The RalA GTPase is a central regulator of insulin exocytosis from pancreatic islet beta cells

Journal of Biological Chemistry

Volumn 283, Issue 26, 2008, Pages 17939-17945

  Lopez, Jamie A ^a   Kwan, Edwin P ^b   Xie, Li ^b   He, Yu ^b   James, David E ^a   Gaisano, Herbert Y ^b  

^a GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GRANULATION; HORMONES; MAMMALS; SEMICONDUCTOR SWITCHES;

BETA CELLS; BIPHASIC; CRITICAL COMPONENTS; DIRECT INTERACTIONS; EXOCYST COMPLEXES; INSULIN EXOCYTOSISES; INSULIN GRANULES; INSULIN RELEASES; INSULIN SECRETIONS; PANCREATIC BETA CELLS; PANCREATIC ISLETS; SECOND PHASES;

INSULIN;

GUANOSINE TRIPHOSPHATASE; INSULIN; RAL PROTEIN; RALA PROTEIN; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; RALA PROTEIN, HUMAN; RALA PROTEIN, MOUSE; RALA PROTEIN, RAT;

ANIMAL CELL; ARTICLE; CELL GRANULE; CONTROLLED STUDY; DEPOLARIZATION; EXOCYTOSIS; FLUORESCENCE MICROSCOPY; GENE OVEREXPRESSION; INSULIN METABOLISM; INSULIN RELEASE; INSULINOMA; LENTIVIRINAE; MALE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; APOPTOSIS; C57BL MOUSE; CYTOLOGY; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; PATCH CLAMP; PHYSIOLOGY; RAT;

MAMMALIA;

ANIMALS; APOPTOSIS; EXOCYTOSIS; GENE EXPRESSION REGULATION; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MALE; MICE; MICE, INBRED C57BL; PATCH-CLAMP TECHNIQUES; RAL GTP-BINDING PROTEINS; RATS;

EID: 49649090688     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800321200     Document Type: Article

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