Design, synthesis, and antiviral evaluation of purine-β-lactam and purine-aminopropanol hybrids

Journal of Medicinal Chemistry

Volumn 55, Issue 11, 2012, Pages 5637-5641

  D'Hooghe, Matthias ^a   Mollet, Karen ^a   De Vreese, Rob ^a   Jonckers, Tim H M ^b   Dams, Géry ^b   De Kimpe, Norbert ^a  

^a GHENT UNIVERSITY   (Belgium)

^b JANSSEN RESEARCH FOUNDATION   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAM DERIVATIVE; PURINE AMINOPROPANOL; PURINE BETA LACTAM; PURINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ANTIVIRAL ACTIVITY; ARTICLE; CHIKUNGUNYA ALPHAVIRUS; CHIMERA; CONTROLLED STUDY; COXSACKIE VIRUS B; CYTOMEGALOVIRUS; CYTOTOXICITY; DENGUE VIRUS 2; DRUG DESIGN; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HYBRID; IN VITRO STUDY; INFLUENZA VIRUS; NUCLEOPHILICITY; PHARMACOPHORE; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; RING OPENING; STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; DRUG DESIGN; HEPATITIS VIRUSES; HUMANS; LACTAMS; ORTHOMYXOVIRIDAE; PROPANOLAMINES; PURINES; RNA VIRUSES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84862290167     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300383k     Document Type: Article

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