-
2
-
-
0141741347
-
Parkinson's disease: Mechanisms and models
-
Dauer, W.; Przedborski, S. Parkinson's disease: mechanisms and models. Neuron, 2003, 39, 889-909.
-
(2003)
Neuron
, vol.39
, pp. 889-909
-
-
Dauer, W.1
Przedborski, S.2
-
3
-
-
36248938279
-
The pathogenesis of cell death in Parkinson's disease
-
Olanow, C.W. The pathogenesis of cell death in Parkinson's disease. Mov. Disord., 2007, 22, S335-S342.
-
(2007)
Mov. Disord
, vol.22
-
-
Olanow, C.W.1
-
4
-
-
0034329742
-
Apoptosis in neurodegenerative disorders
-
Mattson, M.P. Apoptosis in neurodegenerative disorders. Nat. Rev. Mol. Cell Biol., 2000, 1, 120-129.
-
(2000)
Nat. Rev. Mol. Cell Biol
, vol.1
, pp. 120-129
-
-
Mattson, M.P.1
-
5
-
-
79959242100
-
Mitochondrial contribution to Parkinson's disease pathogenesis
-
Schapira, A.H.; Gegg, M. Mitochondrial contribution to Parkinson's disease pathogenesis. Parkinsons Dis., 2011, 2011, 159160.
-
(2011)
Parkinsons Dis
, vol.2011
, pp. 159160
-
-
Schapira, A.H.1
Gegg, M.2
-
6
-
-
67649319285
-
Mitochondria in the etiology of Parkinson's disease
-
Schapira, A.H. Mitochondria in the etiology of Parkinson's disease. Handb. Clin. Neurol., 2007, 83, 479-491.
-
(2007)
Handb. Clin. Neurol
, vol.83
, pp. 479-491
-
-
Schapira, A.H.1
-
7
-
-
80855139395
-
Mitochondrial pathology in Parkinson's disease
-
Schapira, A.H. Mitochondrial pathology in Parkinson's disease. Mt. Sinai J. Med., 2011, 78(6), 872-881.
-
(2011)
Mt. Sinai J. Med
, vol.78
, Issue.6
, pp. 872-881
-
-
Schapira, A.H.1
-
8
-
-
34247631275
-
Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease
-
Sulzer, D. Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease. Trends Neurosci., 2007, 30, 244-250.
-
(2007)
Trends Neurosci
, vol.30
, pp. 244-250
-
-
Sulzer, D.1
-
9
-
-
57649155208
-
Oxidative stress in Parkinson's disease: A mechanism of pathogenic and therapeutic significance
-
Zhou, C.; Huang, Y.; Przedborski, S. Oxidative stress in Parkinson's disease: a mechanism of pathogenic and therapeutic significance. Ann. NY Acad. Sci., 2008, 1147, 93-104.
-
(2008)
Ann. NY Acad. Sci
, vol.1147
, pp. 93-104
-
-
Zhou, C.1
Huang, Y.2
Przedborski, S.3
-
10
-
-
77956228435
-
Novel cell death signaling pathways in neurotoxicity models of dopaminergic degeneration: Relevance to oxidative stress and neuroinflammation in Parkinson's disease
-
Kanthasamy, A.; Jin, H.; Mehrotra, S.; Mishra, R.; Kanthasamy, A.; Rana, A. Novel cell death signaling pathways in neurotoxicity models of dopaminergic degeneration: relevance to oxidative stress and neuroinflammation in Parkinson's disease. Neurotoxicology, 2010, 31(5), 555-561.
-
(2010)
Neurotoxicology
, vol.31
, Issue.5
, pp. 555-561
-
-
Kanthasamy, A.1
Jin, H.2
Mehrotra, S.3
Mishra, R.4
Kanthasamy, A.5
Rana, A.6
-
11
-
-
77956216928
-
Reactive oxygen species: Stuck in the middle of neurodegeneration
-
Patten, D.A.; Germain, M.; Kelly, M.A.; Slack, R.S. Reactive oxygen species: stuck in the middle of neurodegeneration. J. Alzheimers Dis., 2010, 20(Suppl 2), S357-S367.
-
(2010)
J. Alzheimers Dis
, vol.20
, Issue.SUPPL. 2
-
-
Patten, D.A.1
Germain, M.2
Kelly, M.A.3
Slack, R.S.4
-
12
-
-
63849244747
-
Increased oxidation of certain glycolysis and energy metabolism enzymes in the frontal cortex in Lewy body diseases
-
Gómez, A.; Ferrer, I. Increased oxidation of certain glycolysis and energy metabolism enzymes in the frontal cortex in Lewy body diseases. J. Neurosci. Res., 2009, 87(4), 1002-1013.
-
(2009)
J. Neurosci. Res
, vol.87
, Issue.4
, pp. 1002-1013
-
-
Gómez, A.1
Ferrer, I.2
-
13
-
-
0032710609
-
Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease
-
Liberatore, G.T.; Jackson-Lewis, V.; Vukosavic, S.; Mandir, A.S.; Vila, M.; McAuliffe, W.G.; Dawson, V.L.; Dawson, T.M.; Przedborski, S. Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease. Nat. Med., 1999, 5, 1354-1355.
-
(1999)
Nat. Med
, vol.5
, pp. 1354-1355
-
-
Liberatore, G.T.1
Jackson-Lewis, V.2
Vukosavic, S.3
Mandir, A.S.4
Vila, M.5
McAuliffe, W.G.6
Dawson, V.L.7
Dawson, T.M.8
Przedborski, S.9
-
14
-
-
0035144650
-
Oxidative post-translational modifications of alpha-synuclein in the 1- methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease
-
Przedborski, S.; Chen, Q.; Vila, M.; Giasson, B.I.; Djaldatti, R.; Vukosavic, S.; Souza, J.M.; Jackson-Lewis, V.; Lee, V.M.; Ischiropoulos, H. Oxidative post-translational modifications of alpha-synuclein in the 1- methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease. J. Neurochem., 2001, 76, 637-640.
-
(2001)
J. Neurochem
, vol.76
, pp. 637-640
-
-
Przedborski, S.1
Chen, Q.2
Vila, M.3
Giasson, B.I.4
Djaldatti, R.5
Vukosavic, S.6
Souza, J.M.7
Jackson-Lewis, V.8
Lee, V.M.9
Ischiropoulos, H.10
-
15
-
-
0037378026
-
Oxidative Stress in Parkinson's Disease
-
Jenner, P. Oxidative Stress in Parkinson's Disease. Ann. Neurol., 2003, 53(Suppl 3), S26-S38.
-
(2003)
Ann. Neurol
, vol.53
, Issue.SUPPL. 3
-
-
Jenner, P.1
-
16
-
-
68149156531
-
Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: How neurons are lost in the Bermuda triangle
-
Tsika, E.; Ischiropoulos, H.; Malkus, K.A. Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle. Mol. Neurodegener., 2009, 4, 24.
