-
1
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
DOI 10.1126/science.1072994
-
Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356. (Pubitemid 34790756)
-
(2002)
Science
, vol.297
, Issue.5580
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
3
-
-
59849110667
-
List of drugs in development for neurodegenerative diseases. Update June 2008
-
Pogacic V, Herrling P (2009) List of drugs in development for neurodegenerative diseases. Update June 2008. Neurodegener Dis 6, 37-86.
-
(2009)
Neurodegener Dis
, vol.6
, pp. 37-86
-
-
Pogacic, V.1
Herrling, P.2
-
4
-
-
77949408552
-
Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB
-
Resnick SM, Sojkova J, Zhou Y, An Y, Ye W, Holt DP, Dannals RF, Mathis CA, Klunk WE, Ferrucci L, Kraut MA, Wong DF. Longitudinal cognitive decline is associated with fibrillar amyloid-beta measured by [11C]PiB. Neurology 74, 807-815
-
Neurology
, vol.74
, pp. 807-815
-
-
Resnick, S.M.1
Sojkova, J.2
Zhou, Y.3
An, Y.4
Ye, W.5
Holt, D.P.6
Dannals, R.F.7
Mathis, C.A.8
Klunk, W.E.9
Ferrucci, L.10
Kraut, M.A.11
Wong, D.F.12
-
5
-
-
73549106106
-
Cognitive decline and brain volume loss as signatures of cere-bralamyloid-beta peptide depositionidentified with Pittsburgh compound B: Cognitive decline associated with Abeta deposition
-
Storandt M, Mintun MA, Head D, Morris JC (2009) Cognitive decline and brain volume loss as signatures of cere-bralamyloid-beta peptide depositionidentified with Pittsburgh compound B: cognitive decline associated with Abeta deposition. Arch Neurol 66, 1476-1481.
-
(2009)
Arch Neurol
, vol.66
, pp. 1476-1481
-
-
Storandt, M.1
Mintun, M.A.2
Head, D.3
Morris, J.C.4
-
6
-
-
34447326955
-
Amyloid imaging in Alzheimer's disease
-
DOI 10.1097/WCO.0b013e3281a47744, PII 0001905220070800000005
-
Nordberg A (2007) Amyloid imaging in Alzheimer's disease. Curr Opin Neurol 20, 398-402. (Pubitemid 47051985)
-
(2007)
Current Opinion in Neurology
, vol.20
, Issue.4
, pp. 398-402
-
-
Nordberg, A.1
-
7
-
-
0035691112
-
CSF total tau, Aβ42 and phosphorylated tau protein as biomarkers for Alzheimer's disease
-
Blennow K, Vanmechelen E, Hampel H (2001) CSF total tau, Abeta42 and phosphorylated tau protein as biomarkers for Alzheimer's disease. Mol Neurobiol 24, 87-97. (Pubitemid 34066679)
-
(2001)
Molecular Neurobiology
, vol.24
, Issue.1-3
, pp. 87-97
-
-
Blennow, K.1
Vanmechelen, E.2
Hampel, H.3
-
8
-
-
0037514257
-
1-42 and Increased Tau Levels in Cerebrospinal Fluid of Patients with Alzheimer Disease
-
DOI 10.1001/jama.289.16.2094
-
Sunderland T, Linker G, Mirza N, Putnam KT, Friedman DL, Kimmel LH, Bergeson J, Manetti GJ, Zimmermann M, Tang B, Bartko JJ, Cohen RM (2003) Decreased beta-amyloid1-42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease. JAMA 289, 2094-2103. (Pubitemid 37430211)
-
(2003)
Journal of the American Medical Association
, vol.289
, Issue.16
, pp. 2094-2103
-
-
Sunderland, T.1
Linker, G.2
Mirza, N.3
Putnam, K.T.4
Friedman, D.L.5
Kimmel, L.H.6
Bergeson, J.7
Manetti, G.J.8
Zimmermann, M.9
Tang, B.10
Bartko, J.J.11
Cohen, R.M.12
-
9
-
-
70349499185
-
Plasma biomarkers for mild cognitive impairment and Alzheimer's disease
-
Song F, Poljak A, Smythe GA, Sachdev P (2009) Plasma biomarkers for mild cognitive impairment and Alzheimer's disease. Brain Res Rev 61, 69-80.
