A novel antiviral intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-cell decay in vivo

Journal of Virology

Volumn 77, Issue 8, 2003, Pages 5037-5038

  Markowitz, Martin ^a,d   Louie, Michael ^a   Hurley, Arlene ^a   Sun, Eugene ^b   Di Mascio, Michele ^c   Perelson, Alan S ^c   Ho, David D ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b ABBOTT LABORATORIES   (United States)

^c LOS ALAMOS NATIONAL LABORATORY   (United States)

^d AARON DIAMOND AIDS RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; CD4 ANTIGEN; EFAVIRENZ; LAMIVUDINE; LOPINAVIR PLUS RITONAVIR; TENOFOVIR;

ANTIVIRAL ACTIVITY; ARTICLE; CELL DEATH; CELL FUNCTION; CELL KINETICS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DRUG POTENCY; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; NONHUMAN; NONLINEAR REGRESSION ANALYSIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS REPLICATION;

ANTI-HIV AGENTS; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; HIV INFECTIONS; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; MODELS, BIOLOGICAL; REVERSE TRANSCRIPTASE INHIBITORS; RNA, VIRAL; VIRUS REPLICATION;

EID: 0037385686     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.77.8.5037-5038.2003     Document Type: Article

References (7)

1. Ho, D. D., A. U. Neumann, A. S. Perelson, W. Chen, J. M. Leonard, and M. Markowitz. 1995. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373:123-126.
2. Louie, M., C. Hogan, M. Di Mascio, A. Hurley, V. Simon, J. Rooney, N. Ruiz, S. Brun, E. Sun, A. S. Perelson, D. D. Ho, and M. Markowitz. Determining the relative efficacy of highly active antiretroviral therapy. J. Infect. Dis. in press.
3. Palella, F. J., Jr., K. M. Delaney, A. C. Moorman, M. O. Loveless, J. Fuhrer, G. A. Satten, D. J. Aschman, S. D. Holmberg, et al. 1998. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N. Engl. J. Med. 338:853-860.
4. Perelson, A. S., P. Essunger, Y. Cao, M. Vesanen, A. Hurley, K. Saksela, M. Markowitz, and D. D. Ho. 1997. Decay characteristics of HIV-1-infected compartments during combination therapy. Nature 387:188-191.
5. Perelson, A. S., A. U. Neumann, M. Markowitz, J. M. Leonard, and D. D. Ho. 1996. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 271:1582-1586.
6. Ramratnam, B., S. Bonhoeffer, J. Binley, A. Hurley, L. Zhang, J. E. Mittler, M. Markowitz, J. P. Moore, A. S. Perelson, and D. D. Ho. 1999. Rapid production and clearance of HIV-1 and hepatitis C virus assessed by large volume plasma apheresis. Lancet 354:1782-1785.
7. Yeni, P. G., S. M. Hammer, C. C. Carpenter, D. A. Cooper, M. A. Fischl, J. M. Gatell, B. G. Gazzard, M. S. Hirsch, D. M. Jacobsen, D. A. Katzenstein, J. S. Montaner, D. D. Richman, M. S. Saag, M. Schechter, R. T. Schooley, M. A. Thompson, S. Vella, and P. A. Volberding. 2002. Antiretroviral treatment for adult HIV infection in 2002: updated recommendations of the International AIDS Society - USA Panel. JAMA 288:222-235.