Estimation of recombinant protein production in Pichia pastoris based on a constraint-based model

Journal of Process Control

Volumn 22, Issue 6, 2012, Pages 1139-1151

  Tortajada, Marta ^a   Llaneras, Francisco ^b   Ramón, Daniel ^a   Picó, Jesús ^c  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSITY OF GIRONA   (Spain)

^c UNIVERSITAT POLITÈCNICA DE VALÈNCIA   (Spain)

Author keywords

Constraint based model; Pichia pastoris; Possibilistic metabolic flux analysis; Protein productivity prediction; Uncertainty

Indexed keywords

BIOMASS GROWTH; CONSTRAINT-BASED; CROSS VALIDATION; EXCHANGE RATES; EXPERIMENTAL CONDITIONS; EXTRACELLULAR; INDUSTRIAL ENVIRONMENTS; METABOLIC FLUX ANALYSIS; P. PASTORIS; PICHIA PASTORIS; POSSIBILISTIC; PROTEIN ESTIMATION; PROTEIN PRODUCTION; RECOMBINANT PROTEIN PRODUCTIONS; ROBUST PARAMETERS; STRUCTURED MODEL; UNCERTAINTY;

BIOMASS; ENZYME ACTIVITY; ESTIMATION; FORECASTING; METABOLISM; PRODUCTIVITY; RECOMBINANT PROTEINS; UNCERTAINTY ANALYSIS; YEAST;

ECOLOGY;

EID: 84862219473     PISSN: 09591524     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jprocont.2012.03.009     Document Type: Article

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