-
(2009)
Brain Res Rev
, vol.61
, pp. 69-80
-
-
Song, F.1
Poljak, A.2
Smythe, G.A.3
Sachdev, P.4
-
10
-
-
73249130406
-
Toward an Alzheimer's disease diagnosis via high-resolution blood gene expression
-
Fehlbaum-Beurdeley P, Jarrige-Le Prado AC, Pallares D, Carriere J, Guihal C, Soucaille C,Rouet F, Drouin D, Sol O, Jordan H, Wu D, Lei L, Einstein R, Schweighoffer F, Bracco L (2010) Toward an Alzheimer's disease diagnosis via high-resolution blood gene expression. Alzheimers Dement 6, 25-38.
-
(2010)
Alzheimers Dement
, vol.6
, pp. 25-38
-
-
Fehlbaum-Beurdeley, P.1
Jarrige-Le Prado, A.C.2
Pallares, D.3
Carriere, J.4
Guihal, C.5
Soucaille, C.6
Rouet, F.7
Drouin, D.8
Sol, O.9
Jordan, H.10
Wu, D.11
Lei, L.12
Einstein, R.13
Schweighoffer, F.14
Bracco, L.15
-
11
-
-
72149095179
-
Blood-based biomarkers of microvascular pathology in Alzheimer's disease
-
Ewers M, Mielke MM, Hampel H (2010) Blood-based biomarkers of microvascular pathology in Alzheimer's disease. Exp Gerontol 45, 75-79.
-
(2010)
Exp Gerontol
, vol.45
, pp. 75-79
-
-
Ewers, M.1
Mielke, M.M.2
Hampel, H.3
-
12
-
-
35948933394
-
Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins
-
DOI 10.1038/nm1653, PII NM1653
-
Ray S, Britschgi M, Herbert C, Takeda-Uchimura Y, Boxer A, Blennow K, Friedman LF, Galasko DR, Jutel M, Karydas A, Kaye JA, Leszek J, Miller BL, Minthon L,Quinn JF, Rabinovi-ci GD, Robinson WH, Sabbagh MN,SoYT, Sparks DL, Taba-ton M, Tinklenberg J, Yesavage JA, Tibshirani R, Wyss-Coray T (2007) Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Nat Med 13, 1359-1362. (Pubitemid 350073592)
-
(2007)
Nature Medicine
, vol.13
, Issue.11
, pp. 1359-1362
-
-
Ray, S.1
Britschgi, M.2
Herbert, C.3
Takeda-Uchimura, Y.4
Boxer, A.5
Blennow, K.6
Friedman, L.F.7
Galasko, D.R.8
Jutel, M.9
Karydas, A.10
Kaye, J.A.11
Leszek, J.12
Miller, B.L.13
Minthon, L.14
Quinn, J.F.15
Rabinovici, G.D.16
Robinson, W.H.17
Sabbagh, M.N.18
So, Y.T.19
Sparks, D.L.20
Tabaton, M.21
Tinklenberg, J.22
Yesavage, J.A.23
Tibshirani, R.24
Wyss-Coray, T.25
more..
-
13
-
-
70449434560
-
Biological marker candidates of Alzheimer's disease in blood, plasma, and serum
-
Schneider P, Hampel H, Buerger K (2009) Biological marker candidates of Alzheimer's disease in blood, plasma, and serum. CNS Neurosci Ther 15, 358-374.
-
(2009)
CNS Neurosci Ther
, vol.15
, pp. 358-374
-
-
Schneider, P.1
Hampel, H.2
Buerger, K.3
-
14
-
-
58549087156
-
Proteome-based identification of plasma proteins associated with hippocampal metabolism in early Alzheimer's disease
-
Thambisetty M, Hye A, Foy C, Daly E, Glover A, Cooper A, Simmons A, Murphy D, Lovestone S (2008) Proteome-based identification of plasma proteins associated with hippocampal metabolism in early Alzheimer's disease. J Neurol 255, 1712-1720.
-
(2008)
J Neurol
, vol.255
, pp. 1712-1720
-
-
Thambisetty, M.1
Hye, A.2
Foy, C.3
Daly, E.4
Glover, A.5
Cooper, A.6
Simmons, A.7
Murphy, D.8
Lovestone, S.9
-
15
-
-
77954510398
-
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease
-
Thambisetty M, Simmons A, Velayudhan L, Hye A, Campbell J, Zhang Y, Wahlund LO, Westman E, Kinsey A, Guntert A, Proitsi P, Powell J, Causevic M, Killick R, Lunnon K, Lyn-ham S, Broadstock M, Choudhry F, Howlett DR, Williams RJ, Sharp SI, Mitchelmore C, Tunnard C,Leung R, Foy C, O'Brien D, Breen G, Furney SJ, Ward M, Kloszewska I, Mecocci P, Soininen H, Tsolaki M, Vellas B, Hodges A, Murphy DG, Parkins S, Richardson JC, Resnick SM, Ferrucci L, Wong DF, Zhou Y, Muehlboeck S, Evans A, Francis PT, Spenger C, Lovestone S. Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease. Arch Gen Psychiatry 67, 739-748.