-
(2009)
Mol. Neurodegener
, vol.4
, pp. 24
-
-
Tsika, E.1
Ischiropoulos, H.2
Malkus, K.A.3
-
17
-
-
19444387198
-
Free radicals and antioxidants in human health: Current status and future prospects
-
Devasagayam, T.P.; Tilak, J.C.; Boloor, K.K.; Sane, K.S.; Ghaskadbim, S.S.; Lele, R.D. Free radicals and antioxidants in human health: current status and future prospects. J. Assoc. Phys. Ind., 2004, 52, 794-804.
-
(2004)
J. Assoc. Phys. Ind
, vol.52
, pp. 794-804
-
-
Devasagayam, T.P.1
Tilak, J.C.2
Boloor, K.K.3
Sane, K.S.4
Ghaskadbim, S.S.5
Lele, R.D.6
-
18
-
-
0029053451
-
Superoxide radical and superoxide dismutases
-
Fridovitch, I. Superoxide radical and superoxide dismutases. Ann. Rev. Biochem., 1995, 64, 97-112.
-
(1995)
Ann. Rev. Biochem
, vol.64
, pp. 97-112
-
-
Fridovitch, I.1
-
19
-
-
33846863589
-
Nitric oxide and peroxynitrite in health and disease
-
Pacher, P.; Beckman, J.S.; Liaudet, S. Nitric oxide and peroxynitrite in health and disease. Physiol Rev., 2007 87, (1), 315-424.
-
(2007)
Physiol Rev
, vol.87
, Issue.1
, pp. 315-424
-
-
Pacher, P.1
Beckman, J.S.2
Liaudet, S.3
-
20
-
-
33749986298
-
Free radicals and antioxidants in normal physiological functions and human disease
-
Valko, M.; Leibfritz, D.; Moncol, J.; Cronin, M. T.D.; Mazur, M.; Telser, J. Free radicals and antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol., 2007, 39, 44-84.
-
(2007)
Int. J. Biochem. Cell Biol
, vol.39
, pp. 44-84
-
-
Valko, M.1
Leibfritz, D.2
Moncol, J.3
Cronin, M.T.D.4
Mazur, M.5
Telser, J.6
-
21
-
-
0036086130
-
Free radicals in the physiological control of cell function
-
Dröge, W. Free radicals in the physiological control of cell function. Physiol. Rev., 2002, 82, 47-95.
-
(2002)
Physiol. Rev
, vol.82
, pp. 47-95
-
-
Dröge, W.1
-
22
-
-
0034693038
-
Superoxide reacts with nitric oxide to nitrate tyrosine at physiological pH via peroxynitrite
-
Reiter, C. D.; Teng, R. J.; Beckman, J. S. Superoxide reacts with nitric oxide to nitrate tyrosine at physiological pH via peroxynitrite. J. Biol. Chem., 2000, 275(42), 32460-32466.
-
(2000)
J. Biol. Chem
, vol.275
, Issue.42
, pp. 32460-32466
-
-
Reiter, C.D.1
Teng, R.J.2
Beckman, J.S.3
-
23
-
-
11244318376
-
Resveratrol protects against peroxynitrite-induced thiol oxidation in blood platelets
-
Olas, B.; Nowak, P.; Wachowicz, B. Resveratrol protects against peroxynitrite-induced thiol oxidation in blood platelets. Cell Mol. Biol. Lett., 2004, 9(4A), 577-587.
-
(2004)
Cell Mol. Biol. Lett
, vol.9
, Issue.4 A
, pp. 577-587
-
-
Olas, B.1
Nowak, P.2
Wachowicz, B.3
-
24
-
-
0026484388
-
The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
-
Fahn, S.; Cohen, G. The oxidant stress hypothesis in Parkinson's disease: evidence supporting it. Ann. Neurol., 1992, 32, 804-812.
-
(1992)
Ann. Neurol
, vol.32
, pp. 804-812
-
-
Fahn, S.1
Cohen, G.2
-
25
-
-
0022475372
-
Lipid peroxidation as cause of nigral cell death in Parkinson's disease
-
Dexter, D.; Carter, C.; Agid, F. Lipid peroxidation as cause of nigral cell death in Parkinson's disease. Lancet, 1986, 8507, 639-640.
-
(1986)
Lancet
, vol.8507
, pp. 639-640
-
-
Dexter, D.1
Carter, C.2
Agid, F.3
-
26
-
-
34250016055
-
Apoptotic neuronal death in Parkinson's disease: Involvement of nitric oxide
-
Singh, S.; Dikshit, M. Apoptotic neuronal death in Parkinson's disease: involvement of nitric oxide. Brain Res. Rev., 2007, 54, 233-250.
-
(2007)
Brain Res. Rev
, vol.54
, pp. 233-250
-
-
Singh, S.1
Dikshit, M.2
-
27
-
-
33845932083
-
S-nitrosylation of Bcl-2 inhibits its ubiquitin-proteasomal degradation. A novel antiapoptotic mechanism that suppresses apoptosis
-
Azad, N.; Vallyathan, V.; Wang, L.; Tantishaiyakul, V.; Stehlik, C.; Leonard, S.S.; Rojanasakul, Y. S-nitrosylation of Bcl-2 inhibits its ubiquitin-proteasomal degradation. A novel antiapoptotic mechanism that suppresses apoptosis. J. Biol. Chem., 2006, 281, 34124-34134.
-
(2006)
J. Biol. Chem
, vol.281
, pp. 34124-34134
-
-
Azad, N.1
Vallyathan, V.2
Wang, L.3
Tantishaiyakul, V.4
Stehlik, C.5
Leonard, S.S.6
Rojanasakul, Y.7
-
28
-
-
79952857040
-
Regulation of neuronal oxidative and nitrosative stress by endogenous protective pathways and disease processes
-
Hardingham, G.E.; Lipton, S.A. Regulation of neuronal oxidative and nitrosative stress by endogenous protective pathways and disease processes. Antiox. Redox Signal., 2011, 14(8), 1421-1424.
-
(2011)
Antiox. Redox Signal
, vol.14
, Issue.8
, pp. 1421-1424
-
-
Hardingham, G.E.1
Lipton, S.A.2
-
29
-
-
0031577534
-
Inhibition of caspase-3 by S-nitrosation and oxidation caused by nitric oxide
-
Mohr, S.; Zech, B.; Lapetina, E.G.; Brune, B. Inhibition of caspase-3 by S-nitrosation and oxidation caused by nitric oxide. Biochem. Biophys. Res. Commun., 1997, 238, 387-391.
-
(1997)
Biochem. Biophys. Res. Commun
, vol.238
, pp. 387-391
-
-
Mohr, S.1
Zech, B.2
Lapetina, E.G.3
Brune, B.4
-
30
-
-
0030878073
-
Oxidative DNA damage in the parkinsonian brain: An apparent selective increase in 8- hydroxyguanine levels in substantia nigra
-
Alam, Z.I.; Jenner, A.; Daniel, S.E.; Lees, A.J.; Cairns, N., Marsden, C.D.; Jenner, P.; Halliwell, B. Oxidative DNA damage in the parkinsonian brain: an apparent selective increase in 8- hydroxyguanine levels in substantia nigra. J. Neurochem., 1997, 69(3), 1196-1203.
