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Volumn 90, Issue 5, 2012, Pages 543-561

Evolutionary dynamics of HIV at multiple spatial and temporal scales

Author keywords

Coevolution; Drug resistance; Evolutionary dynamics; HIV; Immune escape; Virulence

Indexed keywords

ANTIRETROVIRUS AGENT; HUMAN IMMUNODEFICIENCY VIRUS VACCINE;

EID: 84862514242     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-012-0892-1     Document Type: Review
Times cited : (16)

References (173)
  • 1
    • 0035282386 scopus 로고    scopus 로고
    • Infectious diseases: Considerations for the 21st century
    • doi:10.1086/319235
    • Fauci AS (2001) Infectious diseases: considerations for the 21st century. Clin Infect Dis 32:675-685. doi:10.1086/319235
    • (2001) Clin Infect Dis , vol.32 , pp. 675-685
    • Fauci, A.S.1
  • 2
    • 53349099717 scopus 로고    scopus 로고
    • On the greatly exaggerated reports of the death of infectious diseases
    • doi:10.1086/592123
    • Pier GB (2008) On the greatly exaggerated reports of the death of infectious diseases. Clin Infect Dis 47:1113-1114. doi:10.1086/592123
    • (2008) Clin Infect Dis , vol.47 , pp. 1113-1114
    • Pier, G.B.1
  • 3
    • 46349097945 scopus 로고    scopus 로고
    • Stewart: Mistaken or maligned?
    • doi:10.1086/589579
    • Spellberg B (2008) Dr. William H. Stewart: mistaken or maligned? Clin Infect Dis 47:294. doi:10.1086/589579
    • (2008) Clin Infect Dis , vol.47 , pp. 294
    • Spellberg, B.1    William, H.2
  • 4
    • 77951065603 scopus 로고    scopus 로고
    • Joint United Nations Programme on HIV/AIDS and World Health Organization. Accessed 2 Jan 2012
    • Joint United Nations Programme on HIV/AIDS and World Health Organization (2009) AIDS epidemic update. Available: http://www.who.int/hiv/data/en/. Accessed 2 Jan 2012
    • (2009) AIDS Epidemic Update
  • 5
    • 79959310876 scopus 로고    scopus 로고
    • HIV surveillance-United States, 1981-2008
    • CDC
    • CDC (2011) HIV surveillance-United States, 1981-2008. MMWR 60:689-693
    • (2011) MMWR , vol.60 , pp. 689-693
  • 8
    • 0029075130 scopus 로고
    • Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase
    • Mansky LM, Temin HM (1995) Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase. J Virol 69:5087-5094
    • (1995) J Virol , vol.69 , pp. 5087-5094
    • Mansky, L.M.1    Temin, H.M.2
  • 9
    • 33847247125 scopus 로고    scopus 로고
    • Theory of lethal mutagenesis for viruses
    • doi:10.1128/JVI.01624-06
    • Bull JJ, Sanjuán R, Wilke CO (2007) Theory of lethal mutagenesis for viruses. J Virol 81:2930-2939. doi:10.1128/JVI.01624-06
    • (2007) J Virol , vol.81 , pp. 2930-2939
    • Bull, J.J.1    Sanjuán, R.2    Wilke, C.O.3
  • 10
    • 0037108885 scopus 로고    scopus 로고
    • Error catastrophe and antiviral strategy
    • doi:10.1073/pnas.212514799
    • Eigen M (2002) Error catastrophe and antiviral strategy. Proc Natl Acad Sci USA 99:13374-13376. doi:10.1073/pnas.212514799
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13374-13376
    • Eigen, M.1
  • 12
    • 0027071241 scopus 로고
    • What is a quasispecies?
    • doi:10.1016/0169-5347(92)90145-2
    • Nowk MA (1992) What is a quasispecies? Trends Ecol Evol 7:118-121. doi:10.1016/0169-5347(92)90145-2
    • (1992) Trends Ecol Evol , vol.7 , pp. 118-121
    • Nowk, M.A.1
  • 13
    • 84975263995 scopus 로고    scopus 로고
    • Viral evolution under the pressure of an adaptive immune system: Optimal mutation rates for viral escape
    • doi:10.1002/cplx.10067
    • Kamp C, Wilke CO, Adami C, Bornholdt S (2002) Viral evolution under the pressure of an adaptive immune system: optimal mutation rates for viral escape. Complexity 8:28-33. doi:10.1002/cplx.10067
    • (2002) Complexity , vol.8 , pp. 28-33
    • Kamp, C.1    Wilke, C.O.2    Adami, C.3    Bornholdt, S.4
  • 14
    • 67349283815 scopus 로고    scopus 로고
    • Mutating away from your enemies: The evolution of mutation rate in a host-parasite system
    • doi:10.1016/j.tpb.2009.03.003
    • M'Gonigle LK, Shen JJ, Otto SP (2009) Mutating away from your enemies: the evolution of mutation rate in a host-parasite system. Theor Popul Biol 75:301-311. doi:10.1016/j.tpb.2009.03.003
    • (2009) Theor Popul Biol , vol.75 , pp. 301-311
    • M'gonigle, L.K.1    Shen, J.J.2    Otto, S.P.3
  • 15
    • 77956820495 scopus 로고    scopus 로고
    • Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication
    • doi:10.1128/JVI.00915-10
    • Abram ME, Ferris AL, Shao W, Alvord WG, Hughes SH (2010) Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication. J Virol 84:9864-9878. doi:10.1128/JVI.00915-10
    • (2010) J Virol , vol.84 , pp. 9864-9878
    • Abram, M.E.1    Ferris, A.L.2    Shao, W.3    Alvord, W.G.4    Hughes, S.H.5
  • 17
    • 33846502673 scopus 로고    scopus 로고
    • Is HIV-1 evolving to a less virulent form in humans?
    • Ariën KK, Vanham G, Arts EJ (2007) Is HIV-1 evolving to a less virulent form in humans? Nat Rev Micro 5:141-151
    • (2007) Nat Rev Micro , vol.5 , pp. 141-151
    • Ariën, K.K.1    Vanham, G.2    Arts, E.J.3
  • 19
    • 0038363470 scopus 로고    scopus 로고
    • Hypermutation of HIV-1 DNA in the absence of the Vif protein
    • doi:10.1126/science.1083338
    • Lecossier D, Bouchonnet F, Clavel F, Hance AJ (2003) Hypermutation of HIV-1 DNA in the absence of the Vif protein. Science 300:1112. doi:10.1126/science.1083338
    • (2003) Science , vol.300 , pp. 1112
    • Lecossier, D.1    Bouchonnet, F.2    Clavel, F.3    Hance, A.J.4
  • 20
    • 42649120310 scopus 로고    scopus 로고
    • The APOBEC3 cytidine deaminases: An innate defensive network opposing exogenous retroviruses and endogenous retroelements
    • doi:10.1146/annurev.immunol.26.021607.090350
    • Chiu Y-L, Greene WC (2008) The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements. Annu Rev Immunol 26:317-353. doi:10.1146/annurev.immunol.26.021607.090350
    • (2008) Annu Rev Immunol , vol.26 , pp. 317-353
    • Chiu, Y.-L.1    Greene, W.C.2
  • 22
    • 30944461040 scopus 로고    scopus 로고
    • Molecular epidemiology of HIV- 1 variants in the global AIDS pandemic: An update
    • Thomson MM, Nájera R (2005) Molecular epidemiology of HIV- 1 variants in the global AIDS pandemic: an update. AIDS Rev 7:210-224
    • (2005) AIDS Rev , vol.7 , pp. 210-224
    • Thomson, M.M.1    Nájera, R.2
  • 23
    • 33745059199 scopus 로고    scopus 로고
    • Chimpanzee reservoirs of pandemic and nonpandemic HIV-1
    • doi:10.1126/science.1126531
    • Keele BF, Van Heuverswyn F, Li Y, Bailes E, Takehisa J et al (2006) Chimpanzee reservoirs of pandemic and nonpandemic HIV-1. Science 313:523-526. doi:10.1126/science.1126531
    • (2006) Science , vol.313 , pp. 523-526
    • Keele, B.F.1    Van Heuverswyn, F.2    Li, Y.3    Bailes, E.4    Takehisa, J.5
  • 24
    • 25144446304 scopus 로고    scopus 로고
    • Simian Immunodeficiency virus infection in free-ranging sooty mangabeys (Cercocebus atys atys) from the Taï Forest, Côte d'Ivoire: Implications for the origin of epidemic human immunodeficiency virus type 2
    • doi:10.1128/JVI.79.19.12515-12527.2005