-
Arch Gen Psychiatry
, vol.67
, pp. 739-748
-
-
Thambisetty, M.1
Simmons, A.2
Velayudhan, L.3
Hye, A.4
Campbell, J.5
Zhang, Y.6
Wahlund, L.O.7
Westman, E.8
Kinsey, A.9
Guntert, A.10
Proitsi, P.11
Powell, J.12
Causevic, M.13
Killick, R.14
Lunnon, K.15
Lyn-Ham, S.16
Broadstock, M.17
Choudhry, F.18
Howlett, D.R.19
Williams, R.J.20
Sharp, S.I.21
Mitchelmore, C.22
Tunnard Cleung, R.23
Foy, C.24
O'Brien, D.25
Breen, G.26
Furney, S.J.27
Ward, M.28
Kloszewska, I.29
Mecocci, P.30
Soininen, H.31
Tsolaki, M.32
Vellas, B.33
Hodges, A.34
Murphy, D.G.35
Parkins, S.36
Richardson, J.C.37
Resnick, S.M.38
Ferrucci, L.39
Wong, D.F.40
Zhou, Y.41
Muehlboeck, S.42
Evans, A.43
Francis, P.T.44
Spenger, C.45
Lovestone, S.46
more..
-
16
-
-
0034108966
-
One-year age changes in MRI brain volumes in older adults
-
Resnick SM, Goldszal AF, Davatzikos C, Golski S, Kraut MA, Metter EJ, Bryan RN, Zonderman AB (2000) One-year age changes in MRI brain volumes in older adults. Cereb Cortex 10, 464-472. (Pubitemid 30318453)
-
(2000)
Cerebral Cortex
, vol.10
, Issue.5
, pp. 464-472
-
-
Resnick, S.M.1
Goldszal, A.F.2
Davatzikos, C.3
Golski, S.4
Kraut, M.A.5
Metter, E.J.6
Bryan, R.N.7
Zonderman, A.B.8
-
17
-
-
33750596715
-
Proteome-based plasma biomarkers for Alzheimer's disease
-
DOI 10.1093/brain/awl279
-
Hye A, Lynham S, Thambisetty M, Causevic M, Campbell J, Byers HL, Hooper C, Rijsdijk F, Tabrizi SJ, Banner S, Shaw CE, Foy C, Poppe M, Archer N, Hamilton G, Powell J, Brown RG, Sham P, Ward M, Lovestone S (2006) Proteome-based plasma biomarkers for Alzheimer's disease. Brain 129, 3042-3050. (Pubitemid 44684524)
-
(2006)
Brain
, vol.129
, Issue.11
, pp. 3042-3050
-
-
Hye, A.1
Lynham, S.2
Thambisetty, M.3
Causevic, M.4
Campbell, J.5
Byers, H.L.6
Hooper, C.7
Rijsdijk, F.8
Tabrizi, S.J.9
Banner, S.10
Shaw, C.E.11
Foy, C.12
Poppe, M.13
Archer, N.14
Hamilton, G.15
Powell, J.16
Brown, R.G.17
Sham, P.18
Ward, M.19
Lovestone, S.20
more..
-
18
-
-
0025257612
-
Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI
-
Hixson JE, Vernier DT (1990) Restriction isotyping of human apolipoprotein E by gene amplification and cleavage with HhaI. J Lipid Res 31, 545-548. (Pubitemid 20107994)
-
(1990)
Journal of Lipid Research
, vol.31
, Issue.3
, pp. 545-548
-
-
Hixson, J.E.1
Vernier, D.T.2
-
19
-
-
11144325691
-
Partial least-squares regression: A tutorial
-
Geladi P, Kowalski BR (1986) Partial least-squares regression: a tutorial. Analytica Chimica Acta 185, 1-17.
-
(1986)
Analytica Chimica Acta
, vol.185
, pp. 1-17
-
-
Geladi, P.1
Kowalski, B.R.2
-
20
-
-
51349166667
-
Longitudinal cerebral blood flow and amyloid deposition: An emerging pattern?
-
Sojkova J, Beason-Held L, Zhou Y, An Y, Kraut MA, Ye W, Ferrucci L, Mathis CA, Klunk WE, Wong DF, Resnick SM (2008) Longitudinal cerebral blood flow and amyloid deposition: an emerging pattern? J Nucl Med 49, 1465-1471.
