    • (1995) J Neuroimmunol , vol.58 , pp. 101-110
    • Morgan, T.E.1
  • 91
    • 33751301109 scopus 로고    scopus 로고
    • Clusterin and DNA repair: A new function in cancer for a key player in apoptosis and cell cycle control
    • Shannan B et al (2006) Clusterin and DNA repair: a new function in cancer for a key player in apoptosis and cell cycle control. J Mol Histol 37:183-188
    • (2006) J Mol Histol , vol.37 , pp. 183-188
    • Shannan, B.1
  • 92
    • 35948985487 scopus 로고    scopus 로고
    • Clusterin isoforms differentially affect growth and motility of prostate cells: Possible implications in prostate tumorigenesis
    • Moretti RM et al (2007) Clusterin isoforms differentially affect growth and motility of prostate cells: possible implications in prostate tumorigenesis. Cancer Res 67:10325-10333
    • (2007) Cancer Res , vol.67 , pp. 10325-10333
    • Moretti, R.M.1
  • 93
    • 1842589298 scopus 로고    scopus 로고
    • Modulation of different clusterin isoforms in human colon tumorigenesis
    • Pucci S et al (2004) Modulation of different clusterin isoforms in human colon tumorigenesis. Oncogene 23:2298-2304
    • (2004) Oncogene , vol.23 , pp. 2298-2304
    • Pucci, S.1
  • 94
    • 0037142616 scopus 로고    scopus 로고
    • Clusterin (SGP-2) transient overexpression decreases proliferation rate of SV40-immortalized human prostate epithelial cells by slowing down cell cycle progression
    • Bettuzzi S et al (2002) Clusterin (SGP-2) transient overexpression decreases proliferation rate of SV40-immortalized human prostate epithelial cells by slowing down cell cycle progression. Oncogene 21:4328-4334
    • (2002) Oncogene , vol.21 , pp. 4328-4334
    • Bettuzzi, S.1
  • 95
    • 0042912014 scopus 로고    scopus 로고
    • Overexpression of the cytoprotective protein clusterin decreases radiosensitivity in the human LNCaP prostate tumour model
    • Zellweger T et al (2003) Overexpression of the cytoprotective protein clusterin decreases radiosensitivity in the human LNCaP prostate tumour model. BJU Int 92:463-469
    • (2003) BJU Int , vol.92 , pp. 463-469
    • Zellweger, T.1
  • 96
    • 33947177730 scopus 로고    scopus 로고
    • Linking cell-cycle dysfunction in Alzheimer's disease to a failure of synaptic plasticity
    • Arendt T, Bruckner MK (2007) Linking cell-cycle dysfunction in Alzheimer's disease to a failure of synaptic plasticity. Biochim Biophys Acta 1772:413-421
    • (2007) Biochim Biophys Acta , vol.1772 , pp. 413-421
    • Arendt, T.1    Bruckner, M.K.2
  • 97
    • 84855320950 scopus 로고    scopus 로고
    • CLU in Alzheimer's disease
    • Wu ZC et al (2012) CLU in Alzheimer's disease. Adv Clin Chem 56:155-165
    • (2012) Adv Clin Chem , vol.56 , pp. 155-165
    • Wu, Z.C.1
  • 98
    • 79955754364 scopus 로고    scopus 로고
    • Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults
    • Braskie MN et al (2011) Common Alzheimer's disease risk variant within the CLU gene affects white matter microstructure in young adults. J Neurosci 31:6764-6770
    • (2011) J Neurosci , vol.31 , pp. 6764-6770
    • Braskie, M.N.1
  • 99
    • 80052755526 scopus 로고    scopus 로고
    • Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin gene
    • Lancaster TM et al (2011) Neural hyperactivation in carriers of the Alzheimer's risk variant on the clusterin gene. Eur Neuropsychopharmacol 21:880-884
    • (2011) Eur Neuropsychopharmacol , vol.21 , pp. 880-884
    • Lancaster, T.M.1
  • 100
    • 79952899509 scopus 로고    scopus 로고
    • Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old
    • Mengel-From J et al (2011) Genetic variations in the CLU and PICALM genes are associated with cognitive function in the oldest old. Neurobiol Aging 32:554.e7-554.e11
    • (2011) Neurobiol Aging , vol.32
    • Mengel-From, J.1
  • 101
    • 35448992437 scopus 로고    scopus 로고
    • Beneficial effects of r-h-CLU on disease severity in different animal models of peripheral neuropathies
    • Dati G et al (2007) Beneficial effects of r-h-CLU on disease severity in different animal models of peripheral neuropathies. J Neuroimmunol 190:8-17
    • (2007) J Neuroimmunol , vol.190 , pp. 8-17
    • Dati, G.1
  • 102
    • 24144439279 scopus 로고    scopus 로고
    • An oral apoJ peptide renders HDL anti-inflammatory in mice and monkeys and dramatically reduces atherosclerosis in apolipoprotein E-null mice
    • Navab M et al (2005) An oral apoJ peptide renders HDL anti-inflammatory in mice and monkeys and dramatically reduces atherosclerosis in apolipoprotein E-null mice. Arterioscler Thromb Vasc Biol 25:1932-1937
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1932-1937
    • Navab, M.1
  • 103
    • 75149138378 scopus 로고    scopus 로고
    • The pursuit of susceptibility genes for Alzheimer's disease: Progress and prospects
    • Sleegers K et al (2010) The pursuit of susceptibility genes for Alzheimer's disease: progress and prospects. Trends Genet 26:84-93
    • (2010) Trends Genet , vol.26 , pp. 84-93
    • Sleegers, K.1
  • 104
    • 77952888035 scopus 로고    scopus 로고
    • Valproic acid stimulates clusterin expression in human astrocytes: Implications for Alzheimer's disease
    • Nuutinen Tet al (2010)Valproic acid stimulates clusterin expression in human astrocytes: implications for Alzheimer's disease. Neurosci Lett 475:64-68
    • (2010) Neurosci Lett , vol.475 , pp. 64-68
    • Nuutinen, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.