Synthesis, chiral high performance liquid chromatographic resolution and enantiospecific activity of a potent new geranylgeranyl transferase inhibitor, 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic Acid

Journal of Medicinal Chemistry

Volumn 53, Issue 9, 2010, Pages 3454-3464

  McKenna, Charles E ^a   Kashemirov, Boris A ^a   Błazewska, Katarzyna M ^a   Mallard Favier, Isabelle ^a   Stewart, Charlotte A ^c   Rojas, Javier ^c   Lundy, Mark W ^b   Ebetino, Frank H ^b   Baron, Rudi A ^d   Dunford, James E ^e   Kirsten, Marie L ^d   Seabra, Miguel C ^d   Bala, Joy L ^a   Marma, Mong S ^a   Rogers, Michael J ^c   Coxon, Fraser P ^c  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b PROCTER AND GAMBLE PHARMACEUTICALS   (United States)

^c UNIVERSITY OF ABERDEEN   (United Kingdom)

^d NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3 PYRIDYL) 1 HYDROXYETHYLIDENEBIS(PHOSPHONIC ACID); 2 (DIETHOXYPHOSPHORYL) 2 HYDROXY 3 IMIDAZO[1,2 A]PYRIDIN 3 YL PROPIONIC ACID ETHYL ESTER; 2 AMINO 3 IMIDAZO[1,2 A]PYRIDIN 3 YL ACRYLIC ACID ETHYL ESTER; 2 AZIDO 3 IMIDAZO[1,2 A]PYRIDIN 3 YL ACRYLIC ACID ETHYL ESTER; 2 HYDROXY 3 IMIDAZO[1,2 A]PYRIDIN 3 YL 2 PHOSPHONOPROPIONIC ACID; 2 HYDROXY 3 IMIDAZO[1,2 A]PYRIDIN 3 YL ACRYLIC ACID ETHYL ESTER; 3 (3 PYRIDYL) 2-HYDROXY 2 PHOSPHONOPROPANOIC ACID; ETHYL AZIDOACETATE; GERANYLTRANSFERASE; IMIDAZO[1,2 A]PYRIDIN 3 CARBALDEHYDE; MINODRONIC ACID; RAB PROTEIN; RISEDRONIC ACID; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; BIOLOGICAL ACTIVITY; CARBON NUCLEAR MAGNETIC RESONANCE; CELL VIABILITY; CHIRALITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENANTIOSELECTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; PROTEIN PRENYLATION; PROTON NUCLEAR MAGNETIC RESONANCE; RABBIT;

ALKYL AND ARYL TRANSFERASES; BONE DENSITY CONSERVATION AGENTS; BONE RESORPTION; CELL LINE; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; ETIDRONIC ACID; HUMANS; LACTATES; ORGANOPHOSPHORUS COMPOUNDS; OSTEOPOROSIS; PHOSPHONIC ACIDS; PROTEIN PRENYLATION; RAB GTP-BINDING PROTEINS; STEREOISOMERISM;

EID: 77952025403     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm900232u     Document Type: Article

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