-
(1997)
J. Neurochem
, vol.69
, Issue.3
, pp. 1196-1203
-
-
Alam, Z.I.1
Jenner, A.2
Daniel, S.E.3
Lees, A.J.4
Cairns, N.5
Marsden, C.D.6
Jenner, P.7
Halliwell, B.8
-
31
-
-
34547673497
-
Peroxynitrite: Biochemistry, pathophysiology and development of therapeutics
-
Szabo, C.; Ischiropoulos, H.; Radi, R. Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nat. Rev. Drug Discov., 2007, 6, 662-680.
-
(2007)
Nat. Rev. Drug Discov
, vol.6
, pp. 662-680
-
-
Szabo, C.1
Ischiropoulos, H.2
Radi, R.3
-
33
-
-
75949120541
-
Dysfunctional mitochondria uphold calpain activation: Contribution to Parkinson's disease pathology
-
Esteves, A.R.; Arduino, D.M.; Swerdlow, R.H.; Oliveira, C.R.; Cardoso, S.M. Dysfunctional mitochondria uphold calpain activation: contribution to Parkinson's disease pathology. Neurobiol. Dis., 2010, 3, 723-730.
-
(2010)
Neurobiol. Dis
, vol.3
, pp. 723-730
-
-
Esteves, A.R.1
Arduino, D.M.2
Swerdlow, R.H.3
Oliveira, C.R.4
Cardoso, S.M.5
-
34
-
-
68649112842
-
Oxidative and nitrosative stress in Parkinson's disease
-
Tsang, A.H.K.; Chung, K.K.K. Oxidative and nitrosative stress in Parkinson's disease. Biochim. Biophys. Acta, 2009, 1792, 643-650.
-
(2009)
Biochim. Biophys. Acta
, vol.1792
, pp. 643-650
-
-
Tsang, A.H.K.1
Chung, K.K.K.2
-
35
-
-
50949117770
-
Dopaminergic neuron-specific oxidative stress caused by dopamine itself
-
Miyazaki, I.; Asanuma, M. Dopaminergic neuron-specific oxidative stress caused by dopamine itself. Acta Med. Okayama, 2008, 62(3), 141-150.
-
(2008)
Acta Med. Okayama
, vol.62
, Issue.3
, pp. 141-150
-
-
Miyazaki, I.1
Asanuma, M.2
-
36
-
-
0028834228
-
Peroxynitrite-mediated inhibition of DOPA synthesis in PC12 cells
-
Ischiropoulos, H.; Duran, D.; Horwitz, J. Peroxynitrite-mediated inhibition of DOPA synthesis in PC12 cells. J. Neurochem., 1995, 65, 2366-2372.
-
(1995)
J. Neurochem
, vol.65
, pp. 2366-2372
-
-
Ischiropoulos, H.1
Duran, D.2
Horwitz, J.3
-
37
-
-
0030250041
-
Carbon dioxide enhancement of peroxynitrite-mediated protein tyrosine nitration
-
Gow, A.; Duran, D.; Thom, S.R.; Ischiropoulos, H. Carbon dioxide enhancement of peroxynitrite-mediated protein tyrosine nitration. Arch. Biochem. Biophys., 1996, 333(1), 42-48.
-
(1996)
Arch. Biochem. Biophys
, vol.333
, Issue.1
, pp. 42-48
-
-
Gow, A.1
Duran, D.2
Thom, S.R.3
Ischiropoulos, H.4
-
38
-
-
0026034279
-
Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: An X-ray microanalysis
-
Hirsch, E.C.; Brandel, J.P.; Galle, P.; Javoy-Agid, F.; Agid, Y. Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis. J. Neurochem., 1991, 56, 446-451.
-
(1991)
J. Neurochem
, vol.56
, pp. 446-451
-
-
Hirsch, E.C.1
Brandel, J.P.2
Galle, P.3
Javoy-Agid, F.4
Agid, Y.5
-
39
-
-
78650114695
-
Mitochondrial protein tyrosine nitration
-
Castro, L.; Demicheli, V.; Tórtora, V.; Radi, R. Mitochondrial protein tyrosine nitration. Free Radic. Res., 2011, 45(1), 37-52.
-
(2011)
Free Radic. Res
, vol.45
, Issue.1
, pp. 37-52
-
-
Castro, L.1
Demicheli, V.2
Tórtora, V.3
Radi, R.4
-
40
-
-
58249093939
-
How mitochondria produce reactive oxygen species
-
Murphy, M.P. How mitochondria produce reactive oxygen species. Biochem. J., 2009, 417, 1-13.
-
(2009)
Biochem. J
, vol.417
, pp. 1-13
-
-
Murphy, M.P.1
-
41
-
-
55849122639
-
Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis
-
Henchcliffe, C.; Flint Beal, M. Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis. Nat. Clin. Prac. Neurol., 2008, 4, 600-609.
-
(2008)
Nat. Clin. Prac. Neurol
, vol.4
, pp. 600-609
-
-
Henchcliffe, C.1
Flint Beal, M.2
-
42
-
-
0142150051
-
Mitochondrial formation of reactive oxygen species
-
Turrens, J.F. Mitochondrial formation of reactive oxygen species. J. Physiol., 2003, 552, 335-344.
-
(2003)
J. Physiol
, vol.552
, pp. 335-344
-
-
Turrens, J.F.1
-
43
-
-
57649233079
-
The role of mitochondria in reactive oxygen species metabolism and signaling
-
Starkov, A.A. The role of mitochondria in reactive oxygen species metabolism and signaling. Ann. NY Acad. Sci., 2008, 1147, 37-52.
-
(2008)
Ann. NY Acad. Sci
, vol.1147
, pp. 37-52
-
-
Starkov, A.A.1
-
44
-
-
0033937733
-
The role of mitochondria in the pathogenesis of neurodegenerative diseases
-
Manfredi, G.; Beal, M.F. The role of mitochondria in the pathogenesis of neurodegenerative diseases. Brain Pathol., 2000, 10, 462-472.
-
(2000)
Brain Pathol
, vol.10
, pp. 462-472
-
-
Manfredi, G.1
Beal, M.F.2
-
45
-
-
48249156188
-
Mitochondrial disorders in the nervous system
-
DiMauro, S.; Schon, E.A. Mitochondrial disorders in the nervous system. Ann. Rev. Neuroscience, 2008, 31, 91-123.
-
(2008)
Ann. Rev. Neuroscience
, vol.31
, pp. 91-123
-
-
Dimauro, S.1
Schon, E.A.2
-
46
-
-
33750347347
-
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
-
Lin, M.T.; Flint Beal, M. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature, 2006, 443, 787-795.
-
(2006)
Nature
, vol.443
, pp. 787-795
-
-
Lin, M.T.1
Flint Beal, M.2
-
47
-
-
37049004489
-
Mitochondria in the aetiology and pathogenesis of Parkinson's disease
-
Schapira, A.H. Mitochondria in the aetiology and pathogenesis of Parkinson's disease. Lancet Neurol., 2008, 7, 97-109.