    • Santiago ML, Range F, Keele BF, Li Y, Bailes E et al (2005) Simian Immunodeficiency virus infection in free-ranging sooty mangabeys (Cercocebus atys atys) from the Taï Forest, Côte d'Ivoire: implications for the origin of epidemic human immunodeficiency virus type 2. J Virol 79:12515-12527. doi:10.1128/JVI.79.19.12515-12527.2005
    • (2005) J Virol , vol.79 , pp. 12515-12527
    • Santiago, M.L.1    Range, F.2    Keele, B.F.3    Li, Y.4    Bailes, E.5
  • 25
    • 53349127137 scopus 로고    scopus 로고
    • Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960
    • doi:10.1038/nature07390
    • Worobey M, Gemmel M, Teuwen DE, Haselkorn T, Kunstman K et al (2008) Direct evidence of extensive diversity of HIV-1 in Kinshasa by 1960. Nature 455:661-664. doi:10.1038/nature07390
    • (2008) Nature , vol.455 , pp. 661-664
    • Worobey, M.1    Gemmel, M.2    Teuwen, D.E.3    Haselkorn, T.4    Kunstman, K.5
  • 26
    • 12144290751 scopus 로고    scopus 로고
    • Naturally acquired simian retrovirus infections in central African hunters
    • doi:10.1016/S0140-6736(04)15787-5
    • Wolfe ND, Switzer WM, Carr JK, Bhullar VB, Shanmugam Vet al (2004) Naturally acquired simian retrovirus infections in central African hunters. Lancet 363:932-937. doi:10.1016/S0140-6736(04)15787-5
    • (2004) Lancet , vol.363 , pp. 932-937
    • Wolfe, N.D.1    Switzer, W.M.2    Carr, J.K.3    Bhullar, V.B.4    Shanmugam, V.5
  • 27
    • 0023091646 scopus 로고
    • Transmission dynamics of HIV infection
    • doi:10.1038/326137a0
    • May RM, Anderson RM (1987) Transmission dynamics of HIV infection. Nature 326:137-142. doi:10.1038/326137a0
    • (1987) Nature , vol.326 , pp. 137-142
    • May, R.M.1    Anderson, R.M.2
  • 29
    • 77956316616 scopus 로고    scopus 로고
    • High GUD incidence in the early 20th century created a particularly permissive time window for the origin and initial spread of epidemic HIV strains
    • doi:10.1371/journal.pone.0009936
    • de Sousa JD, Müller V, Lemey P, Vandamme A-M (2010) High GUD incidence in the early 20th century created a particularly permissive time window for the origin and initial spread of epidemic HIV strains. PLoS One 5:e9936. doi:10.1371/journal.pone.0009936
    • (2010) PLoS One , vol.5
    • De Sousa, J.D.1    Müller, V.2    Lemey, P.3    Vandamme, A.-M.4
  • 30
    • 34447340466 scopus 로고    scopus 로고
    • Discovery and analysis of the first endogenous lentivirus
    • doi:10.1073/pnas.0700471104
    • Katzourakis A, Tristem M, Pybus OG, Gifford RJ (2007) Discovery and analysis of the first endogenous lentivirus. Proc Natl Acad Sci USA 104:6261-6265. doi:10.1073/pnas.0700471104
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 6261-6265
    • Katzourakis, A.1    Tristem, M.2    Pybus, O.G.3    Gifford, R.J.4
  • 31
    • 0037343278 scopus 로고    scopus 로고
    • Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia
    • Silvestri G, Sodora DL, Koup RA, Paiardini M, O'Neil SP et al (2003) Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. Immunity 18:441-452
    • (2003) Immunity , vol.18 , pp. 441-452
    • Silvestri, G.1    Sodora, D.L.2    Koup, R.A.3    Paiardini, M.4    O'neil, S.P.5
  • 32
    • 45549092692 scopus 로고    scopus 로고
    • Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques
    • Estes JD, Gordon SN, Zeng M, Chahroudi AM, Dunham RM et al (2008) Early resolution of acute immune activation and induction of PD-1 in SIV-infected sooty mangabeys distinguishes nonpathogenic from pathogenic infection in rhesus macaques. J Immunol 180:6798-6807
    • (2008) J Immunol , vol.180 , pp. 6798-6807
    • Estes, J.D.1    Gordon, S.N.2    Zeng, M.3    Chahroudi, A.M.4    Dunham, R.M.5
  • 33
    • 48749103238 scopus 로고    scopus 로고
    • Impact of MHC class i diversity on immune control of immunodeficiency virus replication
    • doi:10.1038/nri2357
    • Goulder PJR, Watkins DI (2008) Impact of MHC class I diversity on immune control of immunodeficiency virus replication. Nat Rev Immunol 8:619-630. doi:10.1038/nri2357
    • (2008) Nat Rev Immunol , vol.8 , pp. 619-630
    • Goulder, P.J.R.1    Watkins, D.I.2
  • 34
    • 0033524838 scopus 로고    scopus 로고
    • Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes
    • doi:10.1126/science.283.5403.857
    • Schmitz JE, Kuroda MJ, Santra S, Sasseville VG, Simon MA et al (1999) Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes. Science 283:857-860. doi:10.1126/science.283.5403.857
    • (1999) Science , vol.283 , pp. 857-860
    • Schmitz, J.E.1    Kuroda, M.J.2    Santra, S.3    Sasseville, V.G.4    Simon, M.A.5
  • 35
    • 67049119333 scopus 로고    scopus 로고
    • Dating the age of the SIV lineages that gave rise to HIV-1 and HIV-2
    • doi:10.1371/journal.pcbi.1000377
    • Wertheim JO, Worobey M (2009) Dating the age of the SIV lineages that gave rise to HIV-1 and HIV-2. PLoS Comput Biol 5:e1000377. doi:10.1371/journal. pcbi.1000377
    • (2009) PLoS Comput Biol , vol.5
    • Wertheim, J.O.1    Worobey, M.2
  • 36
    • 53849133821 scopus 로고    scopus 로고
    • Evolutionary history and phylogeography of human viruses
    • doi:10.1146/annurev.micro.62.081307.162912
    • Holmes EC (2008) Evolutionary history and phylogeography of human viruses. Annu Rev Microbiol 62:307-328. doi:10.1146/annurev.micro.62.081307. 162912
    • (2008) Annu Rev Microbiol , vol.62 , pp. 307-328
    • Holmes, E.C.1
  • 37
    • 77956685623 scopus 로고    scopus 로고
    • Island biogeography reveals the deep history of SIV
    • doi:10.1126/science.1193550
    • Worobey M, Telfer P, Souquière S, Hunter M, Coleman CA et al (2010) Island biogeography reveals the deep history of SIV. Science 329:1487. doi:10.1126/science.1193550
    • (2010) Science , vol.329 , pp. 1487
    • Worobey, M.1    Telfer, P.2    Souquière, S.3    Hunter, M.4    Coleman, C.A.5
  • 38
    • 80054941662 scopus 로고    scopus 로고
    • Purifying selection can obscure the ancient age of viral lineages
    • doi:10.1093/molbev/msr170
    • Wertheim JO, Kosakovsky Pond SL (2011) Purifying selection can obscure the ancient age of viral lineages. Mol Biol Evol 28:3355-3365. doi:10.1093/molbev/msr170
    • (2011) Mol Biol Evol , vol.28 , pp. 3355-3365
    • Wertheim, J.O.1    Kosakovsky Pond, S.L.2
  • 39
    • 34547761762 scopus 로고    scopus 로고
    • Recombination confounds the early evolutionary history of human immunodeficiency virus type 1: Subtype G is a circulating recombinant form
    • doi:10.1128/JVI.00463-07
    • Abecasis AB, Lemey P, Vidal N, de Oliveira T, Peeters M et al (2007) Recombination confounds the early evolutionary history of human immunodeficiency virus type 1: subtype G is a circulating recombinant form. J Virol 81:8543-8551. doi:10.1128/JVI.00463-07
    • (2007) J Virol , vol.81 , pp. 8543-8551
    • Abecasis, A.B.1    Lemey, P.2    Vidal, N.3    De Oliveira, T.4    Peeters, M.5
  • 40
    • 0348230957 scopus 로고    scopus 로고
    • Quorum sensing and biofilm formation in Streptococcal infections
    • doi:10.1172/JCI20430
    • Cvitkovitch DG, Li Y-H, Ellen RP (2003) Quorum sensing and biofilm formation in Streptococcal infections. J Clin Invest 112:1626-1632. doi:10.1172/JCI20430
    • (2003) J Clin Invest , vol.112 , pp. 1626-1632
    • Cvitkovitch, D.G.1    Li, Y.-H.2    Ellen, R.P.3
  • 41
    • 58249100073 scopus 로고    scopus 로고
    • Is a new and general theory of molecular systematics emerging?