-
(2008)
J Nucl Med
, vol.49
, pp. 1465-1471
-
-
Sojkova, J.1
Beason-Held, L.2
Zhou, Y.3
An, Y.4
Kraut, M.A.5
Ye, W.6
Ferrucci, L.7
Mathis, C.A.8
Klunk, W.E.9
Wong, D.F.10
Resnick, S.M.11
-
21
-
-
27544513056
-
Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B
-
DOI 10.1038/sj.jcbfm.9600146, PII 9600146
-
Price JC, Klunk WE, Lopresti BJ, Lu X, Hoge JA, Ziolko SK, Holt DP, Meltzer CC, DeKosky ST, Mathis CA (2005) Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B. J Cereb Blood Flow Metab 25, 1528-1547. (Pubitemid 41541962)
-
(2005)
Journal of Cerebral Blood Flow and Metabolism
, vol.25
, Issue.11
, pp. 1528-1547
-
-
Price, J.C.1
Klunk, W.E.2
Lopresti, B.J.3
Lu, X.4
Hoge, J.A.5
Ziolko, S.K.6
Holt, D.P.7
Meltzer, C.C.8
DeKosky, S.T.9
Mathis, C.A.10
-
22
-
-
34248185525
-
11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease
-
DOI 10.1016/j.neuroimage.2007.03.004, PII S1053811907001814
-
Zhou Y, Resnick SM, Ye W, Fan H, Holt DP, Klunk WE, Mathis CA, Dannals R, WongDF (2007) Usinga reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease. Neuroimage 36, 298-312. (Pubitemid 46710457)
-
(2007)
NeuroImage
, vol.36
, Issue.2
, pp. 298-312
-
-
Zhou, Y.1
Resnick, S.M.2
Ye, W.3
Fan, H.4
Holt, D.P.5
Klunk, W.E.6
Mathis, C.A.7
Dannals, R.8
Wong, D.F.9
-
23
-
-
0041669248
-
An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets
-
DOI 10.1016/S1053-8119(03)00169-1
-
Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH (2003) An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. Neuroimage 19, 1233-1239. (Pubitemid 36918259)
-
(2003)
NeuroImage
, vol.19
, Issue.3
, pp. 1233-1239
-
-
Maldjian, J.A.1
Laurienti, P.J.2
Kraft, R.A.3
Burdette, J.H.4
-
24
-
-
70449435231
-
Identifying early markers of Alzheimer's disease using quantitative multiplex proteomic immunoassay panels
-
Soares HD, Chen Y, Sabbagh M, Rohrer A, Schrijvers E, Breteler M (2009) Identifying early markers of Alzheimer's disease using quantitative multiplex proteomic immunoassay panels. Ann N Y Acad Sci 1180, 56-67.
-
(2009)
Ann N y Acad Sci
, vol.1180
, pp. 56-67
-
-
Soares, H.D.1
Chen, Y.2
Sabbagh, M.3
Rohrer, A.4
Schrijvers, E.5
Breteler, M.6
-
25
-
-
34047272692
-
A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease
-
Coon KD, Myers AJ, CraigDW, Webster JA, Pearson JV, Lince DH, Zismann VL, Beach TG, Leung D, Bryden L, Halperin RF, Marlowe L, Kaleem M, Walker DG, Ravid R, Heward CB, Rogers J, Papassotiropoulos A, Reiman EM, Hardy J, Stephan DA (2007) A high-density whole-genome association study reveals that APOEis the major susceptibility gene for sporadic late-onset Alzheimer's disease. J Clin Psychiatry 68, 613-618. (Pubitemid 46663046)
-
(2007)
Journal of Clinical Psychiatry
, vol.68
, Issue.4
, pp. 613-618
-
-
Coon, K.D.1
Myers, A.J.2
Craig, D.W.3
Webster, J.A.4
Pearson, J.V.5
Lince, D.H.6
Zismann, V.L.7
Beach, T.G.8
Leung, D.9
Bryden, L.10
Halperin, R.F.11
Marlowe, L.12
Kaleem, M.13
Walker, D.G.14
Ravid, R.15
Heward, C.B.16
Rogers, J.17
Papassotiropoulos, A.18
Reiman, E.M.19
Hardy, J.20
Stephan, D.A.21
more..
-
26
-
-
68249134074
-
The role of apolipoprotein e in Alzheimer's disease
-
Kim J, Basak JM, Holtzman DM (2009) The role of apolipoprotein E in Alzheimer's disease. Neuron 63, 287-303.
