A competitive nucleotide binding inhibitor: In vitro characterization of Rab7 GTPase inhibition

ACS Chemical Biology

Volumn 7, Issue 6, 2012, Pages 1095-1108

  Agola, Jacob O ^a,b   Hong, Lin ^a   Surviladze, Zurab ^a   Ursu, Oleg ^a   Waller, Anna ^a,b   Strouse, J Jacob ^a,b   Simpson, Denise S ^c   Schroeder, Chad E ^c   Oprea, Tudor I ^a   Golden, Jennifer E ^c   Aubé, Jeffrey ^c   Buranda, Tione ^a,b   Sklar, Larry A ^a,b   Wandinger Ness, Angela ^a,b  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

^c UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (BENZOYLCARBAMOTHIOYLAMINO) 5,5 DIMETHYL 4,7 DIHYDROTHIENO[2,3 C]PYRAN 3 CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; ENZYME INHIBITOR; GUANOSINE DIPHOSPHATE; MOLECULAR SCAFFOLD; RAB7 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISSOCIATION; DRUG MECHANISM; DRUG POTENCY; ENZYME INHIBITION; FLOW CYTOMETRY; HIGH THROUGHPUT SCREENING; IN VITRO STUDY; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

BINDING, COMPETITIVE; CARBOXYLIC ACIDS; ENZYME INHIBITORS; GUANOSINE TRIPHOSPHATE; HUMANS; MODELS, MOLECULAR; NUCLEOTIDES; PROTEIN BINDING; RAB GTP-BINDING PROTEINS; RECOMBINANT PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 84862549205     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb3001099     Document Type: Article

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