    • Edwards SV (2009) Is a new and general theory of molecular systematics emerging? Evolution 63:1-19
    • (2009) Evolution , vol.63 , pp. 1-19
    • Edwards, S.V.1
  • 42
    • 79955380843 scopus 로고    scopus 로고
    • Comparing two Bayesian methods for gene tree/species tree reconstruction: Simulations with incomplete lineage sorting and horizontal gene transfer
    • Chung Y, Ané C (2011) Comparing two Bayesian methods for gene tree/species tree reconstruction: simulations with incomplete lineage sorting and horizontal gene transfer. Syst Biol 60:261
    • (2011) Syst Biol , vol.60 , pp. 261
    • Chung, Y.1    Ané, C.2
  • 43
    • 0002027029 scopus 로고
    • A new evolutionary law
    • doi:10.1038/344864a0
    • Valen V (1973) A new evolutionary law. Evol Theory 1:1-30. doi:10.1038/344864a0
    • (1973) Evol Theory , vol.1 , pp. 1-30
    • Valen, V.1
  • 44
    • 0021085051 scopus 로고
    • Epidemiology and genetics in the coevolution of parasites and hosts
    • May RM, Anderson RM (1983) Epidemiology and genetics in the coevolution of parasites and hosts. Proc R Soc B 219:281-313
    • (1983) Proc R Soc B , vol.219 , pp. 281-313
    • May, R.M.1    Anderson, R.M.2
  • 45
    • 0029126910 scopus 로고
    • Coinfection and the evolution of parasite virulence
    • doi:10.1098/rspb.1995.0138
    • May RM, Nowak MA (1995) Coinfection and the evolution of parasite virulence. Proc R Soc B 261:209-215. doi:10.1098/rspb.1995.0138
    • (1995) Proc R Soc B , vol.261 , pp. 209-215
    • May, R.M.1    Nowak, M.A.2
  • 46
    • 0028031923 scopus 로고
    • Superinfection and the evolution of parasite virulence
    • Nowak MA, May RM (1994) Superinfection and the evolution of parasite virulence. Proc R Soc B 255(1342):81-89
    • (1994) Proc R Soc B , vol.255 , Issue.1342 , pp. 81-89
    • Nowak, M.A.1    May, R.M.2
  • 47
    • 79953078481 scopus 로고    scopus 로고
    • A strong case for viral genetic factors in HIV virulence
    • doi:10.3390/v3030204
    • Müller V, Fraser C, Herbeck JT (2011) A strong case for viral genetic factors in HIV virulence. Viruses 3:204-216. doi:10.3390/v3030204
    • (2011) Viruses , vol.3 , pp. 204-216
    • Müller, V.1    Fraser, C.2    Herbeck, J.T.3
  • 48
    • 80055080332 scopus 로고    scopus 로고
    • Transmission selects for HIV-1 strains of intermediate virulence: A modelling approach
    • doi:10.1371/journal.pcbi.1002185
    • Shirreff G, Pellis L, Laeyendecker O, Fraser C (2011) Transmission selects for HIV-1 strains of intermediate virulence: a modelling approach. PLoS Comput Biol 7:e1002185. doi:10.1371/journal.pcbi.1002185
    • (2011) PLoS Comput Biol , vol.7
    • Shirreff, G.1    Pellis, L.2    Laeyendecker, O.3    Fraser, C.4
  • 49
    • 84155168018 scopus 로고    scopus 로고
    • Is the virulence of HIV changing? A meta-analysis of trends in prognostic markers of HIV disease progression and transmission
    • doi:10.1097/QAD.0b013e32834db418
    • Herbeck JT,Müller V,Maust BS, Ledergerber B, Torti C et al (2012) Is the virulence of HIV changing? A meta-analysis of trends in prognostic markers of HIV disease progression and transmission. AIDS 26:193-205. doi:10.1097/QAD.0b013e32834db418
    • (2012) AIDS , vol.26 , pp. 193-205
    • Herbeck, J.T.1    Müller, V.2    Maust, B.S.3    Ledergerber, B.4    Torti, C.5
  • 50
    • 20444393131 scopus 로고    scopus 로고
    • HIV dynamics with multiple infections of target cells
    • doi:10.1073/pnas.0407498102
    • Dixit NM, Perelson AS (2005) HIV dynamics with multiple infections of target cells. Proc Natl Acad Sci USA 102:8198-8203. doi:10.1073/pnas.0407498102
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 8198-8203
    • Dixit, N.M.1    Perelson, A.S.2
  • 51
    • 79961176993 scopus 로고    scopus 로고
    • Effect of multiple infection of cells on the evolutionary dynamics of HIV in vivo: Implications for host adaptation mechanisms
    • doi:10.1258/ebm.2011.011062
    • Wodarz D, Levy DN (2011) Effect of multiple infection of cells on the evolutionary dynamics of HIV in vivo: implications for host adaptation mechanisms. Exp Biol Med 236:926-937. doi:10.1258/ebm.2011.011062
    • (2011) Exp Biol Med , vol.236 , pp. 926-937
    • Wodarz, D.1    Levy, D.N.2
  • 52
    • 2942549839 scopus 로고    scopus 로고
    • Phenotypic mixing and hiding may contribute to memory in viral quasispecies
    • doi:10.1186/1471-2180-3-11
    • Wilke CO, Novella IS (2003) Phenotypic mixing and hiding may contribute to memory in viral quasispecies. BMC Microbiol 3:11. doi:10.1186/1471-2180-3-11
    • (2003) BMC Microbiol , vol.3 , pp. 11
    • Wilke, C.O.1    Novella, I.S.2
  • 53
    • 1042309181 scopus 로고
    • Virus strains of identical phenotype but different genotype
    • Novick A, Szilard L (1951) Virus strains of identical phenotype but different genotype. Science 113:34-35
    • (1951) Science , vol.113 , pp. 34-35
    • Novick, A.1    Szilard, L.2
  • 55
    • 79951974746 scopus 로고    scopus 로고
    • The role of recombination for the coevolutionary dynamics of HIV and the immune response
    • doi:10.1371/journal.pone.0016052
    • Mostowy R, Kouyos RD, Fouchet D, Bonhoeffer S (2011) The role of recombination for the coevolutionary dynamics of HIV and the immune response. PLoS One 6:e16052. doi:10.1371/journal.pone.0016052
    • (2011) PLoS One , vol.6
    • Mostowy, R.1    Kouyos, R.D.2    Fouchet, D.3    Bonhoeffer, S.4
  • 56
    • 1042291295 scopus 로고    scopus 로고
    • Recombination in HIV and the evolution of drug resistance: For better or for worse?
    • doi:10.1002/bies.10386
    • Bretscher MT, Althaus CL, Müller V, Bonhoeffer S (2004) Recombination in HIV and the evolution of drug resistance: for better or for worse? Bioessays 26:180-188. doi:10.1002/bies.10386
    • (2004) Bioessays , vol.26 , pp. 180-188
    • Bretscher, M.T.1    Althaus, C.L.2    Müller, V.3    Bonhoeffer, S.4
  • 57
    • 0037062939 scopus 로고    scopus 로고
    • Recombination: Multiply infected spleen cells in HIV patients
    • doi:10.1038/418144a
    • Jung A, Maier R, Vartanian J-P, Bocharov G, Jung Vet al (2002) Recombination: multiply infected spleen cells in HIV patients. Nature 418:144. doi:10.1038/418144a
    • (2002) Nature , vol.418 , pp. 144
    • Jung, A.1    Maier, R.2    Vartanian, J.-P.3    Bocharov, G.4    Jung, V.5
  • 58
    • 79960569795 scopus 로고    scopus 로고
    • Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule
    • doi:10.1073/pnas.1107729108
    • Josefsson L, King MS, Makitalo B, Brännström J, Shao W et al (2011) Majority of CD4+ T cells from peripheral blood of HIV-1-infected individuals contain only one HIV DNA molecule. Proc Natl Acad Sci 108:11199-11204. doi:10.1073/pnas.1107729108
    • (2011) Proc Natl Acad Sci , vol.108 , pp. 11199-11204
    • Josefsson, L.1    King, M.S.2    Makitalo, B.3    Brännström, J.4    Shao, W.5
  • 59
    • 79955043851 scopus 로고    scopus 로고
    • Estimate of effective recombination rate and average selection coefficient for HIV in chronic infection
    • Batorsky R, Kearney MF, Palmer SE, Maldarelli F, Rouzine IM et al (2011) Estimate of effective recombination rate and average selection coefficient for HIV in chronic infection. Proc Natl Acad Sci USA. Available: http://www.ncbi.nlm.nih.gov/pubmed/21436045
    • (2011) Proc Natl Acad Sci USA
    • Batorsky, R.1    Kearney, M.F.2    Palmer, S.E.3    Maldarelli, F.4    Rouzine, I.M.5
  • 60
    • 76749139978 scopus 로고    scopus 로고
    • Recombination rate and selection strength in HIV intra-patient evolution
    • doi:10.1371/journal.pcbi.1000660
    • Neher RA, Leitner T (2010) Recombination rate and selection strength in HIV intra-patient evolution. PLoS Comput Biol 6: e1000660. doi:10.1371/journal. pcbi.1000660
    • (2010) PLoS Comput Biol , vol.6
    • Neher, R.A.1    Leitner, T.2
  • 62
    • 0027962542 scopus 로고
    • A model for AIDS pathogenesis
    • doi:10.1002/sim.4780131916
    • Schenzle D (1994) A model for AIDS pathogenesis. Stat Med 13:2067-2079. doi:10.1002/sim.4780131916
    • (1994) Stat Med , vol.13 , pp. 2067-2079
    • Schenzle, D.1
  • 63
    • 0029052478 scopus 로고
    • Antigenic oscillations and shifting immunodominance in HIV-1 infections
    • Nowak MA, May RM, Phillips RE, Rowland-Jones S, Lalloo DG et al (1995) Antigenic oscillations and shifting immunodominance in HIV-1 infections. Nature 375:606-611
    • (1995) Nature , vol.375 , pp. 606-611
    • Nowak, M.A.1    May, R.M.2    Phillips, R.E.3    Rowland-Jones, S.4    Lalloo, D.G.5
  • 65
    • 0030026113 scopus 로고    scopus 로고
    • Reduction of HIV concentration during acute infection: Independence from a specific immune response
    • Phillips AN (1996) Reduction of HIV concentration during acute infection: independence from a specific immune response. Science 271:497
    • (1996) Science , vol.271 , pp. 497
    • Phillips, A.N.1
  • 66
    • 33746555576 scopus 로고    scopus 로고
    • HIV/AIDS epidemiology, pathogenesis, prevention, and treatment
    • doi:10.1016/S0140-6736(06)69157-5
    • Simon V, Ho DD, Abdool Karim Q (2006) HIV/AIDS epidemiology, pathogenesis, prevention, and treatment. Lancet 368:489-504. doi:10.1016/S0140-6736(06)69157-5
    • (2006) Lancet , vol.368 , pp. 489-504
    • Simon, V.1    Ho, D.D.2    Abdool Karim, Q.3
  • 67
    • 0022967777 scopus 로고
    • CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication
    • doi:10.1126/science.2431484
    • Walker C, Moody D, Stites D, Levy J (1986) CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 234:1563-1566. doi:10.1126/science.2431484
    • (1986) Science , vol.234 , pp. 1563-1566
    • Walker, C.1    Moody, D.2    Stites, D.3    Levy, J.4
  • 68
    • 0034790979 scopus 로고    scopus 로고
    • Role of CD8+ lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment
    • Lifson JD, Rossio JL, Piatak M, Parks T, Li L et al (2001) Role of CD8+ lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatment. J Virol 75:10187-10199
    • (2001) J Virol , vol.75 , pp. 10187-10199
    • Lifson, J.D.1    Rossio, J.L.2    Piatak, M.3    Parks, T.4    Li, L.5
  • 70
    • 0037456827 scopus 로고    scopus 로고
    • Antibody neutralization and escape by HIV-1
    • Wei X, Decker JM, Wang S, Hui H, Kappes JC et al (2003) Antibody neutralization and escape by HIV-1. Nature 422:307-312
    • (2003) Nature , vol.422 , pp. 307-312
    • Wei, X.1    Decker, J.M.2    Wang, S.3    Hui, H.4    Kappes, J.C.5
  • 71
    • 77957582392 scopus 로고    scopus 로고
    • Innate immune activation in primary HIV-1 infection
    • doi:10.1086/655657
    • Chang JJ, Altfeld M (2010) Innate immune activation in primary HIV-1 infection. J Infect Dis 202:S297-S301. doi:10.1086/655657
    • (2010) J Infect Dis , vol.202
    • Chang, J.J.1    Altfeld, M.2
  • 73
    • 81755187285 scopus 로고    scopus 로고
    • Assessing predicted HIV-1 replicative capacity in a clinical setting
    • doi:10.1371/journal.ppat.1002321
    • Kouyos RD, vonWyl V, Hinkley T, Petropoulos CJ, Haddad M et al (2011) Assessing predicted HIV-1 replicative capacity in a clinical setting. PLoS Pathog 7:e1002321. doi:10.1371/journal.ppat.1002321
    • (2011) PLoS Pathog , vol.7
    • Kouyos, R.D.1    Von Wyl, V.2    Hinkley, T.3    Petropoulos, C.J.4    Haddad, M.5
  • 74
    • 3543078012 scopus 로고    scopus 로고
    • HIV and SIV CTL escape: Implications for vaccine design
    • doi:10.1038/nri1417
    • Goulder PJR, Watkins DI (2004) HIV and SIV CTL escape: implications for vaccine design. Nat Rev Immunol 4:630-640. doi:10.1038/nri1417
    • (2004) Nat Rev Immunol , vol.4 , pp. 630-640
    • Goulder, P.J.R.1    Watkins, D.I.2
  • 75
    • 0025827529 scopus 로고
    • Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition
    • doi:10.1038/354453a0
    • Phillips RE, Rowland-Jones S, Nixon DF, Gotch FM, Edwards JP et al (1991) Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature 354:453-459. doi:10.1038/354453a0
    • (1991) Nature , vol.354 , pp. 453-459
    • Phillips, R.E.1    Rowland-Jones, S.2    Nixon, D.F.3    Gotch, F.M.4    Edwards, J.P.5
  • 76
    • 48249088137 scopus 로고    scopus 로고
    • Dynamics of immune escape during HIV/SIV infection
    • doi:10.1371%2Fjournal.pcbi.1000103
    • Althaus CL, De Boer RJ (2008) Dynamics of immune escape during HIV/SIV infection. PLoS Comput Biol 4:e1000103.doi:10.1371%2Fjournal.pcbi.1000103
    • (2008) PLoS Comput Biol , vol.4
    • Althaus, C.L.1    De Boer, R.J.2
  • 77
    • 27144513224 scopus 로고    scopus 로고
    • Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution
    • doi:10.1128/JVI.79.21.13239-13249.2005
    • Allen TM, Altfeld M, Geer SC, Kalife ET, Moore C et al (2005) Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution. J Virol 79:13239-13249. doi:10.1128/JVI.79.21.13239-13249. 2005
    • (2005) J Virol , vol.79 , pp. 13239-13249
    • Allen, T.M.1    Altfeld, M.2    Geer, S.C.3    Kalife, E.T.4    Moore, C.5
  • 78
    • 57149090493 scopus 로고    scopus 로고
    • Phylogenetic dependency networks: Inferring patterns of CTL escape and codon covariation in HIV-1 Gag
    • doi:10.1371%2Fjournal.pcbi.1000225
    • Carlson JM, Brumme ZL, Rousseau CM, Brumme CJ, Matthews P et al (2008) Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag. PLoS Comput Biol 4:e1000225. doi:10.1371%2Fjournal. pcbi.1000225
    • (2008) PLoS Comput Biol , vol.4
    • Carlson, J.M.1    Brumme, Z.L.2    Rousseau, C.M.3    Brumme, C.J.4    Matthews, P.5
  • 79
    • 68949209789 scopus 로고    scopus 로고
    • HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins
    • doi:10.1371/journal.pone.0006687
    • Brumme ZL, John M, Carlson JM, Brumme CJ, Chan D et al (2009) HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins. PLoS One 4:e6687. doi:10.1371/journal.pone.0006687
    • (2009) PLoS One , vol.4
    • Brumme, Z.L.1    John, M.2    Carlson, J.M.3    Brumme, C.J.4    Chan, D.5
  • 80
    • 20344399376 scopus 로고    scopus 로고
    • The HIV coreceptor switch: A population dynamical perspective
    • doi:10.1016/j.tim.2005.04.005
    • Regoes RR, Bonhoeffer S (2005) The HIV coreceptor switch: a population dynamical perspective. Trends Microbiol 13:269-277. doi:10.1016/j.tim.2005.04. 005
    • (2005) Trends Microbiol , vol.13 , pp. 269-277
    • Regoes, R.R.1    Bonhoeffer, S.2
  • 81
    • 59049094482 scopus 로고    scopus 로고
    • HIV pathogenesis: 25 years of progress and persistent challenges
    • doi:10.1097/QAD.0b013e3283217f9f
    • Levy JA (2009) HIV pathogenesis: 25 years of progress and persistent challenges. AIDS 23:147-160. doi:10.1097/QAD.0b013e3283217f9f
    • (2009) AIDS , vol.23 , pp. 147-160
    • Levy, J.A.1
  • 82
    • 0036500559 scopus 로고    scopus 로고
    • HIV-1 infection in individuals with the CCR5-[Delta] 32/ [Delta] 32 genotype: Acquisition of syncytium-inducing virus at seroconversion
    • Sheppard HW, Celum C, Michael NL, O'Brien S, Dean M et al (2002) HIV-1 infection in individuals with the CCR5-[Delta] 32/ [Delta] 32 genotype: acquisition of syncytium-inducing virus at seroconversion. J Acquir Immune Defic Syndr 29:307
    • (2002) J Acquir Immune Defic Syndr , vol.29 , pp. 307
    • Sheppard, H.W.1    Celum, C.2    Michael, N.L.3    O'brien, S.4    Dean, M.5
  • 83
    • 33750497815 scopus 로고    scopus 로고
    • Stable coreceptor usage of HIV in patients with ongoing treatment failure on HAART
    • doi:10.1016/j.jcv.2006.08.008
    • Lehmann C, Däumer M, Boussaad I, Sing T, Beerenwinkel N et al (2006) Stable coreceptor usage of HIV in patients with ongoing treatment failure on HAART. J Clin Virol 37:300-304. doi:10.1016/j.jcv.2006.08.008
    • (2006) J Clin Virol , vol.37 , pp. 300-304
    • Lehmann, C.1    Däumer, M.2    Boussaad, I.3    Sing, T.4    Beerenwinkel, N.5
  • 84
    • 0032554603 scopus 로고    scopus 로고
    • Virus dynamics: The effect of target cell limitation and immune responses on virus evolution
    • Regoes RR, Wodarz D, Nowak MA (1998) Virus dynamics: the effect of target cell limitation and immune responses on virus evolution. J Theor Biol 191:451-462
    • (1998) J Theor Biol , vol.191 , pp. 451-462
    • Regoes, R.R.1    Wodarz, D.2    Nowak, M.A.3
  • 85
    • 41049083274 scopus 로고    scopus 로고
    • From HIV infection to AIDS: A dynamically induced percolation transition?
    • doi:10.1098/rspb.2002.2095
    • Kamp C, Bornholdt S (2002) From HIV infection to AIDS: a dynamically induced percolation transition? Proc R Soc B 269:2035-2040. doi:10.1098/rspb. 2002.2095
    • (2002) Proc R Soc B , vol.269 , pp. 2035-2040
    • Kamp, C.1    Bornholdt, S.2
  • 86
    • 56049094796 scopus 로고    scopus 로고
    • The evolutionary selective advantage of HIV-1 escape variants and the contribution of escape to the HLAassociated risk of AIDS progression
    • doi:10.1371/journal.pone.0003486
    • Asquith B (2008) The evolutionary selective advantage of HIV-1 escape variants and the contribution of escape to the HLAassociated risk of AIDS progression. PLoS One 3:e3486. doi:10.1371/journal.pone.0003486
    • (2008) PLoS One , vol.3
    • Asquith, B.1
  • 87
    • 79957888573 scopus 로고    scopus 로고
    • Mechanisms of HIVassociated lymphocyte apoptosis: 2010
    • Cummins NW, Badley AD (2010) Mechanisms of HIVassociated lymphocyte apoptosis: 2010. Cell Death and Dis 1:e99
    • (2010) Cell Death and Dis , vol.1
    • Cummins, N.W.1    Badley, A.D.2
  • 88
    • 0037820578 scopus 로고    scopus 로고
    • Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS
    • doi:10.1099/vir.0.19110-0
    • Alimonti JB, Ball TB, Fowke KR (2003) Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS. J Gen Virol 84:1649-1661. doi:10.1099/vir.0.19110-0
    • (2003) J Gen Virol , vol.84 , pp. 1649-1661
    • Alimonti, J.B.1    Ball, T.B.2    Fowke, K.R.3
  • 89
    • 34249700290 scopus 로고    scopus 로고
    • Understanding the slow depletion of memory CD4+ T cells in HIV infection
    • doi:10.1371/journal.pmed.0040177
    • Yates A, Stark J, Klein N, Antia R, Callard R (2007) Understanding the slow depletion of memory CD4+ T cells in HIV infection. PLoS Med 4:e177. doi:10.1371/journal.pmed.0040177
    • (2007) PLoS Med , vol.4
    • Yates, A.1    Stark, J.2    Klein, N.3    Antia, R.4    Callard, R.5
  • 90
    • 26244453946 scopus 로고    scopus 로고
    • The role of mutation accumulation in HIV progression
    • doi:10.1098/rspb.2005.3083
    • Galvani AP (2005) The role of mutation accumulation in HIV progression. Proc R Soc B 272:1851-1858. doi:10.1098/rspb.2005.3083
    • (2005) Proc R Soc B , vol.272 , pp. 1851-1858
    • Galvani, A.P.1
  • 91
    • 45549105435 scopus 로고    scopus 로고
    • Has HIV evolved to induce immune pathogenesis?
