Tetrahydrobiopterin deficiency increases neuronal vulnerability to hypoxia

Journal of Neurochemistry

Volumn 82, Issue 5, 2002, Pages 1148-1159

  Delgado Esteban, María ^a   Almeida, Angeles ^a,b   Medina, Jose M ^a  

^a UNIVERSITY OF SALAMANCA   (Spain)

^b HOSPITAL UNIVERSITARIO DE SALAMANCA   (Spain)

Author keywords

Glutathione; Mitochondria; Neurones; Nitric oxide; Tetrahydrobiopterin

Indexed keywords

CATALASE; GLUTATHIONE; HEMOGLOBIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PEROXYNITRITE; PYRIMIDINE DERIVATIVE; SUPEROXIDE DISMUTASE; TETRAHYDROBIOPTERIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL HYPOXIA; CONTROLLED STUDY; DEPOLARIZATION; NERVE CELL; NERVE CELL LESION; NEUROPATHOLOGY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEFICIENCY; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIOXIDANTS; BIOPTERIN; CELL DEATH; CELL HYPOXIA; CELLS, CULTURED; CYCLIC GMP; ENZYME INHIBITORS; GTP CYCLOHYDROLASE; HYPOXANTHINES; HYPOXIA, BRAIN; MITOCHONDRIA; NEURONS; NITRIC OXIDE SYNTHASE; OXIDATIVE STRESS; PEROXYNITROUS ACID; RATS; RATS, WISTAR;

ANIMALIA;

EID: 0036724608     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.01055.x     Document Type: Article

References (63)

1. The ferrousdioxy complex of neuronal nitric oxide synthase. Divergent effects of 1-arginine and tetrahydrobiopterin on its stability
2. Nitric oxide synthases: Structure, function and inhibition
3. A transient inhibition of mitochondrial ATP synthesis by nitric oxide synthase activation triggered apoptosis in primary cortical neurons
4. A rapid method for the isolation of metabolically active mitochondria from rat neurons and astrocytes in primary culture
5. Glutamate neurotoxicity is associated with nitric oxide-mediated mitochondrial dysfunction and glutathione depletion
6. Nitric oxide mediates glutamate-induced mitochondrial depolarization in rat cortical neurons
7. Oxygen and glucose deprivation induces mitochondrial dysfunction and oxidative stress in neurones but not in astrocytes in primary culture
8. Tetrahydrobiopterin metabolism in the temporal lobe of patients dying with senile dementia of Alzheimer type
9. Increased inducible nitric oxide synthase protein but limited nitric oxide formation occurs in astrocytes of the hph-1 (tetrahydrobiopterin deficiency) mouse
10. Apparent hydroxyl radical production by peroxy-nitrite: Implications for endothelial injury from nitric oxide and superoxide
11. 2,4-Diamino-6-hydroxypirimidine, an inhibitor of tetrahydrobiopterin synthesis, down-regulates the expression of iNOS protein and mRNA in primary murine macrophages
12. Roles of nitric oxide in brain hypoxia-ischemia
13. Induction of nitric oxide synthase inhibits gap junction permeability in cultured rat astrocytes
14. Effect of peroxynitrite on the mitochondrial respiratory chain: Differential susceptibility of neurones and astrocytes in primary cultures
15. Nitric oxide-mediated mitochondrial damage in the brain: Mechanisms and implications for neurodegenerative diseases
16. Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures
17. Nitric oxide: A physiologic messenger molecule
18. Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidase
19. 2+ homeostasis
20. Reactive oxygen radicals in signaling and damage in the ischemic brain
21. Therapeutic efficacy of tetrahydrobiopterin in Parkinson's disease
22. Nitric oxide neurotoxicity
23. Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures
24. D-Glucose prevents glutathione oxidation and mitochondrial damage after glutamate receptor stimulation in rat cortical primary neurons
25. Glutathione content as an indicator for the presence of metabolic pathways of amino acids in astroglial cultures
26. Effects of metabolic inhibition of the membrane properties of isolated mouse primary sensory neurones
27. Possible effects of tetrahydrobiopterin treatment in six children with autism-clinical and positron emission tomography data: A pilot study
28. Dystonia with motor delay in compound heterozygotes for GTP-cyclohydrolase I gene mutations
29. Biopterin. III. Purification and characterization of enzymes involved in the cerebral synthesis of 7,8-dihydrobiopterin
30. Induction of glucose-6-phosphate dehydrogenase by lipopolysaccharide contributes to preventing nitric oxide-mediated glutathione depletion in cultured rat astrocytes
31. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests a role as intercellular messenger in the brain
32. 2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase
33. Estimation of tetra-hydrobiopterin and other pterins in cerebrospinal fluid using reversed-phase high-performance liquid chromatography with electrochemical and fluorescence detection
34. The chemistry of pernitrites. Part I. Kinetics of decomposition of pernitrous acid
35. Formation of a pterin radical in the reaction of the heme domain of inducible nitric oxide synthase with oxygen
36. Acceleration of oxidative stress-induced endothelial cell death by nitric oxide synthase dysfunction accompanied with decrease in tetrahydrobiopterin content
37. Localization of mitochondria in living cells with rhodamine 123
38. New tetrahydrobiopterin-dependent systems
39. Mitochondrial deenergization underlies neuronal calcium overload following a prolonged glutamate challenge
40. Preparation of succinate cytochrome c reductase and the cytochrome b-c1 particle, and reconstitution of succinate cytochrome c reductase
41. Nitric oxide synthases in mammals
42. Self-protection of PC12 cells by 6R-tetrahydrobiopterin from nitric oxide toxicity
43. Nitrosyl hemoglobin production during reperfusion after focal cerebral-ischemia in rats
44. Protein measurement with the Folin phenol reagent
45. Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts
46. Nitric oxide synthase structure and mechanism
47. Neurodegenerative disorders and ischemic brain diseases
48. Nitric oxide synthase-catalyzed activation of oxygen and reduction of citochromes: Reaction mechanisms and possible physiological implications
49. Nitric oxide: Physiology, pathophysiology and pharmacology
50. Biosynthesis and metabolism of tetrahydrobiopterin and molybdopterin
51. Mitochondrial membrane potential and neuronal glutamate excitotoxicity: Mortality and millivolts
52. Atypical phenylketonuria with defective biopterin metabolism. Monotherapy with tetrahydrobiopterin or sepiapterin, screening and study of biosynthesis in man
53. Protein tyrosine nitration in mouse peritoneal macrophages activated in vitro and in vivo: Evidence against an essential role of peroxynitrite
54. Generation of superoxide by purified brain nitric oxide synthase
55. Subfractionation of mitochondria and isolation of the proteins of oxidative phosphorylation
56. Mitochondria, oxygen free radicals, disease and aging
57. Apoptosis and the nervous system
58. Role of tetrahydrobiopterin availability in the regulation of nitric oxide synthase expression in human mesangial cells
59. Formation of a protonated trihydrobiopterin radical cation in the first reaction cycle of neuronal and endothelial nitric oxide synthase detected by electron paramagnetic resonance spectroscopy
60. Tetrahydrobiopterin biosynthesis, regeneration and functions
61. Tetrahydrobiopterin-dependent inhibition of superoxide generation from neuronal nitric oxide synthase
62. Rapid kinetic studies link tetrahydrobiopterin radical formation to heme-dioxy reduction and arginine hydroxylation in inducible nitric-oxide synthase
63. Cytochrome oxidase from beef heart mitochondria