-
(2008)
Lancet Neurol
, vol.7
, pp. 97-109
-
-
Schapira, A.H.1
-
48
-
-
33646948530
-
Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled
-
Keeney, P.M.; Xie, J.; Capaldi, R.A.; Bennett, J.P. Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled. J. Neurosci., 2006, 26, 5256-5264.
-
(2006)
J. Neurosci
, vol.26
, pp. 5256-5264
-
-
Keeney, P.M.1
Xie, J.2
Capaldi, R.A.3
Bennett, J.P.4
-
49
-
-
67349203932
-
Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species
-
Fato, R.; Bergamini, C.; Bortolus, M.; Maniero, A.L.; Leoni, S.; Ohnishi, T.; Lenaz, G. Differential effects of mitochondrial Complex I inhibitors on production of reactive oxygen species. Biochim. Biophys. Acta, 2009, 1787, 384-392.
-
(2009)
Biochim. Biophys. Acta
, vol.1787
, pp. 384-392
-
-
Fato, R.1
Bergamini, C.2
Bortolus, M.3
Maniero, A.L.4
Leoni, S.5
Ohnishi, T.6
Lenaz, G.7
-
50
-
-
56349113200
-
Generation of reactive oxygen species by mitochondrial complex I: Implications in neurodegeneration
-
Fato, R.; Bergamini, C.; Leoni, S.; Strocchi, P.; Lenaz, G. Generation of reactive oxygen species by mitochondrial complex I: implications in neurodegeneration. Neurochem. Res., 2008, 33, 2487-2501.
-
(2008)
Neurochem. Res
, vol.33
, pp. 2487-2501
-
-
Fato, R.1
Bergamini, C.2
Leoni, S.3
Strocchi, P.4
Lenaz, G.5
-
51
-
-
0032560572
-
Persistent inhibition of cell respiration by nitric oxide: Crucial role of Snitrosylation of mitochondrial complex I and protective action of glutathione
-
Clementi, E.; Brown, G.C.; Feelisch, M.; Moncada, S. Persistent inhibition of cell respiration by nitric oxide: crucial role of Snitrosylation of mitochondrial complex I and protective action of glutathione. Proc. Natl. Acad. Sci. USA, 1998, 95, 7631-7636.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 7631-7636
-
-
Clementi, E.1
Brown, G.C.2
Feelisch, M.3
Moncada, S.4
-
52
-
-
0024390719
-
Mitochondrial complex I deficiency in Parkinson's disease
-
Schapira, A.H.V.; Cooper, J.M.; Dexter, D.; Jenner, P.; Clark, J.B.; Marsden, C.D. Mitochondrial complex I deficiency in Parkinson's disease. Lancet, 1989, 1(8649), 1269.
-
(1989)
Lancet
, vol.1
, Issue.8649
, pp. 1269
-
-
Schapira, A.H.V.1
Cooper, J.M.2
Dexter, D.3
Jenner, P.4
Clark, J.B.5
Marsden, C.D.6
-
53
-
-
0027435899
-
Iron induced oxidative stress and mitochondrial dysfunction: Relevance to Parkinson's disease
-
Hartley, A.; Cooper, J.M.; Schapira, A.H. Iron induced oxidative stress and mitochondrial dysfunction: relevance to Parkinson's disease. Brain Res., 1993, 627, 349-353.
-
(1993)
Brain Res
, vol.627
, pp. 349-353
-
-
Hartley, A.1
Cooper, J.M.2
Schapira, A.H.3
-
54
-
-
0027185713
-
Altered mitochondrial function, iron metabolism and glutathione levels in Parkinson's disease
-
Jenner, P. Altered mitochondrial function, iron metabolism and glutathione levels in Parkinson's disease. Acta Neurol. Scand., 1993, 87, 6-13.
-
(1993)
Acta Neurol. Scand
, vol.87
, pp. 6-13
-
-
Jenner, P.1
-
55
-
-
77951939586
-
Iron-mediated oxidative stress plays an essential role in ferritin-induced cell death
-
Bresgen, N.; Jaksch, H.; Lacher, H.; Ohlenschläger, I.; Uchida, K.; Eckl, P.M. Iron-mediated oxidative stress plays an essential role in ferritin-induced cell death. Free Radic. Biol. Med., 2010, 48(10), 1347-1357.
-
(2010)
Free Radic. Biol. Med
, vol.48
, Issue.10
, pp. 1347-1357
-
-
Bresgen, N.1
Jaksch, H.2
Lacher, H.3
Ohlenschläger, I.4
Uchida, K.5
Eckl, P.M.6
-
56
-
-
34249034604
-
Individual dopaminergic neurons show raised iron levels in Parkinson disease
-
Oakley, A.E.; Collingwood, J.F.; Dobson, J.; Love, G.; Perrott, H.R.; Edwardson, J.A.; Elstner, M.; Morris, C.M. Individual dopaminergic neurons show raised iron levels in Parkinson disease. J. Neurol., 2007, 68(21), 1820-1825.
-
(2007)
J. Neurol
, vol.68
, Issue.21
, pp. 1820-1825
-
-
Oakley, A.E.1
Collingwood, J.F.2
Dobson, J.3
Love, G.4
Perrott, H.R.5
Edwardson, J.A.6
Elstner, M.7
Morris, C.M.8
-
57
-
-
0038799736
-
Oxidative DNA damage: Mechanisms, mutation, and disease
-
Cooke, M.S.; Evans, M.D.; Dizdaroglu, M.; Lunec, J. Oxidative DNA damage: mechanisms, mutation, and disease. FASEB, 2003, 17, 1195-1214.
-
(2003)
FASEB
, vol.17
, pp. 1195-1214
-
-
Cooke, M.S.1
Evans, M.D.2
Dizdaroglu, M.3
Lunec, J.4
-
58
-
-
0032911488
-
Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons
-
Zhang, J.; Perry, G.; Smith, M.A.; Robertson, D.; Olson, S.G.; Doyle G.; Graham, D.G.; Montine, T.J. Parkinson's disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. Am. J. Pathol., 1999, 154, 1423-1429.
-
(1999)
Am. J. Pathol
, vol.154
, pp. 1423-1429
-
-
Zhang, J.1
Perry, G.2
Smith, M.A.3
Robertson, D.4
Olson, S.G.5
Doyle, G.6
Graham, D.G.7
Montine, T.J.8
-
59
-
-
10744231633
-
Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease
-
Simon, D.K.; Lin, M. T.; Zheng, L.; Liu, G-J.; Ahn, C.H.; Kim, L.M.; Beal, M.F.; Johns, D. Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson's disease. Neurobiol. Aging, 2004, 25(1), 71-81.
-
(2004)
Neurobiol. Aging
, vol.25
, Issue.1
, pp. 71-81
-
-
Simon, D.K.1
Lin, M.T.2
Zheng, L.3
Liu, G.-J.4
Ahn, C.H.5
Kim, L.M.6
Beal, M.F.7
Johns, D.8
-
60
-
-
0024541837
-
Mitochondrial DNA, mutations as an important contributor to ageing and degenerative diseases
-
Linnane, A.W.; Marzuki, S.; Ozawa, T.; Tanaka, M. Mitochondrial DNA, mutations as an important contributor to ageing and degenerative diseases. Lancet, 1989, 1, 642-645.