    • doi:10.1016/j.it.2008.04.005
    • Bartha I, Simon P, Müller V (2008) Has HIV evolved to induce immune pathogenesis? Trends Immunol 29:322-328. doi:10.1016/j.it.2008.04.005
    • (2008) Trends Immunol , vol.29 , pp. 322-328
    • Bartha, I.1    Simon, P.2    Müller, V.3
  • 92
    • 34548689151 scopus 로고    scopus 로고
    • Human immunodeficiency virus controllers: Mechanisms of durable virus control in the absence of antiretroviral therapy
    • Deeks SG, Walker BD (2007) Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy. Immunity 27:406-416
    • (2007) Immunity , vol.27 , pp. 406-416
    • Deeks, S.G.1    Walker, B.D.2
  • 93
    • 78650598765 scopus 로고    scopus 로고
    • The quest for a T cellbased immune correlate of protection against HIV: A story of trials and errors
    • doi:10.1038/nri2890
    • Koup RA, Graham BS, Douek DC (2011) The quest for a T cellbased immune correlate of protection against HIV: a story of trials and errors. Nat Rev Immunol 11:65-70. doi:10.1038/nri2890
    • (2011) Nat Rev Immunol , vol.11 , pp. 65-70
    • Koup, R.A.1    Graham, B.S.2    Douek, D.C.3
  • 94
    • 77953791222 scopus 로고    scopus 로고
    • Control of HIV-1 in elite suppressors despite ongoing replication and evolution in plasma virus
    • doi:10.1128/JVI.00548-10
    • O'Connell KA, Brennan TP, Bailey JR, Ray SC, Siliciano RF et al (2010) Control of HIV-1 in elite suppressors despite ongoing replication and evolution in plasma virus. J Virol 84(14):7018-7028. doi:10.1128/JVI.00548-10
    • (2010) J Virol , vol.84 , Issue.14 , pp. 7018-7028
    • O'connell, K.A.1    Brennan, T.P.2    Bailey, J.R.3    Ray, S.C.4    Siliciano, R.F.5
  • 95
    • 77957194223 scopus 로고    scopus 로고
    • Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: Associations with HLA type and clinical parameters
    • doi:10.1128/JVI.01084-10
    • Wright JK, Brumme ZL, Carlson JM, Heckerman D, Kadie CM et al (2010) Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters. J Virol 84:10820-10831. doi:10.1128/JVI.01084-10
    • (2010) J Virol , vol.84 , pp. 10820-10831
    • Wright, J.K.1    Brumme, Z.L.2    Carlson, J.M.3    Heckerman, D.4    Kadie, C.M.5
  • 96
    • 58149398654 scopus 로고    scopus 로고
    • HLA associated alterations in replication capacity of chimeric NL4-3 viruses encoding gag-protease from HIV-1 elite controllers
    • doi:10.1128/JVI.01471-08
    • Miura T, Brockman MA, Brumme ZL, Brumme CJ, Pereyra F et al (2008) HLA associated alterations in replication capacity of chimeric NL4-3 viruses encoding gag-protease from HIV-1 elite controllers. J Virol 83:140-149. doi:10.1128/JVI.01471-08
    • (2008) J Virol , vol.83 , pp. 140-149
    • Miura, T.1    Brockman, M.A.2    Brumme, Z.L.3    Brumme, C.J.4    Pereyra, F.5
  • 97
    • 63149157476 scopus 로고    scopus 로고
    • HLA associated viral mutations are common in human immunodeficiency virus type 1 elite controllers
    • Miura T, Brumme CJ, Brockman MA, Brumme ZL, Pereyra F et al (2009) HLA associated viral mutations are common in human immunodeficiency virus type 1 elite controllers. J Virol 83:3407-3412
    • (2009) J Virol , vol.83 , pp. 3407-3412
    • Miura, T.1    Brumme, C.J.2    Brockman, M.A.3    Brumme, Z.L.4    Pereyra, F.5
  • 98
    • 0025871325 scopus 로고
    • Mathematical biology of HIV infections: Antigenic variation and diversity threshold
    • Nowak MA, May RM (1991) Mathematical biology of HIV infections: antigenic variation and diversity threshold. Math Biosci 106:1-21
    • (1991) Math Biosci , vol.106 , pp. 1-21
    • Nowak, M.A.1    May, R.M.2
  • 99
    • 4043060710 scopus 로고    scopus 로고
    • Correlates of immune protection in HIV-1 infection: What we know, what we don't know, what we should know
    • Pantaleo G, Koup RA (2004) Correlates of immune protection in HIV-1 infection: what we know, what we don't know, what we should know. Nat Med 10:806-810
    • (2004) Nat Med , vol.10 , pp. 806-810
    • Pantaleo, G.1    Koup, R.A.2
  • 100
    • 80052953336 scopus 로고    scopus 로고
    • Converging on an HIV vaccine
    • doi:10.1126/science.1211919
    • Korber B, Gnanakaran S (2011) Converging on an HIV vaccine. Science 333:1589-1590. doi:10.1126/science.1211919
    • (2011) Science , vol.333 , pp. 1589-1590
    • Korber, B.1    Gnanakaran, S.2
  • 101
    • 79955476669 scopus 로고    scopus 로고
    • The study of elite controllers: A pure academic exercise or a potential pathway to an HIV-1 vaccine?
    • doi:10.1097/COH.0b013e3283457868
    • Blankson JN (2011) The study of elite controllers: a pure academic exercise or a potential pathway to an HIV-1 vaccine? Curr Opin HIVAIDS 6:147-150. doi:10.1097/COH.0b013e3283457868
    • (2011) Curr Opin HIVAIDS , vol.6 , pp. 147-150
    • Blankson, J.N.1
  • 102
    • 0036181249 scopus 로고    scopus 로고
    • Viral persistence: HIV's strategies of immune system evasion
    • doi:10.1146/annurev.med.53.082901.104053
    • Johnson WE, Desrosiers RC (2002) Viral persistence: HIV's strategies of immune system evasion. Annu Rev Med 53:499-518. doi:10.1146/annurev.med.53. 082901.104053
    • (2002) Annu Rev Med , vol.53 , pp. 499-518
    • Johnson, W.E.1    Desrosiers, R.C.2
  • 103
    • 0000752778 scopus 로고
    • The evolution of life history traits: A critique of the theory and a review of the data
    • Stearns SC (1977) The evolution of life history traits: a critique of the theory and a review of the data. Annu Rev Ecol Syst 8:145-171
    • (1977) Annu Rev Ecol Syst , vol.8 , pp. 145-171
    • Stearns, S.C.1
  • 104
    • 0016936143 scopus 로고
    • Life-history tactics: A review of the ideas
    • Stearns SC (1976) Life-history tactics: a review of the ideas. Q Rev Biol 51(1):3-47
    • (1976) Q Rev Biol , vol.51 , Issue.1 , pp. 3-47
    • Stearns, S.C.1
  • 105
    • 1842741699 scopus 로고    scopus 로고
    • HIV evolution: CTL escape mutation and reversion after transmission
    • Leslie AJ, Pfafferott KJ, Chetty P, Draenert R, Addo MM et al (2004) HIV evolution: CTL escape mutation and reversion after transmission. Nat Med 10:282-289
    • (2004) Nat Med , vol.10 , pp. 282-289
    • Leslie, A.J.1    Pfafferott, K.J.2    Chetty, P.3    Draenert, R.4    Addo, M.M.5
  • 106
    • 63949087100 scopus 로고    scopus 로고
    • Adaptation of HIV-1 to human leukocyte antigen class i
    • doi:10.1038/nature07746
    • Kawashima Y, Pfafferott K, Frater J, Matthews P, Payne R et al (2009) Adaptation of HIV-1 to human leukocyte antigen class I. Nature 458:641-645. doi:10.1038/nature07746
    • (2009) Nature , vol.458 , pp. 641-645
    • Kawashima, Y.1    Pfafferott, K.2    Frater, J.3    Matthews, P.4    Payne, R.5
  • 107
    • 72749120811 scopus 로고    scopus 로고
    • No evidence for competition between cytotoxic T-lymphocyte responses in HIV-1 infection
    • doi:10.1098/rspb.2009.1232
    • Fryer HR, Scherer A, Oxenius A, Phillips R,McLean AR (2009) No evidence for competition between cytotoxic T-lymphocyte responses in HIV-1 infection. Proc R Soc B. doi:10.1098/rspb.2009.1232
    • (2009) Proc R Soc B
    • Fryer, H.R.1    Scherer, A.2    Oxenius, A.3    Phillips, R.4    McLean, A.R.5
  • 108
    • 33746629789 scopus 로고    scopus 로고
    • Origins of HIV and the evolution of resistance to AIDS
    • doi:10.1126/science.1123016
    • Heeney JL, Dalgleish AG, Weiss RA (2006) Origins of HIV and the evolution of resistance to AIDS. Science 313:462-466. doi:10.1126/science.1123016
    • (2006) Science , vol.313 , pp. 462-466
    • Heeney, J.L.1    Dalgleish, A.G.2    Weiss, R.A.3
  • 109
    • 79751468870 scopus 로고    scopus 로고
    • Pathogenic mechanisms of HIV disease
    • doi:10.1146/annurevpathol-011110-130254
    • Moir S, Chun T-W, Fauci AS (2011) Pathogenic mechanisms of HIV disease. Annu Rev Pathol 6:223-248. doi:10.1146/annurevpathol-011110-130254
    • (2011) Annu Rev Pathol , vol.6 , pp. 223-248
    • Moir, S.1    Chun, T.-W.2    Fauci, A.S.3
  • 110
    • 78449265378 scopus 로고    scopus 로고
    • Host genetics and HIV-1: The final phase?
