Promiscuous enzyme-catalyzed regioselective Michael addition of purine derivatives to α,β-unsaturated carbonyl compounds in organic solvent

Tetrahedron

Volumn 65, Issue 12, 2009, Pages 2531-2536

  Wang, Jun Liang ^a   Xu, Jian Ming ^a   Wu, Qi ^a   Lv, De Shui ^a   Lin, Xian Fu ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

, Unsaturated compounds; d Aminoacylase; Michael addition; Purine derivatives

Indexed keywords

1,5 BIS (3 OXOBUTYL) 1,5 DIHYDRO PYRAZOLO(3,4 D)PYRIMIDIN 4 ONE; 1,9 BIS(3 OXOBUTYL) 1,9 DIHYDRO PURIN 6 ONE; 3 (6 BENZYLAMINO PURIN 1 YL)PROPIONIC ACID METHYL ESTER; 3 (6 BENZYLAMINO PURIN 9 YL) 2 METHYL PROPIONIC ACID METHYL ESTER; 3 (6 BENZYLAMINO PURIN 9 YL) 2 METHYL PROPIONIC ACID VINYL ESTER; 3 (6 BENZYLAMINO PURIN 9 YL)BUTYRIC ACID METHYL ESTER; 3 (6 BENZYLAMINO PURIN 9 YL)BUTYRIC ACID VINYL ESTER; 3 (6 BENZYLAMINO PURIN 9 YL)PROPIONIC ACID BUTYL ESTER; 3 (6 BENZYLAMINO PURIN 9 YL)PROPIONIC ACID ETHYL ESTER; 3 (6 BENZYLAMINO PURIN 9 YL)PROPIONIC ACID METHYL ESTER; 3 (6 BENZYLAMINO PURIN 9 YL)PROPIONITRILE; 3 [1 (2 CYANOETHYL) 4 OXO 1,4 DIHYDRO PYRAZOLO(3,4 D)PYRIMIDIN 5 YL]PROPIONITRILE; 3 [1 (2 METHOXYCARBONYLETHYL) 6 OXO 1,6 DIHYDROPURIN 9 YL]PROPIONIC ACID METHYL ESTER; 3 [5 (2 METHOXYCARBONYL ETHYL) 4 OXO 4,5 DIHYROPYRAZOLO(3,4 D)PYRIMIDIN 1 YL]PROPIONIC ACID METHYL ESTER; 3 [6 (3 METHYL 5 NITRO 3H IMIDAZOL 4 YLSULFANYL)PURIN 9 YL]PROPIONIC ACID METHYL ESTER; 3 [9 (2 CYANO ETHYL) 6 OXO 6,9 DIHYDRO PURIN 1 YL]PROPIONITRILE; 4 (6 BENZYLAMINO PURIN 9 YL)BUTAN 2 ONE; 4 (6 CHLORO PURIN 9 YL)BUTAN 2 ONE; 4 [6 (3 METHYL 5 NITRO 3H IMIDAZOL 4 YLSULFANYL)PURIN 9 YL]BUTAN 2 ONE; 4 [6 (3 METHYL 5 NITRO 3H IMIDAZOL 4 YLSULFNAYL)PURIN 9 YL]BUTYRONITRILE; AMINOACYLASE; CARBONYL DERIVATIVE; DIMETHYL SULFOXIDE; ORGANIC SOLVENT; PURINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVITY; MICHAEL ADDITION; PRIORITY JOURNAL; STEREOCHEMISTRY; TEMPERATURE;

EID: 60149103177     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2009.01.056     Document Type: Article

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