-
(1989)
Lancet
, vol.1
, pp. 642-645
-
-
Linnane, A.W.1
Marzuki, S.2
Ozawa, T.3
Tanaka, M.4
-
61
-
-
59349086549
-
Mitochondrial DNA mutations and aging: Devils in the details?
-
Khrapko, K.; Vijg, J. Mitochondrial DNA mutations and aging: devils in the details? Trends Genet., 2009, 25, 91-98.
-
(2009)
Trends Genet
, vol.25
, pp. 91-98
-
-
Khrapko, K.1
Vijg, J.2
-
62
-
-
33644859083
-
The ubiquitin proteolytic system. From a vague idea, through basic mechanisms, and onto human diseases and drug targeting
-
Ciechanover, A. The ubiquitin proteolytic system. From a vague idea, through basic mechanisms, and onto human diseases and drug targeting. Neurology, 2006, 66(1) S7-S19.
-
(2006)
Neurology
, vol.66
, Issue.1
-
-
Ciechanover, A.1
-
63
-
-
0035072229
-
Degradation of oxidized proteins by the 20S proteasome
-
Davies, K.J. Degradation of oxidized proteins by the 20S proteasome. Biochimie, 2001, 83(3-4), 301-310.
-
(2001)
Biochimie
, vol.83
, Issue.3-4
, pp. 301-310
-
-
Davies, K.J.1
-
64
-
-
33745315287
-
S-nitrosylated proteindisulphide isomerase links protein misfolding to neurodegeneration
-
Uehara, T.; Nakamura, T.; Yao, D.; Shi, Z.Q.; Gu, Z.; Ma, Y.; Masliah, E.; Nomura, Y.; Lipton, S.A. S-nitrosylated proteindisulphide isomerase links protein misfolding to neurodegeneration, Nature, 2006, 441, 513-517.
-
(2006)
Nature
, vol.441
, pp. 513-517
-
-
Uehara, T.1
Nakamura, T.2
Yao, D.3
Shi, Z.Q.4
Gu, Z.5
Ma, Y.6
Masliah, E.7
Nomura, Y.8
Lipton, S.A.9
-
65
-
-
79956323688
-
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy
-
Thomas, K.J.; McCoy, M.K.; Blackinton, J.; Beilina, A.; van der Brug, M.; Sandebring, A.; Miller, D.; Maric, D.; Cedazo-Minguez, A.; Cookson, M.R. DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy. Hum. Mol. Genet., 2011, 20(1), 40-50.
-
(2011)
Hum. Mol. Genet
, vol.20
, Issue.1
, pp. 40-50
-
-
Thomas, K.J.1
McCoy, M.K.2
Blackinton, J.3
Beilina, A.4
van der Brug, M.5
Sandebring, A.6
Miller, D.7
Maric, D.8
Cedazo-Minguez, A.9
Cookson, M.R.10
-
66
-
-
30744443484
-
Dopamine covalently modifies and functionally inactivates parkin
-
LaVoie, M.J.; Ostaszewski, B.L.; Weihofen, A.; Schlossmacher, M.G.; Selkoe, D.J. Dopamine covalently modifies and functionally inactivates parkin. Nat. Med., 2005, 11, 1214-1221.
-
(2005)
Nat. Med
, vol.11
, pp. 1214-1221
-
-
Lavoie, M.J.1
Ostaszewski, B.L.2
Weihofen, A.3
Schlossmacher, M.G.4
Selkoe, D.J.5
-
67
-
-
0344875488
-
Inactivation of parkin by oxidative stress and C-terminal truncations: A protective role of molecular chaperones
-
Winklhofer, K.F.; Henn, I.H.; Kay-Jackson, P.C.; Heller, U.; Tatzelt, J. Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones, J. Biol. Chem., 2003, 278, 47199-47208.
-
(2003)
J. Biol. Chem
, vol.278
, pp. 47199-47208
-
-
Winklhofer, K.F.1
Henn, I.H.2
Kay-Jackson, P.C.3
Heller, U.4
Tatzelt, J.5
-
68
-
-
2542534741
-
S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function
-
Chung, K.K.; Thomas, B.; Li, X.; Pletnikova, O.; Troncoso, J.C.; Marsh, L.; Dawson, V.L.; Dawson, T.M. S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function. Science, 2004, 304, 1328-1331.
-
(2004)
Science
, vol.304
, pp. 1328-1331
-
-
Chung, K.K.1
Thomas, B.2
Li, X.3
Pletnikova, O.4
Troncoso, J.C.5
Marsh, L.6
Dawson, V.L.7
Dawson, T.M.8
-
69
-
-
3242733689
-
Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity
-
Yao, D.; Gu, Z.; Nakamura, T.; Shi, Z.Q.; Ma, Y.; Gaston, B.; Palmer, L.A.; Rockenstein, E.M.; Zhang, Z.; Masliah, E.; Uehara, T.; Lipton, S.A. Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity. Proc. Natl. Acad. Sci. USA, 2004, 101, 10810-10814.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 10810-10814
-
-
Yao, D.1
Gu, Z.2
Nakamura, T.3
Shi, Z.Q.4
Ma, Y.5
Gaston, B.6
Palmer, L.A.7
Rockenstein, E.M.8
Zhang, Z.9
Masliah, E.10
Uehara, T.11
Lipton, S.A.12
-
70
-
-
2442481789
-
Mitochondrial dysfunction and oxidative damage in parkin-deficient mice
-
Palacino, J.J.; Sagi, D.; Goldberg, M.S.; Krauss, S.; Motz, C.; Wacker, M.; Klose, J.; Shen, J. Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. J. Biol. Chem., 2004, 279, 18614-18622.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 18614-18622
-
-
Palacino, J.J.1
Sagi, D.2
Goldberg, M.S.3
Krauss, S.4
Motz, C.5
Wacker, M.6
Klose, J.7
Shen, J.8
-
71
-
-
56349137588
-
Mitochondrial respiratory dysfunction in familiar Parkinsonism associated with PINK1 mutation
-
Piccoli, C.; Sardanelli, A.; Scrima, R.; Ripoli, M.; Quarato, G.; D'Aprile, A; Bellomo, F.; Scacco, S.; Michele, G.; Filla, A.; Iuso, A.; Boffoli, D.; Capitanio, N.; Papa, S. Mitochondrial respiratory dysfunction in familiar Parkinsonism associated with PINK1 mutation. Neurochem. Res., 2008, 33(12), 2565-2574.
-
(2008)
Neurochem. Res
, vol.33
, Issue.12
, pp. 2565-2574
-
-
Piccoli, C.1
Sardanelli, A.2
Scrima, R.3
Ripoli, M.4
Quarato, G.5
D'Aprile, A.6
Bellomo, F.7
Scacco, S.8
Michele, G.9
Filla, A.10
Iuso, A.11
Boffoli, D.12
Capitanio, N.13
Papa, S.14
-
72
-
-
49649097747
-
Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
-
Gautier, C.A.; Kitada, T.; Shen, J. Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc. Natl. Acad. Sci. USA, 2008, 105(32), 11364-11369.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, Issue.32
, pp. 11364-11369
-
-
Gautier, C.A.1
Kitada, T.2
Shen, J.3
-
73
-
-
27944444154
-
Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism
-
Silvestri, L.; Caputo, V.; Bellacchio, E.; Atorino, L.; Dallapiccola, B.; Valente, E.M.; Casari, G. Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism. Hum. Mol. Genet., 2005, 14, 3477-3492.