    • doi:10.1371/journal.ppat.1001033
    • Fellay J, Shianna KV, Telenti A, Goldstein DB (2010) Host genetics and HIV-1: the final phase? PLoS Pathog 6:e1001033. doi:10.1371/journal.ppat.1001033
    • (2010) PLoS Pathog , vol.6
    • Fellay, J.1    Shianna, K.V.2    Telenti, A.3    Goldstein, D.B.4
  • 111
    • 53349160053 scopus 로고    scopus 로고
    • Challenges in the development of an HIV-1 vaccine
    • Barouch DH (2008) Challenges in the development of an HIV-1 vaccine. Nature 455:613-619
    • (2008) Nature , vol.455 , pp. 613-619
    • Barouch, D.H.1
  • 112
    • 0035856919 scopus 로고    scopus 로고
    • Imperfect vaccines and the evolution of pathogen virulence
    • doi:10.1038/414751a
    • Gandon S, Mackinnon MJ, Nee S, Read AF (2001) Imperfect vaccines and the evolution of pathogen virulence. Nature 414:751-756. doi:10.1038/414751a
    • (2001) Nature , vol.414 , pp. 751-756
    • Gandon, S.1    MacKinnon, M.J.2    Nee, S.3    Read, A.F.4
  • 113
    • 35648988965 scopus 로고    scopus 로고
    • Identifying HIV-1 dual infections
    • doi:10.1186/1742-4690-4-67
    • van der Kuyl AC, Cornelissen M (2007) Identifying HIV-1 dual infections. Retrovirology 4:67. doi:10.1186/1742-4690-4-67
    • (2007) Retrovirology , vol.4 , pp. 67
    • Van Der Kuyl, A.C.1    Cornelissen, M.2
  • 114
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators
    • doi:10.1056/NEJM199803263381301
    • Palella FJ Jr, Delaney KM, Moorman AC, Loveless MO, Fuhrer J et al (1998) Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 338:853-860. doi:10.1056/NEJM199803263381301
    • (1998) N Engl J Med , vol.338 , pp. 853-860
    • Palella Jr., F.J.1    Delaney, K.M.2    Moorman, A.C.3    Loveless, M.O.4    Fuhrer, J.5
  • 115
    • 0030902875 scopus 로고    scopus 로고
    • Pre-existence and emergence of drug resistance in HIV-1 infection
    • Bonhoeffer S, Nowak MA (1997) Pre-existence and emergence of drug resistance in HIV-1 infection. Proc R Soc B 264:631-637
    • (1997) Proc R Soc B , vol.264 , pp. 631-637
    • Bonhoeffer, S.1    Nowak, M.A.2
  • 116
    • 0032568196 scopus 로고    scopus 로고
    • The frequency of resistant mutant virus before antiviral therapy
    • Ribeiro RM, Bonhoeffer S, Nowak MA (1998) The frequency of resistant mutant virus before antiviral therapy. AIDS 12:461
    • (1998) AIDS , vol.12 , pp. 461
    • Ribeiro, R.M.1    Bonhoeffer, S.2    Nowak, M.A.3
  • 117
    • 46049096485 scopus 로고    scopus 로고
    • Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs
    • Shen L, Peterson S, Sedaghat AR, McMahon MA, Callender M et al (2008) Dose-response curve slope sets class-specific limits on inhibitory potential of anti-HIV drugs. Nat Med 14:762-766
    • (2008) Nat Med , vol.14 , pp. 762-766
    • Shen, L.1    Peterson, S.2    Sedaghat, A.R.3    McMahon, M.A.4    Callender, M.5
  • 118
    • 79956291343 scopus 로고    scopus 로고
    • Dose-response curve slope is a missing dimension in the analysis of HIV-1 drug resistance
    • doi:10.1073/pnas.1018360108
    • Sampah MES, Shen L, Jilek BL, Siliciano RF (2011) Dose-response curve slope is a missing dimension in the analysis of HIV-1 drug resistance. Proc Natl Acad Sci USA 108:7613-7618. doi:10.1073/pnas.1018360108
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 7613-7618
    • Sampah, M.E.S.1    Shen, L.2    Jilek, B.L.3    Siliciano, R.F.4
  • 121
    • 33751021082 scopus 로고    scopus 로고
    • Stochastic or deterministic: What is the effective population size of HIV-1?
    • doi:16/j.tim.2006.10.001
    • Kouyos RD, Althaus CL, Bonhoeffer S (2006) Stochastic or deterministic: what is the effective population size of HIV-1? Trends Microbiol 14:507-511. doi:16/j.tim.2006.10.001
    • (2006) Trends Microbiol , vol.14 , pp. 507-511
    • Kouyos, R.D.1    Althaus, C.L.2    Bonhoeffer, S.3
  • 122
    • 67249121143 scopus 로고    scopus 로고
    • Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy
    • Dinoso JB, Kim SY, Wiegand AM, Palmer SE, Gange SJ et al (2009) Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. Proc Natl Acad Sci 106:9403
    • (2009) Proc Natl Acad Sci , vol.106 , pp. 9403
    • Dinoso, J.B.1    Kim, S.Y.2    Wiegand, A.M.3    Palmer, S.E.4    Gange, S.J.5
  • 123
    • 0033577801 scopus 로고    scopus 로고
    • Constant mean viral copy number per infected cell in tissues regardless of high, low, or undetectable plasma HIV RNA
    • doi:10.1084/jem.189.10.1545
    • Hockett RD, Michael Kilby J, Derdeyn CA, Saag MS, Sillers M et al (1999) Constant mean viral copy number per infected cell in tissues regardless of high, low, or undetectable plasma HIV RNA. J Exp Med 189:1545-1554. doi:10.1084/jem.189.10.1545
    • (1999) J Exp Med , vol.189 , pp. 1545-1554
    • Hockett, R.D.1    Michael Kilby, J.2    Derdeyn, C.A.3    Saag, M.S.4    Sillers, M.5
  • 124
    • 0037385686 scopus 로고    scopus 로고
    • A novel antiviral intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-cell decay in vivo
    • doi:10.1128/JVI.77.8.5037-5038.2003
    • Markowitz M, Louie M, Hurley A, Sun E, Di Mascio M et al (2003) A novel antiviral intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-cell decay in vivo. J Virol 77:5037-5038. doi:10.1128/JVI.77.8.5037-5038.2003
    • (2003) J Virol , vol.77 , pp. 5037-5038
    • Markowitz, M.1    Louie, M.2    Hurley, A.3    Sun, E.4    Di Mascio, M.5
  • 126
    • 0032824180 scopus 로고    scopus 로고
    • Linkage disequilibrium test implies a large effective population number for HIV in vivo
    • Rouzine I, Coffin J (1999) Linkage disequilibrium test implies a large effective population number for HIV in vivo. Proc Natl Acad Sci USA 96:10758
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 10758
    • Rouzine, I.1    Coffin, J.2
  • 127
    • 0004732896 scopus 로고    scopus 로고
    • Analysis of HIV-1 env gene sequences reveals evidence for a low effective number in the viral population
    • Brown AJL (1997) Analysis of HIV-1 env gene sequences reveals evidence for a low effective number in the viral population. Proc Natl Acad Sci USA 94:1862
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1862
    • Ajl, B.1
  • 128
    • 33747646240 scopus 로고    scopus 로고
    • Resistance development over 144 weeks in treatment-naive patients receiving tenofovir disoproxil fumarate or stavudine with lamivudine and efavirenz in Study 903*
    • Margot N, Lu B, Cheng A, Miller M (2006) Resistance development over 144 weeks in treatment-naive patients receiving tenofovir disoproxil fumarate or stavudine with lamivudine and efavirenz in Study 903* HIV Med 7:442-450
    • (2006) HIV Med , vol.7 , pp. 442-450
    • Margot, N.1    Lu, B.2    Cheng, A.3    Miller, M.4
  • 129
    • 70449633111 scopus 로고    scopus 로고
    • A novel method for determining the inhibitory potential of anti-HIV drugs
    • doi:10.1016/j.tips.2009.09.003
    • Shen L, Rabi SA, Siliciano RF (2009) A novel method for determining the inhibitory potential of anti-HIV drugs. Trends Pharmacol Sci 30:610-616. doi:10.1016/j.tips.2009.09.003
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 610-616
    • Shen, L.1    Rabi, S.A.2    Siliciano, R.F.3
  • 130
    • 1642540589 scopus 로고    scopus 로고
    • HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse
    • Jolly C, Kashefi K, Hollinshead M, Sattentau QJ (2004) HIV-1 cell to cell transfer across an Env-induced, actin-dependent synapse. J Exp Med 199:283
    • (2004) J Exp Med , vol.199 , pp. 283
    • Jolly, C.1    Kashefi, K.2    Hollinshead, M.3    Sattentau, Q.J.4
  • 131
    • 44349094889 scopus 로고    scopus 로고
    • Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses
    • Groot F, Welsch S, Sattentau QJ (2008) Efficient HIV-1 transmission from macrophages to T cells across transient virological synapses. Blood 111:4660
    • (2008) Blood , vol.111 , pp. 4660
    • Groot, F.1    Welsch, S.2    Sattentau, Q.J.3
  • 132
    • 80052395837 scopus 로고    scopus 로고
    • Cellto- cell spread of HIV permits ongoing replication despite antiretroviral therapy
    • doi:10.1038/nature10347
    • Sigal A, Kim JT, Balazs AB, Dekel E, Mayo A et al (2011) Cellto- cell spread of HIV permits ongoing replication despite antiretroviral therapy. Nature 477:95-98. doi:10.1038/nature10347
    • (2011) Nature , vol.477 , pp. 95-98
    • Sigal, A.1    Kim, J.T.2    Balazs, A.B.3    Dekel, E.4    Mayo, A.5
  • 134
    • 0036176509 scopus 로고    scopus 로고
    • The challenge of viral reservoirs in HIV-1 infection
    • Blankson JN, Persaud D, Siliciano RF (2002) The challenge of viral reservoirs in HIV-1 infection. Annu Rev Med 53:557-593
    • (2002) Annu Rev Med , vol.53 , pp. 557-593