-
(2009)
Neuron
, vol.63
, pp. 287-303
-
-
Kim, J.1
Basak, J.M.2
Holtzman, D.M.3
-
27
-
-
34248579291
-
Imaging β-amyloid burden in aging and dementia
-
DOI 10.1212/01.wnl.0000261919.22630.ea, PII 0000611420070515000012
-
Rowe CC, Ng S, Ackermann U, Gong SJ, Pike K, Savage G, Cowie TF, Dickinson KL, Maruff P, Darby D, Smith C, Woodward M, Merory J, Tochon-Danguy H, O'Keefe G, Klunk WE, Mathis CA, Price JC, Masters CL, Villemagne VL (2007) Imaging beta-amyloid burden in aging and dementia. Neurology 68, 1718-1725. (Pubitemid 46763260)
-
(2007)
Neurology
, vol.68
, Issue.20
, pp. 1718-1725
-
-
Rowe, C.C.1
Ng, S.2
Ackermann, U.3
Gong, S.J.4
Pike, K.5
Savage, G.6
Cowie, T.F.7
Dickinson, K.L.8
Maruff, P.9
Darby, D.10
Smith, C.11
Woodward, M.12
Merory, J.13
Tochon-Danguy, H.14
O'Keefe, G.15
Klunk, W.E.16
Mathis, C.A.17
Price, J.C.18
Masters, C.L.19
Villemagne, V.L.20
more..
-
28
-
-
0035853154
-
Declining brain activity in cognitively normal apolipoprotein E ε4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent alzheimer's disease
-
DOI 10.1073/pnas.061509598
-
Reiman EM, Caselli RJ, Chen K, Alexander GE, Bandy D, Frost J (2001) Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease. Proc Natl Acad Sci U S A 98, 3334-3339. (Pubitemid 32220846)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.6
, pp. 3334-3339
-
-
Reiman, E.M.1
Caselli, R.J.2
Chen, K.3
Alexander, G.E.4
Bandy, D.5
Frost, J.6
-
29
-
-
12944259210
-
Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease
-
DOI 10.1073/pnas.090106797
-
Small GW, Ercoli LM, Silverman DH, Huang SC, Komo S, Bookheimer SY, Lavretsky H, Miller K, Siddarth P, Rasgon NL, Mazziotta JC, Saxena S, Wu HM, Mega MS, Cummings JL, Saunders AM, Pericak-Vance MA, Roses AD, Barrio JR, Phelps ME (2000) Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease. Proc Natl Acad Sci U S A 97, 6037-6042. (Pubitemid 30367519)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.11
, pp. 6037-6042
-
-
Small, G.W.1
Ercoli, L.M.2
Silverman, D.H.S.3
Huang, S.-C.4
Komo, S.5
Bookheimer, S.Y.6
Lavretsky, H.7
Miller, K.8
Siddarth, P.9
Rasgon, N.L.10
Mazziotta, J.C.11
Saxena, S.12
Wu, H.M.13
Mega, M.S.14
Cummings, J.L.15
Saunders, A.M.16
Pericak-Vance, M.A.17
Roses, A.D.18
Barrio, J.R.19
Phelps, M.E.20
more..
-
30
-
-
58149395966
-
Medial temporal lobe atrophy on MRI scans and the diagnosis of Alzheimer disease
-
DuaraR,Loewenstein DA, Potter E, Appel J, Greig MT, Urs R, Shen Q, Raj A, Small B, Barker W, Schofield E, Wu Y, Potter H (2008) Medial temporal lobe atrophy on MRI scans and the diagnosis of Alzheimer disease. Neurology 71, 1986-1992.
-
(2008)
Neurology
, vol.71
, pp. 1986-1992
-
-
Duararloewenstein, D.A.1
Potter, E.2
Appel, J.3
Greig, M.T.4
Urs, R.5
Shen, Q.6
Raj, A.7
Small, B.8
Barker, W.9
Schofield, E.10
Wu, Y.11
Potter, H.12
-
31
-
-
4544244613
-
Research issues and strategies for genomic and proteomic biomarker discovery and validation: A statistical perspective
-
DOI 10.1517/14622416.5.6.709
-
Feng Z, Prentice R, Srivastava S (2004) Research issues and strategies for genomic and proteomic biomarker discovery and validation: a statistical perspective. Pharmacogenomics 5, 709-719. (Pubitemid 39236584)
-
(2004)
Pharmacogenomics
, vol.5
, Issue.6
, pp. 709-719
-
-
Feng, Z.1
Prentice, R.2
Srivastava, S.3
-
32
-
-
77649314191
-
APOE predicts amyloid-beta but not tau alzheimer's pathology in cognitively normal aging
-
Morris JC, Roe CM, Xiong C, Fagan AM, Goate AM, Holtzman DM, Mintun MA (2010) APOE predicts amyloid-beta but not tau alzheimer's pathology in cognitively normal aging. Ann Neurol 67, 122-131.