-
(2005)
Hum. Mol. Genet
, vol.14
, pp. 3477-3492
-
-
Silvestri, L.1
Caputo, V.2
Bellacchio, E.3
Atorino, L.4
Dallapiccola, B.5
Valente, E.M.6
Casari, G.7
-
74
-
-
79954616687
-
Lu CSPARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons
-
Wang, H.L.; Chou, A.H.; Wu, A.S.; Chen, S.Y.; Weng, Y.H.; Kao, Y.C.; Yeh, T.H.; Chu, P.J.; Lu CSPARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons. Biochim. Biophys. Acta, 2011, 1812(6), 674-684.
-
(2011)
Biochim. Biophys. Acta
, vol.1812
, Issue.6
, pp. 674-684
-
-
Wang, H.L.1
Chou, A.H.2
Wu, A.S.3
Chen, S.Y.4
Weng, Y.H.5
Kao, Y.C.6
Yeh, T.H.7
Chu, P.J.8
-
75
-
-
44049099669
-
Mitochondrial import and accumulation of alpha- synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain
-
Devi, L.; Raghavendran, V.; Prabhu, B.M.; Avadhani, N.G.; Anandatheertha-varada, H.K. Mitochondrial import and accumulation of alpha- synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain. J. Biol. Chem., 2008, 283, 9089-9100.
-
(2008)
J. Biol. Chem
, vol.283
, pp. 9089-9100
-
-
Devi, L.1
Raghavendran, V.2
Prabhu, B.M.3
Avadhani, N.G.4
Anandatheertha-Varada, H.K.5
-
76
-
-
0031017290
-
Generation of reactive oxygen species by tyrosine hydroxylase: A possible contribution to the degeneration of Dopaminergic neurons
-
Haavik, J.; Almas, B.; Flatmark, T. Generation of reactive oxygen species by tyrosine hydroxylase: A possible contribution to the degeneration of Dopaminergic neurons? J. Neurochem., 1997, 68, 328-332.
-
(1997)
J. Neurochem
, vol.68
, pp. 328-332
-
-
Haavik, J.1
Almas, B.2
Flatmark, T.3
-
77
-
-
33845746706
-
Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: Relevance for the pathogenesis of Parkinson's disease
-
Thomas, M.P.; Chartrand, K.; Reynolds, A.; Vitvitsky, V.; Banerjee, R.; Gendelman, H.E. Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: relevance for the pathogenesis of Parkinson's disease. J. Neurochem., 2007, 100, 503-519.
-
(2007)
J. Neurochem
, vol.100
, pp. 503-519
-
-
Thomas, M.P.1
Chartrand, K.2
Reynolds, A.3
Vitvitsky, V.4
Banerjee, R.5
Gendelman, H.E.6
-
78
-
-
1642527499
-
DJ-1 has a role in antioxidative stress to prevent cell death
-
Taira, T.; Saito, Y.; Niki, T.; Iguchi-Ariga, S.M.; Takahashi, K.; Ariga, H. DJ-1 has a role in antioxidative stress to prevent cell death. EMBO Rep., 2004, 5, 213-218.
-
(2004)
EMBO Rep
, vol.5
, pp. 213-218
-
-
Taira, T.1
Saito, Y.2
Niki, T.3
Iguchi-Ariga, S.M.4
Takahashi, K.5
Ariga, H.6
-
79
-
-
13944279784
-
Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: An ES- derived cell model of primary Parkinsonism
-
Martinat, C.; Shendelman, S.; Jonason, A.; Leete, T.; Beal, M.F.; Yang, L.; Floss, T.; Abeliovich, A. Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism. PLoS Biol., 2004, 2, e327.
-
(2004)
PLoS Biol
, vol.2
-
-
Martinat, C.1
Shendelman, S.2
Jonason, A.3
Leete, T.4
Beal, M.F.5
Yang, L.6
Floss, T.7
Abeliovich, A.8
-
80
-
-
29444437871
-
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration
-
Smith, W.W.; Pei, Z.; Jiang, H.; Moore, D.J.; Liang, Y.; West, A.B.; Dawson, V.L.; Dawson, T.M.; Ross, C.A. Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. Proc. Natl. Acad. Sci. USA, 2005, 102, 18676-18681.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 18676-18681
-
-
Smith, W.W.1
Pei, Z.2
Jiang, H.3
Moore, D.J.4
Liang, Y.5
West, A.B.6
Dawson, V.L.7
Dawson, T.M.8
Ross, C.A.9
-
81
-
-
0032842038
-
Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: Implications for Parkinson's disease
-
Berman, S.B.; Hastings, T.G. Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease. J. Neurochem., 1999, 73(3), 1127-1137.
-
(1999)
J. Neurochem
, vol.73
, Issue.3
, pp. 1127-1137
-
-
Berman, S.B.1
Hastings, T.G.2
-
82
-
-
0345328791
-
Mitochondrial impairment is accompanied by impaired oxidative DNA repair in the nucleus
-
Delsite, R.L.; Rasmussen, L.J.; Rasmussen, A.K.; Kalen, A.; Goswami, P.C.; Singh, K.K. Mitochondrial impairment is accompanied by impaired oxidative DNA repair in the nucleus. Mutagenesis, 2003, 18(6), 497-503.
-
(2003)
Mutagenesis
, vol.18
, Issue.6
, pp. 497-503
-
-
Delsite, R.L.1
Rasmussen, L.J.2
Rasmussen, A.K.3
Kalen, A.4
Goswami, P.C.5
Singh, K.K.6
-
83
-
-
28544441181
-
Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: Clinical, pathological, olfactory and functional imaging and genetic data
-
Khan, N.L.; Jain, S.; Lynch, J.M.; Pavese, N.; Abou-Sleiman, P.; Holton, J.L.; Healy, D.G.; Gilks, W.P.; Sweeney, M.G.; Ganguly, M.; Gibbons, V.; Gandhi, S.; Vaughan, J.; Eunson, L.H.; Katzenschlager, R.; Gayton, J.; Lennox, G.; Revesz, T.; Nicholl, D.; Bhatia, K.P.; Quinn, N.; Brooks, D.; Lees, A.J.; Davis, M.B.; Piccini, P.; Singleton, A.B.; Wood, N.W. Mutations in the gene LRRK2 encoding dardarin (PARK8) cause familial Parkinson's disease: clinical, pathological, olfactory and functional imaging and genetic data. Brain, 2005, 128(Pt 12), 2786-2796.