    • Blankson, J.N.1    Persaud, D.2    Siliciano, R.F.3
  • 135
    • 0347951393 scopus 로고    scopus 로고
    • The contribution of monocyte infection and trafficking to viral persistence, and maintenance of the viral reservoir in HIV infection
    • Crowe S, Zhu T, Muller WA (2003) The contribution of monocyte infection and trafficking to viral persistence, and maintenance of the viral reservoir in HIV infection. J Leukocyt Biol 74:635-641
    • (2003) J Leukocyt Biol , vol.74 , pp. 635-641
    • Crowe, S.1    Zhu, T.2    Muller, W.A.3
  • 136
    • 4444235837 scopus 로고    scopus 로고
    • Independent evolution of human immunodeficiency virus (HIV) drug resistance mutations in diverse areas of the brain in HIV-infected patients, with and without dementia, on antiretroviral treatment
    • Smit TK, Brew BJ, Tourtellotte W, Morgello S, Gelman BB et al (2004) Independent evolution of human immunodeficiency virus (HIV) drug resistance mutations in diverse areas of the brain in HIV-infected patients, with and without dementia, on antiretroviral treatment. J Virol 78:10133
    • (2004) J Virol , vol.78 , pp. 10133
    • Smit, T.K.1    Brew, B.J.2    Tourtellotte, W.3    Morgello, S.4    Gelman, B.B.5
  • 137
    • 78650338104 scopus 로고    scopus 로고
    • HIV-1 viral escape in cerebrospinal fluid of subjects on suppressive antiretroviral treatment
    • Edén A, Fuchs D, Hagberg L, Nilsson S, Spudich S et al (2010) HIV-1 viral escape in cerebrospinal fluid of subjects on suppressive antiretroviral treatment. J Infect Dis 202:1819
    • (2010) J Infect Dis , vol.202 , pp. 1819
    • Edén, A.1    Fuchs, D.2    Hagberg, L.3    Nilsson, S.4    Spudich, S.5
  • 138
    • 0036399460 scopus 로고    scopus 로고
    • HIV coreceptor usage and drug treatment
    • Regoes R, Bonhoeffer S (2002) HIV coreceptor usage and drug treatment. J Theor Biol 217:443-457
    • (2002) J Theor Biol , vol.217 , pp. 443-457
    • Regoes, R.1    Bonhoeffer, S.2
  • 139
    • 70449713920 scopus 로고    scopus 로고
    • Accelerated immunodeficiency by anti-CCR5 treatment in HIV infection
    • doi:10.1371/journal.pcbi.1000467
    • Weinberger AD, Perelson AS, Ribeiro RM, Weinberger LS (2009) Accelerated immunodeficiency by anti-CCR5 treatment in HIV infection. PLoS Comput Biol 5:e1000467. doi:10.1371/journal.pcbi.1000467
    • (2009) PLoS Comput Biol , vol.5
    • Weinberger, A.D.1    Perelson, A.S.2    Ribeiro, R.M.3    Weinberger, L.S.4
  • 140
    • 0037062513 scopus 로고    scopus 로고
    • Diversity and complexity of HIV-1 drug resistance: A bioinformatics approach to predicting phenotype from genotype
    • doi:10.1073/pnas.112177799
    • Beerenwinkel N, Schmidt B,Walter H, Kaiser R, Lengauer T et al (2002) Diversity and complexity of HIV-1 drug resistance: a bioinformatics approach to predicting phenotype from genotype. Proc Natl Acad Sci 99:8271-8276. doi:10.1073/pnas.112177799
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 8271-8276
    • Beerenwinkel, N.1    Schmidt Bwalter, H.2    Kaiser, R.3    Lengauer, T.4
  • 142
    • 79960669663 scopus 로고    scopus 로고
    • HIV-1 mutational pathways under multidrug therapy
    • doi:10.1186/1742-6405-8-26
    • Lawyer G, Altmann A, Thielen A, Zazzi M, Sönnerborg A et al (2011) HIV-1 mutational pathways under multidrug therapy. AIDS Res Ther 8:26. doi:10.1186/1742-6405-8-26
    • (2011) AIDS Res Ther , vol.8 , pp. 26
    • Lawyer, G.1    Altmann, A.2    Thielen, A.3    Zazzi, M.4    Sönnerborg, A.5
  • 143
    • 0036182633 scopus 로고    scopus 로고
    • Ribavirin's antiviral mechanism of action: Lethal mutagenesis?
    • doi:10.1007/s00109-001-0308-0
    • Crotty S, Cameron C, Andino R (2002) Ribavirin's antiviral mechanism of action: lethal mutagenesis? J Mol Med 80:86-95. doi:10.1007/s00109-001-0308-0
    • (2002) J Mol Med , vol.80 , pp. 86-95
    • Crotty, S.1    Cameron, C.2    Andino, R.3
  • 144
    • 34249339797 scopus 로고    scopus 로고
    • Cornering HIV: Taking advantage of interactions between selective pressures
    • doi:10.1016/j.mehy.2006.12.012
    • Ávila-Ríos S, Reyes-Terán G, Espinosa E (2007) Cornering HIV: taking advantage of interactions between selective pressures. Med Hypotheses 69:422-431. doi:10.1016/j.mehy.2006.12.012
    • (2007) Med Hypotheses , vol.69 , pp. 422-431
    • Ávila-Ríos, S.1    Reyes-Terán, G.2    Espinosa, E.3
  • 145
    • 0036499181 scopus 로고    scopus 로고
    • Follicular dendritic cells and the persistence of HIVinfectivity: The role of antibodies and Fc-gamma receptors
    • Smith-Franklin BA, Keele BF, Tew JG, Gartner S, Szakal AK et al (2002) Follicular dendritic cells and the persistence of HIVinfectivity: the role of antibodies and Fc-gamma receptors. J Immunol 168:2408
    • (2002) J Immunol , vol.168 , pp. 2408
    • Smith-Franklin, B.A.1    Keele, B.F.2    Tew, J.G.3    Gartner, S.4    Szakal, A.K.5
  • 146
    • 18844368812 scopus 로고    scopus 로고
    • Bacterial persistence: A model of survival in changing environments
    • doi:10.1534/genetics.104.035352
    • Kussell E, Kishony R, Balaban NQ, Leibler S (2005) Bacterial persistence: a model of survival in changing environments. Genetics 169:1807-1814. doi:10.1534/genetics.104.035352
    • (2005) Genetics , vol.169 , pp. 1807-1814
    • Kussell, E.1    Kishony, R.2    Balaban, N.Q.3    Leibler, S.4
  • 147
    • 34247185027 scopus 로고    scopus 로고
    • The latent reservoir for HIV-1 in resting CD4+ T cells: A barrier to cure
    • doi:10.1097/01.COH.0000209582.82328.b8
    • Siliciano JD, Siliciano RF (2006) The latent reservoir for HIV-1 in resting CD4+ T cells: a barrier to cure. Curr Opin HIV AIDS 1:121-128. doi:10.1097/01.COH.0000209582.82328.b8
    • (2006) Curr Opin HIV AIDS , vol.1 , pp. 121-128
    • Siliciano, J.D.1    Siliciano, R.F.2
  • 149
    • 22744441386 scopus 로고    scopus 로고
    • Stochastic gene expression in a lentiviral positivefeedback loop: HIV-1 Tat fluctuations drive phenotypic diversity
    • doi:10.1016/j.cell.2005.06.006
    • Weinberger LS, Burnett JC, Toettcher JE, Arkin AP, Schaffer DV (2005) Stochastic gene expression in a lentiviral positivefeedback loop: HIV-1 Tat fluctuations drive phenotypic diversity. Cell 122:169-182. doi:10.1016/j.cell. 2005.06.006
    • (2005) Cell , vol.122 , pp. 169-182
    • Weinberger, L.S.1    Burnett, J.C.2    Toettcher, J.E.3    Arkin, A.P.4    Schaffer, D.V.5
  • 150
    • 33846360341 scopus 로고    scopus 로고
    • An HIV feedback resistor: Autoregulatory circuit deactivator and noise buffer
    • doi:10.1371/journal.pbio.0050009
    • Weinberger LS, Shenk T (2006) An HIV feedback resistor: autoregulatory circuit deactivator and noise buffer. PLoS Biol 5:e9. doi:10.1371/journal.pbio. 0050009
    • (2006) PLoS Biol , vol.5
    • Weinberger, L.S.1    Shenk, T.2
  • 151
    • 68049129695 scopus 로고    scopus 로고
    • Stochastic gene expression as a molecular switch for viral latency
    • doi:10.1016/j.mib.2009.06.016
    • Singh A, Weinberger LS (2009) Stochastic gene expression as a molecular switch for viral latency. Curr Opin Microbiol 12:460-466. doi:10.1016/j.mib. 2009.06.016
    • (2009) Curr Opin Microbiol , vol.12 , pp. 460-466
    • Singh, A.1    Weinberger, L.S.2
  • 153
    • 67651173920 scopus 로고    scopus 로고
    • The epidemiology of transmission of drug resistant HIV-1
    • Leitner T (ed). Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos
    • van de Vijver D, Wensing AMJ, Boucher CAB (2007) The epidemiology of transmission of drug resistant HIV-1. In: Leitner T (ed) HIV Sequence Compendium 2007. Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, Los Alamos
    • (2007) HIV Sequence Compendium 2007
    • Van De Vijver, D.1    Wensing, A.M.J.2    Boucher, C.A.B.3
  • 154
    • 62749131195 scopus 로고    scopus 로고
    • Demonstration of sustained drug-resistant human immunodeficiency virus type 1 lineages circulating among treatment-naïve individuals
    • doi:10.1128/JVI.01556-08
    • Hué S, Gifford RJ, Dunn D, Fernhill E, Pillay D (2009) Demonstration of sustained drug-resistant human immunodeficiency virus type 1 lineages circulating among treatment-naïve individuals. J Virol 83:2645-2654. doi:10.1128/JVI.01556-08
    • (2009) J Virol , vol.83 , pp. 2645-2654
    • Hué, S.1    Gifford, R.J.2    Dunn, D.3    Fernhill, E.4    Pillay, D.5
  • 155
    • 43949110248 scopus 로고    scopus 로고
    • Persistence of transmitted drug resistance among subjects with primary human immunodeficiency virus infection
    • doi:10.1128/JVI.02579-07
    • Little SJ, Frost SDW, Wong JK, Smith DM, Pond SLK et al (2008) Persistence of transmitted drug resistance among subjects with primary human immunodeficiency virus infection. J Virol 82:5510-5518. doi:10.1128/JVI.02579-07