-
(2010)
Ann Neurol
, vol.67
, pp. 122-131
-
-
Morris, J.C.1
Roe, C.M.2
Xiong, C.3
Fagan, A.M.4
Goate, A.M.5
Holtzman, D.M.6
Mintun, M.A.7
-
33
-
-
66149084048
-
Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease
-
Reiman EM, Chen K, Liu X, Bandy D, Yu M, Lee W, Ayutyanont N, Keppler J, Reeder SA, Langbaum JB, Alexander GE, Klunk WE, Mathis CA, Price JC, Aizenstein HJ, DeKosky ST, Caselli RJ (2009) Fibrillar amyloid-beta burden in cognitively normal people at 3 levels of genetic risk for Alzheimer's disease. Proc Natl Acad Sci U S A 106, 6820-6825.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 6820-6825
-
-
Reiman, E.M.1
Chen, K.2
Liu, X.3
Bandy, D.4
Yu, M.5
Lee, W.6
Ayutyanont, N.7
Keppler, J.8
Reeder, S.A.9
Langbaum, J.B.10
Alexander, G.E.11
Klunk, W.E.12
Mathis, C.A.13
Price, J.C.14
Aizenstein, H.J.15
Dekosky, S.T.16
Caselli, R.J.17
-
34
-
-
0029042862
-
Identification of fast and slow decliners in Alzheimer disease: A different approach
-
Brooks JO, 3rd, Yesavage JA (1995) Identification of fast and slow decliners in Alzheimer disease: a different approach. Alzheimer Dis Assoc Disord 9 Suppl 1, S19-25.
-
(1995)
Alzheimer Dis Assoc Disord
, vol.9
, Issue.SUPPL. 1
-
-
Brooks III, J.O.1
Yesavage, J.A.2
-
35
-
-
66249141245
-
Age, neuropathology, and dementia
-
Savva GM, Wharton SB, Ince PG, Forster G, Matthews FE, Brayne C (2009) Age, neuropathology, and dementia. N Engl J Med 360, 2302-2309.
-
(2009)
N Engl J Med
, vol.360
, pp. 2302-2309
-
-
Savva, G.M.1
Wharton, S.B.2
Ince, P.G.3
Forster, G.4
Matthews, F.E.5
Brayne, C.6
-
36
-
-
4143138471
-
In vivo effects of ApoE and clusterin on amyloid-beta metabolism and neuropathology
-
Holtzman DM (2004) In vivo effects of ApoE and clusterin on amyloid-beta metabolism and neuropathology. J Mol Neurosci 23, 247-254.
-
(2004)
J Mol Neurosci
, vol.23
, pp. 247-254
-
-
Holtzman, D.M.1
-
37
-
-
77449126153
-
Extracellular chaperones modulate the effects of Alzheimer's patient cerebrospinal fluid on Abeta(1-42) toxicity and uptake
-
Yerbury JJ, Wilson MR (2010) Extracellular chaperones modulate the effects of Alzheimer's patient cerebrospinal fluid on Abeta(1-42) toxicity and uptake. Cell Stress Chaperones 15, 115-121.
-
(2010)
Cell Stress Chaperones
, vol.15
, pp. 115-121
-
-
Yerbury, J.J.1
Wilson, M.R.2
-
38
-
-
63249134826
-
Alpha2-Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species
-
Yerbury JJ, Kumita JR, Meehan S, Dobson CM, Wilson MR (2009) alpha2-Macroglobulin and haptoglobin suppress amyloid formation by interacting with prefibrillar protein species. J Biol Chem 284, 4246-4254.