-
(2005)
Brain
, vol.128
, Issue.Pt 12
, pp. 2786-2796
-
-
Khan, N.L.1
Jain, S.2
Lynch, J.M.3
Pavese, N.4
Abou-Sleiman, P.5
Holton, J.L.6
Healy, D.G.7
Gilks, W.P.8
Sweeney, M.G.9
Ganguly, M.10
Gibbons, V.11
Gandhi, S.12
Vaughan, J.13
Eunson, L.H.14
Katzenschlager, R.15
Gayton, J.16
Lennox, G.17
Revesz, T.18
Nicholl, D.19
Bhatia, K.P.20
Quinn, N.21
Brooks, D.22
Lees, A.J.23
Davis, M.B.24
Piccini, P.25
Singleton, A.B.26
Wood, N.W.27
more..
-
84
-
-
25644439977
-
Immobilization stress causes increases in tetrahydrobiopterin, dopamine, and neuro- melanin and oxidative damage in the nigrostriatal system
-
Kim, S.T.; Chang, J.W.; Choi, J.H.; Kim, S.W.; Hwang, O. Immobilization stress causes increases in tetrahydrobiopterin, dopamine, and neuro- melanin and oxidative damage in the nigrostriatal system. J. Neurochem., 2005, 95, 89-98.
-
(2005)
J. Neurochem
, vol.95
, pp. 89-98
-
-
Kim, S.T.1
Chang, J.W.2
Choi, J.H.3
Kim, S.W.4
Hwang, O.5
-
85
-
-
0037879052
-
The mitochondrial membrane potential (deltapsi(m)) in apoptosis: An update
-
Ly, J.D.; Grubb, D.R.; Lawen, A. The mitochondrial membrane potential (deltapsi(m)) in apoptosis: an update. Apoptosis, 2003, 8, 115-128.
-
(2003)
Apoptosis
, vol.8
, pp. 115-128
-
-
Ly, J.D.1
Grubb, D.R.2
Lawen, A.3
-
86
-
-
0033032999
-
Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary spastic paraplegia and Friedreich's ataxia
-
Schapira, A.H. Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary spastic paraplegia and Friedreich's ataxia. Biochim. Biophys. Acta, 1999, 1410, 159-170.
-
(1999)
Biochim. Biophys. Acta
, vol.1410
, pp. 159-170
-
-
Schapira, A.H.1
-
87
-
-
0038201683
-
Effects of amphetamines on mitochondrial function: Role of free radicals and oxidative stress
-
Brown, J.M.; Yamamoto, B.K. Effects of amphetamines on mitochondrial function: role of free radicals and oxidative stress. Pharmacol. Ther., 2003, 99, 45-53.
-
(2003)
Pharmacol. Ther
, vol.99
, pp. 45-53
-
-
Brown, J.M.1
Yamamoto, B.K.2
-
88
-
-
0037632905
-
Dopamine-dependent cytotoxicity of tetrahydrobiopterin: A possible mechanism for selective neurodegeneration in Parkinson's disease
-
Choi, H.J.; Kim, S.W.; Lee, S.Y.; Hwang, O. Dopamine-dependent cytotoxicity of tetrahydrobiopterin: a possible mechanism for selective neurodegeneration in Parkinson's disease. J. Neurochem., 2003, 86, 143-152.
-
(2003)
J. Neurochem
, vol.86
, pp. 143-152
-
-
Choi, H.J.1
Kim, S.W.2
Lee, S.Y.3
Hwang, O.4
-
89
-
-
0029433534
-
Tyrosine hydroxylase: Human isoforms, structure and regulation in physiology and pathology
-
Nagatsu, T. Tyrosine hydroxylase: human isoforms, structure and regulation in physiology and pathology. Essays Biochem., 1995, 30, 15-35.
-
(1995)
Essays Biochem
, vol.30
, pp. 15-35
-
-
Nagatsu, T.1
-
90
-
-
0029586876
-
Immunocytochemical localization of GTP cyclohydrolase I in the brain, adrenal gland, and liver of mice
-
Nagatsu, I.; Ichinose, H.; Sakai, M.; Titani, K.; Suzuki, M.; Nagatsu, T. Immunocytochemical localization of GTP cyclohydrolase I in the brain, adrenal gland, and liver of mice. J. Neural Transm. Gen. Sect., 1995, 102, 175-188.
-
(1995)
J. Neural Transm. Gen. Sect
, vol.102
, pp. 175-188
-
-
Nagatsu, I.1
Ichinose, H.2
Sakai, M.3
Titani, K.4
Suzuki, M.5
Nagatsu, T.6
-
91
-
-
0030017489
-
Intricate regulation of tyrosine hydroxylase activity and gene expression
-
Kumer, S.C.; Vrana, K.E. Intricate regulation of tyrosine hydroxylase activity and gene expression. J. Neurochem., 1996, 67, 443-462.
-
(1996)
J. Neurochem
, vol.67
, pp. 443-462
-
-
Kumer, S.C.1
Vrana, K.E.2
-
92
-
-
44249120317
-
Activation of tyrosine hydroxylase mRNA translation by cAMP in midbrain dopaminergic neurons
-
Chen, X.; Xu, L.; Radcliffe, P.; Sun, B.; Tank, A.W. Activation of tyrosine hydroxylase mRNA translation by cAMP in midbrain dopaminergic neurons. Mol. Pharmacol., 2008, 3(6), 1816-1828.
-
(2008)
Mol. Pharmacol
, vol.3
, Issue.6
, pp. 1816-1828
-
-
Chen, X.1
Xu, L.2
Radcliffe, P.3
Sun, B.4
Tank, A.W.5
-
93
-
-
9744239461
-
Tyrosine hydroxylase phosphorylation: Regulation and consequences
-
Dunkley, P.R.; Bobrovskaya, L.; Graham, M.E.; von Nagy-Felsobuki, E.I.; Dickson, P.W. Tyrosine hydroxylase phosphorylation: regulation and consequences. J. Neurochemistry, 2004, 91, 1025-1043.
-
(2004)
J. Neurochemistry
, vol.91
, pp. 1025-1043
-
-
Dunkley, P.R.1
Bobrovskaya, L.2
Graham, M.E.3
von Nagy-Felsobuki, E.I.4
Dickson, P.W.5
-
94
-
-
0025353854
-
Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40
-
Haycock, J.W. Phosphorylation of tyrosine hydroxylase in situ at serine 8, 19, 31, and 40. J. Biol. Chem., 1990, 265(20), 11662-11691.
-
(1990)
J. Biol. Chem
, vol.265
, Issue.20
, pp. 11662-11691
-
-
Haycock, J.W.1
-
95
-
-
0027053393
-
Regulation of tyrosine hydroxylase gene transcription rate and tyrosine hydroxylase mRNA stability by cyclic AMP and glucocorticoid
-
Fossom, L.H.; Sterling, C.R.; Tank, A.W. Regulation of tyrosine hydroxylase gene transcription rate and tyrosine hydroxylase mRNA stability by cyclic AMP and glucocorticoid. Mol. Pharmacol., 1992, 42(5), 898-908.
