Optimization of cell density and dilution rate in Pichia pastoris continuous fermentations for production of recombinant proteins

Journal of Industrial Microbiology and Biotechnology

Volumn 31, Issue 7, 2004, Pages 330-334

  Zhang, Wenhui ^a,c   Liu, Chih Ping ^b   Inan, Mehmet ^a   Meagher, Michael M ^a  

^a UNIVERSITY OF NEBRASKA LINCOLN   (United States)

^b Pepgen Corporation   (United States)

^c XOMA   (United States)

Author keywords

Continuous fermentation; Interferon ; Model; Optimization; Pichia pastoris; Response surface methodology

Indexed keywords

METHANOL;

ARTICLE; CALCULATION; CELL DENSITY; CHEMOSTAT; CONTINUOUS FERMENTATION; DILUTION; FED BATCH FERMENTATION; GROWTH RATE; MOLECULAR MODEL; NONHUMAN; PICHIA PASTORIS; PREDICTION; PROTEIN SYNTHESIS; RESPONSE SURFACE METHOD; WETTABILITY;

BIOMASS; BIOREACTORS; BIOTECHNOLOGY; CULTURE MEDIA; FEEDBACK; FERMENTATION; INDUSTRIAL MICROBIOLOGY; INTERFERON TYPE I; MATHEMATICS; METHANOL; PICHIA; PREGNANCY PROTEINS; RECOMBINANT PROTEINS;

PICHIA; PICHIA PASTORIS;

EID: 4544331237     PISSN: 13675435     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10295-004-0155-4     Document Type: Article

References (9)

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