-
(2009)
J Biol Chem
, vol.284
, pp. 4246-4254
-
-
Yerbury, J.J.1
Kumita, J.R.2
Meehan, S.3
Dobson, C.M.4
Wilson, M.R.5
-
39
-
-
47249142795
-
Enhanced clearance of Aβ in brain by sustaining the plasmin proteolysis cascade
-
DOI 10.1073/pnas.0710823105
-
Jacobsen JS, Comery TA, Martone RL, Elokdah H, Crandall DL, Oganesian A, Aschmies S, Kirksey Y, Gonzales C, Xu J, ZhouH,Atchison K,Wagner E,Zaleska MM, Das I,Arias RL, Bard J, Riddell D, Gardell SJ, Abou-Gharbia M, Robichaud A, Magolda R, Vlasuk GP, Bjornsson T, Reinhart PH, Pangalos MN (2008) Enhanced clearanceofAbetain brainbysustaining the plasmin proteolysis cascade. Proc Natl Acad Sci U S A 105, 8754-8759. (Pubitemid 351987752)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.25
, pp. 8754-8759
-
-
Jacobsen, J.S.1
Comery, T.A.2
Martone, R.L.3
Elokdah, H.4
Crandall, D.L.5
Oganesian, A.6
Aschmies, S.7
Kirksey, Y.8
Gonzales, C.9
Xu, J.10
Zhou, H.11
Atchison, K.12
Wagner, E.13
Zaleska, M.M.14
Das, I.15
Arias, R.L.16
Bard, J.17
Riddell, D.18
Gardell, S.J.19
Abou-Gharbia, M.20
Robichaud, A.21
Magolda, R.22
Vlasuk, G.P.23
Bjornsson, T.24
Reinhart, P.H.25
Pangalos, M.N.26
more..
-
40
-
-
16844363404
-
Tissue plasminogen activator in central nervous system physiology and pathology
-
DOI 10.1160/TH04-12-0838
-
Melchor JP, Strickland S (2005) Tissue plasminogen activator in central nervous system physiology and pathology. Thromb Haemost 93, 655-660. (Pubitemid 40485400)
-
(2005)
Thrombosis and Haemostasis
, vol.93
, Issue.4
, pp. 655-660
-
-
Melchor, J.P.1
Strickland, S.2
-
41
-
-
70349336014
-
Parental history of Alzheimer disease associated with lower plasma apolipoprotein e levels
-
van Vliet P, Westendorp RG, Eikelenboom P, Comijs HC, Frolich M, Bakker E, van der Flier W, van Exel E (2009) Parental history of Alzheimer disease associated with lower plasma apolipoprotein E levels. Neurology 73, 681-687.
-
(2009)
Neurology
, vol.73
, pp. 681-687
-
-
Van Vliet, P.1
Westendorp, R.G.2
Eikelenboom, P.3
Comijs, H.C.4
Frolich, M.5
Bakker, E.6
Van Der Flier, W.7
Van Exel, E.8
-
43
-
-
0033835758
-
Apolipoprotein e polymorphism and serum concentration in Alzheimer's disease in nine European centres: The ApoEurope study ApoEurope group
-
Siest G, Bertrand P, Qin B, Herbeth B, Serot JM, Masana L, Ribalta J, Passmore AP, Evans A, Ferrari M, Franceschi M, Shepherd J, Cuchel M, Beisiegel U, Zuchowsky K, Rukavina AS, Sertic J, Stojanov M, Kostic V, Mitrevski A, Petrova V, Sass C, Merched A, Salonen JT, Tiret L, Visvikis S (2000) Apolipoprotein E polymorphism and serum concentration in Alzheimer's disease in nine European centres: the ApoEurope study. ApoEurope group. Clin Chem Lab Med 38, 721-730.
-
(2000)
Clin Chem Lab Med
, vol.38
, pp. 721-730
-
-
Siest, G.1
Bertrand, P.2
Qin, B.3
Herbeth, B.4
Serot, J.M.5
Masana, L.6
Ribalta, J.7
Passmore, A.P.8
Evans, A.9
Ferrari, M.10
Franceschi, M.11
Shepherd, J.12
Cuchel, M.13
Beisiegel, U.14
Zuchowsky, K.15
Rukavina, A.S.16
Sertic, J.17
Stojanov, M.18
Kostic, V.19
Mitrevski, A.20
Petrova, V.21
Sass, C.22
Merched, A.23
Salonen, J.T.24
Tiret, L.25
Visvikis, S.26
more..
-
44
-
-
0027202611
-
Polymorphisms of the apolipoprotein B and E genes and their relationship to plasma lipid variables in healthy Chinese men
-
Evans AE, Zhang W, Moreel JF, Bard JM, Ricard S, Poirier O, Tiret L, Fruchart JC, Cambien F (1993) Polymorphisms of the apolipoprotein B and E genes and their relationship to plasma lipid variables in healthy Chinese men. Hum Genet 92, 191-197. (Pubitemid 23272288)
-
(1993)
Human Genetics
, vol.92
, Issue.2
, pp. 191-197
-
-
Evans, A.E.1
Zhang, W.2
Moreel, J.F.R.3
Bard, J.M.4
Ricard, S.5
Poirier, O.6
Tiret, L.7
Fruchart, J.C.8
Cambien, F.9
-
45
-
-
69849093730
-
The effect of apoE genotype and sex on ApoE plasma concentration is determined by dietary fat in healthy subjects
-
Moreno JA, Perez-Jimenez F, Moreno-Luna R, Perez-Martinez P, Fuentes-Jimenez F, Marin C, Portugal H, Lairon D, Lopez-Miranda J (2009) The effect of apoE genotype and sex on ApoE plasma concentration is determined by dietary fat in healthy subjects. Br J Nutr 101, 1745-1752.
