Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis

Journal of Biological Chemistry

Volumn 287, Issue 25, 2012, Pages 21142-21151

  Conus, Sébastien ^a   Pop, Cristina ^b   Snipas, Scott J ^b   Salvesen, Guy S ^b   Simon, Hans Uwe ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC PH; ACTIVATION MECHANISMS; ACTIVE SITE; CASPASE-3 ACTIVATION; CASPASES; CATHEPSIN D; CELL-FREE ASSAYS; DIRECT ACTIVATION; FAST ACTIVATION; HOMODIMERIZATION; IN-VITRO; INFLAMMATORY RESPONSE; NEUTROPHIL APOPTOSIS; PHARMACOLOGICAL INHIBITORS; SITE-SPECIFIC;

KETONES; RECOMBINANT PROTEINS;

CELL DEATH;

CASPASE 10; CASPASE 8; CASPASE 9; CATHEPSIN D; KETONE DERIVATIVE; PEPSTATIN; UNCLASSIFIED DRUG; VALYLALANYLLYSINE FLUOROMETHYL KETONE;

APOPTOSIS; ARTICLE; CELL ASSAY; CELL FREE SYSTEM; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME STABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; PH; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; UPREGULATION;

APOPTOSIS; CASPASE 10; CASPASE 8; CASPASE 9; CATHEPSIN D; ENZYME ACTIVATION; FEMALE; HUMANS; MALE; NEUTROPHILS; PROTEIN MULTIMERIZATION; PROTEOLYSIS; RECOMBINANT PROTEINS;

EID: 84862285729     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.306399     Document Type: Article

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