Regulation of neuronal oxidative and nitrosative stress by endogenous protective pathways and disease processes

Antioxidants and Redox Signaling

Volumn 14, Issue 8, 2011, Pages 1421-1424

  Hardingham, Giles E ^a   Lipton, Stuart A ^b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROTROPHIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; TRANSCRIPTION FACTOR NRF2;

ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; APOPTOSIS; BRAIN NERVE CELL; CALORIC RESTRICTION; CELL DEATH; CELL PROTECTION; CELL STRESS; CHRONIC DISEASE; HUMAN; HYPEROXIA; ISCHEMIA; NEUROLOGIC DISEASE; NEUROPROTECTION; NITROSATIVE STRESS; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FOLDING; REVIEW; SYNAPSE; UPREGULATION;

ANIMALS; ANTIOXIDANTS; DISEASE PROGRESSION; HUMANS; NERVOUS SYSTEM; NEURONS; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

EID: 79952857040     PISSN: 15230864     EISSN: None     Source Type: Journal    
DOI: 10.1089/ars.2010.3573     Document Type: Review

References (31)

1. Bell KFS and Hardingham GE. CNS peroxiredoxins and their regulation in health and disease. Antioxid Redox Signal 14: 1467-1477, 2011.
2. Brown GC and Borutaite V. Regulation of apoptosis by the redox state of cytochrome c. Biochim Biophys Acta 1777: 877-881, 2008.
3. Chen H, Yoshioka H, Kim GS, Jung JE, Okami N, Sakata H, Maier CM, Narasimhan P, Goeders CE, and Chan PH. Oxidative stress in ischemic brain damage: mechanisms of cell death and potential molecular targets for neuroprotection. Antioxid Redox Signal 14: 1505-1517, 2011.
4. Cui L, Jeong H, Borovecki F, Parkhurst CN, Tanese N, and Krainc D. Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell 127: 59-69, 2006. (Pubitemid 44466642)
5. Fang J, Nakamura T, Cho DH, Gu Z, and Lipton SA. Snitrosylation of peroxiredoxin 2 promotes oxidative stressinduced neuronal cell death in Parkinson's disease. Proc Natl Acad Sci USA 104: 18742-18747, 2007. (Pubitemid 350210767)
6. Franklin JL. Redox regulation of the intrinsic pathway in neuronal apoptosis. Antioxid Redox Signal 14: 1437-1448, 2011.
7. Gu Z, Kaul M, Yan B, Kridel SJ, Cui J, Strongin A, Smith JW, Liddington RC, and Lipton SA. S-nitrosylation of matrix metalloproteinases: signaling pathway to neuronal cell death. Science 297: 1186-1190, 2002. (Pubitemid 36193354)
8. Halliwell B. Oxidative stress and neurodegeneration: where are we now? J Neurochem 97: 1634-1658, 2006. (Pubitemid 43873658)
9. Hardingham GE. Pro-survival signalling from the NMDA receptor. Biochem Soc Trans 34: 936-938, 2006. (Pubitemid 44796454)
10. Hardingham GE. Coupling of the NMDA receptor to neuroprotective and neurodestructive events. Biochem Soc Trans 37: 1147-1160, 2009.
11. Ikonomidou C and Kaindl AM. Neuronal death and oxidative stress in the developing brain. Antioxid Redox Signal 14: 1535-1550, 2011.
12. Johnson JA, Johnson DA, Kraft AD, Calkins MJ, Jakel RJ, Vargas MR, and Chen PC. The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration. Ann N Y Acad Sci 1147: 61-69, 2008.
13. Kamat CD, Gadal S, Mhatre M, Williamson KS, Pye QN, and Hensley K. Antioxidants in central nervous system diseases: preclinical promise and translational challenges. J Alzheimers Dis 15: 473-493, 2008.
14. Leveille F, Soriano FX, Papadia S, and Hardingham GE. Excitotoxic insults lead to peroxiredoxin hyperoxidation. Oxid Med Cell Longev 2: 110-113, 2009.
15. Lewerenz J and Maher P. Control of redox state and redox signaling by neural antioxidant systems. Antioxid Redox Signal 14: 1449-1465, 2011.