-
(2009)
Br J Nutr
, vol.101
, pp. 1745-1752
-
-
Moreno, J.A.1
Perez-Jimenez, F.2
Moreno-Luna, R.3
Perez-Martinez, P.4
Fuentes-Jimenez, F.5
Marin, C.6
Portugal, H.7
Lairon, D.8
Lopez-Miranda, J.9
-
46
-
-
0034100992
-
ApoE polymorphism accounts for only part of the genetic variation in quantitative ApoE levels
-
DOI 10.1002/(SICI)1098-2272(200004)18:4<331::AID-GEPI6>3.0.CO;2-V
-
Neale MC, de Knijff P, Havekes LM, Boomsma DI (2000) ApoE polymorphism accounts for only part of the genetic variation in quantitative ApoE levels. Genet Epidemiol 18, 331-340. (Pubitemid 30252592)
-
(2000)
Genetic Epidemiology
, vol.18
, Issue.4
, pp. 331-340
-
-
Neale, M.C.1
De Knijff, P.2
Havekes, L.M.3
Boomsma, D.I.4
-
47
-
-
9144224765
-
ApoE and Clusterin Cooperatively Suppress Aβ Levels and Deposition: Evidence that ApoE Regulates Extracellular Aβ Metabolism In Vivo
-
DOI 10.1016/S0896-6273(03)00850-X
-
DeMattos RB, Cirrito JR, Parsadanian M, May PC, O'Dell MA, Taylor JW, Harmony JA, Aronow BJ, Bales KR, Paul SM, Holtzman DM (2004) ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo. Neuron 41, 193-202. (Pubitemid 38125181)
-
(2004)
Neuron
, vol.41
, Issue.2
, pp. 193-202
-
-
DeMattos, R.B.1
Cirrito, J.R.2
Parsadanian, M.3
May, P.C.4
O'Dell, M.A.5
Taylor, J.W.6
Harmony, J.A.K.7
Aronow, B.J.8
Bales, K.R.9
Paul, S.M.10
Holtzman, D.M.11
-
48
-
-
0021145680
-
Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation
-
Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL (1984) Alzheimer's disease: cell-specific pathology isolates the hip-pocampal formation. Science 225, 1168-1170. (Pubitemid 14029099)
-
(1984)
Science
, vol.225
, Issue.4667
, pp. 1168-1170
-
-
Hyman, B.T.1
Van Hoesen, G.W.2
Damasio, A.R.3
Barnes, C.L.4
-
49
-
-
67549086859
-
In vivo mapping of amyloid toxicity in Alzheimer disease
-
Frisoni GB, Lorenzi M, Caroli A, Kemppainen N, Nagren K, Rinne JO (2009) In vivo mapping of amyloid toxicity in Alzheimer disease. Neurology 72, 1504-1511.
-
(2009)
Neurology
, vol.72
, pp. 1504-1511
-
-
Frisoni, G.B.1
Lorenzi, M.2
Caroli, A.3
Kemppainen, N.4
Nagren, K.5
Rinne, J.O.6
-
50
-
-
67650875899
-
Amyloid deposition is associated with impaired default network function in older persons without dementia
-
Sperling RA, Laviolette PS, O'Keefe K, O'Brien J, Rentz DM, Pihlajamaki M, Marshall G, Hyman BT, Selkoe DJ, Hedden T, Buckner RL, Becker JA, Johnson KA (2009) Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron 63, 178-188.
-
(2009)
Neuron
, vol.63
, pp. 178-188
-
-
Sperling, R.A.1
Laviolette, P.S.2
O'Keefe, K.3
O'Brien, J.4
Rentz, D.M.5
Pihlajamaki, M.6
Marshall, G.7
Hyman, B.T.8
Selkoe, D.J.9
Hedden, T.10
Buckner, R.L.11
Becker, J.A.12
Johnson, K.A.13
-
51
-
-
77951776829
-
Citron M Alzheimer's disease: Strategies for disease modification
-
Citron M Alzheimer's disease: strategies for disease modification. Nat Rev Drug Discov 9, 387-398.
-
Nat Rev Drug Discov
, vol.9
, pp. 387-398
-
-
|