-
(1992)
Mol. Pharmacol
, vol.42
, Issue.5
, pp. 898-908
-
-
Fossom, L.H.1
Sterling, C.R.2
Tank, A.W.3
-
96
-
-
80054834577
-
Protein Kinase c-dependent dephosphorylation of tyrosine hydroxylase requires the B56d heterotrimeric form of protein phosphatase 2A
-
Ahn, J.-H.; Kim, Y.; Kim, H-S.; Greengard, P.; Nairn, A.C. Protein Kinase c-dependent dephosphorylation of tyrosine hydroxylase requires the B56d heterotrimeric form of protein phosphatase 2A. PLoS ONE, 2011, 6(1), e26292.
-
(2011)
PLoS ONE
, vol.6
, Issue.1
-
-
Ahn, J.-H.1
Kim, Y.2
Kim, H.-S.3
Greengard, P.4
Nairn, A.C.5
-
97
-
-
0041589260
-
The autoxidation of tetrahydrobiopterin revisited. Proof of superoxide formation from reaction of tetrahydrobiopterin with molecular oxygen
-
Kirsch, M.; Korth, H.G.; Stenert, V.; Sustmann, R.; de Groot, H. The autoxidation of tetrahydrobiopterin revisited. Proof of superoxide formation from reaction of tetrahydrobiopterin with molecular oxygen. J. Biol. Chem., 2003, 278(27), 24481-24490.
-
(2003)
J. Biol. Chem
, vol.278
, Issue.27
, pp. 24481-24490
-
-
Kirsch, M.1
Korth, H.G.2
Stenert, V.3
Sustmann, R.4
de Groot, H.5
-
98
-
-
0029833673
-
Restoration of endothelium-dependent vasodilation after reperfusion injury by tetrahydrobiopterin
-
Tiefenbacher, C.P.; Chilian, W.M.; Mitchell, M.; DeFily, D.V. Restoration of endothelium-dependent vasodilation after reperfusion injury by tetrahydrobiopterin. Circulation, 1996, 94, 1423-1429.
-
(1996)
Circulation
, vol.94
, pp. 1423-1429
-
-
Tiefenbacher, C.P.1
Chilian, W.M.2
Mitchell, M.3
Defily, D.V.4
-
99
-
-
0035860682
-
Tetrahydrobiopterin Scavenges Superoxide in Dopaminergic Neurons
-
Nakamura, K.; Bindokas, V.P.; Kowlessur, D.; Elas, M.; Milstien, S.; Marks, J.D.; Halpern, H.J.; Kang, U.J. Tetrahydrobiopterin Scavenges Superoxide in Dopaminergic Neurons. J. Biol. Chem., 2001, 276(37), 34402-34407.
-
(2001)
J. Biol. Chem
, vol.276
, Issue.37
, pp. 34402-34407
-
-
Nakamura, K.1
Bindokas, V.P.2
Kowlessur, D.3
Elas, M.4
Milstien, S.5
Marks, J.D.6
Halpern, H.J.7
Kang, U.J.8
-
100
-
-
0036724608
-
Tetrahydrobiopterin deficiency increases neuronal vulnerability to hypoxia
-
Delgado-Esteban, M.; Almeida, A.; Medina, J.M. Tetrahydrobiopterin deficiency increases neuronal vulnerability to hypoxia. J. Neurochem., 2002, 82(5), 1148-1159.
-
(2002)
J. Neurochem
, vol.82
, Issue.5
, pp. 1148-1159
-
-
Delgado-Esteban, M.1
Almeida, A.2
Medina, J.M.3
-
101
-
-
0037962138
-
Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects
-
Ihlemann, N.; Rask-Madsen, C.; Perner, A.; Dominguez, H.; Hermann, T.; Køber, L.; Torp-Pedersen, C. Tetrahydrobiopterin restores endothelial dysfunction induced by an oral glucose challenge in healthy subjects. Am. J. Physiol. Heart Circ. Physiol., 2003, 285(2), H875-H882.
-
(2003)
Am. J. Physiol. Heart Circ. Physiol
, vol.285
, Issue.2
-
-
Ihlemann, N.1
Rask-Madsen, C.2
Perner, A.3
Dominguez, H.4
Hermann, T.5
Køber, L.6
Torp-Pedersen, C.7
-
102
-
-
0034141542
-
Effects of phosphorylation on binding of catecholamines to tyrosine hydroxylase: Specificity and thermodynamics
-
Ramsey, A.J.; Fitzpatrick, P.F. Effects of phosphorylation on binding of catecholamines to tyrosine hydroxylase: Specificity and thermodynamics. Biochemistry, 2000, 39, 773-778.
-
(2000)
Biochemistry
, vol.39
, pp. 773-778
-
-
Ramsey, A.J.1
Fitzpatrick, P.F.2
-
103
-
-
0032560609
-
Effects of phosphorylation of serine-40 of tyrosine hydroxylase in binding of catecholamines-Evidence for a novel regulatory mechnanism
-
Ramsey, A.J.; Fitzpatrick, P.F. Effects of phosphorylation of serine-40 of tyrosine hydroxylase in binding of catecholamines-Evidence for a novel regulatory mechnanism. Biochemistry, 1998, 37, 8980-8986.
-
(1998)
Biochemistry
, vol.37
, pp. 8980-8986
-
-
Ramsey, A.J.1
Fitzpatrick, P.F.2
-
104
-
-
1842612454
-
Dopamine neurons release transmitter via a flickering fusion pore
-
Staal, R.G.; Mosharov, E.V.; Sulzer, D. Dopamine neurons release transmitter via a flickering fusion pore. Nat. Neurosci., 2004, 7(4), 341-346.
-
(2004)
Nat. Neurosci
, vol.7
, Issue.4
, pp. 341-346
-
-
Staal, R.G.1
Mosharov, E.V.2
Sulzer, D.3
-
105
-
-
34547467082
-
Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration
-
Caudle, W.M.; Richardson, J.R.; Wang, M.Z.; Taylor, T.N.; Guillot, T.S.; McCormack, A.L.; Colebrooke, R.E.; Di Monte, D.A.; Emson, P.C.; Miller, G.W. Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration. J. Neurosci., 2007, 27(30), 8138-8148.
-
(2007)
J. Neurosci
, vol.27
, Issue.30
, pp. 8138-8148
-
-
Caudle, W.M.1
Richardson, J.R.2
Wang, M.Z.3
Taylor, T.N.4
Guillot, T.S.5
McCormack, A.L.6
Colebrooke, R.E.7
Di Monte, D.A.8
Emson, P.C.9
Miller, G.W.10
-
106
-
-
41149108952
-
α-Synuclein aggregation alters tyrosine hydroxylase phosphorilation and immunoreactivity: Lessons from viral trasduction of knockout mice
-
Alerte, T.N.M.; Akinfolarin, A.A.; Friedrich, E.E.; Mader, S.A.; Hong, C-S.; Ruth G., Perez, R.G. α-Synuclein aggregation alters tyrosine hydroxylase phosphorilation and immunoreactivity: lessons from viral trasduction of knockout mice. Neurosci. Lett., 2008, 435(1), 24-29.
-
(2008)
Neurosci. Lett
, vol.435
, Issue.1
, pp. 24-29
-
-
Alerte, T.N.M.1
Akinfolarin, A.A.2
Friedrich, E.E.3
Mader, S.A.4
Hong, C.-S.5
Ruth, G.6
Perez, R.G.7
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