    • (2008) J Virol , vol.82 , pp. 5510-5518
    • Little, S.J.1    Frost, S.D.W.2    Wong, J.K.3    Smith, D.M.4    Slk, P.5
  • 156
    • 33750447962 scopus 로고    scopus 로고
    • The role of compensatory mutations in the emergence of drug resistance
    • doi:10.1371/journal.pcbi.0020137
    • Handel A, Regoes RR, Antia R (2006) The role of compensatory mutations in the emergence of drug resistance. PLoS Comput Biol 2:e137. doi:10.1371/journal. pcbi.0020137
    • (2006) PLoS Comput Biol , vol.2
    • Handel, A.1    Regoes, R.R.2    Antia, R.3
  • 157
    • 77951223398 scopus 로고    scopus 로고
    • Compensation of fitness costs and reversibility of antibiotic resistance mutations
    • 10.1128/AAC.01460-09
    • Schulz zurWiesch P, Engelstadter J, Bonhoeffer S (2010) Compensation of fitness costs and reversibility of antibiotic resistance mutations. Antimicrob Agents Chemother 54:2085-2095, 10.1128/AAC.01460-09
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 2085-2095
    • Schulz Zurwiesch, P.1    Engelstadter, J.2    Bonhoeffer, S.3
  • 158
    • 77954757141 scopus 로고    scopus 로고
    • The effect of transmitted HIV-1 drug resistance on pre-therapy viral load
    • doi:10.1097/QAD.0b013e32833c1d93
    • Harrison L, Castro H, Cane P, Pillay D, Booth C et al (2010) The effect of transmitted HIV-1 drug resistance on pre-therapy viral load. AIDS 24:1917-1922. doi:10.1097/QAD.0b013e32833c1d93
    • (2010) AIDS , vol.24 , pp. 1917-1922
    • Harrison, L.1    Castro, H.2    Cane, P.3    Pillay, D.4    Booth, C.5
  • 159
    • 79955477986 scopus 로고    scopus 로고
    • Effect of transmitted drug resistance on virological and immunological response to initial combination antiretroviral therapy for HIV (EuroCoord-CHAIN joint project): A European multicohort study
    • doi:10.1016/S1473-3099(11)70032-9
    • Wittkop L, Günthard HF, de Wolf F, Dunn D, Cozzi-Lepri A et al (2011) Effect of transmitted drug resistance on virological and immunological response to initial combination antiretroviral therapy for HIV (EuroCoord-CHAIN joint project): a European multicohort study. Lancet Infect Dis 11:363-371. doi:10.1016/S1473-3099(11)70032-9
    • (2011) Lancet Infect Dis , vol.11 , pp. 363-371
    • Wittkop, L.1    Günthard, H.F.2    De Wolf, F.3    Dunn, D.4    Cozzi-Lepri, A.5
  • 160
    • 76249130812 scopus 로고    scopus 로고
    • Evolutionary dynamics of complex networks of HIV drugresistant strains: The case of San Francisco
    • doi:10.1126/science.1180556
    • Smith RJ, Okano JT, Kahn JS, Bodine EN, Blower S (2010) Evolutionary dynamics of complex networks of HIV drugresistant strains: the case of San Francisco. Science 327(5966): 697-701. doi:10.1126/science.1180556
    • (2010) Science , vol.327 , Issue.5966 , pp. 697-701
    • Smith, R.J.1    Okano, J.T.2    Kahn, J.S.3    Bodine, E.N.4    Blower, S.5
  • 161
    • 79952032570 scopus 로고    scopus 로고
    • Population biological principles of drug-resistance evolution in infectious diseases
    • doi:10.1016/S1473-3099(10)70264-4
    • zur Wiesch PA, Kouyos R, Engelstädter J, Regoes RR, Bonhoeffer S (2011) Population biological principles of drug-resistance evolution in infectious diseases. Infect Dis 11:236-247. doi:10.1016/S1473-3099(10)70264-4
    • (2011) Infect Dis , vol.11 , pp. 236-247
    • Zur Wiesch, P.A.1    Kouyos, R.2    Engelstädter, J.3    Regoes, R.R.4    Bonhoeffer, S.5
  • 162
    • 77949568092 scopus 로고    scopus 로고
    • Call of the wild: Antibiotic resistance genes in natural environments
    • doi:10.1038/nrmicro2312
    • Allen HK, Donato J, Wang HH, Cloud-Hansen KA, Davies J et al (2010) Call of the wild: antibiotic resistance genes in natural environments. Nat Rev Micro 8:251-259. doi:10.1038/nrmicro2312
    • (2010) Nat Rev Micro , vol.8 , pp. 251-259
    • Allen, H.K.1    Donato, J.2    Wang, H.H.3    Cloud-Hansen, K.A.4    Davies, J.5
  • 163
    • 0026705492 scopus 로고
    • Epidemiology of drug resistance: Implications for a post-antimicrobial era
    • doi:10.1126/science.257.5073.1050
    • Cohen ML (1992) Epidemiology of drug resistance: implications for a post-antimicrobial era. Science 257:1050-1055. doi:10.1126/science.257.5073.1050
    • (1992) Science , vol.257 , pp. 1050-1055
    • Cohen, M.L.1
  • 164
    • 0026752606 scopus 로고
    • An outbreak of multidrug-resistant tuberculosis among hospitalized patients with the acquired immunodeficiency syndrome
    • Edlin BR, Tokars JI, Grieco MH, Crawford JT, Williams J et al (1992) An outbreak of multidrug-resistant tuberculosis among hospitalized patients with the acquired immunodeficiency syndrome. N Engl J Med 326:1514-1521
    • (1992) N Engl J Med , vol.326 , pp. 1514-1521
    • Edlin, B.R.1    Tokars, J.I.2    Grieco, M.H.3    Crawford, J.T.4    Williams, J.5
  • 165
    • 7044285767 scopus 로고    scopus 로고
    • Modeling epidemics of multidrugresistant M. tuberculosis of heterogeneous fitness
    • doi:10.1038/nm1110
    • Cohen T, Murray M (2004) Modeling epidemics of multidrugresistant M. tuberculosis of heterogeneous fitness. Nat Med 10:1117-1121. doi:10.1038/nm1110
    • (2004) Nat Med , vol.10 , pp. 1117-1121
    • Cohen, T.1    Murray, M.2
  • 166
    • 33646034630 scopus 로고    scopus 로고
    • Adherence-resistance relationships for protease and non-nucleoside reverse transcriptase inhibitors explained by virological fitness
    • doi:10.1097/01.aids.0000199825.34241.49
    • Bangsberg DR, Acosta EP, Gupta R, Guzman D, Riley ED et al (2006) Adherence-resistance relationships for protease and non-nucleoside reverse transcriptase inhibitors explained by virological fitness. AIDS 20:223-231. doi:10.1097/01.aids.0000199825.34241.49
    • (2006) AIDS , vol.20 , pp. 223-231
    • Bangsberg, D.R.1    Acosta, E.P.2    Gupta, R.3    Guzman, D.4    Riley, E.D.5
  • 167
    • 77955454024 scopus 로고    scopus 로고
    • HIV, transmitted drug resistance, and the paradox of preexposure prophylaxis
    • doi:10.1073/pnas.1006061107
    • Supervie V, García-Lerma JG, Heneine W, Blower S (2010) HIV, transmitted drug resistance, and the paradox of preexposure prophylaxis. Proc Natl Acad Sci USA 107:12381-12386. doi:10.1073/pnas.1006061107
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 12381-12386
    • Supervie, V.1    García-Lerma, J.G.2    Heneine, W.3    Blower, S.4
  • 168
    • 12144273186 scopus 로고    scopus 로고
    • The antiretroviral rollout and drug-resistant HIV in Africa: Insights from empirical data and theoretical models
    • Blower S, Bodine E, Kahn J, McFarland W (2005) The antiretroviral rollout and drug-resistant HIV in Africa: insights from empirical data and theoretical models. AIDS 19:1-14
    • (2005) AIDS , vol.19 , pp. 1-14
    • Blower, S.1    Bodine, E.2    Kahn, J.3    McFarland, W.4
  • 169
    • 0032710838 scopus 로고    scopus 로고
    • Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infection
    • Shankarappa R, Margolick JB, Gange SJ, Rodrigo AG, Upchurch D et al (1999) Consistent viral evolutionary changes associated with the progression of human immunodeficiency virus type 1 infection. J Virol 73:10489-10502
    • (1999) J Virol , vol.73 , pp. 10489-10502
    • Shankarappa, R.1    Margolick, J.B.2    Gange, S.J.3    Rodrigo, A.G.4    Upchurch, D.5
  • 170
    • 58149175798 scopus 로고    scopus 로고
    • Dynamic correlation between intrahost HIV-1 quasispecies evolution and disease progression
    • doi:10.1371%2Fjournal.pcbi.1000240
    • Lee HY, Perelson AS, Park S-C, Leitner T (2008) Dynamic correlation between intrahost HIV-1 quasispecies evolution and disease progression. PLoS Comput Biol 4:e1000240. doi:10.1371%2Fjournal.pcbi.1000240
    • (2008) PLoS Comput Biol , vol.4
    • Lee, H.Y.1    Perelson, A.S.2    Park, S.-C.3    Leitner, T.4
  • 171
    • 44649102135 scopus 로고    scopus 로고
    • Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
    • doi:10.1073/pnas.0802203105
    • Keele BF, Giorgi EE, Salazar-Gonzalez JF, Decker JM, Pham KT et al (2008) Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection. Proc Natl Acad Sci USA 105:7552-7557. doi:10.1073/pnas.0802203105
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7552-7557
    • Keele, B.F.1    Giorgi, E.E.2    Salazar-Gonzalez, J.F.3    Decker, J.M.4    Pham, K.T.5
  • 173
    • 26244453946 scopus 로고    scopus 로고
    • The role of mutation accumulation in HIV progression
    • doi:10.1098/rspb.2005.3083
    • Galvani AP (2005) The role of mutation accumulation in HIV progression. Proc R Soc B 272:1851-1858. doi:10.1098/rspb.2005.3083
    • (2005) Proc R Soc B , vol.272 , pp. 1851-1858
    • Galvani, A.P.1


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