16. Lipton SA, Choi YB, Pan ZH, Lei SZ, Chen HS, Sucher NJ, Loscalzo J, Singel DJ, and Stamler JS. A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364: 626-632, 1993. (Pubitemid 23274719)
17. Mariani E, Polidori MC, Cherubini A, and Mecocci P. Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview. J Chromatogr B Analyt Technol Biomed Life Sci 827: 65-75, 2005. (Pubitemid 41551598)
18. McMahon M, Itoh K, Yamamoto M, and Hayes JD. Keap1- dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem 278: 21592-21600, 2003. (Pubitemid 36792558)
19. Nakamura T and Lipton SA. S-nitrosylation of critical protein thiols mediates protein misfolding and mitochondrial dysfunction in neurodegenerative diseases. Antioxid Redox Signal 14: 1479-1492, 2011.
20. Okamoto S, Pouladi MA, Talantova M, Yao D, Xia P, Ehrnhoefer DE, Zaidi R, Clemente A, Kaul M, Graham RK, Zhang D, Vincent Chen HS, Tong G, Hayden MR, and Lipton SA. Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin. Nat Med 15: 1407-1413, 2009.
21. Papadia S, Soriano FX, Leveille F, Martel MA, Dakin KA, Hansen HH, Kaindl A, Sifringer M, Fowler J, Stefovska V, McKenzie G, Craigon M, Corriveau R, Ghazal P, Horsburgh K, Yankner BA, Wyllie DJ, Ikonomidou C, and Hardingham GE. Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci 11: 476-487, 2008. (Pubitemid 351441886)
22. Patenaude A, Murthy MR, and Mirault ME. Emerging roles of thioredoxin cycle enzymes in the central nervous system. Cell Mol Life Sci 62: 1063-1080, 2005. (Pubitemid 40868526)
23. Rashidian J, Rousseaux MW, Venderova K, Qu D, Callaghan SM, Phillips M, Bland RJ, During MJ, Mao Z, Slack RS, and Park DS. Essential role of cytoplasmic cdk5 and Prx2 in multiple ischemic injury models, in vivo. J Neurosci 29: 12497-12505, 2009.
24. Satoh T, Kosaka K, Itoh K, Kobayashi A, Yamamoto M, Shimojo Y, Kitajima C, Cui J, Kamins J, Okamoto S, Izumi M, Shirasawa T, and Lipton SA. Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1=Nrf2 pathway via S-alkylation of targeted cysteines on Keap1. J Neurochem 104: 1116-1131, 2008. (Pubitemid 351143643)
25. Shahani N and Sawa A. Nitric oxide signaling and nitrosative stress in neurons: role for S-nitrosylation. Antioxid Redox Signal 14: 1493-1504, 2011.
26. Shih AY, Li P, and Murphy TH. A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo. J Neurosci 25: 10321-10335, 2005. (Pubitemid 41636229)
27. Soriano FX, Léveillé F, Papadia S, Bell KFS, Puddifoot C, and Hardingham GE. Neuronal activity controls the antagonistic balance between peroxisome proliferator-activated receptorg coactivator-1a and silencing mediator of retinoic acid and thyroid hormone receptors in regulating antioxidant defenses. Antioxid Redox Signal 14: 1425-1436, 2011.
28. Soriano FX, Leveille F, Papadia S, Higgins LG, Varley J, Baxter P, Hayes JD, and Hardingham GE. Induction of sul- firedoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1, 2-dithiole-3-thione. J Neurochem 107: 533-543, 2008.
29. St.-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jager S, Handschin C, Zheng K, Lin J, Yang W, Simon DK, Bachoo R, and Spiegelman BM. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 127: 397-408, 2006. (Pubitemid 44572377)
30. Texel SJ and Mattson MP. Impaired adaptive cellular responses to oxidative stress and the pathogenesis of Alzheimer's disease. Antioxid Redox Signal 14: 1519-1534, 2011.
31. Yang L, Calingasan NY, Thomas B, Chaturvedi RK, Kiaei M, Wille EJ, Liby KT, Williams C, Royce D, Risingsong R, Musiek ES, Morrow JD, Sporn M, and Beal MF. Neuroprotective effects of the triterpenoid, CDDO methyl amide, a potent inducer of Nrf2-mediated transcription. PLoS One 4: e5757, 2009.